CN101773661B - 用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物 - Google Patents
用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物 Download PDFInfo
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- CN101773661B CN101773661B CN2010100010787A CN201010001078A CN101773661B CN 101773661 B CN101773661 B CN 101773661B CN 2010100010787 A CN2010100010787 A CN 2010100010787A CN 201010001078 A CN201010001078 A CN 201010001078A CN 101773661 B CN101773661 B CN 101773661B
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Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
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|---|---|---|---|
| US61515204P | 2004-10-01 | 2004-10-01 | |
| US60/615,152 | 2004-10-01 | ||
| US70762605P | 2005-08-11 | 2005-08-11 | |
| US60/707,626 | 2005-08-11 |
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| CN2005800412034A Division CN101068829B (zh) | 2004-10-01 | 2005-09-30 | 用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物 |
Publications (2)
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|---|---|
| CN101773661A CN101773661A (zh) | 2010-07-14 |
| CN101773661B true CN101773661B (zh) | 2013-09-25 |
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| CN2010100010787A Expired - Fee Related CN101773661B (zh) | 2004-10-01 | 2005-09-30 | 用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物 |
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| BR (1) | BRPI0516737A (enExample) |
| CA (1) | CA2583494C (enExample) |
| DK (1) | DK1802650T3 (enExample) |
| ES (1) | ES2373450T3 (enExample) |
| IL (1) | IL182315A (enExample) |
| MX (1) | MX2007003538A (enExample) |
| NZ (1) | NZ554514A (enExample) |
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| PT (1) | PT1802650E (enExample) |
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| SI (1) | SI1802650T1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| ATE412005T1 (de) | 2004-11-22 | 2008-11-15 | Astellas Pharma Inc | Zyklosporinanalog |
| CN105169369B (zh) * | 2005-09-30 | 2019-10-18 | 中美华世通生物医药科技（武汉）有限公司 | 治疗和预防丙型肝炎感染的方法和药物组合物 |
| CA2623864C (en) | 2005-09-30 | 2014-12-16 | Scynexis, Inc. | Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection |
| PL1957518T3 (pl) | 2005-10-26 | 2016-07-29 | Astellas Pharma Inc | Nowe cykliczne związki peptydowe |
| UA100666C2 (uk) | 2006-04-11 | 2013-01-25 | Новартіс Аг | Інгібітори нсv/віл та їх застосування |
| EP2023918B1 (en) | 2006-05-19 | 2011-03-23 | Scynexis, Inc. | Cyclosporins for the treatment and prevention of ocular disorders |
| KR101089112B1 (ko) * | 2006-06-02 | 2011-12-06 | 피씨 제스띠옹 에스.아.에스. | 활성 전자 관리 |
| SG175621A1 (en) * | 2006-10-12 | 2011-11-28 | Novartis Ag | Use of modified cyclosporins |
| US7576057B2 (en) | 2006-11-20 | 2009-08-18 | Scynexis, Inc. | Cyclic peptides |
| WO2008127613A1 (en) * | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
| KR20100017547A (ko) | 2007-05-02 | 2010-02-16 | 아스텔라스세이야쿠 가부시키가이샤 | 신규 시클릭 펩티드 화합물 |
| WO2009148615A1 (en) * | 2008-06-06 | 2009-12-10 | Scynexis, Inc. | Cyclosporin analogs and their use in the treatment of hcv infections |
| JP5820722B2 (ja) * | 2008-06-06 | 2015-11-24 | スシネキス インク | シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用 |
| AU2009276241A1 (en) | 2008-07-30 | 2010-02-04 | Ciclofilin Pharmaceuticals Corp. | Nonimmunosuppressive cyclosporine analogue molecules |
| CA2748389A1 (en) | 2008-12-31 | 2010-07-08 | Scynexis, Inc. | Derivatives of cyclosporin a |
| AU2010203656A1 (en) * | 2009-01-07 | 2011-07-21 | Scynexis, Inc. | Cyclosporine derivative for use in the treatment of HCV and HIV infection |
| EP2391376A4 (en) | 2009-01-30 | 2012-08-01 | Enanta Pharm Inc | ANALOGUES OF CYCLOSPORIN FOR PREVENTING OR TREATING HEPATITIS C INFECTION |
| US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| PH12012500827A1 (en) | 2009-10-30 | 2013-01-07 | Boehringer Ingelheim Int | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
| CN102869367A (zh) | 2009-12-09 | 2013-01-09 | 西尼克斯公司 | 新颖的环肽 |
| PH12012501216A1 (en) * | 2009-12-18 | 2012-11-05 | Boehringer Ingelheim Int | Hcv combination therapy |
| KR20120125610A (ko) | 2009-12-30 | 2012-11-16 | 싸이넥시스, 인크. | 시클로스포린 유사체 |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| CN107007815A (zh) | 2010-07-16 | 2017-08-04 | 美国科技环球有限公司 | 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用 |
| WO2012021796A2 (en) | 2010-08-12 | 2012-02-16 | S&T Global, Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| AU2011311880B2 (en) | 2010-10-08 | 2014-07-24 | Novartis Ag | Vitamin E formulations of sulfamide NS3 inhibitors |
| AU2011336266B2 (en) * | 2010-12-03 | 2017-04-06 | S&T Global Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| LT2651965T (lt) | 2010-12-15 | 2019-01-10 | Contravir Pharmaceuticals, Inc. | Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis |
| RU2448690C1 (ru) * | 2011-03-15 | 2012-04-27 | Открытое акционерное общество "Биосинтез" | Твердая лекарственная форма пролонгированного действия нестероидного противовоспалительного средства кетопрофен, способ получения |
| CN103987399A (zh) * | 2011-08-19 | 2014-08-13 | 美国科技环球有限公司 | 用于治疗和预防病毒感染的新型环孢菌素衍生物 |
| CA2874548A1 (en) | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
| US8906853B2 (en) | 2012-11-28 | 2014-12-09 | Enanta Pharmaceuticals, Inc. | [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection |
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- 2005-09-30 PL PL05815625T patent/PL1802650T3/pl unknown
- 2005-09-30 NZ NZ554514A patent/NZ554514A/en not_active IP Right Cessation
- 2005-09-30 WO PCT/US2005/035533 patent/WO2006039668A2/en not_active Ceased
- 2005-09-30 MX MX2007003538A patent/MX2007003538A/es active IP Right Grant
- 2005-09-30 KR KR1020077009820A patent/KR101309409B1/ko not_active Expired - Fee Related
- 2005-09-30 DK DK05815625.8T patent/DK1802650T3/da active
- 2005-09-30 EP EP05815625A patent/EP1802650B1/en not_active Expired - Lifetime
- 2005-09-30 PT PT05815625T patent/PT1802650E/pt unknown
- 2005-09-30 AT AT05815625T patent/ATE530561T1/de active
- 2005-09-30 ES ES05815625T patent/ES2373450T3/es not_active Expired - Lifetime
- 2005-09-30 CN CN2010100010787A patent/CN101773661B/zh not_active Expired - Fee Related
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| AU2005292162A1 (en) | 2006-04-13 |
| ES2373450T3 (es) | 2012-02-03 |
| HK1108703A1 (en) | 2008-05-16 |
| SI1802650T1 (sl) | 2012-03-30 |
| RU2399628C2 (ru) | 2010-09-20 |
| MX2007003538A (es) | 2008-01-16 |
| JP5139065B2 (ja) | 2013-02-06 |
| ATE530561T1 (de) | 2011-11-15 |
| PT1802650E (pt) | 2011-12-30 |
| BRPI0516737A (pt) | 2008-04-29 |
| CN101773661A (zh) | 2010-07-14 |
| NZ554514A (en) | 2010-10-29 |
| DK1802650T3 (da) | 2012-02-06 |
| IL182315A0 (en) | 2007-07-24 |
| JP2008514732A (ja) | 2008-05-08 |
| PL1802650T3 (pl) | 2012-04-30 |
| EP1802650A4 (en) | 2008-08-20 |
| AU2005292162B2 (en) | 2011-11-10 |
| CA2583494A1 (en) | 2006-04-13 |
| WO2006039668B1 (en) | 2007-05-31 |
| US20100167996A1 (en) | 2010-07-01 |
| JP2012167113A (ja) | 2012-09-06 |
| IL182315A (en) | 2013-08-29 |
| CA2583494C (en) | 2014-01-21 |
| KR101309409B1 (ko) | 2013-09-23 |
| RU2007116119A (ru) | 2008-11-10 |
| EP1802650B1 (en) | 2011-10-26 |
| KR20070073841A (ko) | 2007-07-10 |
| WO2006039668A2 (en) | 2006-04-13 |
| WO2006039668A3 (en) | 2007-04-19 |
| EP1802650A2 (en) | 2007-07-04 |
| US20120264679A1 (en) | 2012-10-18 |
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