AU2002311833B2 - Spiropyrazole compounds - Google Patents

Spiropyrazole compounds Download PDF

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Publication number
AU2002311833B2
AU2002311833B2 AU2002311833A AU2002311833A AU2002311833B2 AU 2002311833 B2 AU2002311833 B2 AU 2002311833B2 AU 2002311833 A AU2002311833 A AU 2002311833A AU 2002311833 A AU2002311833 A AU 2002311833A AU 2002311833 B2 AU2002311833 B2 AU 2002311833B2
Authority
AU
Australia
Prior art keywords
alkyl
group
phenyl
compound
triazospiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002311833A
Other languages
English (en)
Other versions
AU2002311833A1 (en
Inventor
Parviz Gharagozloo
R. Richard Goehring
Donald Kyle
Gary Lee
Sam Victory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of AU2002311833A1 publication Critical patent/AU2002311833A1/en
Application granted granted Critical
Publication of AU2002311833B2 publication Critical patent/AU2002311833B2/en
Assigned to EURO-CELTIQUE S.A. reassignment EURO-CELTIQUE S.A. Alteration of Name(s) in Register under S187 Assignors: EURO-CELTIQUE, S.A.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AU2002311833A 2001-04-18 2002-04-18 Spiropyrazole compounds Ceased AU2002311833B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18
US60/284,675 2001-04-18
PCT/US2002/012376 WO2002085355A1 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Publications (2)

Publication Number Publication Date
AU2002311833A1 AU2002311833A1 (en) 2003-04-17
AU2002311833B2 true AU2002311833B2 (en) 2005-04-28

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002311833A Ceased AU2002311833B2 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Country Status (27)

Country Link
US (2) US6635653B2 (https=)
EP (1) EP1385515B1 (https=)
JP (1) JP4342181B2 (https=)
KR (1) KR100628292B1 (https=)
CN (1) CN1516584A (https=)
AT (1) ATE403429T1 (https=)
AU (1) AU2002311833B2 (https=)
BR (1) BR0209127A (https=)
CA (1) CA2444634C (https=)
CY (1) CY1108454T1 (https=)
CZ (1) CZ20032849A3 (https=)
DE (1) DE60228071D1 (https=)
DK (1) DK1385515T3 (https=)
ES (1) ES2312584T3 (https=)
HU (1) HUP0401333A3 (https=)
IL (2) IL158485A0 (https=)
MX (1) MXPA03009604A (https=)
NO (1) NO20034660L (https=)
NZ (1) NZ528978A (https=)
PL (1) PL367263A1 (https=)
PT (1) PT1385515E (https=)
RU (1) RU2299883C2 (https=)
SI (1) SI1385515T1 (https=)
UA (1) UA74439C2 (https=)
WO (1) WO2002085355A1 (https=)
YU (1) YU82403A (https=)
ZA (1) ZA200308103B (https=)

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WO2004034983A2 (en) * 2002-10-17 2004-04-29 Euro-Celtique, S.A. Preparation of triazospiro compounds
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
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US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
AU2005228410A1 (en) 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
ATE478075T1 (de) 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
CN103202840B (zh) 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
EP2280008B1 (en) 2007-01-16 2013-05-29 Purdue Pharma L.P. Heterocyclic-substituted piperidines as orl-1 ligands
JP5490677B2 (ja) 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
TW201322983A (zh) * 2007-08-31 2013-06-16 Purdue Pharma Lp 經取代之喹□啉型哌啶化合物及其用途
CN102105465B (zh) 2008-07-21 2015-03-11 普渡制药公司 取代的喹喔啉型桥连哌啶化合物及其用途
UA107943C2 (xx) * 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
JP5872585B2 (ja) 2010-12-22 2016-03-01 パーデュー、ファーマ、リミテッド、パートナーシップ リン置換キノキサリンタイプピペリジン化合物とその使用
AU2012324015A1 (en) 2011-12-01 2013-06-20 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thererof
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
BR112019001398A2 (pt) 2016-07-29 2019-05-07 Janssen Pharmaceutica Nv métodos para tratamento de câncer de próstata
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

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Also Published As

Publication number Publication date
JP4342181B2 (ja) 2009-10-14
US20040087641A1 (en) 2004-05-06
SI1385515T1 (sl) 2008-12-31
NZ528978A (en) 2004-06-25
DE60228071D1 (de) 2008-09-18
IL158485A (en) 2009-09-01
UA74439C2 (uk) 2005-12-15
KR100628292B1 (ko) 2006-09-27
US20030027834A1 (en) 2003-02-06
JP2004531531A (ja) 2004-10-14
NO20034660D0 (no) 2003-10-17
EP1385515B1 (en) 2008-08-06
US6635653B2 (en) 2003-10-21
ZA200308103B (en) 2004-10-18
EP1385515A1 (en) 2004-02-04
KR20040008159A (ko) 2004-01-28
BR0209127A (pt) 2006-03-21
WO2002085355A1 (en) 2002-10-31
NO20034660L (no) 2003-12-17
DK1385515T3 (da) 2008-10-27
IL158485A0 (en) 2004-05-12
CY1108454T1 (el) 2014-04-09
YU82403A (sh) 2006-08-17
CN1516584A (zh) 2004-07-28
HUP0401333A2 (hu) 2004-10-28
CA2444634C (en) 2011-06-07
PT1385515E (pt) 2008-09-15
RU2003133455A (ru) 2005-05-10
CZ20032849A3 (en) 2004-03-17
RU2299883C2 (ru) 2007-05-27
PL367263A1 (en) 2005-02-21
ES2312584T3 (es) 2009-03-01
HUP0401333A3 (en) 2004-11-29
ATE403429T1 (de) 2008-08-15
EP1385515A4 (en) 2004-06-30
MXPA03009604A (es) 2004-04-02
HK1062885A1 (en) 2004-12-03
CA2444634A1 (en) 2002-10-31

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Legal Events

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NA Applications received for extensions of time, section 223

Free format text: AN APPLICATION TO EXTEND THE TIME FROM 15 APR 2004 TO 15 SEP 2005 IN WHICH TO FILE SEARCH RESULTS HAS BEEN FILED .

NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO FILE SEARCH RESULTS HAS BEEN EXTENDED TO 15 SEP 2005.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired