RU2367442C2 - Способ нормализации мочеиспускания при нарушении функции почек - Google Patents
Способ нормализации мочеиспускания при нарушении функции почек Download PDFInfo
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- RU2367442C2 RU2367442C2 RU2005131938/15A RU2005131938A RU2367442C2 RU 2367442 C2 RU2367442 C2 RU 2367442C2 RU 2005131938/15 A RU2005131938/15 A RU 2005131938/15A RU 2005131938 A RU2005131938 A RU 2005131938A RU 2367442 C2 RU2367442 C2 RU 2367442C2
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- RU
- Russia
- Prior art keywords
- patient
- furosemide
- renal function
- diuretic
- amide
- Prior art date
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| RU2802873C1 (ru) * | 2022-11-16 | 2023-09-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Применение ореганола а, обладающего диуретической активностью |
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| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| CA2522971A1 (en) | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20070238740A1 (en) * | 2003-08-28 | 2007-10-11 | Nitromed, Inc. | Nitrosated And Nitrosylated Cardiovascular Compounds, Compositions And Methods Of Use |
| AU2005237466A1 (en) * | 2004-04-16 | 2005-11-10 | Novacardia, Inc. | Combination therapy comprising an adenosine A1 receptor antagonist and an aldosterone inhibitor |
| AU2006216665A1 (en) * | 2005-02-24 | 2006-08-31 | Nicox S.A. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
| CA2608111A1 (en) * | 2005-04-22 | 2006-11-02 | Novacardia, Inc. | Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions |
| WO2007069675A1 (ja) * | 2005-12-14 | 2007-06-21 | Kyowa Hakko Kogyo Co., Ltd. | キサンチン誘導体の易吸収性経口製剤 |
| CA2648281A1 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466435A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | Kw-3902在充血性心脏衰竭和急性体液超负荷患者中实现利尿作用的用途 |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| WO2008121893A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
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| WO1999055339A1 (en) * | 1998-04-24 | 1999-11-04 | Biogen, Inc. | Adenosine a1 receptor antagonist containing composition and method for restoring diuretic and renal function |
| EP0970696A1 (en) * | 1998-05-05 | 2000-01-12 | Kyowa Hakko Kogyo Co., Ltd. | Combination of loop diuretics with adenosine A1-receptor antagonists |
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| SE416810C (sv) | 1977-10-14 | 1982-07-19 | Draco Ab | Forfarande for framstellning av xantinderivat med antiallergisk aktivitet |
| FR2531085A1 (fr) | 1982-07-28 | 1984-02-03 | Adir | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4769377A (en) | 1983-02-18 | 1988-09-06 | The Johns Hopkins University | Adenosine receptor antagonists |
| DE8817122U1 (de) | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
| US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| SE9000207L (sv) | 1990-01-22 | 1991-07-23 | Nobel Chemicals Ab | Laekemedel samt anvaendningen av detsamma |
| DE4019892A1 (de) | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| AU2297192A (en) | 1991-06-28 | 1993-01-25 | Sepracor, Inc. | Optically pure s(-) nadolol for treatment of cardiovascular disorders |
| CA2093403C (en) | 1992-04-08 | 1999-08-10 | Fumio Suzuki | Therapeutic agent for parkinson's disease |
| TW252044B (https=) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| DE4238367A1 (de) | 1992-11-13 | 1994-05-19 | Boehringer Ingelheim Kg | Diuretisches Mittel |
| US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
| US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| US5736528A (en) | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
| CN1049117C (zh) | 1994-09-16 | 2000-02-09 | 赵明玉 | 预防和治疗偏头痛的偏头痛片 |
| DE69628276T2 (de) | 1995-07-26 | 2004-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Zubereitung von xanthinderivaten als feste dispersion |
| US6210687B1 (en) | 1996-08-07 | 2001-04-03 | Kyowa Hakko Kogyo Co., Ltd. | Fat emulsion containing xanthine derivative |
| US6187780B1 (en) | 1998-04-16 | 2001-02-13 | Boehringer Ingelheim Pharma Kg | Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity |
| DE19816857A1 (de) | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US20020115687A1 (en) | 1998-04-24 | 2002-08-22 | Evan Beckman | Method and composition for restoring diuretic and renal function |
| UA74141C2 (uk) | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| CN100390178C (zh) | 1999-11-12 | 2008-05-28 | 拜奥根Idec马萨诸塞公司 | 作为腺苷受体拮抗剂的多环烷基嘌呤 |
| HUP0203371A3 (en) | 1999-11-12 | 2005-02-28 | Biogen Idec Ma Inc Cambridge | Adenosine receptor antagonists and methods of making and using the same |
| US20050038017A1 (en) | 1999-12-22 | 2005-02-17 | Wolff Andrew A. | Method and composition for restoring diuretic and renal function |
| CZ20031513A3 (cs) | 2000-12-01 | 2003-09-17 | Biogen, Inc. | Kondenzované purinové deriváty jako antagonisty A1 adenosinového receptoru |
| HUP0302455A3 (en) | 2000-12-18 | 2005-05-30 | Novartis Ag | Combination pharmaceutical compositions containing amplodipine and benazepril and their use |
| UA80258C2 (en) | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| US20040229901A1 (en) | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| US20060293312A1 (en) | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| CA2522971A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20050070524A1 (en) | 2003-06-06 | 2005-03-31 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders |
| AU2005237466A1 (en) | 2004-04-16 | 2005-11-10 | Novacardia, Inc. | Combination therapy comprising an adenosine A1 receptor antagonist and an aldosterone inhibitor |
| CA2565037A1 (en) | 2004-04-28 | 2005-11-10 | Cv Therapeutics, Inc. | Purine derivatives as a1 adenosine receptor antagonists |
| CA2648281A1 (en) | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| CN101466435A (zh) | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | Kw-3902在充血性心脏衰竭和急性体液超负荷患者中实现利尿作用的用途 |
| CN101466383A (zh) | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| EP2061793A2 (en) | 2006-08-22 | 2009-05-27 | Novacardia, Inc. | Kw-3902 conjugates that do not cross the blood-brain barrier |
-
2004
- 2004-04-23 CA CA002522971A patent/CA2522971A1/en not_active Abandoned
- 2004-04-23 KR KR1020057020243A patent/KR20060004959A/ko not_active Ceased
- 2004-04-23 US US10/830,617 patent/US7579331B2/en not_active Expired - Fee Related
- 2004-04-23 AR ARP040101381A patent/AR044069A1/es unknown
- 2004-04-23 BR BRPI0409699-1A patent/BRPI0409699A/pt not_active IP Right Cessation
- 2004-04-23 TW TW093111522A patent/TW200500070A/zh unknown
- 2004-04-23 MX MXPA05011371A patent/MXPA05011371A/es not_active Application Discontinuation
- 2004-04-23 CN CNA2004800105597A patent/CN1859913A/zh active Pending
- 2004-04-23 RU RU2005131938/15A patent/RU2367442C2/ru not_active IP Right Cessation
- 2004-04-23 WO PCT/US2004/012518 patent/WO2004096228A1/en not_active Ceased
- 2004-04-23 NZ NZ543109A patent/NZ543109A/en unknown
- 2004-04-23 JP JP2006513242A patent/JP2006524699A/ja not_active Withdrawn
- 2004-04-23 EP EP04760339A patent/EP1620107A1/en not_active Withdrawn
- 2004-04-23 AU AU2004233852A patent/AU2004233852A1/en not_active Abandoned
-
2005
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- 2005-10-11 US US11/248,479 patent/US20060030572A1/en not_active Abandoned
- 2005-11-17 ZA ZA200509311A patent/ZA200509311B/en unknown
- 2005-11-23 NO NO20055536A patent/NO20055536L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999055339A1 (en) * | 1998-04-24 | 1999-11-04 | Biogen, Inc. | Adenosine a1 receptor antagonist containing composition and method for restoring diuretic and renal function |
| EP0970696A1 (en) * | 1998-05-05 | 2000-01-12 | Kyowa Hakko Kogyo Co., Ltd. | Combination of loop diuretics with adenosine A1-receptor antagonists |
Non-Patent Citations (1)
| Title |
|---|
| РЕЗНИК М.И. Секреты урологии. - М.: БИНОМ, СПб.: Невский Диалект, 2000, глава 12: Диагностика острой почечной недостаточности, с.48-55. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2802873C1 (ru) * | 2022-11-16 | 2023-09-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Применение ореганола а, обладающего диуретической активностью |
Also Published As
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|---|---|
| CN1859913A (zh) | 2006-11-08 |
| TW200500070A (en) | 2005-01-01 |
| AR044069A1 (es) | 2005-08-24 |
| CA2522971A1 (en) | 2004-11-11 |
| KR20060004959A (ko) | 2006-01-16 |
| US20060030572A1 (en) | 2006-02-09 |
| US20060035911A1 (en) | 2006-02-16 |
| ZA200509311B (en) | 2006-10-25 |
| RU2005131938A (ru) | 2006-06-27 |
| NZ543109A (en) | 2008-06-30 |
| EP1620107A1 (en) | 2006-02-01 |
| BRPI0409699A (pt) | 2006-04-18 |
| US20050004145A1 (en) | 2005-01-06 |
| NO20055536L (no) | 2005-12-29 |
| JP2006524699A (ja) | 2006-11-02 |
| WO2004096228A1 (en) | 2004-11-11 |
| NO20055536D0 (no) | 2005-11-23 |
| AU2004233852A1 (en) | 2004-11-11 |
| MXPA05011371A (es) | 2005-12-01 |
| US7579331B2 (en) | 2009-08-25 |
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