RU2487878C1 - Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства - Google Patents

Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства Download PDF

Info

Publication number
RU2487878C1
RU2487878C1 RU2012120329/04A RU2012120329A RU2487878C1 RU 2487878 C1 RU2487878 C1 RU 2487878C1 RU 2012120329/04 A RU2012120329/04 A RU 2012120329/04A RU 2012120329 A RU2012120329 A RU 2012120329A RU 2487878 C1 RU2487878 C1 RU 2487878C1
Authority
RU
Russia
Prior art keywords
guanine
germanium
derivative
complex
acyclovir
Prior art date
Application number
RU2012120329/04A
Other languages
English (en)
Russian (ru)
Inventor
Александр Дмитриевич Исаев
Игорь Валерьевич Амбросов
Тамаз Омарович Манашеров
Светлана Константиновна Матело
Original Assignee
Общество С Ограниченной Ответственностью "Вдс Фарма"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to RU2012120329/04A priority Critical patent/RU2487878C1/ru
Application filed by Общество С Ограниченной Ответственностью "Вдс Фарма" filed Critical Общество С Ограниченной Ответственностью "Вдс Фарма"
Priority to AU2012380376A priority patent/AU2012380376B2/en
Priority to PT12876796T priority patent/PT2851368T/pt
Priority to IN9234DEN2014 priority patent/IN2014DN09234A/en
Priority to TR2019/01561T priority patent/TR201901561T4/tr
Priority to KR1020147035216A priority patent/KR101717280B1/ko
Priority to CA2873390A priority patent/CA2873390C/en
Priority to ES12876796T priority patent/ES2710915T3/es
Priority to CN201280073187.7A priority patent/CN104302651B/zh
Priority to EP12876796.9A priority patent/EP2851368B1/en
Priority to US14/400,081 priority patent/US9745337B2/en
Priority to JP2015512600A priority patent/JP5993088B2/ja
Priority to PCT/RU2012/000897 priority patent/WO2013172732A1/ru
Priority to PL12876796T priority patent/PL2851368T3/pl
Priority to DK12876796.9T priority patent/DK2851368T3/en
Priority to BR112014027919A priority patent/BR112014027919B1/pt
Application granted granted Critical
Publication of RU2487878C1 publication Critical patent/RU2487878C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/30—Germanium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2012120329/04A 2012-05-16 2012-05-16 Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства RU2487878C1 (ru)

Priority Applications (16)

Application Number Priority Date Filing Date Title
RU2012120329/04A RU2487878C1 (ru) 2012-05-16 2012-05-16 Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства
US14/400,081 US9745337B2 (en) 2012-05-16 2012-11-01 Complex compounds of germanium, methods for producing same, and drugs
IN9234DEN2014 IN2014DN09234A (cg-RX-API-DMAC7.html) 2012-05-16 2012-11-01
TR2019/01561T TR201901561T4 (tr) 2012-05-16 2012-11-01 Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar.
KR1020147035216A KR101717280B1 (ko) 2012-05-16 2012-11-01 게르마늄의 착체 화합물, 이를 제조하는 방법, 및 약물
CA2873390A CA2873390C (en) 2012-05-16 2012-11-01 Complex compounds of germanium, methods for producing same, and drugs
AU2012380376A AU2012380376B2 (en) 2012-05-16 2012-11-01 Complex compounds of germanium, methods for producing same, and drugs
CN201280073187.7A CN104302651B (zh) 2012-05-16 2012-11-01 锗的配位化合物、其生产方法和药物
EP12876796.9A EP2851368B1 (en) 2012-05-16 2012-11-01 Complex compounds of germanium, methods for producing same, and drugs
PT12876796T PT2851368T (pt) 2012-05-16 2012-11-01 Compostos complexos de germânio, métodos para a sua produção e fármacos
JP2015512600A JP5993088B2 (ja) 2012-05-16 2012-11-01 ゲルマニウムの錯化合物、その生産方法、及び薬物
PCT/RU2012/000897 WO2013172732A1 (ru) 2012-05-16 2012-11-01 Комплексные соединения германия, способы их получения и лекарственные средства
PL12876796T PL2851368T3 (pl) 2012-05-16 2012-11-01 Związki kompleksowe germanu, sposoby ich wytwarzania i leki
DK12876796.9T DK2851368T3 (en) 2012-05-16 2012-11-01 COMPLEX COMPOUNDS OF GERMANIUM, PROCEDURES FOR PRODUCING THEREOF, AND PHARMACEUTICALS
BR112014027919A BR112014027919B1 (pt) 2012-05-16 2012-11-01 compostos complexos de germânio, métodos de produção dos mesmos e medicamentos.
ES12876796T ES2710915T3 (es) 2012-05-16 2012-11-01 Compuestos complejos de germanio, métodos para la producción de los mismos y fármacos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2012120329/04A RU2487878C1 (ru) 2012-05-16 2012-05-16 Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства

Publications (1)

Publication Number Publication Date
RU2487878C1 true RU2487878C1 (ru) 2013-07-20

Family

ID=48791166

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012120329/04A RU2487878C1 (ru) 2012-05-16 2012-05-16 Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства

Country Status (16)

Country Link
US (1) US9745337B2 (cg-RX-API-DMAC7.html)
EP (1) EP2851368B1 (cg-RX-API-DMAC7.html)
JP (1) JP5993088B2 (cg-RX-API-DMAC7.html)
KR (1) KR101717280B1 (cg-RX-API-DMAC7.html)
CN (1) CN104302651B (cg-RX-API-DMAC7.html)
AU (1) AU2012380376B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014027919B1 (cg-RX-API-DMAC7.html)
CA (1) CA2873390C (cg-RX-API-DMAC7.html)
DK (1) DK2851368T3 (cg-RX-API-DMAC7.html)
ES (1) ES2710915T3 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN09234A (cg-RX-API-DMAC7.html)
PL (1) PL2851368T3 (cg-RX-API-DMAC7.html)
PT (1) PT2851368T (cg-RX-API-DMAC7.html)
RU (1) RU2487878C1 (cg-RX-API-DMAC7.html)
TR (1) TR201901561T4 (cg-RX-API-DMAC7.html)
WO (1) WO2013172732A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2626954C2 (ru) * 2015-11-11 2017-08-02 Общество С Ограниченной Ответственностью "Вдс Фарма" Комплексные соединения германия с аминокислотами и липоевой кислотой
RU2752934C1 (ru) * 2020-10-16 2021-08-11 Александр Дмитриевич Исаев Комплексные соединения германия с ациклическими полиолами и способ их получения

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114133398B (zh) * 2021-12-31 2022-11-22 中南民族大学 氨基酸取代的阿昔洛韦类三环核苷衍生物及其合成方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674823A (en) * 1969-04-02 1972-07-04 Daiichi Yakuhin Sangyo Kk Compound of germanic acid and cysteine
DE3212817C2 (cg-RX-API-DMAC7.html) * 1982-04-06 1988-12-08 Sanum-Kehlbeck Gmbh & Co Kg, 2812 Hoya, De
RU2104032C1 (ru) * 1997-03-11 1998-02-10 Общество с ограниченной ответственностью "Снежный барс" Способ усиления лечебного эффекта лекарственных средств
RU2233286C2 (ru) * 1998-08-17 2004-07-27 Евгений Владимирович Соловьев Биохимические комплексы германия с высокой терапевтической активностью и широким спектром использования

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616208A (en) * 1967-09-29 1971-10-26 Parke Davis & Co Fermentation process for 9-(beta-d-arabinofuranosyl)adenine
JPS4924213A (cg-RX-API-DMAC7.html) 1972-06-19 1974-03-04
EP0477871A3 (en) 1990-09-28 1992-12-02 Nippon Kayaku Kabushiki Kaisha Antiviral composition, containing guanine derivatives
CN1154359A (zh) * 1996-01-12 1997-07-16 常达正 氨基酸锗的制备方法及其应用
NZ334423A (en) * 1996-09-05 2000-07-28 Primamedic Ltd 1:2 complex of germanium and 1,3-dicarboxylic acid
US6448227B1 (en) 1999-02-22 2002-09-10 Gernot Treusch Therapeutically effective substance mixture
RU2240792C2 (ru) 2002-07-30 2004-11-27 Государственное учреждение Научно-исследовательский институт вирусологии им. Д.И. Ивановского РАМН Комбинации на основе нетропсина или его бис-производного, обладающие антигерпетической активностью
RU2233280C1 (ru) 2003-03-25 2004-07-27 Научно-исследовательский институт физической и органической химии Ростовского государственного университета СОЛИ-10-ω-АРИЛОКСИАЛКИЛ-2,3,4,10-ТЕТРАГИДРОПИРИМИДО[1,2-A]БЕНЗИМИДАЗОЛА, ОБЛАДАЮЩИЕ МЕСТНОАНЕСТЕЗИРУЮЩИМ ДЕЙСТВИЕМ
DE10343365A1 (de) 2003-09-17 2005-04-14 Biosphings Ag Pharmazeutische Formulierungen von Xanthogenaten und Hemmstoffen der viralen Nukleinsäurereplikation
RU2476436C1 (ru) * 2012-01-25 2013-02-27 Общество С Ограниченной Ответственностью "Вдс Фарма" Комплексные соединения германия с аминокислотами и карбоновыми кислотами

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674823A (en) * 1969-04-02 1972-07-04 Daiichi Yakuhin Sangyo Kk Compound of germanic acid and cysteine
DE3212817C2 (cg-RX-API-DMAC7.html) * 1982-04-06 1988-12-08 Sanum-Kehlbeck Gmbh & Co Kg, 2812 Hoya, De
RU2104032C1 (ru) * 1997-03-11 1998-02-10 Общество с ограниченной ответственностью "Снежный барс" Способ усиления лечебного эффекта лекарственных средств
RU2233286C2 (ru) * 1998-08-17 2004-07-27 Евгений Владимирович Соловьев Биохимические комплексы германия с высокой терапевтической активностью и широким спектром использования

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2626954C2 (ru) * 2015-11-11 2017-08-02 Общество С Ограниченной Ответственностью "Вдс Фарма" Комплексные соединения германия с аминокислотами и липоевой кислотой
RU2752934C1 (ru) * 2020-10-16 2021-08-11 Александр Дмитриевич Исаев Комплексные соединения германия с ациклическими полиолами и способ их получения
WO2022081041A1 (ru) * 2020-10-16 2022-04-21 Александр Дмитриевич ИСАЕВ Комплексные соединения германия с ациклическими полиолами и способ их получения

Also Published As

Publication number Publication date
CA2873390A1 (en) 2013-11-21
KR20150011386A (ko) 2015-01-30
BR112014027919A2 (pt) 2017-06-27
KR101717280B1 (ko) 2017-03-17
JP5993088B2 (ja) 2016-09-14
CA2873390C (en) 2017-10-24
EP2851368A4 (en) 2016-02-10
DK2851368T3 (en) 2019-02-25
TR201901561T4 (tr) 2019-02-21
AU2012380376B2 (en) 2015-10-01
PT2851368T (pt) 2019-02-11
IN2014DN09234A (cg-RX-API-DMAC7.html) 2015-07-10
CN104302651B (zh) 2017-04-12
WO2013172732A1 (ru) 2013-11-21
US9745337B2 (en) 2017-08-29
CN104302651A (zh) 2015-01-21
EP2851368B1 (en) 2019-01-02
JP2015518823A (ja) 2015-07-06
PL2851368T3 (pl) 2019-06-28
AU2012380376A1 (en) 2014-12-04
EP2851368A1 (en) 2015-03-25
ES2710915T3 (es) 2019-04-29
US20150126726A1 (en) 2015-05-07
BR112014027919B1 (pt) 2020-02-04

Similar Documents

Publication Publication Date Title
CN103232490B (zh) 具有抑制hiv-1/hbv病毒复制活性的核苷类化合物、制备方法及抗病毒方面的应用
JPH031310B2 (cg-RX-API-DMAC7.html)
JPH031309B2 (cg-RX-API-DMAC7.html)
RU2487878C1 (ru) Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства
DE60032915T2 (de) Gallium komplexe von 3-hydroxy-4-pyronen zur behandlung von durch intrazelluläre prokaryoten, dns- und retro-viren verursachten infektionen
US4093716A (en) Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof
WO2007058568A2 (fr) Sels et melanges d'acide 9-oxoacridine-10-acetique et de 1-alkylamino-1-desoxypolyols, compositions pharmaceutiques les contenant, et methodes de traitement associees
US20170232010A1 (en) Drug with activity against the herpes virus family
RU2401121C1 (ru) Фармацевтическая композиция для лечения и профилактики вирусных инфекций и сифилиса на основе экстрактов растительного происхождения и способ лечения и профилактики вирусных инфекций и сифилиса
US10471064B2 (en) Medicament for treating peripheral neuropathies
WO2009109531A2 (en) Combination therapy
EP1669357A8 (en) Substance which exhibits antiviral and antibacterial activity and is based on derivatives of 2,8-dithioxo-1h-pyrano[ 2,3-d,6,5-d'] dipyrimidine and 10-aza-analogue thereof
US6140367A (en) Use of ethylene diamine disuccinate for preparing a medicament with antiviral properties
US11202774B2 (en) 5-substituted 2,4-thiazolidinediones (thiohydantoins), pseudothiohydantoins, and propseudothiohydantoins for use as antiviral agents
US20200046715A1 (en) Medicament for Treating Peripheral Neuropathies
JP2018027915A (ja) 網膜神経節細胞死抑制活性を有する経口用組成物
CA1098040A (en) Antiviral agent
WO2016159833A1 (ru) Лекарственное средство с гепатопротекторной активностью
CN110655534A (zh) 替诺福韦脂质单酯化合物及其制备方法和应用
US20140213600A1 (en) Medicament for treating peripheral neuropathies
JP2007505846A (ja) キサントゲン酸塩及びウイルス核酸複製の阻害剤（例えばアシクロビル）の医薬調製物

Legal Events

Date Code Title Description
QB4A Licence on use of patent

Free format text: LICENCE

Effective date: 20170314

QC41 Official registration of the termination of the licence agreement or other agreements on the disposal of an exclusive right

Free format text: LICENCE FORMERLY AGREED ON 20170314

Effective date: 20191014

QB4A Licence on use of patent

Free format text: LICENCE FORMERLY AGREED ON 20191015

Effective date: 20191015

QB4A Licence on use of patent

Free format text: LICENCE FORMERLY AGREED ON 20210810

Effective date: 20210810