RU2354372C2 - Парентеральное, внутривенное и пероральное введение оксазолидинонов для лечения инфекционных поражений стопы при диабете - Google Patents
Парентеральное, внутривенное и пероральное введение оксазолидинонов для лечения инфекционных поражений стопы при диабете Download PDFInfo
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- RU2354372C2 RU2354372C2 RU2004131830/14A RU2004131830A RU2354372C2 RU 2354372 C2 RU2354372 C2 RU 2354372C2 RU 2004131830/14 A RU2004131830/14 A RU 2004131830/14A RU 2004131830 A RU2004131830 A RU 2004131830A RU 2354372 C2 RU2354372 C2 RU 2354372C2
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- Prior art keywords
- foot
- infectious
- treating
- lesion
- diabetes
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
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| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| JP4579502B2 (ja) * | 2003-05-02 | 2010-11-10 | キヤノン株式会社 | 構造体及びその製造方法、該構造体を含むトナー並びにそれを用いた画像形成方法及び装置 |
| MXPA05013132A (es) | 2003-06-03 | 2006-05-25 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo y metodos de produccion y su uso. |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| US7129259B2 (en) | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| WO2006008640A1 (en) * | 2004-07-15 | 2006-01-26 | Pharmacia & Upjohn Company Llc | Non-aqueous suspension containing a drug having an unpleasant taste |
| PE20060619A1 (es) * | 2004-07-29 | 2006-07-11 | Ferrer Int | Derivados de oxazolidinona como antibacterianos |
| US8399660B2 (en) | 2005-06-08 | 2013-03-19 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
| EP1745784A1 (en) * | 2005-06-27 | 2007-01-24 | Ferrer Internacional, S.A. | Oxazolidinone derivatives and use thereof as antibiotics |
| ATE449773T1 (de) | 2005-06-29 | 2009-12-15 | Pharmacia & Upjohn Co Llc | Homomorpholinoxazolidinone als antibakterielle mittel |
| US9427468B2 (en) * | 2007-08-22 | 2016-08-30 | Trustees Of Dartmouth College | Compositions and methods for diagnosing and treating community-acquired methicillin-resistant Staphylococcus aureus |
| UY32493A (es) * | 2009-03-16 | 2010-10-29 | Astrazeneca Ab | " (5r)-3-[4-[1-[(2s)-2,3-dihidroxipropanoil]-3,6-dihidro-2h-piridin-4-il]-3,5-difluorofenil]-5-(isoxazol-3-iloximetil)oxazolidin-2-ona, sus sales farmacéuticamente aceptables, sus ésteres hidrolizables y aplicaciones" |
| WO2012082992A1 (en) * | 2010-12-15 | 2012-06-21 | Biovista, Inc. | Compositions and methods for cancer treatment |
Citations (2)
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| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| RU2105003C1 (ru) * | 1992-05-08 | 1998-02-20 | Дзе Апджон Компани | Производное оксазолидинона или его фармацевтически приемлемая соль, способ лечения микробных инфекций у теплокровных животных |
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| US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
| US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
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| DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
| ATE233766T1 (de) * | 1994-11-15 | 2003-03-15 | Upjohn Co | Antibakterielle bizyklische oxazin und thiazin- oxazolidinone |
| HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| CA2228647A1 (en) * | 1995-09-01 | 1997-03-13 | Pharmacia & Upjohn Company | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings |
| DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
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-
2003
- 2003-03-21 CA CA002476545A patent/CA2476545A1/en not_active Abandoned
- 2003-03-21 JP JP2003581774A patent/JP2005527575A/ja not_active Withdrawn
- 2003-03-21 US US10/394,912 patent/US20030216330A1/en not_active Abandoned
- 2003-03-21 WO PCT/US2003/008882 patent/WO2003084534A1/en not_active Ceased
- 2003-03-21 IL IL16419503A patent/IL164195A0/xx unknown
- 2003-03-21 KR KR10-2004-7015307A patent/KR20040095328A/ko not_active Ceased
- 2003-03-21 EP EP03719451A patent/EP1490059A1/en not_active Withdrawn
- 2003-03-21 CN CNA038073471A patent/CN1642543A/zh active Pending
- 2003-03-21 RU RU2004131830/14A patent/RU2354372C2/ru not_active IP Right Cessation
- 2003-03-21 NZ NZ535648A patent/NZ535648A/en unknown
- 2003-03-21 AU AU2003223334A patent/AU2003223334A1/en not_active Abandoned
- 2003-03-21 PL PL03372661A patent/PL372661A1/xx not_active Application Discontinuation
- 2003-03-21 MX MXPA04009356A patent/MXPA04009356A/es not_active Application Discontinuation
- 2003-03-21 BR BR0308806-5A patent/BR0308806A/pt not_active IP Right Cessation
-
2004
- 2004-09-23 ZA ZA200407734A patent/ZA200407734B/en unknown
- 2004-10-28 NO NO20044672A patent/NO20044672L/no not_active Application Discontinuation
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| RU2105003C1 (ru) * | 1992-05-08 | 1998-02-20 | Дзе Апджон Компани | Производное оксазолидинона или его фармацевтически приемлемая соль, способ лечения микробных инфекций у теплокровных животных |
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| RICHARD TL. Et al. "The diabetic foot". J Am Acad Orthop Surg 1995; 3:218-225. WAGNER А et al. "Highly resistant pathogens, especially methicillin-resistant Staph, aureus, in diabetic patients with foot infections". DMW Deutsche Medizinische Wochenschrift, 2001, vol.126, no 48, р.1353-1356. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1642543A (zh) | 2005-07-20 |
| ZA200407734B (en) | 2005-06-24 |
| CA2476545A1 (en) | 2003-10-16 |
| WO2003084534A1 (en) | 2003-10-16 |
| AU2003223334A1 (en) | 2003-10-20 |
| RU2004131830A (ru) | 2005-04-10 |
| US20030216330A1 (en) | 2003-11-20 |
| MXPA04009356A (es) | 2005-01-25 |
| JP2005527575A (ja) | 2005-09-15 |
| NZ535648A (en) | 2007-05-31 |
| IL164195A0 (en) | 2005-12-18 |
| BR0308806A (pt) | 2005-01-04 |
| KR20040095328A (ko) | 2004-11-12 |
| NO20044672L (no) | 2004-12-23 |
| PL372661A1 (en) | 2005-07-25 |
| EP1490059A1 (en) | 2004-12-29 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20090322 |