JP4919957B2 - 口腔乾燥症用新規組成物 - Google Patents
口腔乾燥症用新規組成物 Download PDFInfo
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- JP4919957B2 JP4919957B2 JP2007524259A JP2007524259A JP4919957B2 JP 4919957 B2 JP4919957 B2 JP 4919957B2 JP 2007524259 A JP2007524259 A JP 2007524259A JP 2007524259 A JP2007524259 A JP 2007524259A JP 4919957 B2 JP4919957 B2 JP 4919957B2
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Confectionery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
口腔乾燥症用に使用するポリマーの最適化のための官能試験を、小規模パネルテストを用いて行った。官能試験結果としては、以下が挙げられる。
口腔乾燥症用に使用するポリマーの最適化のためのさらなる官能試験を、6人のパネリストから成る小規模パネルテストによって行った。
CMC溶液にPVPを加えることで、ポリマー溶液の官能特性が向上した。PVPはCMC溶液の粘着性を顕著に(p=0.01)減少させ、口腔での質感をより滑らかにした。CMC+PVP溶液の口の感触および後味はより心地よいものであった。口はさらに潤った。両方のポリマー溶液は適度に粘着性を有していると知覚された。CMC+PVP溶液は、CMC溶液と比較してより粘性がありゲル状(よりねばねばしている)であると知覚される傾向があった。このことは、溶液の粘度を増すポリマー全体がさらに多く存在するという事実からも説明される。
この小規模パネルテストでは、キサンタン溶液と、キサンタンおよびPVPの混合物との官能特性の間に顕著な差は見られなかった。PVPをキサンタン溶液に加えると、ねばねばした感覚が増すために、溶液の口の感触の心地よさおよび口腔での質感の滑らかさがわずかに減少する傾向があり、これはこの系でポリマー全体が増加したことで説明することができる。しかしながら、PVPを加えると口をコートする能力が高まった。両方のポリマーの溶液は、口を適度に潤し滑らかにすると受け取られた。重要なことに、PVPを加えるとキサンタン溶液の粘着性が減少した。
PVPをキサンタン+CMC溶液に加えると、溶液の口腔での質感の滑らかさが顕著に(p=0.03)向上した。PVPにはキサンタン+CMC溶液の粘着性を減少させ、より心地よい口の感触をもたらし、口を潤し滑らかにする傾向があった。キサンタン+CMC+PVP溶液は、溶液の粘度を増すポリマー全体がさらに多く存在するという事実ゆえに、さらに粘着性を有していると知覚された。
Claims (8)
- ポリビニルピロリドン(PVP)またはそのコポリマー、アニオン性粘膜付着性ポリマーおよび口腔で許容される担体または賦形剤を含む口腔乾燥症の症状を治療するための口腔ケア組成物であって、粘膜付着性ポリマーがカルボキシメチルセルロースナトリウムとキサンタンガムの組み合わせである、前記組成物。
- 該ポリビニルピロリドンのコポリマーがビニルピロリドン/ビニルアセテート(VP/VA)コポリマー、またはビニルピロリドン/ビニルアルコール(VP/VOH)コポリマーである、請求項1記載の組成物。
- PVPまたはVP/VAコポリマーを含む請求項1または2に記載の組成物。
- 該PVPまたはそのコポリマーが0.1〜20重量%の量で存在する、請求項1〜3のいずれか1項に記載の組成物。
- 該アニオン性粘膜付着性ポリマーが0.02〜20重量%の範囲で存在する、請求項1〜4のいずれか1項に記載の組成物。
- 該PVPまたはそのコポリマーと該アニオン性粘膜付着性ポリマーとの比が5:1〜1:1である、請求項1〜5のいずれか1項に記載の組成物。
- 口腔内で潤滑剤として使用するための、請求項1〜6のいずれか1項に記載の組成物。
- 口腔内の水分補給に使用される、請求項1〜7のいずれか1項に記載の組成物。
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GB0417193A GB0417193D0 (en) | 2004-08-02 | 2004-08-02 | Novel compositions |
GB0502077.1 | 2005-02-01 | ||
GB0502077A GB0502077D0 (en) | 2005-02-01 | 2005-02-01 | Novel composition |
PCT/EP2005/008327 WO2006013081A1 (en) | 2004-08-02 | 2005-07-29 | Novel composition for xerostomia |
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US (2) | US9044500B2 (ja) |
EP (2) | EP1793799B1 (ja) |
JP (1) | JP4919957B2 (ja) |
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AU (1) | AU2005268926B2 (ja) |
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ES2344911T3 (es) | 2010-09-09 |
AU2005268926A1 (en) | 2006-02-09 |
DE602005021126D1 (de) | 2010-06-17 |
AU2005268926B2 (en) | 2011-10-13 |
CA2575605C (en) | 2014-05-20 |
ZA200700965B (en) | 2017-09-27 |
US20080317703A1 (en) | 2008-12-25 |
JP2008508338A (ja) | 2008-03-21 |
WO2006013081A1 (en) | 2006-02-09 |
BRPI0514037A (pt) | 2008-05-27 |
US10350238B2 (en) | 2019-07-16 |
BRPI0514037B1 (pt) | 2018-05-22 |
PT1793799E (pt) | 2010-07-29 |
BRPI0514037B8 (pt) | 2021-05-25 |
US9044500B2 (en) | 2015-06-02 |
CA2575605A1 (en) | 2006-02-09 |
US20130295041A1 (en) | 2013-11-07 |
EP2263644A2 (en) | 2010-12-22 |
MX2007001384A (es) | 2007-04-19 |
EP1793799B1 (en) | 2010-05-05 |
GC0001377A (en) | 2011-03-31 |
EP1793799A1 (en) | 2007-06-13 |
ATE466566T1 (de) | 2010-05-15 |
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