RU2399628C2 - Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с - Google Patents

Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с Download PDF

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RU2399628C2
RU2399628C2 RU2007116119/04A RU2007116119A RU2399628C2 RU 2399628 C2 RU2399628 C2 RU 2399628C2 RU 2007116119/04 A RU2007116119/04 A RU 2007116119/04A RU 2007116119 A RU2007116119 A RU 2007116119A RU 2399628 C2 RU2399628 C2 RU 2399628C2
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carbon atoms
cyclosporin
different
same
branched chain
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RU2007116119/04A
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RU2007116119A (ru
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Ханс Георг ФЛИРИ (GB)
Ханс Георг ФЛИРИ
Дэвид Ренвик ХОУК (US)
Дэвид Ренвик ХОУК
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Скайнексис, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • C07K7/645Cyclosporins; Related peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2007116119/04A 2004-10-01 2005-09-30 Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с RU2399628C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61515204P 2004-10-01 2004-10-01
US60/615,152 2004-10-01
US70762605P 2005-08-11 2005-08-11
US60/707,626 2005-08-11

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RU2007116119A RU2007116119A (ru) 2008-11-10
RU2399628C2 true RU2399628C2 (ru) 2010-09-20

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US (2) US20100167996A1 (enExample)
EP (1) EP1802650B1 (enExample)
JP (2) JP5139065B2 (enExample)
KR (1) KR101309409B1 (enExample)
CN (1) CN101773661B (enExample)
AT (1) ATE530561T1 (enExample)
AU (1) AU2005292162B2 (enExample)
BR (1) BRPI0516737A (enExample)
CA (1) CA2583494C (enExample)
DK (1) DK1802650T3 (enExample)
ES (1) ES2373450T3 (enExample)
IL (1) IL182315A (enExample)
MX (1) MX2007003538A (enExample)
NZ (1) NZ554514A (enExample)
PL (1) PL1802650T3 (enExample)
PT (1) PT1802650E (enExample)
RU (1) RU2399628C2 (enExample)
SI (1) SI1802650T1 (enExample)
WO (1) WO2006039668A2 (enExample)

Cited By (2)

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RU2448690C1 (ru) * 2011-03-15 2012-04-27 Открытое акционерное общество "Биосинтез" Твердая лекарственная форма пролонгированного действия нестероидного противовоспалительного средства кетопрофен, способ получения
RU2492181C2 (ru) * 2009-01-30 2013-09-10 Энанта Фармасьютикалс, Инк. Аналоги циклоспорина для предупреждения или лечения инфекции гепатита с

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JP5322647B2 (ja) * 2005-09-30 2013-10-23 スシネキス インク ウイルス感染の治療及び予防のためのシクロスポリンaのアリールアルキル及びヘテロアリールアルキル誘導体
JP5517454B2 (ja) * 2005-09-30 2014-06-11 スシネキス インク C型肝炎感染の治療及び予防のための方法及び医薬組成物
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CN101557819A (zh) * 2006-10-12 2009-10-14 诺瓦提斯公司 修饰的环孢素的用途
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CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
CN103179966B (zh) 2010-10-08 2017-03-15 诺瓦提斯公司 磺酰胺ns3抑制剂的维生素e制剂
AU2011336266B2 (en) * 2010-12-03 2017-04-06 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
HRP20190096T1 (hr) 2010-12-15 2019-02-22 Contravir Pharmaceuticals, Inc. Molekule analoga ciklosporina modificirani na amino kiselini 1 i 3
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JP2015519368A (ja) 2012-06-01 2015-07-09 アラーガン インコーポレイテッドAllergan,Incorporated シクロスポリンa類似体
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
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CN108025039B (zh) * 2015-06-30 2022-07-29 西普拉里斯有限公司 新颖的大环化合物
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Cited By (2)

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RU2492181C2 (ru) * 2009-01-30 2013-09-10 Энанта Фармасьютикалс, Инк. Аналоги циклоспорина для предупреждения или лечения инфекции гепатита с
RU2448690C1 (ru) * 2011-03-15 2012-04-27 Открытое акционерное общество "Биосинтез" Твердая лекарственная форма пролонгированного действия нестероидного противовоспалительного средства кетопрофен, способ получения

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HK1108703A1 (en) 2008-05-16
BRPI0516737A (pt) 2008-04-29
JP2012167113A (ja) 2012-09-06
DK1802650T3 (da) 2012-02-06
PT1802650E (pt) 2011-12-30
CN101773661B (zh) 2013-09-25
JP2008514732A (ja) 2008-05-08
AU2005292162A1 (en) 2006-04-13
SI1802650T1 (sl) 2012-03-30
PL1802650T3 (pl) 2012-04-30
CN101773661A (zh) 2010-07-14
NZ554514A (en) 2010-10-29
ATE530561T1 (de) 2011-11-15
IL182315A (en) 2013-08-29
CA2583494A1 (en) 2006-04-13
CA2583494C (en) 2014-01-21
EP1802650B1 (en) 2011-10-26
IL182315A0 (en) 2007-07-24
JP5139065B2 (ja) 2013-02-06
MX2007003538A (es) 2008-01-16
WO2006039668B1 (en) 2007-05-31
ES2373450T3 (es) 2012-02-03
EP1802650A4 (en) 2008-08-20
US20100167996A1 (en) 2010-07-01
WO2006039668A3 (en) 2007-04-19
KR101309409B1 (ko) 2013-09-23
WO2006039668A2 (en) 2006-04-13
KR20070073841A (ko) 2007-07-10
US20120264679A1 (en) 2012-10-18
AU2005292162B2 (en) 2011-11-10
EP1802650A2 (en) 2007-07-04
RU2007116119A (ru) 2008-11-10

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