RU2493147C2 - Противоопухолевые соединения - Google Patents
Противоопухолевые соединения Download PDFInfo
- Publication number
- RU2493147C2 RU2493147C2 RU2010130180/04A RU2010130180A RU2493147C2 RU 2493147 C2 RU2493147 C2 RU 2493147C2 RU 2010130180/04 A RU2010130180/04 A RU 2010130180/04A RU 2010130180 A RU2010130180 A RU 2010130180A RU 2493147 C2 RU2493147 C2 RU 2493147C2
- Authority
- RU
- Russia
- Prior art keywords
- unsubstituted
- substituted
- hydrogen atom
- alkyl
- compound according
- Prior art date
Links
- 0 C[C@](CCCC[C@](*)*c1cc(*)c(*)cc1)C(*C(*)C(*)=O)=O Chemical compound C[C@](CCCC[C@](*)*c1cc(*)c(*)cc1)C(*C(*)C(*)=O)=O 0.000 description 4
- GZXORYAUQDWNJU-ZRGNYAHOSA-N CC(C)(C)[C@@H](C(N/C=C\CC(C/C=C(\C)/Cl)OCC(N)=O)=O)NC(/C=C\C=C/C(/C)=C/Cc1ccccc1)=O Chemical compound CC(C)(C)[C@@H](C(N/C=C\CC(C/C=C(\C)/Cl)OCC(N)=O)=O)NC(/C=C\C=C/C(/C)=C/Cc1ccccc1)=O GZXORYAUQDWNJU-ZRGNYAHOSA-N 0.000 description 1
- CPDJBAUNDFXRMO-CSMSKROKSA-N CC(C)(C)[C@@H](C(N/C=C\C[C@H](C/C=C(\C)/Cl)O)=O)NC(/C=C\C=C/C(/C)=C/c(cc1)cc(OC)c1O)=O Chemical compound CC(C)(C)[C@@H](C(N/C=C\C[C@H](C/C=C(\C)/Cl)O)=O)NC(/C=C\C=C/C(/C)=C/c(cc1)cc(OC)c1O)=O CPDJBAUNDFXRMO-CSMSKROKSA-N 0.000 description 1
- LWSKXXTZFZXWID-MLGZVGJPSA-N CC(C)(C)[C@@H](C(N/C=C\C[C@H](C/C=C(\C)/Cl)OC(N)=O)=O)NC(/C=C\C=C/C(/C)=C/Cc1ccccc1)=O Chemical compound CC(C)(C)[C@@H](C(N/C=C\C[C@H](C/C=C(\C)/Cl)OC(N)=O)=O)NC(/C=C\C=C/C(/C)=C/Cc1ccccc1)=O LWSKXXTZFZXWID-MLGZVGJPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07123882 | 2007-12-20 | ||
| EP07123882.8 | 2007-12-20 | ||
| PCT/EP2008/068065 WO2009080769A1 (en) | 2007-12-20 | 2008-12-19 | Antitumoral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010130180A RU2010130180A (ru) | 2012-01-27 |
| RU2493147C2 true RU2493147C2 (ru) | 2013-09-20 |
Family
ID=40580474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010130180/04A RU2493147C2 (ru) | 2007-12-20 | 2008-12-19 | Противоопухолевые соединения |
| RU2013112003/04A RU2528393C9 (ru) | 2007-12-20 | 2008-12-19 | Противоопухолевые соединения |
| RU2010130253/04A RU2489429C2 (ru) | 2007-12-20 | 2008-12-19 | Противоопухолевые соединения |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013112003/04A RU2528393C9 (ru) | 2007-12-20 | 2008-12-19 | Противоопухолевые соединения |
| RU2010130253/04A RU2489429C2 (ru) | 2007-12-20 | 2008-12-19 | Противоопухолевые соединения |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US8710264B2 (enExample) |
| EP (3) | EP2231633B1 (enExample) |
| JP (3) | JP5529038B2 (enExample) |
| KR (3) | KR101639772B1 (enExample) |
| CN (4) | CN102190643B (enExample) |
| AT (1) | ATE549313T1 (enExample) |
| AU (2) | AU2008341671B2 (enExample) |
| BR (2) | BRPI0821116B8 (enExample) |
| CA (2) | CA2715203C (enExample) |
| CY (1) | CY1117245T1 (enExample) |
| DK (2) | DK2231590T3 (enExample) |
| ES (3) | ES2384420T3 (enExample) |
| HR (2) | HRP20140015T1 (enExample) |
| IL (3) | IL206396A (enExample) |
| MX (2) | MX2010006795A (enExample) |
| MY (3) | MY148651A (enExample) |
| NZ (3) | NZ597526A (enExample) |
| PL (2) | PL2231590T3 (enExample) |
| PT (2) | PT2231590E (enExample) |
| RS (2) | RS53140B (enExample) |
| RU (3) | RU2493147C2 (enExample) |
| SG (2) | SG170778A1 (enExample) |
| SI (2) | SI2231590T1 (enExample) |
| UA (3) | UA106967C2 (enExample) |
| WO (2) | WO2009080769A1 (enExample) |
| ZA (3) | ZA201004017B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140015T1 (hr) | 2007-12-20 | 2014-02-14 | Pharma Mar, S.A. | Antitumorski spojevi |
| WO2013103155A1 (en) * | 2012-01-05 | 2013-07-11 | Kao Corporation | Agent for reduction of sensory irritation |
| MA38588B1 (fr) | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés bi-aromatiques antibactériens |
| GB201309807D0 (en) * | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| CN108467378A (zh) * | 2017-02-23 | 2018-08-31 | 复旦大学 | 一种二氢吡喃酮类化合物及其制备方法和用途 |
| LT3615544T (lt) | 2017-04-27 | 2023-05-10 | Pharma Mar S.A. | Priešnavikiniai junginiai |
| TWI824043B (zh) | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0111105A2 (en) * | 1982-10-15 | 1984-06-20 | The Wellcome Foundation Limited | Unsaturated aromatic amides as pesticides |
| EP0402646A1 (en) * | 1989-05-23 | 1990-12-19 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| WO1998024759A1 (en) * | 1996-12-04 | 1998-06-11 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| WO2005014574A1 (en) * | 2003-07-25 | 2005-02-17 | Novartis Ag | Substituted lactams and their use as anti-cancer agents |
| RU2004133675A (ru) * | 2002-03-04 | 2005-08-10 | Атон Фарма, Инк. (Us) | Способ индукции конечной дифференцировки |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61109717A (ja) | 1984-11-02 | 1986-05-28 | Teruhiko Beppu | 抗腫瘍剤 |
| JPH06504547A (ja) * | 1990-12-28 | 1994-05-26 | ジョージア・テック・リサーチ・コーポレーション | ペプチドケトアミド、ケト酸およびケトエステル |
| JPH0539283A (ja) | 1991-01-31 | 1993-02-19 | Suntory Ltd | 新規物質Ｓ−５９９１７ａ及びその製造方法 |
| ZA938019B (en) | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
| US5523456A (en) | 1994-09-29 | 1996-06-04 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5681847A (en) * | 1995-12-05 | 1997-10-28 | Harbor Branch Oceanographic Institution, Inc. | Methods of using discodermolide compounds |
| US5834506A (en) | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| US6380400B1 (en) | 1998-09-11 | 2002-04-30 | Victor Fedij | Methods of making dihydropyrone HIV protease inhibitors |
| US6528510B1 (en) | 1998-09-11 | 2003-03-04 | Warner-Lambert Company | HIV protease inhibitors |
| AU2000241948A1 (en) * | 2000-04-04 | 2001-10-15 | Novartis Ag | Method for treating cells resistant to antineoplastic agents |
| RU2006142690A (ru) * | 2004-06-03 | 2008-06-10 | Козан Байосайенсиз Инкорпорейтед (Us) | Соединения лептомицина |
| US7446196B2 (en) | 2004-06-03 | 2008-11-04 | Kosan Biosciences, Incorporated | Leptomycin compounds |
| WO2007014423A1 (en) * | 2005-08-02 | 2007-02-08 | Medvet Science Pty, Ltd. | Exercise apparatus |
| EP2404912A3 (en) | 2006-06-16 | 2012-07-25 | Pharma Mar S.A. | Process and intermediates for the preparation of antitumoral dihydropyran-2-one compounds |
| HRP20140015T1 (hr) | 2007-12-20 | 2014-02-14 | Pharma Mar, S.A. | Antitumorski spojevi |
-
2008
- 2008-12-19 HR HRP20140015AT patent/HRP20140015T1/hr unknown
- 2008-12-19 CA CA2715203A patent/CA2715203C/en active Active
- 2008-12-19 CA CA2710087A patent/CA2710087C/en active Active
- 2008-12-19 UA UAA201009034A patent/UA106967C2/uk unknown
- 2008-12-19 DK DK08865009.8T patent/DK2231590T3/da active
- 2008-12-19 US US12/746,966 patent/US8710264B2/en not_active Expired - Fee Related
- 2008-12-19 PT PT08865009T patent/PT2231590E/pt unknown
- 2008-12-19 BR BRPI0821116A patent/BRPI0821116B8/pt not_active IP Right Cessation
- 2008-12-19 DK DK08864895.1T patent/DK2231633T3/da active
- 2008-12-19 SG SG201102163-1A patent/SG170778A1/en unknown
- 2008-12-19 SG SG201102164-9A patent/SG170779A1/en unknown
- 2008-12-19 RU RU2010130180/04A patent/RU2493147C2/ru active
- 2008-12-19 EP EP08864895.1A patent/EP2231633B1/en active Active
- 2008-12-19 CN CN201110073931.0A patent/CN102190643B/zh not_active Expired - Fee Related
- 2008-12-19 MY MYPI2010002590A patent/MY148651A/en unknown
- 2008-12-19 MY MYPI2010002591A patent/MY155342A/en unknown
- 2008-12-19 CN CN2008801218410A patent/CN101903337B/zh not_active Expired - Fee Related
- 2008-12-19 WO PCT/EP2008/068065 patent/WO2009080769A1/en not_active Ceased
- 2008-12-19 KR KR1020157016575A patent/KR101639772B1/ko not_active Expired - Fee Related
- 2008-12-19 JP JP2010538765A patent/JP5529038B2/ja not_active Expired - Fee Related
- 2008-12-19 MX MX2010006795A patent/MX2010006795A/es active IP Right Grant
- 2008-12-19 PL PL08865009T patent/PL2231590T3/pl unknown
- 2008-12-19 NZ NZ597526A patent/NZ597526A/en not_active IP Right Cessation
- 2008-12-19 JP JP2010538769A patent/JP5727228B2/ja not_active Expired - Fee Related
- 2008-12-19 WO PCT/EP2008/068049 patent/WO2009080761A1/en not_active Ceased
- 2008-12-19 KR KR1020107015965A patent/KR101541436B1/ko not_active Expired - Fee Related
- 2008-12-19 KR KR1020107015968A patent/KR101579553B1/ko not_active Expired - Fee Related
- 2008-12-19 ES ES08865009T patent/ES2384420T3/es active Active
- 2008-12-19 UA UAA201009035A patent/UA104281C2/ru unknown
- 2008-12-19 UA UAA201406894A patent/UA119963C2/uk unknown
- 2008-12-19 MX MX2010006796A patent/MX2010006796A/es active IP Right Grant
- 2008-12-19 AU AU2008341671A patent/AU2008341671B2/en not_active Ceased
- 2008-12-19 RU RU2013112003/04A patent/RU2528393C9/ru active
- 2008-12-19 AU AU2008341670A patent/AU2008341670B2/en not_active Ceased
- 2008-12-19 CN CN200880121840.6A patent/CN101903367B/zh not_active Expired - Fee Related
- 2008-12-19 EP EP13154647.5A patent/EP2597091B1/en active Active
- 2008-12-19 ES ES08864895.1T patent/ES2442140T3/es active Active
- 2008-12-19 RU RU2010130253/04A patent/RU2489429C2/ru active
- 2008-12-19 SI SI200830644T patent/SI2231590T1/sl unknown
- 2008-12-19 NZ NZ586013A patent/NZ586013A/en not_active IP Right Cessation
- 2008-12-19 RS RS20140007A patent/RS53140B/sr unknown
- 2008-12-19 NZ NZ586012A patent/NZ586012A/en not_active IP Right Cessation
- 2008-12-19 MY MYPI2014002392A patent/MY164533A/en unknown
- 2008-12-19 PT PT88648951T patent/PT2231633E/pt unknown
- 2008-12-19 PL PL08864895T patent/PL2231633T3/pl unknown
- 2008-12-19 AT AT08865009T patent/ATE549313T1/de active
- 2008-12-19 CN CN2011100568656A patent/CN102174058A/zh active Pending
- 2008-12-19 EP EP08865009A patent/EP2231590B9/en active Active
- 2008-12-19 US US12/746,974 patent/US9187445B2/en active Active
- 2008-12-19 RS RS20120242A patent/RS52343B/sr unknown
- 2008-12-19 HR HRP20120464AT patent/HRP20120464T1/hr unknown
- 2008-12-19 ES ES13154647.5T patent/ES2578606T3/es active Active
- 2008-12-19 BR BRPI0821114A patent/BRPI0821114B8/pt not_active IP Right Cessation
- 2008-12-19 SI SI200831122T patent/SI2231633T1/sl unknown
-
2010
- 2010-06-04 ZA ZA2010/04017A patent/ZA201004017B/en unknown
- 2010-06-04 ZA ZA2010/04018A patent/ZA201004018B/en unknown
- 2010-06-15 IL IL206396A patent/IL206396A/en active IP Right Grant
- 2010-06-15 IL IL206397A patent/IL206397A/en active IP Right Grant
-
2011
- 2011-08-31 ZA ZA2011/06371A patent/ZA201106371B/en unknown
-
2013
- 2013-11-24 IL IL229594A patent/IL229594A/en active IP Right Grant
-
2014
- 2014-01-27 CY CY20141100069T patent/CY1117245T1/el unknown
- 2014-04-10 JP JP2014080887A patent/JP5860088B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-12 US US14/824,699 patent/US9827257B2/en not_active Expired - Fee Related
- 2015-08-12 US US14/824,690 patent/US9750759B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0111105A2 (en) * | 1982-10-15 | 1984-06-20 | The Wellcome Foundation Limited | Unsaturated aromatic amides as pesticides |
| EP0402646A1 (en) * | 1989-05-23 | 1990-12-19 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| WO1998024759A1 (en) * | 1996-12-04 | 1998-06-11 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| RU2004133675A (ru) * | 2002-03-04 | 2005-08-10 | Атон Фарма, Инк. (Us) | Способ индукции конечной дифференцировки |
| WO2005014574A1 (en) * | 2003-07-25 | 2005-02-17 | Novartis Ag | Substituted lactams and their use as anti-cancer agents |
Non-Patent Citations (3)
| Title |
|---|
| GULLEDGE BRIAN et al.: "Microcystin analogues comprised only of adda and a single additional amino acid retain moderate activity as ppl/pp2a inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, 2003, vol.13, no.17, p.2907-2911. * |
| JONES et al.: "Microbial modification of mycophenolic acid", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C: ORGANIC CHEMISTRY, 1970, 12, p.1725-1737. * |
| JONES et al.: "Microbial modification of mycophenolic acid", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C: ORGANIC CHEMISTRY, 1970, 12, p.1725-1737. GULLEDGE BRIAN et al.: "Microcystin analogues comprised only of adda and a single additional amino acid retain moderate activity as ppl/pp2a inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, 2003, vol.13, no.17, p.2907-2911. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
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