KR20150131213A - 인슐린-인크레틴 접합체들 - Google Patents
인슐린-인크레틴 접합체들 Download PDFInfo
- Publication number
- KR20150131213A KR20150131213A KR1020157028780A KR20157028780A KR20150131213A KR 20150131213 A KR20150131213 A KR 20150131213A KR 1020157028780 A KR1020157028780 A KR 1020157028780A KR 20157028780 A KR20157028780 A KR 20157028780A KR 20150131213 A KR20150131213 A KR 20150131213A
- Authority
- KR
- South Korea
- Prior art keywords
- amino acid
- seq
- glucagon
- peptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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| US61/783,491 | 2013-03-14 | ||
| PCT/US2014/020801 WO2014158900A1 (en) | 2013-03-14 | 2014-03-05 | Insulin-incretin conjugates |
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| KR20150131213A true KR20150131213A (ko) | 2015-11-24 |
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| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| US20160024169A1 (en) | 2013-03-14 | 2016-01-28 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
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| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
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| EP3576748B1 (en) * | 2017-02-03 | 2023-04-05 | Vanderbilt University | Systems, compositions and methods for treating diabetes |
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| CN111132996A (zh) | 2017-07-28 | 2020-05-08 | 普林斯顿大学理事会 | 用于重组蛋白表达的融合标签 |
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-
2014
- 2014-03-05 US US14/774,357 patent/US20160024169A1/en not_active Abandoned
- 2014-03-05 AU AU2014241743A patent/AU2014241743B2/en not_active Ceased
- 2014-03-05 BR BR112015023071A patent/BR112015023071A2/pt not_active IP Right Cessation
- 2014-03-05 JP JP2016500671A patent/JP6538645B2/ja not_active Expired - Fee Related
- 2014-03-05 CN CN201480027381.0A patent/CN105324397B/zh not_active Expired - Fee Related
- 2014-03-05 EP EP14773636.7A patent/EP2970511B1/en not_active Not-in-force
- 2014-03-05 KR KR1020157028780A patent/KR20150131213A/ko not_active Abandoned
- 2014-03-05 CA CA2904332A patent/CA2904332A1/en not_active Abandoned
- 2014-03-05 WO PCT/US2014/020801 patent/WO2014158900A1/en not_active Ceased
- 2014-03-05 RU RU2015143472A patent/RU2678134C2/ru not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2016512255A (ja) | 2016-04-25 |
| US20160024169A1 (en) | 2016-01-28 |
| AU2014241743A1 (en) | 2015-09-17 |
| EP2970511A4 (en) | 2016-03-23 |
| RU2015143472A (ru) | 2017-04-28 |
| AU2014241743B2 (en) | 2018-07-05 |
| JP6538645B2 (ja) | 2019-07-03 |
| RU2678134C2 (ru) | 2019-01-23 |
| EP2970511A1 (en) | 2016-01-20 |
| CN105324397A (zh) | 2016-02-10 |
| CN105324397B (zh) | 2020-01-14 |
| US20180194827A1 (en) | 2018-07-12 |
| EP2970511B1 (en) | 2020-09-30 |
| WO2014158900A1 (en) | 2014-10-02 |
| BR112015023071A2 (pt) | 2017-07-18 |
| US10696726B2 (en) | 2020-06-30 |
| CA2904332A1 (en) | 2014-10-02 |
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