UA74439C2 - Сполуки спіропіразолу - Google Patents

Сполуки спіропіразолу

Info

Publication number
UA74439C2
UA74439C2 UA20031110381A UA20031110381A UA74439C2 UA 74439 C2 UA74439 C2 UA 74439C2 UA 20031110381 A UA20031110381 A UA 20031110381A UA 20031110381 A UA20031110381 A UA 20031110381A UA 74439 C2 UA74439 C2 UA 74439C2
Authority
UA
Ukraine
Prior art keywords
spiropyrazole
compounds
compound
formula
disclosed
Prior art date
Application number
UA20031110381A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Р. Річард Герінг
Дональд Кайл
Гарі Лі
Парвіз Гхарагозлоо
Сем Вікторі
Original Assignee
Еро-Селтік, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Еро-Селтік, С.А. filed Critical Еро-Селтік, С.А.
Publication of UA74439C2 publication Critical patent/UA74439C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
UA20031110381A 2001-04-18 2002-04-18 Сполуки спіропіразолу UA74439C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18
PCT/US2002/012376 WO2002085355A1 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Publications (1)

Publication Number Publication Date
UA74439C2 true UA74439C2 (uk) 2005-12-15

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20031110381A UA74439C2 (uk) 2001-04-18 2002-04-18 Сполуки спіропіразолу

Country Status (27)

Country Link
US (2) US6635653B2 (https=)
EP (1) EP1385515B1 (https=)
JP (1) JP4342181B2 (https=)
KR (1) KR100628292B1 (https=)
CN (1) CN1516584A (https=)
AT (1) ATE403429T1 (https=)
AU (1) AU2002311833B2 (https=)
BR (1) BR0209127A (https=)
CA (1) CA2444634C (https=)
CY (1) CY1108454T1 (https=)
CZ (1) CZ20032849A3 (https=)
DE (1) DE60228071D1 (https=)
DK (1) DK1385515T3 (https=)
ES (1) ES2312584T3 (https=)
HU (1) HUP0401333A3 (https=)
IL (2) IL158485A0 (https=)
MX (1) MXPA03009604A (https=)
NO (1) NO20034660L (https=)
NZ (1) NZ528978A (https=)
PL (1) PL367263A1 (https=)
PT (1) PT1385515E (https=)
RU (1) RU2299883C2 (https=)
SI (1) SI1385515T1 (https=)
UA (1) UA74439C2 (https=)
WO (1) WO2002085355A1 (https=)
YU (1) YU82403A (https=)
ZA (1) ZA200308103B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100628292B1 (ko) * 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물
JP4056977B2 (ja) * 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
NZ538307A (en) 2002-09-09 2008-04-30 Janssen Pharmaceutica Nv Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
WO2004034983A2 (en) * 2002-10-17 2004-04-29 Euro-Celtique, S.A. Preparation of triazospiro compounds
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
WO2004103305A2 (en) * 2003-05-16 2004-12-02 Euroceltique S.A. Spiropyrazole compound
WO2005011665A1 (en) * 2003-07-22 2005-02-10 Arakis Ltd. The use of proglumide for the treatment of emesis
US20100028339A1 (en) * 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
AU2005228410A1 (en) 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
ATE478075T1 (de) 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
CN103202840B (zh) 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
EP2280008B1 (en) 2007-01-16 2013-05-29 Purdue Pharma L.P. Heterocyclic-substituted piperidines as orl-1 ligands
JP5490677B2 (ja) 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
TW201322983A (zh) * 2007-08-31 2013-06-16 Purdue Pharma Lp 經取代之喹□啉型哌啶化合物及其用途
CN102105465B (zh) 2008-07-21 2015-03-11 普渡制药公司 取代的喹喔啉型桥连哌啶化合物及其用途
UA107943C2 (xx) * 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
JP5872585B2 (ja) 2010-12-22 2016-03-01 パーデュー、ファーマ、リミテッド、パートナーシップ リン置換キノキサリンタイプピペリジン化合物とその使用
AU2012324015A1 (en) 2011-12-01 2013-06-20 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thererof
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
BR112019001398A2 (pt) 2016-07-29 2019-05-07 Janssen Pharmaceutica Nv métodos para tratamento de câncer de próstata
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157497A (https=) *
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US3325499A (en) 1964-11-02 1967-06-13 Mcneilab Inc 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone
US3923993A (en) * 1973-06-28 1975-12-02 American Home Prod Process for treating neuroendocrinopathic diseases employing fluspirilene
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
WO1995028397A1 (en) 1994-04-14 1995-10-26 Merck & Co., Inc. Alpha1c adrenergic receptor antagonists
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US5767118A (en) 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
US5574044A (en) 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
US6150355A (en) 1995-09-13 2000-11-21 Kyowa Hakko Kogyo Co., Ltd. Phenylpiperidine derivative
WO1997040035A1 (en) 1996-04-19 1997-10-30 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
US6063796A (en) 1997-04-04 2000-05-16 Merck & Co., Inc. Somatostatin agonists
WO1998054168A1 (en) 1997-05-30 1998-12-03 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
EP0921125B1 (en) 1997-12-05 2002-01-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro[4,5]decan-4-on derivatives
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
EA200000683A1 (ru) 1998-01-19 2000-12-25 Пфайзер Инк. Производные ряда 4-(2-кето-1-бензимидазолинил)пиперидина в качестве агонистов orl1-рецептора
EP1072263A4 (en) 1998-03-26 2004-03-31 Japan Tobacco Inc AMID DERIVATIVES AND NOCICEPTINANT AGONISTS
WO1999059997A1 (en) * 1998-05-18 1999-11-25 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
ATE413878T1 (de) 2000-09-06 2008-11-15 Ortho Mcneil Pharm Inc Methode zum bekämpfen der allergien durch verwendung von substituierten pyrazolen
KR100628292B1 (ko) * 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물

Also Published As

Publication number Publication date
JP4342181B2 (ja) 2009-10-14
US20040087641A1 (en) 2004-05-06
SI1385515T1 (sl) 2008-12-31
NZ528978A (en) 2004-06-25
DE60228071D1 (de) 2008-09-18
IL158485A (en) 2009-09-01
KR100628292B1 (ko) 2006-09-27
US20030027834A1 (en) 2003-02-06
JP2004531531A (ja) 2004-10-14
NO20034660D0 (no) 2003-10-17
EP1385515B1 (en) 2008-08-06
US6635653B2 (en) 2003-10-21
ZA200308103B (en) 2004-10-18
EP1385515A1 (en) 2004-02-04
KR20040008159A (ko) 2004-01-28
AU2002311833B2 (en) 2005-04-28
BR0209127A (pt) 2006-03-21
WO2002085355A1 (en) 2002-10-31
NO20034660L (no) 2003-12-17
DK1385515T3 (da) 2008-10-27
IL158485A0 (en) 2004-05-12
CY1108454T1 (el) 2014-04-09
YU82403A (sh) 2006-08-17
CN1516584A (zh) 2004-07-28
HUP0401333A2 (hu) 2004-10-28
CA2444634C (en) 2011-06-07
PT1385515E (pt) 2008-09-15
RU2003133455A (ru) 2005-05-10
CZ20032849A3 (en) 2004-03-17
RU2299883C2 (ru) 2007-05-27
PL367263A1 (en) 2005-02-21
ES2312584T3 (es) 2009-03-01
HUP0401333A3 (en) 2004-11-29
ATE403429T1 (de) 2008-08-15
EP1385515A4 (en) 2004-06-30
MXPA03009604A (es) 2004-04-02
HK1062885A1 (en) 2004-12-03
CA2444634A1 (en) 2002-10-31

Similar Documents

Publication Publication Date Title
YU82403A (sh) Jedinjenja spiropirazola
MXPA03009600A (es) Analogos de nociceptina.
DE60214591D1 (en) Pyrazolpyrimidinfungizide
DE60229736D1 (de) Spiroinden- und spiroindan-verbindungen
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
WO2002072506A3 (en) 7-pyrollyl tetracycline compounds and methods of use thereof
GB0124627D0 (en) Novel compounds
PL369530A1 (en) Chemical compounds
DE60214392D1 (de) 1,4-disubstituierte benzokondensierte cycloalkyl harnstoffverbindungen
MXPA04003886A (es) Tiofen- y tiazolsulfonamidas como agentes antineoplasticos.
MXPA05002307A (es) Composiciones antimicrobianas.
MXPA03009602A (es) Analogos de nociceptina.
MY122829A (en) Linezolid-crystal form ii
SE0004245D0 (sv) Novel compounds and their use
SI1975164T1 (sl) Oktahidrobenzimidazolonske spojine kot analgetiki
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
SV2003000981A (es) Fenil-heterociclil-eteres ref. pcs10973
ATE431328T1 (de) Photopolymerisierbare verbindungen
MXPA05003881A (es) Preparacion de compuestos triazospiro.
TW200420552A (en) Dihydro-furan-2-one derivatives, their intermediates and methods of manufacture
AU4865201A (en) An intermediate and process for its synthesis