RU2609006C2 - Способ получения пеметрекседа и его лизиновой соли - Google Patents

Способ получения пеметрекседа и его лизиновой соли Download PDF

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Publication number
RU2609006C2
RU2609006C2 RU2015108042A RU2015108042A RU2609006C2 RU 2609006 C2 RU2609006 C2 RU 2609006C2 RU 2015108042 A RU2015108042 A RU 2015108042A RU 2015108042 A RU2015108042 A RU 2015108042A RU 2609006 C2 RU2609006 C2 RU 2609006C2
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RU
Russia
Prior art keywords
pemetrexed
salt
lysine
acid
water
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RU2015108042A
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English (en)
Russian (ru)
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RU2015108042A (ru
Inventor
Фабрицио Бонаккорси
Федерико КАЛЬВАНИ
Франко ПАСКИ
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Берлин-Хеми Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2015108042A 2012-08-08 2013-08-08 Способ получения пеметрекседа и его лизиновой соли RU2609006C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000398A ITRM20120398A1 (it) 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina.
ITRM2012A000398 2012-08-08
PCT/IB2013/056497 WO2014024164A1 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof

Publications (2)

Publication Number Publication Date
RU2015108042A RU2015108042A (ru) 2016-09-27
RU2609006C2 true RU2609006C2 (ru) 2017-01-30

Family

ID=47018368

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015108042A RU2609006C2 (ru) 2012-08-08 2013-08-08 Способ получения пеметрекседа и его лизиновой соли

Country Status (23)

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EP (1) EP2882753B1 (enExample)
KR (1) KR102288417B1 (enExample)
CN (1) CN104736540B (enExample)
AU (1) AU2013301156B2 (enExample)
BR (1) BR112015002429A8 (enExample)
CY (1) CY1118514T1 (enExample)
DK (1) DK2882753T3 (enExample)
ES (1) ES2607890T3 (enExample)
HR (1) HRP20170011T1 (enExample)
HU (1) HUE032304T2 (enExample)
IN (1) IN2015DN00833A (enExample)
IT (1) ITRM20120398A1 (enExample)
LT (1) LT2882753T (enExample)
MX (1) MX362858B (enExample)
PL (1) PL2882753T3 (enExample)
PT (1) PT2882753T (enExample)
RS (1) RS55515B1 (enExample)
RU (1) RU2609006C2 (enExample)
SI (1) SI2882753T1 (enExample)
SM (2) SMT201600474T1 (enExample)
TW (1) TWI609017B (enExample)
WO (1) WO2014024164A1 (enExample)
ZA (1) ZA201501549B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107641124A (zh) * 2016-07-22 2018-01-30 上海创诺制药有限公司 一种培美曲塞二酸新晶型及其制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
EP3749317A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
US12246018B2 (en) 2018-02-07 2025-03-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
CN110128427A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞缬氨酸盐
CN110128426B (zh) * 2018-02-09 2021-12-14 鲁南制药集团股份有限公司 培美曲塞谷氨酸盐
CN110128428A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞丙氨酸盐
CN111333658A (zh) * 2020-05-06 2020-06-26 贵州联科中贝制药科技有限公司 一种培美曲塞二钠水合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2127274C1 (ru) * 1992-09-25 1999-03-10 Эли Лилли Энд Компани СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
EP2301909A1 (en) * 2008-05-30 2011-03-30 Shanghai Cdymax Pharmaceuticals Co., Ltd Processes for preparing pemetrexed disodium and its intermediate,4-(4-carbomethoxyphenyl)butanal
EP2409978A2 (en) * 2010-07-22 2012-01-25 Chemi SPA A novel process for the synthesis of pemetrexed disodium salt
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0440795B1 (en) 1988-10-31 1994-10-19 MITSUI TOATSU CHEMICALS, Inc. Process for preparing organic group-substituted sodium aluminum hydride
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
DE19725647A1 (de) 1997-06-18 1998-12-24 Basf Ag Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme
ZA987550B (en) 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
IL150480A0 (en) 2000-02-25 2002-12-01 Lilly Co Eli A NOVEL-CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4, 7-DIHYDRO-4-OXO-3H-PYRROLO[2, 3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR
JP2008543973A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセドの中間体の調製方法
JP2008543975A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法
US9655898B2 (en) 2010-07-28 2017-05-23 Eagle Pharmaceuticals, Inc. Pharmaceutical compositions containing pemetrexed having extended storage stability

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2127274C1 (ru) * 1992-09-25 1999-03-10 Эли Лилли Энд Компани СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
EP2301909A1 (en) * 2008-05-30 2011-03-30 Shanghai Cdymax Pharmaceuticals Co., Ltd Processes for preparing pemetrexed disodium and its intermediate,4-(4-carbomethoxyphenyl)butanal
EP2409978A2 (en) * 2010-07-22 2012-01-25 Chemi SPA A novel process for the synthesis of pemetrexed disodium salt
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed

Also Published As

Publication number Publication date
SI2882753T1 (sl) 2017-02-28
BR112015002429A2 (pt) 2017-07-04
CN104736540A (zh) 2015-06-24
PT2882753T (pt) 2016-12-27
IN2015DN00833A (enExample) 2015-06-12
HK1209426A1 (en) 2016-04-01
ES2607890T3 (es) 2017-04-04
EP2882753A1 (en) 2015-06-17
PL2882753T3 (pl) 2017-04-28
AU2013301156B2 (en) 2017-08-31
SMT201600474T1 (it) 2017-03-08
WO2014024164A1 (en) 2014-02-13
RS55515B1 (sr) 2017-05-31
MX362858B (es) 2019-02-20
EP2882753B1 (en) 2016-10-05
HUE032304T2 (en) 2017-09-28
RU2015108042A (ru) 2016-09-27
BR112015002429A8 (pt) 2019-07-30
TW201412741A (zh) 2014-04-01
KR102288417B1 (ko) 2021-08-11
LT2882753T (lt) 2016-12-12
TWI609017B (zh) 2017-12-21
KR20150045458A (ko) 2015-04-28
CN104736540B (zh) 2017-08-25
SMT201600474B (it) 2017-03-08
DK2882753T3 (en) 2017-01-16
HRP20170011T1 (hr) 2017-03-10
MX2015001712A (es) 2015-08-14
CY1118514T1 (el) 2017-07-12
ITRM20120398A1 (it) 2014-02-09
ZA201501549B (en) 2016-01-27
AU2013301156A1 (en) 2015-02-05

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