RU2522582C2 - Новые противомикробные средства - Google Patents
Новые противомикробные средства Download PDFInfo
- Publication number
- RU2522582C2 RU2522582C2 RU2011124795/04A RU2011124795A RU2522582C2 RU 2522582 C2 RU2522582 C2 RU 2522582C2 RU 2011124795/04 A RU2011124795/04 A RU 2011124795/04A RU 2011124795 A RU2011124795 A RU 2011124795A RU 2522582 C2 RU2522582 C2 RU 2522582C2
- Authority
- RU
- Russia
- Prior art keywords
- heteroaryl
- formula
- compounds
- alkyl
- compound
- Prior art date
Links
- LIWIOZYPTDFUMX-RDJZCZTQSA-N C[C@@H](C(N(CC1)CCN1c(c(F)cc(N(C[C@H](C[n]1nncc1)O1)C1=O)c1)c1F)=O)NC(c1cnccn1)=O Chemical compound C[C@@H](C(N(CC1)CCN1c(c(F)cc(N(C[C@H](C[n]1nncc1)O1)C1=O)c1)c1F)=O)NC(c1cnccn1)=O LIWIOZYPTDFUMX-RDJZCZTQSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2623/DEL/2008 | 2008-11-20 | ||
| IN2623DE2008 | 2008-11-20 | ||
| PCT/IN2009/000658 WO2010058423A2 (en) | 2008-11-20 | 2009-11-18 | Novel antimicrobials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011124795A RU2011124795A (ru) | 2012-12-27 |
| RU2522582C2 true RU2522582C2 (ru) | 2014-07-20 |
Family
ID=42198604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011124795/04A RU2522582C2 (ru) | 2008-11-20 | 2009-11-18 | Новые противомикробные средства |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8841306B2 (enExample) |
| EP (1) | EP2367820B1 (enExample) |
| JP (1) | JP5662940B2 (enExample) |
| KR (1) | KR20110092309A (enExample) |
| CN (1) | CN102224151A (enExample) |
| AR (1) | AR074387A1 (enExample) |
| AU (1) | AU2009318783A1 (enExample) |
| CA (1) | CA2743971A1 (enExample) |
| MX (1) | MX2011005365A (enExample) |
| RU (1) | RU2522582C2 (enExample) |
| WO (1) | WO2010058423A2 (enExample) |
| ZA (1) | ZA201103978B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5855668B2 (ja) * | 2010-10-13 | 2016-02-09 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 結核に対して有用な３−アミノ−ピラゾール誘導体 |
| PT106651A (pt) * | 2012-11-20 | 2014-05-20 | Tecnimede Sociedade Tecnico Medicinal S A | Quinolil hidrazonas para o tratamento de tuberculose e doenças relacionadas |
| CN103450173B (zh) * | 2013-09-07 | 2015-06-03 | 吉首大学 | 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途 |
| US10995097B2 (en) | 2016-03-11 | 2021-05-04 | The Board Of Trustees Of The University Of Illinois | Small molecules active against gram-negative bacteria |
| US11274106B2 (en) | 2017-06-23 | 2022-03-15 | The Board Of Trustees Of The University Of Illinois | Topoisomerase inhibitors with antibacterial and anticancer activity |
| US11896644B2 (en) * | 2020-02-07 | 2024-02-13 | University Of South Florida | Inhibition of beta-arrestin oligomerization in tauopathy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007490B1 (ru) * | 2002-02-25 | 2006-10-27 | Фармация Энд Апджон Компани | N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств |
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| AU667198B2 (en) | 1991-11-01 | 1996-03-14 | Pharmacia & Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| SK283420B6 (sk) | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| DK0718293T3 (da) | 1993-09-06 | 2002-04-22 | Fujisawa Pharmaceutical Co | Cyclodepsipeptidforbindelse |
| DE69614847T2 (de) | 1995-05-11 | 2002-04-04 | Pharmacia & Upjohn Co., Kalamazoo | Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone |
| NZ315469A (en) | 1995-09-01 | 2000-01-28 | Upjohn Co | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| PL345162A1 (en) | 1998-06-05 | 2001-12-03 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| AU1379900A (en) | 1998-11-17 | 2000-06-05 | Bayer Aktiengesellschaft | Novel substituted phenyloxazolidone derivatives |
| PT1181288E (pt) | 1999-05-27 | 2003-12-31 | Upjohn Co | Oxazolidinonas biciclicas como agentes antibacterianos |
| US6608081B2 (en) | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| CN1433413A (zh) | 2000-06-05 | 2003-07-30 | 东亚制药株式会社 | 新的噁唑烷酮衍生物及其制备方法 |
| JP2004501965A (ja) | 2000-06-30 | 2004-01-22 | ファルマシア・アンド・アップジョン・カンパニー | 細菌感染を治療するための組成物および方法 |
| DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
| ATE332299T1 (de) | 2001-04-07 | 2006-07-15 | Astrazeneca Ab | Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika |
| GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| US20040204477A1 (en) | 2001-07-09 | 2004-10-14 | Juergen Moll | Interaction inhibitors of tcf-4 with beta-catenin |
| EP1409464A4 (en) | 2001-07-16 | 2005-11-02 | Ranbaxy Lab Ltd | OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS |
| PL373802A1 (en) | 2002-05-15 | 2005-09-19 | Ranbaxy Laboratories Limited | Polymorphic forms of phenyl oxazolidinone derivatives |
| WO2003097640A1 (en) | 2002-05-22 | 2003-11-27 | Orchid Chemicals & Pharmaceuticals Ltd. | Oxazolidinone derivatives as antibacterial agents |
| WO2004009587A1 (en) | 2002-07-22 | 2004-01-29 | Orchid Chemicals & Pharmaceuticals Ltd | Oxazolidinone derivatives as antibacterial agents |
| US20060293307A1 (en) | 2002-07-29 | 2006-12-28 | Anita Mehta | Oxazolidinone derivatives as antimicrobials |
| EP1578734A1 (en) * | 2002-08-22 | 2005-09-28 | Orchid Chemicals and Pharmaceuticals Ltd | Novel antibacterial agents |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| EP1565186B1 (en) * | 2002-11-21 | 2006-11-02 | Pharmacia & Upjohn Company LLC | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
| GB0229526D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229518D0 (en) | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| CN1237056C (zh) * | 2002-12-25 | 2006-01-18 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物、其制备方法和用途 |
| AU2003215861A1 (en) * | 2003-04-07 | 2004-11-01 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| MXPA05010783A (es) | 2003-04-09 | 2005-12-12 | Pharmacia & Upjohn Co Llc | Derivados antimicrobianos de [3.1.0] biciclohexilfenil-oxazolidinona y analogos. |
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| WO2005003087A2 (en) | 2003-07-01 | 2005-01-13 | Orchid Chemicals And Pharmaceuticals Ltd. | Oxazole derivatives as antibacterial agents |
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| AU2004256084B2 (en) | 2003-07-02 | 2007-10-18 | Kyorin Pharmaceutical Co., Ltd. | Oxazolidinone antibiotics and derivatives thereof |
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| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2005082900A2 (en) | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| WO2005082897A1 (en) | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone antibacterial agents |
| US20080064689A1 (en) | 2004-05-25 | 2008-03-13 | Astrazeneca Ab | 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
| AU2005247671A1 (en) | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as MAO inhibitors for the treatment of bacterial infections |
| WO2006035283A1 (en) | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006043121A1 (en) | 2004-10-20 | 2006-04-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006109056A1 (en) | 2005-04-12 | 2006-10-19 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
| EP1745784A1 (en) | 2005-06-27 | 2007-01-24 | Ferrer Internacional, S.A. | Oxazolidinone derivatives and use thereof as antibiotics |
| CA2614105A1 (en) | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents |
| KR20070038236A (ko) | 2005-10-05 | 2007-04-10 | 일동제약주식회사 | 신규 옥사졸리디논 포름 아미드 유도체 및 그 제조방법 |
| JP2009523764A (ja) | 2006-01-19 | 2009-06-25 | ラボラトリオス・サルバト・ソシエダッド・アノニマ | 抗菌活性を有するジカルボニル化合物 |
| WO2007093904A1 (en) | 2006-02-14 | 2007-08-23 | Pfizer Products Inc. | Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents |
| CN100406455C (zh) | 2006-02-20 | 2008-07-30 | 中国科学院上海药物研究所 | 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途 |
| US8148362B2 (en) | 2006-03-31 | 2012-04-03 | Research Foundation Itsuu Laboratory | Compound having heterocyclic ring |
| CA2692255A1 (en) * | 2007-06-22 | 2008-12-31 | Orchid Research Laboratories Limited | Novel compounds and their use |
| CN101434584A (zh) * | 2007-11-15 | 2009-05-20 | 中山大学 | 具有抗菌活性的手性噁唑烷酮类化合物 |
-
2009
- 2009-11-18 MX MX2011005365A patent/MX2011005365A/es not_active Application Discontinuation
- 2009-11-18 US US13/130,440 patent/US8841306B2/en not_active Expired - Fee Related
- 2009-11-18 AU AU2009318783A patent/AU2009318783A1/en not_active Abandoned
- 2009-11-18 CN CN2009801465662A patent/CN102224151A/zh active Pending
- 2009-11-18 CA CA2743971A patent/CA2743971A1/en not_active Abandoned
- 2009-11-18 RU RU2011124795/04A patent/RU2522582C2/ru not_active IP Right Cessation
- 2009-11-18 KR KR1020117013609A patent/KR20110092309A/ko not_active Ceased
- 2009-11-18 EP EP09827270.1A patent/EP2367820B1/en not_active Not-in-force
- 2009-11-18 WO PCT/IN2009/000658 patent/WO2010058423A2/en not_active Ceased
- 2009-11-18 JP JP2011537013A patent/JP5662940B2/ja not_active Expired - Fee Related
- 2009-11-20 AR ARP090104485A patent/AR074387A1/es not_active Application Discontinuation
-
2011
- 2011-05-30 ZA ZA2011/03978A patent/ZA201103978B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007490B1 (ru) * | 2002-02-25 | 2006-10-27 | Фармация Энд Апджон Компани | N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2367820B1 (en) | 2016-09-21 |
| JP5662940B2 (ja) | 2015-02-04 |
| WO2010058423A9 (en) | 2011-04-28 |
| AU2009318783A1 (en) | 2011-06-23 |
| US8841306B2 (en) | 2014-09-23 |
| MX2011005365A (es) | 2011-06-24 |
| US20110245258A1 (en) | 2011-10-06 |
| ZA201103978B (en) | 2012-09-26 |
| WO2010058423A3 (en) | 2010-12-09 |
| EP2367820A2 (en) | 2011-09-28 |
| EP2367820A4 (en) | 2012-06-20 |
| WO2010058423A2 (en) | 2010-05-27 |
| RU2011124795A (ru) | 2012-12-27 |
| CA2743971A1 (en) | 2010-05-27 |
| KR20110092309A (ko) | 2011-08-17 |
| JP2012509313A (ja) | 2012-04-19 |
| CN102224151A (zh) | 2011-10-19 |
| AR074387A1 (es) | 2011-01-12 |
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