CO6220938A2 - Ligandos de receptor vainilloide novedosos y el uso de los mismos para la produccion de farmacos - Google Patents
Ligandos de receptor vainilloide novedosos y el uso de los mismos para la produccion de farmacosInfo
- Publication number
- CO6220938A2 CO6220938A2 CO09115659A CO09115659A CO6220938A2 CO 6220938 A2 CO6220938 A2 CO 6220938A2 CO 09115659 A CO09115659 A CO 09115659A CO 09115659 A CO09115659 A CO 09115659A CO 6220938 A2 CO6220938 A2 CO 6220938A2
- Authority
- CO
- Colombia
- Prior art keywords
- vinylloid
- pharmacos
- new
- production
- same
- Prior art date
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- Diabetes (AREA)
Abstract
1.- Compuesto sustituido de la fórmula general I.en la cual n es 0, 1, 2, 3, ó 4, R1 es H; F; Cl; Br; I; -SF5; -NO2; -CN; -NH2; -OH; -SH; -C(=O)-NH2; -S(=O)2-NH2; -C(=O)-NH-OH; -C(=O)-OH; -C(=O)-H; -S(=O)2-OH; -C(=NH)-NH2; -C(=NH)-NH-R9; -N=C(NH2)2; -N=C(NHR10)- (NHR11); -O-P(=O)2-O-R12; -NHR13; -NR14R15; -NH-C(= O)-R13; -OR16; -SR17; -C(= O)-NHR18; -C (= O)-NR19R20; -S(= O)2-NHR21; -S(= O)2-NR22R23 -C(= O) -OR24; -C(= O)- -R25; -S(= O)-R26; o -S(=O)2-R27 o un radical de C1-10 alifático no sustituido o al menos monosustituido, lineal o ramificado, saturado o insaturado, R2 es H; F; Cl; Br; I; -SF5; -NO2; -CN; -NH2; -OH; -SH; -C(= O)-NH2; -S(= O)2-NH2; -C(= O)-NH-OH; -C(= O)-OH; -C(= O)-H; -S(= O)2-OH; -C(= NH)-NH2; -C(= NH)-NH-R9; -N= C(NH2)2; -N=C(NHR10)-(NHR11); -O-P(=O)2-O-R12; -NHR13; -NR14R15; -NH-C(=O)-R13; -OR16, -SR17; -C(= O)-NHR18; -C(= O)-NR19R20; -S(= O)2-NHR21; -S(= O)2-NR22R23; -C(= O)-OR24; -C(= O)-R25; -S(= O)-R26; o -S(= O)2-R27 o un radical de C1-10 alifático no sustituido o al menos monosustituido, lineal o ramificado, saturado o insaturado, R3 es H; F; Cl; Br; I; -SF5; -NO2; -CN; -NH2; -OH; -SH; -C(= O)-NH2; -S(= O)2-NH2; -C(= O)-NH-OH; -C(= O)-OH; -C(= O)-H; -S(= O)2-OH; -C(= NH)-NH2; -C(= NH)-NH-R9; -N= C(NH2)2; -N=C(NHR10) - (NHR11); -O-P (= O)2-O-R12; -NHR13; -NR14R15; -NH-C (= O) -R13; -OR16; -SR17; -C(= O) -NHR18; -C (= O) -NR19R20; -S(= O)2-NHR21; -S (= O)2-NR22R23; -C(= O) -OR24; -C(= O)-R25; -S(= O)-R26; o -S(= O)2-R27 o un radical de C1-10 alifático no sustituido o al menos monosustituido, lineal o ramificado, saturado o insaturado, R4 es H; F; Cl; Br; I; -SF5; -NO2; -CN; -NH2; -OH; -SH; -C(= O)-NH2 ; -S(= O)2-NH2; -C(= O)-NH-OH; -C(= O)-OH; -C(= O)-H; -S(= O)2-OH; -C(= NH)-NH2; -C(= NH)-NH-R9; -N= C(NH2)2; -N=C(NHR10) - (NHR11); -O-P(= O)2-O-R12; -NHR13; -NR14R15; -NH-C(= O) -R13; -OR16; -SR17; -C(= O)-NHR18; -C(= O)-NR19R20; -S (= O)2 -NHR21; -S(= O)2 -NR22R23; -C(= O) -OR24; -C (= O) -R25; -S(= O) -R26, o -S(= O)2-R27 o un radical de C1-10 alifático no sustituido ...
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DE102007018151A DE102007018151A1 (de) | 2007-04-16 | 2007-04-16 | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
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CO6220938A2 true CO6220938A2 (es) | 2010-11-19 |
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Application Number | Title | Priority Date | Filing Date |
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CO09115659A CO6220938A2 (es) | 2007-04-16 | 2009-10-16 | Ligandos de receptor vainilloide novedosos y el uso de los mismos para la produccion de farmacos |
Country Status (16)
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US (2) | US8642775B2 (es) |
EP (1) | EP2146962A2 (es) |
JP (1) | JP5557734B2 (es) |
KR (1) | KR101497357B1 (es) |
CN (1) | CN101687799B (es) |
BR (1) | BRPI0810031A2 (es) |
CA (1) | CA2683910A1 (es) |
CO (1) | CO6220938A2 (es) |
DE (1) | DE102007018151A1 (es) |
EC (1) | ECSP099693A (es) |
IL (1) | IL201506A0 (es) |
MX (1) | MX2009011139A (es) |
NZ (2) | NZ580381A (es) |
RU (1) | RU2487120C2 (es) |
WO (1) | WO2008125337A2 (es) |
ZA (1) | ZA200907096B (es) |
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CA2666769A1 (en) * | 2006-10-18 | 2008-04-24 | Merck & Co., Inc. | 2-hydroxy-2-phenyl/thiophenyl propionamides as androgen receptor modulators |
WO2008110351A2 (en) * | 2007-03-15 | 2008-09-18 | Dompe' Pha.R.Ma S.P.A. | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
WO2012158844A1 (en) * | 2011-05-17 | 2012-11-22 | Shionogi & Co., Ltd. | Heterocyclic compounds |
JP2013014534A (ja) * | 2011-07-04 | 2013-01-24 | Daicel Corp | ベンゾイルギ酸化合物、及びその製造方法 |
AU2012289254A1 (en) | 2011-07-26 | 2014-03-13 | Grünenthal GmbH | Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands |
BR112014001908A2 (pt) * | 2011-07-26 | 2017-02-21 | Gruenenthal Gmbh | derivados aza heterocíclicos substituídos |
BR112014010957A2 (pt) * | 2011-11-09 | 2017-06-06 | Gruenenthal Gmbh | derivados de ureia e carboxamida com base em pirazolila substituída transportando uma porção de fenila substituída por um grupo contendo n como ligantes de receptor de vaniloide |
TW201326133A (zh) * | 2011-11-09 | 2013-07-01 | Gruenenthal Gmbh | 以被取代吡唑基甲醯胺及被以一含氧基團取代之含有一苯基基元之尿素衍生物做為類香草素受體之配位體 |
WO2020017569A1 (ja) | 2018-07-17 | 2020-01-23 | 日本ケミファ株式会社 | T型カルシウムチャネル阻害剤 |
JPWO2020203609A1 (es) | 2019-03-29 | 2020-10-08 | ||
RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
CN115417809A (zh) * | 2022-09-05 | 2022-12-02 | 天津药明康德新药开发有限公司 | 一种4,4-二吡咯-2,2-联吡啶的制备方法 |
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EP1204323B1 (en) * | 1999-08-18 | 2004-07-14 | Aventis CropScience GmbH | Fungicides |
GB9919588D0 (en) | 1999-08-18 | 1999-10-20 | Hoechst Schering Agrevo Gmbh | Fungicidal compounds |
US20030153596A1 (en) * | 2000-08-21 | 2003-08-14 | Suh Young Ger | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
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FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
AU2003214116A1 (en) * | 2002-03-14 | 2003-09-22 | Basf Aktiengesellschaft | Z-substituted acrylamides, methods for production thereof and agents comprising the same |
TW200418806A (en) * | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
SE0301446D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
JP2006526660A (ja) | 2003-06-05 | 2006-11-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Vr1レセプターのモジュレーター |
KR100707123B1 (ko) | 2003-07-02 | 2007-04-16 | 그뤼넨탈 게엠베하 | 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물 |
NZ548235A (en) * | 2004-01-22 | 2010-05-28 | Pfizer | Sulfonamide derivatives as beta2 agonists for the treatment of diseases |
WO2005073193A1 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
NZ593684A (en) * | 2005-10-19 | 2012-11-30 | Gruenenthal Chemie | Novel vanilloid receptor ligands and their use for producing medicaments |
DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
-
2007
- 2007-04-16 DE DE102007018151A patent/DE102007018151A1/de not_active Withdrawn
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2008
- 2008-04-15 NZ NZ580381A patent/NZ580381A/en not_active IP Right Cessation
- 2008-04-15 WO PCT/EP2008/002994 patent/WO2008125337A2/de active Application Filing
- 2008-04-15 MX MX2009011139A patent/MX2009011139A/es active IP Right Grant
- 2008-04-15 CA CA002683910A patent/CA2683910A1/en not_active Abandoned
- 2008-04-15 RU RU2009142024/04A patent/RU2487120C2/ru not_active IP Right Cessation
- 2008-04-15 NZ NZ599254A patent/NZ599254A/xx not_active IP Right Cessation
- 2008-04-15 US US12/103,198 patent/US8642775B2/en not_active Expired - Fee Related
- 2008-04-15 EP EP08735252A patent/EP2146962A2/de not_active Withdrawn
- 2008-04-15 BR BRPI0810031-4A2A patent/BRPI0810031A2/pt not_active IP Right Cessation
- 2008-04-15 CN CN200880020516.5A patent/CN101687799B/zh not_active Expired - Fee Related
- 2008-04-15 JP JP2010503393A patent/JP5557734B2/ja not_active Expired - Fee Related
- 2008-04-15 KR KR1020097023888A patent/KR101497357B1/ko not_active IP Right Cessation
-
2009
- 2009-10-12 ZA ZA2009/07096A patent/ZA200907096B/en unknown
- 2009-10-14 IL IL201506A patent/IL201506A0/en unknown
- 2009-10-16 EC EC2009009693A patent/ECSP099693A/es unknown
- 2009-10-16 CO CO09115659A patent/CO6220938A2/es active IP Right Grant
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2011
- 2011-03-31 US US13/077,452 patent/US8791268B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8791268B2 (en) | 2014-07-29 |
KR20100016594A (ko) | 2010-02-12 |
KR101497357B1 (ko) | 2015-03-02 |
US20080262039A1 (en) | 2008-10-23 |
CN101687799B (zh) | 2014-07-23 |
JP2010523726A (ja) | 2010-07-15 |
WO2008125337A3 (de) | 2009-02-26 |
CN101687799A (zh) | 2010-03-31 |
RU2009142024A (ru) | 2011-05-27 |
WO2008125337A2 (de) | 2008-10-23 |
JP5557734B2 (ja) | 2014-07-23 |
ZA200907096B (en) | 2013-03-27 |
US8642775B2 (en) | 2014-02-04 |
CA2683910A1 (en) | 2008-04-16 |
AU2008238245A1 (en) | 2008-10-23 |
NZ599254A (en) | 2013-07-26 |
ECSP099693A (es) | 2009-11-30 |
EP2146962A2 (de) | 2010-01-27 |
DE102007018151A1 (de) | 2008-10-23 |
RU2487120C2 (ru) | 2013-07-10 |
BRPI0810031A2 (pt) | 2014-10-14 |
US20110184020A1 (en) | 2011-07-28 |
MX2009011139A (es) | 2009-10-30 |
IL201506A0 (en) | 2010-05-31 |
NZ580381A (en) | 2012-05-25 |
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