RU2641293C2 - Бензофуразановые антимилоидные соединения и способы - Google Patents

Бензофуразановые антимилоидные соединения и способы Download PDF

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RU2641293C2
RU2641293C2 RU2015110256A RU2015110256A RU2641293C2 RU 2641293 C2 RU2641293 C2 RU 2641293C2 RU 2015110256 A RU2015110256 A RU 2015110256A RU 2015110256 A RU2015110256 A RU 2015110256A RU 2641293 C2 RU2641293 C2 RU 2641293C2
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Russia
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mmol
etoac
added
reaction mixture
mixture
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RU2015110256A
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English (en)
Russian (ru)
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RU2015110256A (ru
Inventor
Марк А. РИД
Томас К. ВУД
Скотт К. БЭНФИЛД
Кристофер Дж. БАРДЕН
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Тревентис Корпорейшн
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B36/00—Heating, cooling or insulating arrangements for boreholes or wells, e.g. for use in permafrost zones
    • E21B36/001—Cooling arrangements
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B36/00—Heating, cooling or insulating arrangements for boreholes or wells, e.g. for use in permafrost zones
    • E21B36/003—Insulating arrangements
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B36/00—Heating, cooling or insulating arrangements for boreholes or wells, e.g. for use in permafrost zones
    • E21B36/04—Heating, cooling or insulating arrangements for boreholes or wells, e.g. for use in permafrost zones using electrical heaters
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L11/00—Hoses, i.e. flexible pipes
    • F16L11/20—Double-walled hoses
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L53/00—Heating of pipes or pipe systems; Cooling of pipes or pipe systems
    • F16L53/30—Heating of pipes or pipe systems
    • F16L53/35—Ohmic-resistance heating
    • F16L53/38—Ohmic-resistance heating using elongate electric heating elements, e.g. wires or ribbons
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L9/00—Rigid pipes
    • F16L9/18—Double-walled pipes; Multi-channel pipes or pipe assemblies
    • F16L9/19—Multi-channel pipes or pipe assemblies
    • F16L9/20—Pipe assemblies
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02G—INSTALLATION OF ELECTRIC CABLES OR LINES, OR OF COMBINED OPTICAL AND ELECTRIC CABLES OR LINES
    • H02G3/00—Installations of electric cables or lines or protective tubing therefor in or on buildings, equivalent structures or vehicles
    • H02G3/36—Installations of cables or lines in walls, floors or ceilings
    • H02G3/38—Installations of cables or lines in walls, floors or ceilings the cables or lines being installed in preestablished conduits or ducts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mining & Mineral Resources (AREA)
  • Geology (AREA)
  • General Engineering & Computer Science (AREA)
  • Fluid Mechanics (AREA)
  • Environmental & Geological Engineering (AREA)
  • Physics & Mathematics (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Structural Engineering (AREA)
  • Civil Engineering (AREA)
  • Architecture (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Laying Of Electric Cables Or Lines Outside (AREA)
RU2015110256A 2012-08-24 2013-08-22 Бензофуразановые антимилоидные соединения и способы RU2641293C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261693011P 2012-08-24 2012-08-24
US61/693,011 2012-08-24
PCT/US2013/056220 WO2014031873A2 (en) 2012-08-24 2013-08-22 Benzofurazan anti-amyloid compounds and methods

Publications (2)

Publication Number Publication Date
RU2015110256A RU2015110256A (ru) 2016-10-10
RU2641293C2 true RU2641293C2 (ru) 2018-01-17

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RU2015110256A RU2641293C2 (ru) 2012-08-24 2013-08-22 Бензофуразановые антимилоидные соединения и способы

Country Status (14)

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US (2) US9328078B2 (enExample)
EP (1) EP2888252B1 (enExample)
JP (1) JP6219955B2 (enExample)
KR (1) KR102046499B1 (enExample)
CN (1) CN104768949A (enExample)
AU (1) AU2013305663B2 (enExample)
BR (1) BR112015003824B1 (enExample)
CA (1) CA2883221C (enExample)
IL (1) IL237305B (enExample)
MX (1) MX365851B (enExample)
NZ (1) NZ705167A (enExample)
RU (1) RU2641293C2 (enExample)
WO (2) WO2014031873A2 (enExample)
ZA (1) ZA201501161B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3110812T3 (pl) * 2014-02-27 2019-10-31 Treventis Corp Związki antyamyloidowe zawierające benzofurazan
DE102014214687A1 (de) * 2014-07-25 2016-01-28 Contitech Techno-Chemie Gmbh Beheizbarer Schlauch
EP3634950B1 (en) 2017-06-06 2022-03-09 Council of Scientific and Industrial Research Cobalt complexes, process for preparation and use thereof
CN108235475B (zh) * 2017-11-27 2021-01-22 安邦电气股份有限公司 一种便于使用的伴热带
CN108566693B (zh) * 2017-11-27 2020-12-25 安邦电气股份有限公司 一种高效率伴热带
WO2022015859A1 (en) * 2020-07-14 2022-01-20 Washington University Compositions for cancer therapy and imaging

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182905C2 (ru) * 1996-10-18 2002-05-27 Берингер Ингельхайм Фарма Кг Производные оксадиазола
WO2003042208A1 (en) * 2001-11-14 2003-05-22 Merck Patent Gmbh Pyrazole derivatives as psychopharmaceuticals

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971416A (en) * 1974-08-16 1976-07-27 Thermon Manufacturing Company Preinsulated pipe assembly and pipeline
JP2002228081A (ja) * 2001-02-06 2002-08-14 Nitta Moore Co 保温・移送用配管
JP2003328402A (ja) * 2002-05-16 2003-11-19 Sekisui Chem Co Ltd ヒータ挿入ガイド付き管
GB0228410D0 (en) * 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
JP2004244958A (ja) * 2003-02-14 2004-09-02 Sekisui Chem Co Ltd 凍結防止用流水配管
GB0328900D0 (en) * 2003-12-12 2004-01-14 Glaxo Group Ltd Novel compounds
US20050282818A1 (en) * 2004-06-22 2005-12-22 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
GB2423811A (en) * 2005-03-02 2006-09-06 Valpar Ind Ltd Improved Beverage Python
JP2012501344A (ja) * 2008-08-29 2012-01-19 トレヴェンティス コーポレイション アミロイド症を治療する組成物及び方法
EP2651405A2 (en) * 2010-12-14 2013-10-23 Electrophoretics Limited Casein kinase 1 (ck1 ) inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182905C2 (ru) * 1996-10-18 2002-05-27 Берингер Ингельхайм Фарма Кг Производные оксадиазола
WO2003042208A1 (en) * 2001-11-14 2003-05-22 Merck Patent Gmbh Pyrazole derivatives as psychopharmaceuticals

Also Published As

Publication number Publication date
BR112015003824B1 (pt) 2022-10-04
RU2015110256A (ru) 2016-10-10
NZ705167A (en) 2017-12-22
KR20150046263A (ko) 2015-04-29
EP2888252B1 (en) 2017-06-07
JP6219955B2 (ja) 2017-10-25
WO2014031873A2 (en) 2014-02-27
IL237305A0 (en) 2015-04-30
EP2888252A4 (en) 2016-01-06
ZA201501161B (en) 2016-06-29
US20150266838A1 (en) 2015-09-24
AU2013305663A1 (en) 2015-03-05
AU2013305663B2 (en) 2017-11-02
CA2883221A1 (en) 2014-02-27
IL237305B (en) 2018-08-30
EP2888252A2 (en) 2015-07-01
CN104768949A (zh) 2015-07-08
WO2014031873A3 (en) 2014-04-17
JP2015526475A (ja) 2015-09-10
US20160264535A1 (en) 2016-09-15
US9328078B2 (en) 2016-05-03
CA2883221C (en) 2020-01-21
KR102046499B1 (ko) 2019-11-19
MX2015002418A (es) 2015-09-21
WO2014031942A1 (en) 2014-02-27
BR112015003824A2 (pt) 2018-05-29
MX365851B (es) 2019-06-17

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