SG183150A1 - Extended release formulations of rasagiline and uses thereof - Google Patents
Extended release formulations of rasagiline and uses thereof Download PDFInfo
- Publication number
- SG183150A1 SG183150A1 SG2012057493A SG2012057493A SG183150A1 SG 183150 A1 SG183150 A1 SG 183150A1 SG 2012057493 A SG2012057493 A SG 2012057493A SG 2012057493 A SG2012057493 A SG 2012057493A SG 183150 A1 SG183150 A1 SG 183150A1
- Authority
- SG
- Singapore
- Prior art keywords
- aminoindan
- propargylamine
- release
- propargyl
- methyl
- Prior art date
Links
- 238000013265 extended release Methods 0.000 title claims abstract description 182
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 title claims abstract description 98
- 229960000245 rasagiline Drugs 0.000 title claims abstract description 90
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 238000009472 formulation Methods 0.000 title claims description 25
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- 208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 18
- RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 claims abstract description 13
- 210000000653 nervous system Anatomy 0.000 claims abstract description 13
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- XJEVHMGJSYVQBQ-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-amine Chemical group C1=CC=C2C(N)CCC2=C1 XJEVHMGJSYVQBQ-UHFFFAOYSA-N 0.000 claims description 43
- JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical group NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 claims description 40
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- 238000013268 sustained release Methods 0.000 claims description 31
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- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 3
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
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| US9943489B2 (en) * | 2010-02-03 | 2018-04-17 | Pharmatwob Ltd. | Extended release formulations of rasagiline and uses thereof |
| CA2758556A1 (en) * | 2011-11-17 | 2013-05-17 | Pharmascience Inc. | Pharmaceutical composition of amphetamine mixed salts |
| CA2860952C (en) * | 2012-01-12 | 2020-09-15 | Pharma Two B Ltd. | Fixed dose combination therapy of parkinson's disease |
| US9504657B2 (en) * | 2012-01-12 | 2016-11-29 | Pharmatwob Ltd. | Fixed dose combination therapy of Parkinson's disease |
| CN103316026B (zh) | 2012-03-23 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 含芬特明和托吡酯的联合产品及其制备方法 |
| CN102579367B (zh) * | 2012-03-23 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 托吡酯缓释药物组合物、其制备方法及用途 |
| WO2013139292A1 (zh) | 2012-03-23 | 2013-09-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种含辛弗林和托吡酯的联合产品 |
| JP2015529196A (ja) * | 2012-08-17 | 2015-10-05 | テバ ファーマシューティカル インダストリーズ リミティド | ラサギリンの非経口製剤 |
| IN2013MU01782A (enExample) * | 2013-05-20 | 2015-06-26 | Cadila Healthcare Ltd | |
| US20150275167A1 (en) * | 2014-03-28 | 2015-10-01 | Corning Incorporated | Composition and method for cell culture sustained release |
| KR20250069686A (ko) * | 2014-09-15 | 2025-05-19 | 제브라 덴마크 에이/에스 | 아리모클로몰 제제 |
| AU2018270505B2 (en) | 2017-05-19 | 2023-09-21 | Biscayne Neurotherapeutics, Inc. | Modified release pharmaceutical compositions of huperzine and methods of using the same |
| CN107049985B (zh) * | 2017-06-07 | 2020-06-19 | 广州帝奇医药技术有限公司 | 一种抗帕金森病药物的长效缓释制剂及其制备方法 |
| KR20210005662A (ko) * | 2018-04-25 | 2021-01-14 | 뉴로센트리아, 인크. | 마그네슘 트레오네이트 조성물 및 이의 용도 |
| ES3031676T3 (en) | 2018-11-19 | 2025-07-10 | Supernus Pharmaceuticals Inc | Use of higher doses of modified release huperzine formulations |
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