RU2299883C2 - Соединения спиропиразола, содержащая их фармацевтическая композиция, способ модуляции опиоидного рецептора и способ лечения с применением таких соединений - Google Patents

Info

Publication number

RU2299883C2

RU2299883C2 RU2003133455/04A RU2003133455A RU2299883C2 RU 2299883 C2 RU2299883 C2 RU 2299883C2 RU 2003133455/04 A RU2003133455/04 A RU 2003133455/04A RU 2003133455 A RU2003133455 A RU 2003133455A RU 2299883 C2 RU2299883 C2 RU 2299883C2

Authority

RU

Russia

Prior art keywords

phenyl

alkyl

triazospiro

group

dec

Prior art date

2001-04-18

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• 108090000137 Opioid Receptors Proteins 0.000 title claims description 10
• -1 decahydronaphthyl Chemical group 0.000 claims abstract description 180
• 239000003814 drug Substances 0.000 claims abstract description 30
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 20
• 150000003839 salts Chemical class 0.000 claims abstract description 17
• 108010020615 nociceptin receptor Proteins 0.000 claims abstract description 15
• 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims abstract description 14
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• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims abstract description 10
• 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 10
• 102000051367 mu Opioid Receptors Human genes 0.000 claims abstract description 10
• 125000001624 naphthyl group Chemical group 0.000 claims abstract description 7
• 239000012453 solvate Substances 0.000 claims abstract description 7
• 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 claims abstract description 6
• 230000036407 pain Effects 0.000 claims abstract description 6
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 5
• YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims abstract description 4
• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims abstract description 4
• 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims abstract description 4
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 4
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims abstract 4
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims abstract 3
• 125000003277 amino group Chemical group 0.000 claims abstract 2
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• NRXZYQITMVTQIB-UHFFFAOYSA-N dec-3-enal Chemical compound CCCCCCC=CCC=O NRXZYQITMVTQIB-UHFFFAOYSA-N 0.000 claims description 56
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• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 29
• 229910052739 hydrogen Inorganic materials 0.000 claims description 26
• 229910052736 halogen Inorganic materials 0.000 claims description 22
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• 125000001424 substituent group Chemical group 0.000 claims description 19
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• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 12
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
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• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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