RU2523900C2 - Средство для чистки зубов, содержащее фторид двухвалентного олова и цитрат цинка и небольшие количества воды - Google Patents
Средство для чистки зубов, содержащее фторид двухвалентного олова и цитрат цинка и небольшие количества воды Download PDFInfo
- Publication number
- RU2523900C2 RU2523900C2 RU2012122014/15A RU2012122014A RU2523900C2 RU 2523900 C2 RU2523900 C2 RU 2523900C2 RU 2012122014/15 A RU2012122014/15 A RU 2012122014/15A RU 2012122014 A RU2012122014 A RU 2012122014A RU 2523900 C2 RU2523900 C2 RU 2523900C2
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- RU
- Russia
- Prior art keywords
- composition
- ions
- source
- polyphosphate
- divalent tin
- Prior art date
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 66
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 title claims abstract description 44
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title claims description 18
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 title claims description 10
- 239000011746 zinc citrate Substances 0.000 title claims description 10
- 235000006076 zinc citrate Nutrition 0.000 title claims description 10
- 229940068475 zinc citrate Drugs 0.000 title claims description 10
- 238000004140 cleaning Methods 0.000 title abstract description 8
- 238000002360 preparation method Methods 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 316
- 229920000388 Polyphosphate Polymers 0.000 claims abstract description 69
- 239000001205 polyphosphate Substances 0.000 claims abstract description 69
- 235000011176 polyphosphates Nutrition 0.000 claims abstract description 69
- -1 fluorine ions Chemical class 0.000 claims abstract description 61
- 229910052718 tin Inorganic materials 0.000 claims abstract description 38
- 229910001432 tin ion Inorganic materials 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 23
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000007853 buffer solution Substances 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 239000011737 fluorine Substances 0.000 claims abstract description 15
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 230000009920 chelation Effects 0.000 claims abstract 2
- 239000000551 dentifrice Substances 0.000 claims description 96
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 239000002562 thickening agent Substances 0.000 claims description 28
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 20
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 19
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 19
- 229910052783 alkali metal Inorganic materials 0.000 claims description 17
- 230000001680 brushing effect Effects 0.000 claims description 17
- 150000002500 ions Chemical class 0.000 claims description 16
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 15
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 15
- 229920005989 resin Polymers 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 9
- 235000011180 diphosphates Nutrition 0.000 claims description 8
- 150000007524 organic acids Chemical class 0.000 claims description 8
- 125000004437 phosphorous atom Chemical group 0.000 claims description 7
- 239000012062 aqueous buffer Substances 0.000 claims description 6
- 239000013522 chelant Substances 0.000 claims description 6
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 claims description 6
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 5
- 229940038773 trisodium citrate Drugs 0.000 claims description 5
- 150000003751 zinc Chemical class 0.000 claims description 3
- 239000011135 tin Substances 0.000 abstract description 32
- 239000004480 active ingredient Substances 0.000 abstract description 13
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 12
- 239000011701 zinc Substances 0.000 abstract description 12
- 229910052725 zinc Inorganic materials 0.000 abstract description 12
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 30
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 27
- 239000012071 phase Substances 0.000 description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 21
- 229940091249 fluoride supplement Drugs 0.000 description 19
- 239000000463 material Substances 0.000 description 18
- 229910021645 metal ion Inorganic materials 0.000 description 15
- 210000000214 mouth Anatomy 0.000 description 15
- 239000000080 wetting agent Substances 0.000 description 14
- 239000000377 silicon dioxide Substances 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 11
- 239000000606 toothpaste Substances 0.000 description 11
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- 239000003082 abrasive agent Substances 0.000 description 10
- 239000004599 antimicrobial Substances 0.000 description 10
- 150000002978 peroxides Chemical class 0.000 description 10
- 238000003860 storage Methods 0.000 description 10
- 208000006558 Dental Calculus Diseases 0.000 description 9
- 239000006172 buffering agent Substances 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 9
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- 235000010418 carrageenan Nutrition 0.000 description 8
- 229920001525 carrageenan Polymers 0.000 description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- 230000008719 thickening Effects 0.000 description 8
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- 150000004676 glycans Chemical class 0.000 description 7
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- 239000000047 product Substances 0.000 description 7
- 230000000750 progressive effect Effects 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
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- 229910019142 PO4 Inorganic materials 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- 239000002280 amphoteric surfactant Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 5
- 230000036571 hydration Effects 0.000 description 5
- 238000006703 hydration reaction Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- 229920001983 poloxamer Polymers 0.000 description 5
- 238000000518 rheometry Methods 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 4
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000003975 dentin desensitizing agent Substances 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 description 4
- 235000013824 polyphenols Nutrition 0.000 description 4
- 229940048084 pyrophosphate Drugs 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 235000015424 sodium Nutrition 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000011775 sodium fluoride Substances 0.000 description 4
- 235000013024 sodium fluoride Nutrition 0.000 description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 150000003606 tin compounds Chemical class 0.000 description 4
- 206010006326 Breath odour Diseases 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 229920000161 Locust bean gum Polymers 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
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- 125000000129 anionic group Chemical group 0.000 description 3
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- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
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- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 2
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- 244000131522 Citrus pyriformis Species 0.000 description 2
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/062452 WO2011053291A1 (en) | 2009-10-29 | 2009-10-29 | Dentifrice comprising stannous fluoride plus zinc citrate and low levels of water |
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| RU2012122014A RU2012122014A (ru) | 2013-12-10 |
| RU2523900C2 true RU2523900C2 (ru) | 2014-07-27 |
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| RU2012122014/15A RU2523900C2 (ru) | 2009-10-29 | 2009-10-29 | Средство для чистки зубов, содержащее фторид двухвалентного олова и цитрат цинка и небольшие количества воды |
Country Status (16)
Cited By (8)
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| RU2699370C2 (ru) * | 2014-12-26 | 2019-09-05 | Колгейт-Палмолив Компани | Композиции в виде средства для чистки зубов с низким содержанием воды |
| RU2702092C2 (ru) * | 2016-06-24 | 2019-10-04 | Колгейт-Палмолив Компани, Сша | Композиции для ухода за полостью рта и способы их применения |
| RU2703563C2 (ru) * | 2016-06-24 | 2019-10-21 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
| RU2704312C2 (ru) * | 2015-05-01 | 2019-10-28 | Колгейт-Палмолив Компани | Композиции в виде средства для чистки зубов с низким содержанием воды |
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| RU2727658C1 (ru) * | 2016-12-21 | 2020-07-22 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
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| RU2706737C2 (ru) * | 2014-12-18 | 2019-11-20 | Габа Интернешнл Холдинг Гмбх | Составы ополаскивателей для рта |
| RU2699370C2 (ru) * | 2014-12-26 | 2019-09-05 | Колгейт-Палмолив Компани | Композиции в виде средства для чистки зубов с низким содержанием воды |
| RU2704312C2 (ru) * | 2015-05-01 | 2019-10-28 | Колгейт-Палмолив Компани | Композиции в виде средства для чистки зубов с низким содержанием воды |
| RU2702092C2 (ru) * | 2016-06-24 | 2019-10-04 | Колгейт-Палмолив Компани, Сша | Композиции для ухода за полостью рта и способы их применения |
| RU2703563C2 (ru) * | 2016-06-24 | 2019-10-21 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
| RU2744896C2 (ru) * | 2016-06-24 | 2021-03-16 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта |
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