HRP20170011T1 - Postupak za izradu pemetrekseda i njegove lizinske soli - Google Patents
Postupak za izradu pemetrekseda i njegove lizinske soli Download PDFInfo
- Publication number
- HRP20170011T1 HRP20170011T1 HRP20170011TT HRP20170011T HRP20170011T1 HR P20170011 T1 HRP20170011 T1 HR P20170011T1 HR P20170011T T HRP20170011T T HR P20170011TT HR P20170011 T HRP20170011 T HR P20170011T HR P20170011 T1 HRP20170011 T1 HR P20170011T1
- Authority
- HR
- Croatia
- Prior art keywords
- pemetrexed
- lysine
- salt
- acid
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000398A ITRM20120398A1 (it) | 2012-08-08 | 2012-08-08 | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| PCT/IB2013/056497 WO2014024164A1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
| EP13777144.0A EP2882753B1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170011T1 true HRP20170011T1 (hr) | 2017-03-10 |
Family
ID=47018368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170011TT HRP20170011T1 (hr) | 2012-08-08 | 2013-08-08 | Postupak za izradu pemetrekseda i njegove lizinske soli |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP2882753B1 (enExample) |
| KR (1) | KR102288417B1 (enExample) |
| CN (1) | CN104736540B (enExample) |
| AU (1) | AU2013301156B2 (enExample) |
| BR (1) | BR112015002429A8 (enExample) |
| CY (1) | CY1118514T1 (enExample) |
| DK (1) | DK2882753T3 (enExample) |
| ES (1) | ES2607890T3 (enExample) |
| HR (1) | HRP20170011T1 (enExample) |
| HU (1) | HUE032304T2 (enExample) |
| IN (1) | IN2015DN00833A (enExample) |
| IT (1) | ITRM20120398A1 (enExample) |
| LT (1) | LT2882753T (enExample) |
| MX (1) | MX362858B (enExample) |
| PL (1) | PL2882753T3 (enExample) |
| PT (1) | PT2882753T (enExample) |
| RS (1) | RS55515B1 (enExample) |
| RU (1) | RU2609006C2 (enExample) |
| SI (1) | SI2882753T1 (enExample) |
| SM (2) | SMT201600474T1 (enExample) |
| TW (1) | TWI609017B (enExample) |
| WO (1) | WO2014024164A1 (enExample) |
| ZA (1) | ZA201501549B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107641124A (zh) * | 2016-07-22 | 2018-01-30 | 上海创诺制药有限公司 | 一种培美曲塞二酸新晶型及其制备方法 |
| CN109836425B (zh) * | 2017-11-24 | 2023-01-24 | 江苏创诺制药有限公司 | 一种合成培美酸的制备工艺 |
| WO2019157138A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pemetrexed and uses thereof |
| CN111954530A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | γ聚谷氨酸化培美曲塞及其用途 |
| CN110128428A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞丙氨酸盐 |
| CN110128426B (zh) * | 2018-02-09 | 2021-12-14 | 鲁南制药集团股份有限公司 | 培美曲塞谷氨酸盐 |
| CN110128427A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞缬氨酸盐 |
| CN111333658A (zh) * | 2020-05-06 | 2020-06-26 | 贵州联科中贝制药科技有限公司 | 一种培美曲塞二钠水合物的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112991A (en) | 1988-10-31 | 1992-05-12 | Mitsui Toatsu Chemicals Incorporated | Process for the preparation of an organo-substituted sodium aluminum hydride |
| KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| US5416211A (en) | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| CZ283281B6 (cs) * | 1992-09-25 | 1998-02-18 | Eli Lilly And Company | Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů |
| DE19725647A1 (de) | 1997-06-18 | 1998-12-24 | Basf Ag | Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme |
| ZA987550B (en) | 1997-09-26 | 2000-02-21 | Lilly Co Eli | Processes and intermediates useful to make antifolates. |
| HU229704B1 (en) | 2000-02-25 | 2014-05-28 | Lilly Co Eli | A novel crystalline form of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process for its preparation |
| KR20090052355A (ko) * | 2006-08-14 | 2009-05-25 | 시코르, 인크. | 순도가 높은 페메트렉세드 이산 및 이의 제조 방법 |
| JP2008543973A (ja) * | 2006-08-14 | 2008-12-04 | シコール インコーポレイティド | ペメトレキセドの中間体の調製方法 |
| CN101591247B (zh) * | 2008-05-30 | 2012-09-05 | 上海希迪制药有限公司 | 合成4-(4-甲酯基苯基)丁醛的方法 |
| IT1401677B1 (it) * | 2010-07-22 | 2013-08-02 | Chemi Spa | Nuovo processo per la sintesi di pemetrexed sale disodico |
| JP2013540104A (ja) | 2010-07-28 | 2013-10-31 | イーグル・ファーマシューティカルズ・インコーポレーテッド | 延長された保存安定性を有するペメトレキセドを含有する医薬組成物 |
| WO2012056285A1 (en) * | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
-
2012
- 2012-08-08 IT IT000398A patent/ITRM20120398A1/it unknown
-
2013
- 2013-08-06 TW TW102128058A patent/TWI609017B/zh active
- 2013-08-08 AU AU2013301156A patent/AU2013301156B2/en active Active
- 2013-08-08 HU HUE13777144A patent/HUE032304T2/en unknown
- 2013-08-08 PT PT137771440T patent/PT2882753T/pt unknown
- 2013-08-08 LT LTEP13777144.0T patent/LT2882753T/lt unknown
- 2013-08-08 SM SM20160474T patent/SMT201600474T1/it unknown
- 2013-08-08 HR HRP20170011TT patent/HRP20170011T1/hr unknown
- 2013-08-08 WO PCT/IB2013/056497 patent/WO2014024164A1/en not_active Ceased
- 2013-08-08 IN IN833DEN2015 patent/IN2015DN00833A/en unknown
- 2013-08-08 KR KR1020157005932A patent/KR102288417B1/ko active Active
- 2013-08-08 ES ES13777144.0T patent/ES2607890T3/es active Active
- 2013-08-08 CN CN201380041935.8A patent/CN104736540B/zh active Active
- 2013-08-08 MX MX2015001712A patent/MX362858B/es active IP Right Grant
- 2013-08-08 RU RU2015108042A patent/RU2609006C2/ru active
- 2013-08-08 RS RS20161202A patent/RS55515B1/sr unknown
- 2013-08-08 BR BR112015002429A patent/BR112015002429A8/pt not_active Application Discontinuation
- 2013-08-08 PL PL13777144T patent/PL2882753T3/pl unknown
- 2013-08-08 SI SI201330427A patent/SI2882753T1/sl unknown
- 2013-08-08 DK DK13777144.0T patent/DK2882753T3/en active
- 2013-08-08 EP EP13777144.0A patent/EP2882753B1/en active Active
-
2015
- 2015-03-06 ZA ZA2015/01549A patent/ZA201501549B/en unknown
-
2016
- 2016-12-28 CY CY20161101351T patent/CY1118514T1/el unknown
- 2016-12-28 SM SM201600474T patent/SMT201600474B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2609006C2 (ru) | 2017-01-30 |
| CY1118514T1 (el) | 2017-07-12 |
| HK1209426A1 (en) | 2016-04-01 |
| ZA201501549B (en) | 2016-01-27 |
| WO2014024164A1 (en) | 2014-02-13 |
| TWI609017B (zh) | 2017-12-21 |
| CN104736540B (zh) | 2017-08-25 |
| EP2882753A1 (en) | 2015-06-17 |
| RU2015108042A (ru) | 2016-09-27 |
| KR20150045458A (ko) | 2015-04-28 |
| KR102288417B1 (ko) | 2021-08-11 |
| CN104736540A (zh) | 2015-06-24 |
| AU2013301156A1 (en) | 2015-02-05 |
| IN2015DN00833A (enExample) | 2015-06-12 |
| AU2013301156B2 (en) | 2017-08-31 |
| ITRM20120398A1 (it) | 2014-02-09 |
| MX2015001712A (es) | 2015-08-14 |
| BR112015002429A8 (pt) | 2019-07-30 |
| HUE032304T2 (en) | 2017-09-28 |
| SMT201600474T1 (it) | 2017-03-08 |
| EP2882753B1 (en) | 2016-10-05 |
| DK2882753T3 (en) | 2017-01-16 |
| PT2882753T (pt) | 2016-12-27 |
| TW201412741A (zh) | 2014-04-01 |
| RS55515B1 (sr) | 2017-05-31 |
| SMT201600474B (it) | 2017-03-08 |
| MX362858B (es) | 2019-02-20 |
| BR112015002429A2 (pt) | 2017-07-04 |
| PL2882753T3 (pl) | 2017-04-28 |
| ES2607890T3 (es) | 2017-04-04 |
| LT2882753T (lt) | 2016-12-12 |
| SI2882753T1 (sl) | 2017-02-28 |
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