RU2625882C2 - Сконструированные белки повторов, которые связываются с сывороточным альбумином - Google Patents

Сконструированные белки повторов, которые связываются с сывороточным альбумином Download PDF

Info

Publication number
RU2625882C2
RU2625882C2 RU2013128896A RU2013128896A RU2625882C2 RU 2625882 C2 RU2625882 C2 RU 2625882C2 RU 2013128896 A RU2013128896 A RU 2013128896A RU 2013128896 A RU2013128896 A RU 2013128896A RU 2625882 C2 RU2625882 C2 RU 2625882C2
Authority
RU
Russia
Prior art keywords
amino acid
group
acid residue
residue selected
seq
Prior art date
Application number
RU2013128896A
Other languages
English (en)
Russian (ru)
Other versions
RU2013128896A (ru
Inventor
Даниель ШТАЙНЕР
Ханс Каспар БИНЦ
Мая ГУЛОТТИ-ГЕОРГИЕВА
Фридер В. МЕРЦ
Дуглас ФИЛЛИПС
Иво ЗОНДЕРЕГГЕР
Original Assignee
Молекьюлер Партнерс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Молекьюлер Партнерс Аг filed Critical Молекьюлер Партнерс Аг
Publication of RU2013128896A publication Critical patent/RU2013128896A/ru
Application granted granted Critical
Publication of RU2625882C2 publication Critical patent/RU2625882C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/60Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013128896A 2010-11-26 2011-11-25 Сконструированные белки повторов, которые связываются с сывороточным альбумином RU2625882C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10192711.9 2010-11-26
EP10192711 2010-11-26
PCT/EP2011/071083 WO2012069654A1 (en) 2010-11-26 2011-11-25 Designed repeat proteins binding to serum albumin

Publications (2)

Publication Number Publication Date
RU2013128896A RU2013128896A (ru) 2015-01-10
RU2625882C2 true RU2625882C2 (ru) 2017-07-20

Family

ID=43858162

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2013128896A RU2625882C2 (ru) 2010-11-26 2011-11-25 Сконструированные белки повторов, которые связываются с сывороточным альбумином
RU2013128895A RU2636552C2 (ru) 2010-11-26 2011-11-25 Улучшенные n-терминальные кэппинг модули для сконструированных белков с анкириновым повтором

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2013128895A RU2636552C2 (ru) 2010-11-26 2011-11-25 Улучшенные n-терминальные кэппинг модули для сконструированных белков с анкириновым повтором

Country Status (13)

Country Link
US (5) US9284361B2 (enExample)
EP (3) EP2643349B1 (enExample)
JP (3) JP6105479B2 (enExample)
KR (3) KR101782790B1 (enExample)
CN (3) CN103403024B (enExample)
AU (2) AU2011333666B2 (enExample)
BR (3) BR112013013043A2 (enExample)
CA (2) CA2818969C (enExample)
DK (1) DK2643349T3 (enExample)
ES (2) ES2981441T3 (enExample)
PL (1) PL2643349T3 (enExample)
RU (2) RU2625882C2 (enExample)
WO (2) WO2012069654A1 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
CN103403024B (zh) 2010-11-26 2017-08-11 分子组合公司 设计的锚蛋白重复蛋白的改进的n‑端加帽模块
DK2846836T3 (da) 2012-05-07 2019-11-11 Allergan Inc Fremgangsmåde til behandling af amd hos patienter, der er refraktære overfor anti-vegf-terapi
MX2014015825A (es) * 2012-06-28 2015-08-10 Molecular Partners Ag Proteinas de repeticion de anquirina diseñadas que se unen al factor de crecimiento derivado de plaquetas.
EP2906591A1 (en) * 2012-10-15 2015-08-19 Universität Zürich Bispecific her2 ligands for cancer therapy
WO2020074469A1 (en) 2018-10-08 2020-04-16 Universität Zürich Her2-binding tetrameric polypeptides
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
WO2014131694A1 (en) 2013-02-26 2014-09-04 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
EP3004152B1 (en) 2013-05-31 2020-09-30 Molecular Partners AG Designed ankyrin repeat proteins binding to hepatocyte growth factor
KR20150097304A (ko) 2014-02-18 2015-08-26 삼성전자주식회사 항 EGFR DARPin을 포함하는 EGFR/HER2 이중 특이 항체
JP2017526053A (ja) 2014-07-07 2017-09-07 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドYeda Research And Development Co.Ltd. コンピュータ計算によるタンパク質設計方法
BR112017020986A2 (pt) * 2015-04-02 2018-08-14 Molecular Partners Ag. proteínas de ligação recombinantes e seu uso
EP3515933B9 (en) 2016-09-22 2023-08-16 Molecular Partners AG Recombinant binding proteins and their use
EP3535397B1 (en) 2016-11-01 2022-01-05 Arrowhead Pharmaceuticals, Inc. Alpha-v beta-6 integrin ligands and uses thereof
US11127483B2 (en) 2017-03-07 2021-09-21 Igc Bio, Inc. Computational pipeline for antibody modeling and design
EP3623382A1 (en) 2018-09-14 2020-03-18 Universität Zürich Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct
US11655293B2 (en) 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
CN111886338A (zh) 2018-03-22 2020-11-03 柏林夏瑞蒂医科大学 Crispr相关蛋白反应性t细胞免疫
EP3807401A1 (en) 2018-06-15 2021-04-21 Universität Bern LIGANDS TO LIGHT OR ITS RECEPTOR LTßR FOR USE IN HAEMATOLOGIC MALIGNANCIES
US20220017433A1 (en) 2018-11-21 2022-01-20 Universität Zürich Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction
EP3677911A3 (en) 2019-01-03 2020-07-29 Universität Basel Use of non-agonist ligands for suppression of metastasis
WO2020144378A1 (en) 2019-01-11 2020-07-16 Universitätsspital Basel Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery
US12465640B2 (en) 2019-02-25 2025-11-11 The University Of Chicago Methods and compositions for treating inflammatory and autoimmune conditions with ECM-affinity peptides linked to anti-inflammatory agents
WO2020207771A1 (en) 2019-04-10 2020-10-15 Universität Zürich A method for determining the likelihood of a patient being responsive to cancer immunotherapy
WO2020245171A1 (en) 2019-06-04 2020-12-10 Molecular Partners Ag Designed ankyrin repeat domain with improved stability
US20220242973A1 (en) * 2019-06-04 2022-08-04 Molecular Partners Ag Recombinant fap binding proteins and their use
UY38739A (es) 2019-06-04 2020-12-31 Molecular Partners Ag Proteínas multiespecíficas
US20220332845A1 (en) 2019-09-05 2022-10-20 Genome Biologics Ug Inhibition of mthfd1l for use in hypertrophic heart disease and heart failure
CN114945584A (zh) 2019-12-11 2022-08-26 分子合作伙伴股份公司 重组肽-mhc复合物结合蛋白及其生成和用途
BR112022011456A2 (pt) 2019-12-11 2022-08-23 Molecular Partners Ag Proteínas recombinantes de ligação a complexo de peptídeo-mhc e geração e uso das mesmas
WO2021122813A1 (en) 2019-12-16 2021-06-24 Universität Basel Angiogenesis promoting agents for prevention of metastatic cancer
WO2021176008A1 (en) 2020-03-04 2021-09-10 Cornell University Agents targeting baf155 or brg1 for use in treatment of advanced prostate cancer
WO2021204781A1 (en) 2020-04-06 2021-10-14 Universität Zürich Artc1 ligands for cancer treatment
TW202208404A (zh) 2020-05-06 2022-03-01 瑞士商分子組合公司 新穎錨蛋白重複結合蛋白質及其用途
US20240279290A1 (en) 2020-05-14 2024-08-22 Molecular Partners Ag Multispecific proteins
WO2021229076A1 (en) * 2020-05-14 2021-11-18 Molecular Partners Ag Recombinant cd40 binding proteins and their use
US12146000B2 (en) 2020-05-19 2024-11-19 Boehringer Ingelheim International Gmbh Bispecific and tetravalent CD137 and FAP molecules for the treatment of cancer
WO2021239844A1 (en) 2020-05-27 2021-12-02 Universitätsspital Basel Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia in prediabetes
WO2021239999A1 (en) 2020-05-28 2021-12-02 Universität Zürich Il-12 pd-l1 ligand fusion protein
US11981710B2 (en) * 2020-08-18 2024-05-14 Athebio Ag N-terminal capping modules of ankyrin repeat domains
EP3957649A1 (en) 2020-08-18 2022-02-23 Athebio AG Improved n-terminal capping modules of ankyrin repeat domains
CA3189257A1 (en) 2020-08-18 2022-02-24 Universitat Zurich A cd25-biased anti-il-2 antibody
CN114106194B (zh) * 2020-08-31 2024-01-16 中国科学院天津工业生物技术研究所 一种用于治疗糖尿病和/或肥胖症的融合蛋白
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
US20240108746A1 (en) 2020-12-16 2024-04-04 Molecular Partners Ag Novel slow-release prodrugs
IL303629A (en) 2020-12-16 2023-08-01 Molecular Partners Ag Recombinant cd3 binding proteins and their use
US20240310378A1 (en) 2021-02-11 2024-09-19 Universität Zürich Use of markers found on lymph node metastatic samples for the prognosis of breast cancer
EP4043481A1 (en) 2021-02-15 2022-08-17 Affilogic Compounds and methods for extending half life of biomolecules
CA3211381A1 (en) 2021-03-09 2022-09-15 Matteo Bianchi Novel darpin based multi-specific t-cell engagers
AU2022233791A1 (en) 2021-03-09 2023-09-28 Molecular Partners Ag Novel darpin based cd123 engagers
WO2022190008A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Protease cleavable prodrugs
JP2024508969A (ja) * 2021-03-09 2024-02-28 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規のDARPinに基づくCD33エンゲージャ
WO2022219185A1 (en) 2021-04-16 2022-10-20 Athebio Ag N-terminal capping modules of ankyrin repeat domains
KR20240045260A (ko) 2021-08-05 2024-04-05 이뮤노스 테라퓨틱스 아게 Hla 융합 단백질을 포함하는 복합 치료제
ES3048639T3 (en) 2021-08-05 2025-12-11 Immunos Therapeutics Ag A modified hla-b57 with increased expression levels
WO2023021006A1 (en) 2021-08-16 2023-02-23 Universität Zürich Il-1 targeting agents for treatment of pitiyriasis rubra pilaris
EP4137508A1 (en) 2021-08-17 2023-02-22 Athebio AG Variants of ankyrin repeat domains
WO2023021050A1 (en) 2021-08-17 2023-02-23 Athebio Ag Variants of ankyrin repeat domains
WO2023036849A1 (en) 2021-09-07 2023-03-16 ETH Zürich Identifying and predicting future coronavirus variants
EP4163380A1 (en) 2021-10-08 2023-04-12 ETH Zurich Device and method for manipulation of extracellular vesicles
WO2023110942A1 (en) 2021-12-14 2023-06-22 Charité-Universitätsmedizin Berlin Prevention of impaired fracture healing
CN118354784A (zh) 2021-12-14 2024-07-16 分子合作伙伴股份公司 具有双重结合特异性的经设计的重复结构域及其用途
EP4260907A1 (en) 2022-04-11 2023-10-18 Universität Zürich Agents for treatment of endometriosis and other benign gynecological neoplasms
WO2024002914A1 (en) 2022-06-27 2024-01-04 Charité-Universitätsmedizin Berlin Prediction of, and composition to improve, tendon healing
AU2023317655A1 (en) 2022-08-01 2025-01-23 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2023194628A2 (en) 2022-08-16 2023-10-12 Athebio Ag Variants of ankyrin repeat domains
WO2024037743A1 (en) 2022-08-16 2024-02-22 Athebio Ag Variants of ankyrin repeat domains
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
WO2024064200A2 (en) * 2022-09-20 2024-03-28 The Texas A&M University System Darpin-containing compositions and methods thereof
JP2026500369A (ja) 2022-12-19 2026-01-06 マックス-プランク-ゲゼルシャフト ツール フェルデルンク デル ヴィッセンシャフテン エー.ファウ. 内因性凝縮体を標的とする手段及び方法
CN121002056A (zh) 2023-02-08 2025-11-21 免疫标记治疗股份公司 β2微球蛋白、HLA重链多肽、和CD47–SIRPα抑制剂的融合蛋白
TW202448926A (zh) 2023-02-17 2024-12-16 比利時商艾伯霖克斯公司 結合新生兒fc受體之多肽
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
WO2024251695A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd47 binding proteins and their use
WO2024251742A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd2 binding proteins and their use
WO2025008519A1 (en) 2023-07-05 2025-01-09 Universität Bern Il-1ra blockers for treatment and prevention of sepsis
WO2025021293A1 (en) 2023-07-25 2025-01-30 Universität Zürich Disruption of rbr1 expression in plant cells
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025146490A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Recombinant cd117 binding proteins and their use
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
US20250332297A1 (en) 2024-01-31 2025-10-30 Molecular Partners Ag Dll3-specific binding constructs and their use in radiotherapy
WO2025202503A1 (en) 2024-03-28 2025-10-02 Universität Zürich Extracellular vesicles carrying cancer specific splice variants

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005087797A1 (en) * 2004-03-09 2005-09-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
RU2299208C2 (ru) * 2001-05-08 2007-05-20 Шеринг Акциенгезельшафт Антраниламидпиридинамиды избирательного действия в качестве ингибиторов vegfr-2 и vegfr-3
WO2008043822A2 (en) * 2006-10-11 2008-04-17 Ablynx N. V. Amino acid sequences that bind to a desired molecule in a conditional manner
WO2009115919A2 (en) * 2008-03-19 2009-09-24 Institut Pasteur Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE151110T1 (de) 1988-09-02 1997-04-15 Protein Eng Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5348867A (en) 1991-11-15 1994-09-20 George Georgiou Expression of proteins on bacterial surface
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
ATE321849T1 (de) 1997-04-23 2006-04-15 Univ Zuerich Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
DK1137812T3 (da) 1998-12-02 2007-05-21 Adnexus Therapeutics Inc DNA-proteinfusioner og anvendelser deraf
EP2180054A1 (en) 1999-12-24 2010-04-28 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20060228364A1 (en) 1999-12-24 2006-10-12 Genentech, Inc. Serum albumin binding peptides for tumor targeting
ATE448301T1 (de) * 2000-09-08 2009-11-15 Univ Zuerich Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
WO2004003019A2 (en) 2002-06-28 2004-01-08 Domantis Limited Immunoglobin single variant antigen-binding domains and dual-specific constructs
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP2284192A3 (en) 2002-11-08 2011-07-20 Ablynx N.V. Camelidae antibodies for sublingual administration
ATE517922T1 (de) 2002-11-08 2011-08-15 Ablynx Nv Stabilisierte einzel-domänen-antikörper in einer pharmazeutischen zusammensetzung ausgestaltet für inhalation
DE05733048T1 (de) 2004-04-06 2007-05-10 Affibody Ab Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung
WO2006040153A2 (en) 2004-10-13 2006-04-20 Ablynx N.V. Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
EP3613767A1 (en) 2005-05-18 2020-02-26 Ablynx N.V. Improved nanobodiestm against tumor cecrosis factor-alpha
JP5042218B2 (ja) 2005-07-08 2012-10-03 ユニバーシティ・オブ・チューリッヒ 融合ポリペプチドの翻訳と同時のトランスロケーションを使用するファージディスプレイ
CA2644712C (en) 2006-03-06 2016-09-13 Amunix, Inc. Unstructured recombinant polymers and uses thereof
CA2663042A1 (en) 2006-09-08 2008-03-13 Ablynx N.V. Serum albumin binding proteins with long half-lives
WO2008043821A1 (en) 2006-10-11 2008-04-17 Ablynx N. V. Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and use thereof
WO2008097497A2 (en) 2007-02-02 2008-08-14 Adnexus, A Bristol-Myers Squibb R & D Company Vegf pathway blockade
CN101970678B (zh) 2007-06-21 2014-08-20 慕尼黑科技大学 具有增加的体内和/或体外稳定性的生物学活性蛋白
CN104710518A (zh) 2007-07-31 2015-06-17 阿菲博迪公司 新白蛋白结合组合物、方法及应用
EP2198022B1 (en) 2007-09-24 2024-03-06 University Of Zurich Designed armadillo repeat proteins
CA2742241C (en) 2008-11-03 2019-12-10 Molecular Partners Ag Binding proteins inhibiting the vegf-a receptor interaction
AR081361A1 (es) * 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
EP2636236A4 (en) * 2010-11-03 2016-06-29 Ericsson Telefon Ab L M RADIO BASE STATION AND METHOD THEREFOR
CN103403024B (zh) 2010-11-26 2017-08-11 分子组合公司 设计的锚蛋白重复蛋白的改进的n‑端加帽模块
EA201391607A1 (ru) 2011-04-29 2014-04-30 Янссен Байотек, Инк. Связывающие il4/il13 белки с повторами и их применение
MX2014015825A (es) 2012-06-28 2015-08-10 Molecular Partners Ag Proteinas de repeticion de anquirina diseñadas que se unen al factor de crecimiento derivado de plaquetas.
EP2738180A1 (en) * 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
BR112017020986A2 (pt) * 2015-04-02 2018-08-14 Molecular Partners Ag. proteínas de ligação recombinantes e seu uso

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2299208C2 (ru) * 2001-05-08 2007-05-20 Шеринг Акциенгезельшафт Антраниламидпиридинамиды избирательного действия в качестве ингибиторов vegfr-2 и vegfr-3
WO2005087797A1 (en) * 2004-03-09 2005-09-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2008043822A2 (en) * 2006-10-11 2008-04-17 Ablynx N. V. Amino acid sequences that bind to a desired molecule in a conditional manner
WO2009115919A2 (en) * 2008-03-19 2009-09-24 Institut Pasteur Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRADLEY C.M. et al, Limits of cooperativity in a structurally modular protein: response of the Notch ankyrin domain to analogous alanine substitutions in each repeat, J. Mol. Biol., 2002, v.324, p.373-386. *
BRADLEY C.M. et al, Limits of cooperativity in a structurally modular protein: response of the Notch ankyrin domain to analogous alanine substitutions in each repeat, J. Mol. Biol., 2002, v.324, p.373-386. INTERLANDI G. et al., Characterization and Further Stabilization of Designed Ankyrin Repeat Proteins by Combining Molecular Dynamics Simulations and Experiments J. Mol. Biol., 2008, v.375, p.837-854. *
INTERLANDI G. et al., Characterization and Further Stabilization of Designed Ankyrin Repeat Proteins by Combining Molecular Dynamics Simulations and Experiments J. Mol. Biol., 2008, v.375, p.837-854. *

Also Published As

Publication number Publication date
EP2643349A1 (en) 2013-10-02
ES2758352T3 (es) 2020-05-05
BR112013012786A2 (pt) 2016-09-13
WO2012069655A3 (en) 2012-07-19
JP2014501509A (ja) 2014-01-23
US20130296221A1 (en) 2013-11-07
US20160250341A1 (en) 2016-09-01
US9775912B2 (en) 2017-10-03
US9221892B2 (en) 2015-12-29
ES2981441T3 (es) 2024-10-08
AU2011333665A1 (en) 2013-06-06
US9717802B2 (en) 2017-08-01
EP2643348B1 (en) 2025-02-12
KR101838037B1 (ko) 2018-03-13
KR101782790B1 (ko) 2017-09-28
EP3514169B1 (en) 2024-03-06
JP6105479B2 (ja) 2017-03-29
KR20170046808A (ko) 2017-05-02
BR112013013043A2 (pt) 2016-09-13
CN113278077A (zh) 2021-08-20
US20130244940A1 (en) 2013-09-19
CN103403024B (zh) 2017-08-11
WO2012069655A2 (en) 2012-05-31
KR20140032356A (ko) 2014-03-14
EP3514169A1 (en) 2019-07-24
EP2643349B1 (en) 2019-09-04
BR112013012786B1 (pt) 2022-02-08
CA2818969C (en) 2020-04-14
CN103459415A (zh) 2013-12-18
CA2818990A1 (en) 2012-05-31
RU2636552C2 (ru) 2017-11-23
AU2011333666B2 (en) 2017-02-02
BR122020011428B1 (pt) 2023-05-16
JP2017048216A (ja) 2017-03-09
KR20140002657A (ko) 2014-01-08
RU2013128895A (ru) 2015-01-10
CN103403024A (zh) 2013-11-20
JP2014501510A (ja) 2014-01-23
US20170313748A1 (en) 2017-11-02
EP2643348A2 (en) 2013-10-02
WO2012069654A1 (en) 2012-05-31
AU2011333665B2 (en) 2016-11-03
US9284361B2 (en) 2016-03-15
CN103459415B (zh) 2021-04-09
JP6173216B2 (ja) 2017-08-02
CA2818969A1 (en) 2012-05-31
DK2643349T3 (da) 2019-11-25
RU2013128896A (ru) 2015-01-10
US20160075767A1 (en) 2016-03-17
US10322190B2 (en) 2019-06-18
AU2011333666A1 (en) 2013-06-06
PL2643349T3 (pl) 2020-03-31
CA2818990C (en) 2021-06-15

Similar Documents

Publication Publication Date Title
RU2625882C2 (ru) Сконструированные белки повторов, которые связываются с сывороточным альбумином
CN1596371A (zh) 新的自组装分子
KR20190013970A (ko) 혈청 알부민 결합 피브로넥틴 iii 형 도메인
JP2022535106A (ja) 改善された安定性を有する設計されたアンキリン反復ドメイン
JP2016027801A (ja) 改良された抗血清アルブミン結合変異体
CN115175691A (zh) 结合血清白蛋白的纤连蛋白iii型结构域及其应用
CN107365361A (zh) 与pd‑l1结合的重复域锚定蛋白及其用途
JP2023507884A (ja) 半減期が延長した薬物およびそのライブラリー、ならびに製造方法と使用
HK40059771A (en) Designed repeat proteins binding to serum albumin
HK40012160A (en) Designed repeat proteins binding to serum albumin
HK40012160B (en) Designed repeat proteins binding to serum albumin
HK1189386B (zh) 设计的与血清白蛋白结合的重复蛋白
WO2025146491A1 (en) Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
HK1189386A (en) Designed repeat proteins binding to serum albumin
HK40081011A (en) Serum albumin-binding fibronectin type iii domains and uses thereof
HK1189387B (en) Improved n-terminal capping modules for designed ankyrin repeat proteins