JP5662940B2 - 新規な抗微生物薬 - Google Patents

新規な抗微生物薬 Download PDF

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Publication number
JP5662940B2
JP5662940B2 JP2011537013A JP2011537013A JP5662940B2 JP 5662940 B2 JP5662940 B2 JP 5662940B2 JP 2011537013 A JP2011537013 A JP 2011537013A JP 2011537013 A JP2011537013 A JP 2011537013A JP 5662940 B2 JP5662940 B2 JP 5662940B2
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JP
Japan
Prior art keywords
heteroaryl
alkoxy
alkyl
aryl
heterocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2011537013A
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English (en)
Japanese (ja)
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JP2012509313A (ja
JP2012509313A5 (enExample
Inventor
ラジェッシュ ジェーン
ラジェッシュ ジェーン
サンジェイ トレハン
サンジェイ トレハン
ジャガッタラン ダス
ジャガッタラン ダス
サンディープ カンワー
サンディープ カンワー
シタラム クマール マガディ
シタラム クマール マガディ
スディール クマール シャルマ
スディール クマール シャルマ
Original Assignee
パナセア バイオテック リミテッド
パナセア バイオテック リミテッド
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Publication of JP2012509313A5 publication Critical patent/JP2012509313A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011537013A 2008-11-20 2009-11-18 新規な抗微生物薬 Expired - Fee Related JP5662940B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2623/DEL/2008 2008-11-20
IN2623DE2008 2008-11-20
PCT/IN2009/000658 WO2010058423A2 (en) 2008-11-20 2009-11-18 Novel antimicrobials

Publications (3)

Publication Number Publication Date
JP2012509313A JP2012509313A (ja) 2012-04-19
JP2012509313A5 JP2012509313A5 (enExample) 2012-12-27
JP5662940B2 true JP5662940B2 (ja) 2015-02-04

Family

ID=42198604

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011537013A Expired - Fee Related JP5662940B2 (ja) 2008-11-20 2009-11-18 新規な抗微生物薬

Country Status (12)

Country Link
US (1) US8841306B2 (enExample)
EP (1) EP2367820B1 (enExample)
JP (1) JP5662940B2 (enExample)
KR (1) KR20110092309A (enExample)
CN (1) CN102224151A (enExample)
AR (1) AR074387A1 (enExample)
AU (1) AU2009318783A1 (enExample)
CA (1) CA2743971A1 (enExample)
MX (1) MX2011005365A (enExample)
RU (1) RU2522582C2 (enExample)
WO (1) WO2010058423A2 (enExample)
ZA (1) ZA201103978B (enExample)

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EP2627653B1 (en) 2010-10-13 2014-12-24 Glaxo Group Limited 3-amino-pyrazole derivatives useful against tuberculosis
PT106651A (pt) * 2012-11-20 2014-05-20 Tecnimede Sociedade Tecnico Medicinal S A Quinolil hidrazonas para o tratamento de tuberculose e doenças relacionadas
CN103450173B (zh) * 2013-09-07 2015-06-03 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途
US10995097B2 (en) * 2016-03-11 2021-05-04 The Board Of Trustees Of The University Of Illinois Small molecules active against gram-negative bacteria
US11274106B2 (en) 2017-06-23 2022-03-15 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and anticancer activity
EP4100023A4 (en) * 2020-02-07 2024-03-13 University of South Florida Inhibition of beta-arrestin oligomerization in tauopathy

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Also Published As

Publication number Publication date
CA2743971A1 (en) 2010-05-27
US8841306B2 (en) 2014-09-23
RU2522582C2 (ru) 2014-07-20
MX2011005365A (es) 2011-06-24
ZA201103978B (en) 2012-09-26
CN102224151A (zh) 2011-10-19
WO2010058423A3 (en) 2010-12-09
EP2367820B1 (en) 2016-09-21
WO2010058423A9 (en) 2011-04-28
EP2367820A2 (en) 2011-09-28
AR074387A1 (es) 2011-01-12
EP2367820A4 (en) 2012-06-20
JP2012509313A (ja) 2012-04-19
KR20110092309A (ko) 2011-08-17
WO2010058423A2 (en) 2010-05-27
RU2011124795A (ru) 2012-12-27
US20110245258A1 (en) 2011-10-06
AU2009318783A1 (en) 2011-06-23

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