RU2348618C2 - Производные 8-гидроксихинолина - Google Patents

Производные 8-гидроксихинолина Download PDF

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RU2348618C2
RU2348618C2 RU2005100842/04A RU2005100842A RU2348618C2 RU 2348618 C2 RU2348618 C2 RU 2348618C2 RU 2005100842/04 A RU2005100842/04 A RU 2005100842/04A RU 2005100842 A RU2005100842 A RU 2005100842A RU 2348618 C2 RU2348618 C2 RU 2348618C2
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substituted
compound
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disease
pbt
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RU2005100842/04A
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RU2005100842A (ru
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Кевин Джеффри БАРНХАМ (AU)
Кевин Джеффри БАРНХАМ
Элизабет Колет Луис ГАУТИЕР (AU)
Элизабет Колет Луис ГАУТИЕР
Гаик Бенг КОК (AU)
Гаик Бенг КОК
Гай КРИППНЕР (AU)
Гай КРИППНЕР
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Прана Биотехнолоджи Лимитэд
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Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781396B2 (en) * 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
EP1565185A4 (en) 2002-11-07 2011-01-05 Technion Res & Dev Foundation NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
EP2058275A1 (en) * 2003-01-07 2009-05-13 Ramot at Tel-Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
EP1663199B1 (en) 2003-09-25 2013-04-03 Tel Aviv University Future Technology Development L.P. Compositions and methods using same for treating amyloid-associated diseases
FR2864535B1 (fr) * 2003-12-24 2006-12-22 Merck Sante Sas Derives acides de quinoline et leurs applications en therapeutique
CA2563038C (en) * 2004-04-02 2013-10-29 Gaik Beng Kok Neurologically-active compounds
WO2006006172A2 (en) * 2004-07-15 2006-01-19 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
ATE539745T1 (de) 2004-08-19 2012-01-15 Univ Tel Aviv Future Tech Dev Zusammensetzungen zur behandlung von amyloid- assoziierten erkrankungen
US7786086B2 (en) 2004-09-08 2010-08-31 Ramot At Tel-Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
US8697674B2 (en) 2004-12-29 2014-04-15 Naturon, Inc. Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
FR2889525A1 (fr) 2005-08-04 2007-02-09 Palumed Sa Nouveaux derives de polyquinoleines et leur utilisation therapeutique.
EP1973928A2 (en) * 2005-10-11 2008-10-01 Ramot at Tel-Aviv University Ltd. Self-assembled fmoc-ff hydrogels
US7879212B2 (en) * 2005-11-03 2011-02-01 Ramot At Tel-Aviv University Ltd. Peptide nanostructure-coated electrodes
US20070179123A1 (en) * 2005-11-08 2007-08-02 Chiang Peter K Methods and compositions for treating diseases associated with pathogenic proteins
KR100821649B1 (ko) * 2006-01-24 2008-04-11 서울시립대학교 산학협력단 클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제
AU2007219615B2 (en) 2006-03-03 2013-11-28 Promis Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases
BRPI0710737A2 (pt) 2006-04-14 2011-05-10 Prana Biotechnology Ltd uso de compostos pb-10 33 éteis para o tratamento de degeneraÇço macular relacionada À idade (amd), assim como referidos compostos
AU2007280984A1 (en) * 2006-07-25 2008-02-07 Envivo Pharmaceutical Inc. Quinoline derivatives
BRPI0715872A2 (pt) * 2006-08-23 2014-08-26 Wyeth Corp Composto; composição farmacêutica; método de preparação do composto; composto preparado pelo método; e método de tratamento de um transtorno em um mamífero necessitado
US7964729B2 (en) * 2006-08-28 2011-06-21 Massachusetts Institute Of Technology Sox-based kinase sensor
US20080173652A1 (en) * 2007-01-23 2008-07-24 Bob Chou Integral heat-resisting structure of a disposable drinking cup
US8440835B2 (en) 2007-02-26 2013-05-14 Massachusetts Institute Of Technology Environmentally sensitive fluorophores
DE102007017654A1 (de) * 2007-04-12 2008-10-16 Henkel Ag & Co. Kgaa Bis(hydroxychinolin)-Metallkomplexe als Bleichkatalysatoren
KR100875493B1 (ko) 2007-05-14 2008-12-22 서울시립대학교 산학협력단 클리오퀴놀 및 그의 유도체를 유효성분으로 함유하는지방형성 억제용 조성물
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
US9321730B2 (en) * 2007-08-21 2016-04-26 The Hong Kong Polytechnic University Method of making and administering quinoline derivatives as anti-cancer agents
JP2009079037A (ja) * 2007-09-06 2009-04-16 Sumitomo Chemical Co Ltd アミロイドβタンパク質の蓄積を抑制するための医薬組成物
US8268849B2 (en) * 2007-09-25 2012-09-18 Board Of Regents Of The University Of Nebraska Multifunctional Antioxidants and methods of use thereof
US12404304B1 (en) 2007-11-14 2025-09-02 Sierra Sciences, Llc Telomerase reverse transcriptase (TERT) expression enhancing compounds and methods for using the same
JP5579618B2 (ja) * 2007-12-07 2014-08-27 プラナ バイオテクノロジー リミティッド 治療および診断用化合物
TWI492943B (zh) 2008-12-05 2015-07-21 大塚製藥股份有限公司 喹啉酮化合物及藥學組成物（二）
WO2010068767A1 (en) 2008-12-10 2010-06-17 The Trustees Of The University Of Pennsylvania Small molecule activators of mitochondrial function
WO2010144102A1 (en) * 2009-06-09 2010-12-16 The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Material Command Pentafluorosulfanyl analogs of mefloquine
EP2261214A1 (en) 2009-06-12 2010-12-15 Splicos Sas Compounds useful to treat premature aging and in particular progeria
WO2010143169A2 (en) * 2009-06-12 2010-12-16 Société Splicos Compounds useful for treating aids
HRP20191460T1 (hr) * 2009-06-12 2019-11-15 Abivax Spojevi korisni za liječenje raka
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
US8680077B2 (en) 2009-07-24 2014-03-25 Duke University Prochelators useful for inhibiting metal-associated toxicity
WO2011022216A1 (en) * 2009-08-17 2011-02-24 High Point Pharmaceuticals, Llc Substituted pyridine derivatives, pharmaceutical compositions, and methods of use to treat oxidative stress
US8409820B2 (en) 2009-08-31 2013-04-02 Massachusetts Institute Of Technology Kinase sensors
EP2353599A1 (en) * 2010-01-28 2011-08-10 University of Ljubljana 8-hydroxyquinolines as inhibitors of cathepsin B
US11701374B1 (en) 2010-05-18 2023-07-18 Sierra Sciences, Inc. 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression
WO2012066330A1 (en) 2010-11-17 2012-05-24 Heptares Therapeutics Limited Compounds useful as a2a receptor inhibitors
EP2465502A1 (en) * 2010-12-15 2012-06-20 Société Splicos Compounds useful for treating AIDS
CN102584698B (zh) * 2012-01-19 2013-10-09 华南师范大学 一类2-取代-3-喹啉酸乙酯化合物及其制备方法和应用
BR112015007095A8 (pt) 2012-09-28 2019-08-20 Warner Babcock Inst For Green Chemistry Llc derivados de di-hidro-6-azafenaleno para o tratamento de doenças do snc, oncológicas e distúrbios relacionados, composição farmacêutica compreendendoos e uso dos referidos derivados
EP2757161A1 (en) 2013-01-17 2014-07-23 Splicos miRNA-124 as a biomarker of viral infection
CN103965105A (zh) * 2013-01-29 2014-08-06 中山大学 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用
CN105452224B (zh) * 2013-04-02 2017-12-26 安基生技新药股份有限公司 作为抗神经退化剂的多官能性喹啉衍生物
US9302992B2 (en) 2013-04-02 2016-04-05 Annji Pharmaceutical Co., Ltd. Multifunctional quinoline derivatives as anti-neurodegenerative agents
SG11201510003VA (en) * 2013-06-05 2016-01-28 Univ British Columbia Anti-fibrogenic compounds, methods and uses thereof
MX382692B (es) 2013-07-05 2025-03-13 Abivax Compuestos bicíclicos útiles para el tratamiento de enfermedades causadas por retrovirus.
CN103349742B (zh) * 2013-07-08 2015-03-25 张雅静 附子萸肉中药冲剂
GB201403595D0 (en) 2014-02-28 2014-04-16 Isis Innovation Quinoline compounds
CN103980194B (zh) * 2014-05-15 2016-09-07 浙江省医学科学院 6,8-双取代喹啉化合物或其药学上可接受的盐及其制备方法和应用
EP2974729A1 (en) 2014-07-17 2016-01-20 Abivax Quinoline derivatives for use in the treatment of inflammatory diseases
EP2975034A1 (en) * 2014-07-17 2016-01-20 Abivax A quinoline derivative for the treatment of inflammatory diseases and AIDS
WO2016095205A1 (en) 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Heteroaryl orexin receptor antagonists
JP6858712B2 (ja) 2015-01-30 2021-04-14 リーバー インスティテュート フォー ブレイン ディベロップメントＬｉｅｂｅｒ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｒａｉｎ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｔ阻害方法及び組成物
US9951057B2 (en) 2015-01-30 2018-04-24 Lieber Institute For Brain Development COMT inhibiting methods and compositions
HUP1500098A2 (hu) 2015-03-09 2016-09-28 Avidin Kft 8-hidroxikinolin származékok új enantiomerjei és szintézisük
WO2017027064A1 (en) 2015-08-12 2017-02-16 The General Hospital Corporation 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents
WO2017091818A1 (en) 2015-11-25 2017-06-01 Lieber Institute For Brain Development Comt inhibiting methods and compositions
CN105367553A (zh) * 2015-12-04 2016-03-02 广东工业大学 一种他克林-8-羟（胺）基喹啉衍生物及其应用
JP7025358B2 (ja) * 2016-07-01 2022-02-24 オールテリティ セラピューティクス リミテッド 免疫グロブリン軽鎖アミロイドーシスを治療する方法
JP7514763B2 (ja) * 2017-10-13 2024-07-11 ザ ユニバーシティー オブ クイーンズランド 亜鉛イオノフォアおよびその使用
CN112823006B (zh) * 2018-10-17 2024-09-17 杜克大学 用作神经保护剂的醌还原酶2抑制剂
MX2021007376A (es) 2018-12-19 2021-09-21 Univ Leland Stanford Junior Moléculas bifuncionales para el direccionamiento lisosómico y composiciones y métodos relacionados.
EP3669873A1 (en) 2018-12-20 2020-06-24 Abivax Quinoline derivatives for use ine the traeatment of inflammation diseases
WO2020242157A1 (ko) * 2019-05-31 2020-12-03 건국대학교 글로컬산학협력단 Iox1의 항생제, 항염증제 및 항패혈증제 용도
EP4089083A1 (en) 2019-09-23 2022-11-16 Accutar Biotechnology Inc. Piperidine-2,6-dione substituted isoindoles in the preparation of substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof
CN111307957A (zh) * 2019-11-25 2020-06-19 澳美制药(苏州)有限公司 药物制剂中吐温80含量的检测方法
IL294564A (en) * 2020-01-10 2022-09-01 Lycia Therapeutics Inc Cell surface receptor binding compounds and conjugates
KR102344676B1 (ko) 2020-02-12 2021-12-30 한국과학기술연구원 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법
CN112362797B (zh) * 2020-10-26 2022-05-27 浙江国正检测技术有限公司 一种饲料中喹诺酮类药物的检测方法
CN112315963B (zh) * 2020-11-05 2022-02-11 中国科学院包头稀土研发中心 一种8-羟基喹啉稀土金属有机配合物在制备抗SARS-CoV-2试剂中的应用及其制备方法
CN112940075B (zh) * 2021-01-07 2023-03-31 渤海大学 一种乙酰胆碱酯酶抑制肽及其应用
CN112666088B (zh) * 2021-01-21 2023-03-28 上海菁一科技有限公司 一种分光光度测试法样品处理测试胶囊
WO2023288033A1 (en) 2021-07-14 2023-01-19 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates
CN115978759B (zh) * 2022-12-30 2024-12-10 海信（广东）空调有限公司 空调器和空调器的控制方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952346A (en) * 1996-10-14 1999-09-14 Hoechst Marion Roussel Deutschland Gmbh Use of non-peptide bradykinin antagonists for the treatment or prevention of Alzheimer's disease
RU2142454C1 (ru) * 1993-06-11 1999-12-10 Астра Актиеболаг Производные 4-амино-3-ацилхинолина, способ их получения, фармацевтический препарат на их основе, способ получения фармацевтического препарата и промежуточное соединение
WO2000023421A1 (en) * 1998-10-22 2000-04-27 Idun Pharmaceuticals, Inc. (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES
EP1074257A1 (en) * 1999-08-05 2001-02-07 Pfizer Products Inc. 2,7-Substituted octahydro-1H-pyrido (1,2-A)pyrazine derivatives as ligands for serotonin receptors
RU2170730C2 (ru) * 1996-05-20 2001-07-20 Дарвин Дискавери Лимитед Хинолиновые карбоксамиды и фармацевтическая композиция на их основе
WO2002024702A1 (en) * 2000-09-19 2002-03-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2002024701A2 (en) * 2000-09-20 2002-03-28 Pharmacia & Upjohn Company Substituted azepino[4,5b)indole derivatives

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682927A (en) * 1968-06-15 1972-08-08 Massimo Carissimi 5,7-bichloro-8-hydroxy-2-acetylamino quinoline
JPS58189165A (ja) * 1982-04-22 1983-11-04 ナシヨナル・リサ−チ・デイベロツプメント・コ−ポレイシヨン 抗菌剤
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
DE3932338A1 (de) 1989-09-28 1991-04-11 Nmi Naturwissenschaftl U Mediz Verfahren zur praeventiven therapie von morbus alzheimer
JPH0597674A (ja) * 1991-10-01 1993-04-20 Nikko Kyodo Co Ltd コラーゲナーゼ阻害剤
WO1997009976A2 (en) * 1995-09-01 1997-03-20 Washington University Method of reducing neurotoxic injury with zinc chelators
DE69706566T2 (de) * 1996-08-13 2002-07-11 P.N. Gerolymatos S.A., Kruoneri Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit
JP3609907B2 (ja) * 1996-09-11 2005-01-12 株式会社クラレ 光学活性テトラヒドロキノリン誘導体の製造方法
EP1007040B1 (en) * 1997-08-21 2002-05-08 P.N. Gerolymatos S.A. Use of phanquinone for the treatment of alzheimer's disease
US5980914A (en) * 1997-08-22 1999-11-09 P.N. Gerolymatos S.A. Clioquinol for the treatment of Parkinson's disease
US6323218B1 (en) 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
JP3546715B2 (ja) * 1998-06-16 2004-07-28 三菱マテリアル株式会社 ８−キノリノール誘導体とその金属錯体の製造方法
US6379666B1 (en) * 1999-02-24 2002-04-30 Edward L. Tobinick TNF inhibitors for the treatment of neurological, retinal and muscular disorders
FR2791263B1 (fr) 1999-03-26 2001-04-27 Halina Zofia Malina Preparations des medicaments bases sur une reponse immunitaire contre l'accumulation de proteines modifiees par l'acide xanthurenique
US6362339B1 (en) * 1999-10-06 2002-03-26 3M Innovative Properties Company Method of making metal 8-quinolinolato complexes
JP2002138081A (ja) * 2000-10-30 2002-05-14 Toyo Ink Mfg Co Ltd キノリン系化合物およびその製造方法
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE10132726A1 (de) 2001-07-05 2003-02-27 Gruenenthal Gmbh Verwendung von substituierten gamma-Lactonverbindungen als Arzneimittel
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
FR2827045B1 (fr) 2001-07-05 2007-08-10 Univ Pasteur Methodes et compositions pour la selection et le developpement de nouveaux agents pharmacologiques ou de nouveaux medicaments
FR2827599A1 (fr) * 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
EA200400648A1 (ru) * 2001-11-08 2005-04-28 Элан Фармасьютикалз, Инк. N, n'-замещенные производные 1,3-диамино-2-гидроксипропана
DE10159453A1 (de) 2001-12-04 2003-06-18 Merck Patent Gmbh Verwendung von 1-Phenyl-oxazolidin-2-on-Verbindungen als Protease
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
BRPI0710737A2 (pt) 2006-04-14 2011-05-10 Prana Biotechnology Ltd uso de compostos pb-10 33 éteis para o tratamento de degeneraÇço macular relacionada À idade (amd), assim como referidos compostos
ES2474865T3 (es) 2006-06-22 2014-07-09 Prana Biotechnology Limited Método de tratamiento de un tumor cerebral glioma

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2142454C1 (ru) * 1993-06-11 1999-12-10 Астра Актиеболаг Производные 4-амино-3-ацилхинолина, способ их получения, фармацевтический препарат на их основе, способ получения фармацевтического препарата и промежуточное соединение
RU2170730C2 (ru) * 1996-05-20 2001-07-20 Дарвин Дискавери Лимитед Хинолиновые карбоксамиды и фармацевтическая композиция на их основе
US5952346A (en) * 1996-10-14 1999-09-14 Hoechst Marion Roussel Deutschland Gmbh Use of non-peptide bradykinin antagonists for the treatment or prevention of Alzheimer's disease
WO2000023421A1 (en) * 1998-10-22 2000-04-27 Idun Pharmaceuticals, Inc. (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES
EP1074257A1 (en) * 1999-08-05 2001-02-07 Pfizer Products Inc. 2,7-Substituted octahydro-1H-pyrido (1,2-A)pyrazine derivatives as ligands for serotonin receptors
WO2002024702A1 (en) * 2000-09-19 2002-03-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2002024701A2 (en) * 2000-09-20 2002-03-28 Pharmacia & Upjohn Company Substituted azepino[4,5b)indole derivatives

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JP2010280737A (ja) 2010-12-16
CA2493536A1 (en) 2004-01-22
CA2493536C (en) 2011-09-06
ES2332715T3 (es) 2010-02-11
KR101149323B1 (ko) 2012-05-30
US20080161353A1 (en) 2008-07-03
DK1539700T3 (da) 2010-01-04
AU2003243836B2 (en) 2009-06-18
ZA200501253B (en) 2006-11-29
US7619091B2 (en) 2009-11-17
US8975278B2 (en) 2015-03-10
EP1539700B1 (en) 2009-08-26
US9169211B2 (en) 2015-10-27
ATE440603T1 (de) 2009-09-15
EP1539700A4 (en) 2006-06-28
CN1681791B (zh) 2013-03-27
US20150025108A1 (en) 2015-01-22
CN1681791A (zh) 2005-10-12
RU2005100842A (ru) 2005-11-20
HK1072940A1 (en) 2005-09-16
JP4694834B2 (ja) 2011-06-08
JP2006504646A (ja) 2006-02-09
US9302993B2 (en) 2016-04-05
MXPA05000708A (es) 2005-08-16
US20060089380A1 (en) 2006-04-27
AU2003243836A1 (en) 2004-02-02
KR20050036954A (ko) 2005-04-20
US20150094334A1 (en) 2015-04-02
EP1539700A1 (en) 2005-06-15

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