KR100628292B1 - 스파이로파이라졸 화합물 - Google Patents

스파이로파이라졸 화합물 Download PDF

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Publication number
KR100628292B1
KR100628292B1 KR1020037013821A KR20037013821A KR100628292B1 KR 100628292 B1 KR100628292 B1 KR 100628292B1 KR 1020037013821 A KR1020037013821 A KR 1020037013821A KR 20037013821 A KR20037013821 A KR 20037013821A KR 100628292 B1 KR100628292 B1 KR 100628292B1
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KR
South Korea
Prior art keywords
phenyl
triazospiro
alkyl
delete
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020037013821A
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English (en)
Korean (ko)
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KR20040008159A (ko
Inventor
고어링리챠드알
카일도날드
리게리
가라고줄파비즈
빅토리샘
Original Assignee
유로-셀티크 소시에떼 아노뉨
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Publication of KR20040008159A publication Critical patent/KR20040008159A/ko
Application granted granted Critical
Publication of KR100628292B1 publication Critical patent/KR100628292B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Dental Preparations (AREA)
KR1020037013821A 2001-04-18 2002-04-18 스파이로파이라졸 화합물 Expired - Fee Related KR100628292B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18
US60/284,675 2001-04-18
PCT/US2002/012376 WO2002085355A1 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Publications (2)

Publication Number Publication Date
KR20040008159A KR20040008159A (ko) 2004-01-28
KR100628292B1 true KR100628292B1 (ko) 2006-09-27

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037013821A Expired - Fee Related KR100628292B1 (ko) 2001-04-18 2002-04-18 스파이로파이라졸 화합물

Country Status (27)

Country Link
US (2) US6635653B2 (https=)
EP (1) EP1385515B1 (https=)
JP (1) JP4342181B2 (https=)
KR (1) KR100628292B1 (https=)
CN (1) CN1516584A (https=)
AT (1) ATE403429T1 (https=)
AU (1) AU2002311833B2 (https=)
BR (1) BR0209127A (https=)
CA (1) CA2444634C (https=)
CY (1) CY1108454T1 (https=)
CZ (1) CZ20032849A3 (https=)
DE (1) DE60228071D1 (https=)
DK (1) DK1385515T3 (https=)
ES (1) ES2312584T3 (https=)
HU (1) HUP0401333A3 (https=)
IL (2) IL158485A0 (https=)
MX (1) MXPA03009604A (https=)
NO (1) NO20034660L (https=)
NZ (1) NZ528978A (https=)
PL (1) PL367263A1 (https=)
PT (1) PT1385515E (https=)
RU (1) RU2299883C2 (https=)
SI (1) SI1385515T1 (https=)
UA (1) UA74439C2 (https=)
WO (1) WO2002085355A1 (https=)
YU (1) YU82403A (https=)
ZA (1) ZA200308103B (https=)

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KR100628292B1 (ko) * 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물
JP4056977B2 (ja) 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
JP4712384B2 (ja) 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
AU2003279276A1 (en) * 2002-10-17 2004-05-04 Euro-Celtique S.A. Preparation of triazospiro compounds
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
WO2004103305A2 (en) * 2003-05-16 2004-12-02 Euroceltique S.A. Spiropyrazole compound
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MXPA06011219A (es) 2004-03-29 2007-05-08 Univ South Florida Tratamiento efectivo de tumores y cancer con triciribina y compuestos relacionados.
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100009928A1 (en) * 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
NZ556628A (en) 2005-03-08 2009-09-25 Janssen Pharmaceutica Nv Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
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US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US8703948B2 (en) 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
EP2397477B1 (en) * 2007-01-16 2014-03-05 Purdue Pharma LP Heterocyclic-substituted piperidine compounds and the uses thereof
CA2683598C (en) 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
MY150602A (en) 2007-08-31 2014-01-30 Purdue Pharma Lp Subtituted-quinoxaline-type piperidine compounds and the uses thereof
KR101333660B1 (ko) 2008-07-21 2013-11-27 시오노기세이야쿠가부시키가이샤 치환-퀴녹살린-형 가교-피페리딘 화합물 및 그의 용도
UA107943C2 (xx) * 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
US9598447B2 (en) 2010-12-22 2017-03-21 Purdue Pharma L.P. Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
AU2012324015A1 (en) 2011-12-01 2013-06-20 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thererof
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
UA124972C2 (uk) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Способи лікування раку передміхурової залози
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

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KR100628292B1 (ko) * 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물

Also Published As

Publication number Publication date
HUP0401333A3 (en) 2004-11-29
SI1385515T1 (sl) 2008-12-31
UA74439C2 (uk) 2005-12-15
JP4342181B2 (ja) 2009-10-14
WO2002085355A1 (en) 2002-10-31
RU2003133455A (ru) 2005-05-10
PL367263A1 (en) 2005-02-21
KR20040008159A (ko) 2004-01-28
IL158485A (en) 2009-09-01
ES2312584T3 (es) 2009-03-01
US20030027834A1 (en) 2003-02-06
ATE403429T1 (de) 2008-08-15
NO20034660D0 (no) 2003-10-17
CZ20032849A3 (en) 2004-03-17
US20040087641A1 (en) 2004-05-06
CA2444634A1 (en) 2002-10-31
HUP0401333A2 (hu) 2004-10-28
DE60228071D1 (de) 2008-09-18
CY1108454T1 (el) 2014-04-09
AU2002311833B2 (en) 2005-04-28
IL158485A0 (en) 2004-05-12
BR0209127A (pt) 2006-03-21
JP2004531531A (ja) 2004-10-14
CN1516584A (zh) 2004-07-28
YU82403A (sh) 2006-08-17
DK1385515T3 (da) 2008-10-27
ZA200308103B (en) 2004-10-18
EP1385515A1 (en) 2004-02-04
PT1385515E (pt) 2008-09-15
NO20034660L (no) 2003-12-17
MXPA03009604A (es) 2004-04-02
US6635653B2 (en) 2003-10-21
HK1062885A1 (en) 2004-12-03
NZ528978A (en) 2004-06-25
CA2444634C (en) 2011-06-07
RU2299883C2 (ru) 2007-05-27
EP1385515B1 (en) 2008-08-06
EP1385515A4 (en) 2004-06-30

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