RU2487120C2 - Новые лиганды ванилоидных рецепторов и их применение для изготовления лекарственных средств - Google Patents

Новые лиганды ванилоидных рецепторов и их применение для изготовления лекарственных средств Download PDF

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RU2487120C2
RU2487120C2 RU2009142024/04A RU2009142024A RU2487120C2 RU 2487120 C2 RU2487120 C2 RU 2487120C2 RU 2009142024/04 A RU2009142024/04 A RU 2009142024/04A RU 2009142024 A RU2009142024 A RU 2009142024A RU 2487120 C2 RU2487120 C2 RU 2487120C2
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Russia
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butyl
group
methyl
radical
optionally
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RU2009142024/04A
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Russian (ru)
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RU2009142024A (ru
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Роберт ФРАНК
Грегор БАРЕНБЕРГ
Томас КРИСТОФ
Клаус ШИНЕ
Жан ДЕ-ВРИ
Дерек СОНДЕРС
Михаэль ПШЕВОСНИ
Бернд ЗУНДЕРМАНН
Чжиу ЛИ
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Грюненталь Гмбх
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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RU2009142024/04A 2007-04-16 2008-04-15 Новые лиганды ванилоидных рецепторов и их применение для изготовления лекарственных средств RU2487120C2 (ru)

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Application Number Priority Date Filing Date Title
DE102007018151A DE102007018151A1 (de) 2007-04-16 2007-04-16 Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
DE102007018151.7 2007-04-16
PCT/EP2008/002994 WO2008125337A2 (de) 2007-04-16 2008-04-15 Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln

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RU2009142024A RU2009142024A (ru) 2011-05-27
RU2487120C2 true RU2487120C2 (ru) 2013-07-10

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US (2) US8642775B2 (enExample)
EP (1) EP2146962A2 (enExample)
JP (1) JP5557734B2 (enExample)
KR (1) KR101497357B1 (enExample)
CN (1) CN101687799B (enExample)
BR (1) BRPI0810031A2 (enExample)
CA (1) CA2683910A1 (enExample)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007313295A1 (en) * 2006-10-18 2008-04-24 Merck Sharp & Dohme Corp. 2-hydroxy-2-phenyl/thiophenyl propionamides as androgen receptor modulators
WO2008110351A2 (en) * 2007-03-15 2008-09-18 Dompe' Pha.R.Ma S.P.A. Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents
DE102007018151A1 (de) * 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
EP2709609B1 (en) * 2011-05-17 2017-10-04 Shionogi & Co., Ltd. Heterocyclic compounds
JP2013014534A (ja) * 2011-07-04 2013-01-24 Daicel Corp ベンゾイルギ酸化合物、及びその製造方法
KR20140049028A (ko) 2011-07-26 2014-04-24 그뤼넨탈 게엠베하 바닐로이드 수용체 리간드로서의 치환된 바이사이클릭 방향족 카복스아미드 및 우레아 유도체
AR087302A1 (es) * 2011-07-26 2014-03-12 Gruenenthal Gmbh Derivados aza heterociclicos sustituidos
TW201326133A (zh) * 2011-11-09 2013-07-01 Gruenenthal Gmbh 以被取代吡唑基甲醯胺及被以一含氧基團取代之含有一苯基基元之尿素衍生物做為類香草素受體之配位體
AU2012334066A1 (en) * 2011-11-09 2014-05-22 Grunenthal Gmbh Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an N-containing group as vanilloid receptor ligands
JPWO2020017569A1 (ja) 2018-07-17 2021-12-02 日本ケミファ株式会社 T型カルシウムチャネル阻害剤
WO2020203609A1 (ja) 2019-03-29 2020-10-08 日本ケミファ株式会社 掻痒を治療するためのt型カルシウムチャネル阻害剤の使用
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
CN115417809A (zh) * 2022-09-05 2022-12-02 天津药明康德新药开发有限公司 一种4,4-二吡咯-2,2-联吡啶的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011965A1 (en) * 1999-08-18 2001-02-22 Aventis Cropscience Gmbh Fungicides
WO2001011966A1 (en) * 1999-08-18 2001-02-22 Aventis Cropscience Gmbh Fungicides
EP1403235A1 (en) * 2001-06-11 2004-03-31 Dainippon Pharmaceutical Co., Ltd. N-arylphenylacetamide derivatives and medicinal compositions containing the same
WO2007039114A1 (en) * 2005-09-20 2007-04-12 Revotar Biopharmaceuticals Ag Novel nitrocatechol derivatives having selectin ligand activity
RU2304435C2 (ru) * 2001-07-10 2007-08-20 Ф.Хоффманн-Ля Рош Аг Применение антагонистов рецептора nk-1 для лечения черепно-мозговой и спинномозговой травмы или повреждения нервной ткани

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60120421T2 (de) * 2000-08-21 2006-12-28 Pacific Corp. Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
FR2836917B1 (fr) 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
EP1487786A2 (de) * 2002-03-14 2004-12-22 Basf Aktiengesellschaft Z-substituierte acrylamide, verfahren zu deren herstellung, sowie sie enthaltende mittel
US7135493B2 (en) * 2003-01-13 2006-11-14 Astellas Pharma Inc. HDAC inhibitor
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
SE0301446D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
EP1628661A2 (en) 2003-06-05 2006-03-01 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
KR100707123B1 (ko) 2003-07-02 2007-04-16 그뤼넨탈 게엠베하 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물
AP2378A (en) 2004-01-22 2012-03-08 Pfizer Sulfonamide derivatives for the treatment of diseases.
US20050165015A1 (en) * 2004-01-23 2005-07-28 Ncube Mghele V. Vanilloid receptor ligands and their use in treatments
PL1940821T3 (pl) * 2005-10-19 2013-08-30 Gruenenthal Gmbh Nowe ligandy receptora waniloidowego i ich zastosowanie do wytwarzania leków
DE102007018151A1 (de) * 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011965A1 (en) * 1999-08-18 2001-02-22 Aventis Cropscience Gmbh Fungicides
WO2001011966A1 (en) * 1999-08-18 2001-02-22 Aventis Cropscience Gmbh Fungicides
EP1403235A1 (en) * 2001-06-11 2004-03-31 Dainippon Pharmaceutical Co., Ltd. N-arylphenylacetamide derivatives and medicinal compositions containing the same
RU2304435C2 (ru) * 2001-07-10 2007-08-20 Ф.Хоффманн-Ля Рош Аг Применение антагонистов рецептора nk-1 для лечения черепно-мозговой и спинномозговой травмы или повреждения нервной ткани
WO2007039114A1 (en) * 2005-09-20 2007-04-12 Revotar Biopharmaceuticals Ag Novel nitrocatechol derivatives having selectin ligand activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
REGISTRY CHEMICAL ABSTRACTS SERVICE, 08.10.2001 CAS RN: 349411-19-4. *
REGISTRY CHEMICAL ABSTRACTS SERVICE, 08.10.2001 CAS RN: 349411-19-4. REGISTRY CHEMICAL ABSTRACTS SERVICE, 08.10.2001 CAS RN: 360770-08-7. REGISTRY CHEMICAL ABSTRACTS SERVICE, 26.05.2006 CAS RN: 885662-85-1. *
REGISTRY CHEMICAL ABSTRACTS SERVICE, 08.10.2001 CAS RN: 360770-08-7. *
REGISTRY CHEMICAL ABSTRACTS SERVICE, 26.05.2006 CAS RN: 885662-85-1. *

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US8642775B2 (en) 2014-02-04
WO2008125337A2 (de) 2008-10-23
AU2008238245A1 (en) 2008-10-23
US20110184020A1 (en) 2011-07-28
ECSP099693A (es) 2009-11-30
IL201506A0 (en) 2010-05-31
US8791268B2 (en) 2014-07-29
CN101687799A (zh) 2010-03-31
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RU2009142024A (ru) 2011-05-27
NZ580381A (en) 2012-05-25
JP2010523726A (ja) 2010-07-15
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US20080262039A1 (en) 2008-10-23
NZ599254A (en) 2013-07-26
CO6220938A2 (es) 2010-11-19
MX2009011139A (es) 2009-10-30
WO2008125337A3 (de) 2009-02-26
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CA2683910A1 (en) 2008-04-16
DE102007018151A1 (de) 2008-10-23

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