RU2607595C2 - Составы разагилина с пролонгированным высвобождением и их применение - Google Patents

Составы разагилина с пролонгированным высвобождением и их применение Download PDF

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Publication number
RU2607595C2
RU2607595C2 RU2012136723A RU2012136723A RU2607595C2 RU 2607595 C2 RU2607595 C2 RU 2607595C2 RU 2012136723 A RU2012136723 A RU 2012136723A RU 2012136723 A RU2012136723 A RU 2012136723A RU 2607595 C2 RU2607595 C2 RU 2607595C2
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Russia
Prior art keywords
salt
coating
active agent
disease
rasagiline
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RU2012136723A
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English (en)
Russian (ru)
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RU2012136723A (ru
Inventor
Йорам СЕЛА
Нурит ЛИВНАХ
Ицхак ЛАМЕНСДОРФ
Томер МАДМОН
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Фарма Ту Б Лтд.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2012136723A 2010-02-03 2011-02-03 Составы разагилина с пролонгированным высвобождением и их применение RU2607595C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30101910P 2010-02-03 2010-02-03
US61/301,019 2010-02-03
PCT/IL2011/000126 WO2011095973A1 (en) 2010-02-03 2011-02-03 Extended release formulations of rasagiline and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2016141314A Division RU2734632C2 (ru) 2010-02-03 2011-02-03 Составы разагилина с пролонгированным высвобождением и их применение

Publications (2)

Publication Number Publication Date
RU2012136723A RU2012136723A (ru) 2014-03-10
RU2607595C2 true RU2607595C2 (ru) 2017-01-10

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RU2012136723A RU2607595C2 (ru) 2010-02-03 2011-02-03 Составы разагилина с пролонгированным высвобождением и их применение
RU2016141314A RU2734632C2 (ru) 2010-02-03 2011-02-03 Составы разагилина с пролонгированным высвобождением и их применение

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JP (3) JP6045347B2 (enExample)
KR (1) KR101791715B1 (enExample)
CN (1) CN102791258B (enExample)
AU (1) AU2011212068B2 (enExample)
BR (1) BR112012019374B1 (enExample)
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RS (1) RS58988B1 (enExample)
RU (2) RU2607595C2 (enExample)
SG (1) SG183150A1 (enExample)
TR (1) TR201909277T4 (enExample)
WO (1) WO2011095973A1 (enExample)
ZA (1) ZA201206462B (enExample)

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CN103316026B (zh) 2012-03-23 2016-05-11 中国人民解放军军事医学科学院毒物药物研究所 含芬特明和托吡酯的联合产品及其制备方法
WO2014028868A1 (en) * 2012-08-17 2014-02-20 Teva Pharmaceutical Industries Ltd. Parenteral formulation of rasagiline
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US20150275167A1 (en) * 2014-03-28 2015-10-01 Corning Incorporated Composition and method for cell culture sustained release
US10709700B2 (en) * 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
CA3064006C (en) * 2017-05-19 2025-09-16 Biscayne Neurotherapeutics Inc Modified release pharmaceutical compositions of huperzine and methods of using the same
CN107049985B (zh) * 2017-06-07 2020-06-19 广州帝奇医药技术有限公司 一种抗帕金森病药物的长效缓释制剂及其制备方法
KR20210005662A (ko) * 2018-04-25 2021-01-14 뉴로센트리아, 인크. 마그네슘 트레오네이트 조성물 및 이의 용도
KR20220015437A (ko) * 2019-05-31 2022-02-08 데날리 테라퓨틱스 인크. 피리미디닐아미노-피라졸 화합물의 변형 방출 제제, 및 치료 방법
KR20210014289A (ko) 2019-07-30 2021-02-09 (주)비씨월드제약 라사길린을 함유하는 서방출성 미립구의 제조방법
AR121619A1 (es) * 2020-03-25 2022-06-22 Inibsa Ginecologia S A Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación
EP4337176B1 (en) * 2021-05-11 2025-07-16 Advicenne Prolonged-release pharmaceutical composition for oral administration of sultiame
CN118680910B (zh) * 2024-08-26 2024-12-03 山东齐都药业有限公司 用于缓释递送雷沙吉兰甲磺酸盐的药物组合物及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
US4415547A (en) * 1982-06-14 1983-11-15 Sterling Drug Inc. Sustained-release pharmaceutical tablet and process for preparation thereof
RU2001614C1 (ru) * 1990-01-03 1993-10-30 Тева Фармасьютикал Индастриз Лтд. (Il) R (+)-N-Пропаргил-1-аминоиндан и его фармацевтически пригодные кислотно-аддитивные соли и фармацевтическа композици , обладающа ингибирующей B-форму фермента моноаминооксидазы активностью
RU2176912C2 (ru) * 1996-03-25 2001-12-20 Американ Хоум Продактс Корпорейшн Композиции длительного высвобождения венлафаксин гидрохлорида, композиция пленочного покрытия, способ обеспечения терапевтически активной концентрации венлафаксина и способ исключения нулевых и пиковых концентраций лекарственного средства
WO2004045515A2 (en) * 2002-11-15 2004-06-03 Teva Pharmaceutical Industries, Ltd. Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis
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WO2009151594A1 (en) * 2008-06-10 2009-12-17 Teva Pharmaceutical Industries, Ltd. Rasagiline soft gelatin capsules

Also Published As

Publication number Publication date
KR101791715B1 (ko) 2017-10-30
EP3517103A1 (en) 2019-07-31
CA2789006C (en) 2018-11-27
US20120301542A1 (en) 2012-11-29
CL2012002175A1 (es) 2013-01-11
ES2733133T3 (es) 2019-11-27
KR20120130292A (ko) 2012-11-30
SG183150A1 (en) 2012-09-27
ZA201206462B (en) 2014-02-26
MX354423B (es) 2018-03-02
NZ602111A (en) 2014-10-31
JP2019048855A (ja) 2019-03-28
JP6440662B2 (ja) 2018-12-19
BR112012019374A2 (pt) 2016-05-03
AU2011212068B2 (en) 2016-08-18
RU2016141314A3 (enExample) 2019-12-20
RU2734632C2 (ru) 2020-10-21
JP2017031189A (ja) 2017-02-09
TR201909277T4 (tr) 2019-07-22
BR112012019374B1 (pt) 2022-01-11
PT2531181T (pt) 2019-07-17
CY1121781T1 (el) 2020-07-31
IL221274A (en) 2017-05-29
JP6770564B2 (ja) 2020-10-14
RU2016141314A (ru) 2018-12-14
JP2013518870A (ja) 2013-05-23
IL221274A0 (en) 2012-10-31
EP2531181A1 (en) 2012-12-12
JP6045347B2 (ja) 2016-12-14
CN102791258A (zh) 2012-11-21
HUE044221T2 (hu) 2019-10-28
US9943489B2 (en) 2018-04-17
AU2011212068A1 (en) 2012-09-20
RS58988B1 (sr) 2019-08-30
CA2789006A1 (en) 2011-08-11
MX2012009079A (es) 2012-12-17
DK2531181T3 (da) 2019-07-15
WO2011095973A1 (en) 2011-08-11
RU2012136723A (ru) 2014-03-10
CN102791258B (zh) 2018-05-08
EP2531181B1 (en) 2019-04-10
PL2531181T3 (pl) 2019-09-30
LT2531181T (lt) 2019-07-10

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