RU2283847C2 - Растворимый мутантный ctla4 и его применение - Google Patents

Растворимый мутантный ctla4 и его применение Download PDF

Info

Publication number
RU2283847C2
RU2283847C2 RU2002131588/13A RU2002131588A RU2283847C2 RU 2283847 C2 RU2283847 C2 RU 2283847C2 RU 2002131588/13 A RU2002131588/13 A RU 2002131588/13A RU 2002131588 A RU2002131588 A RU 2002131588A RU 2283847 C2 RU2283847 C2 RU 2283847C2
Authority
RU
Russia
Prior art keywords
ctla4
mutant
molecule
cell
amino acid
Prior art date
Application number
RU2002131588/13A
Other languages
English (en)
Russian (ru)
Other versions
RU2002131588A (ru
Inventor
Роберт Дж. ПИЧ (US)
Роберт Дж. Пич
Джозеф Р. НАЕМУРА (US)
Джозеф Р. Наемура
Питер С. ЛИНСЛИ (US)
Питер С. ЛИНСЛИ
Юрген БАЙОРАТ (US)
Юрген БАЙОРАТ
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of RU2002131588A publication Critical patent/RU2002131588A/ru
Application granted granted Critical
Publication of RU2283847C2 publication Critical patent/RU2283847C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2002131588/13A 2000-05-26 2001-05-23 Растворимый мутантный ctla4 и его применение RU2283847C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US09/579,927 2000-05-26
US21406500P 2000-06-26 2000-06-26
US60/214,065 2000-06-26

Publications (2)

Publication Number Publication Date
RU2002131588A RU2002131588A (ru) 2004-05-20
RU2283847C2 true RU2283847C2 (ru) 2006-09-20

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002131588/13A RU2283847C2 (ru) 2000-05-26 2001-05-23 Растворимый мутантный ctla4 и его применение

Country Status (41)

Country Link
EP (3) EP1248802B9 (OSRAM)
JP (1) JP4328525B2 (OSRAM)
KR (2) KR100889887B1 (OSRAM)
CN (2) CN1309735C (OSRAM)
AR (1) AR031699A1 (OSRAM)
AT (1) ATE271066T1 (OSRAM)
AU (2) AU2001263466C1 (OSRAM)
BE (1) BE2011C041I2 (OSRAM)
BR (1) BRPI0111191B8 (OSRAM)
CA (1) CA2409748C (OSRAM)
CY (2) CY2011019I2 (OSRAM)
CZ (1) CZ304451B6 (OSRAM)
DE (2) DE60104282T2 (OSRAM)
DK (1) DK1248802T3 (OSRAM)
EC (1) ECSP024365A (OSRAM)
EE (2) EE05458B1 (OSRAM)
EG (1) EG24459A (OSRAM)
ES (2) ES2571852T3 (OSRAM)
FR (1) FR11C0053I2 (OSRAM)
GE (1) GEP20053658B (OSRAM)
HK (1) HK1048126B (OSRAM)
HU (2) HU228137B1 (OSRAM)
IL (1) IL152315A (OSRAM)
LT (1) LT5133B (OSRAM)
LU (1) LU91902I2 (OSRAM)
LV (1) LV12994B (OSRAM)
MX (1) MXPA02011534A (OSRAM)
MY (1) MY136113A (OSRAM)
NO (2) NO330797B1 (OSRAM)
PE (1) PE20011338A1 (OSRAM)
PL (1) PL206267B1 (OSRAM)
PT (1) PT1248802E (OSRAM)
RU (1) RU2283847C2 (OSRAM)
SI (1) SI1248802T1 (OSRAM)
SK (1) SK288131B6 (OSRAM)
TR (1) TR200402703T4 (OSRAM)
TW (2) TWI319405B (OSRAM)
UA (1) UA87432C2 (OSRAM)
UY (1) UY26723A1 (OSRAM)
WO (1) WO2001092337A2 (OSRAM)
ZA (1) ZA200208944B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148049A1 (en) * 2012-03-29 2013-10-03 The General Hospital Corporation Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4)
WO2014004857A1 (en) * 2012-06-27 2014-01-03 Orban Biotech Llc Ctla4 fusion proteins for the treatment of diabetes
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
UY26815A1 (es) 2000-07-03 2002-01-31 Bristol Myers Squibb Co Métodos para tratar enfermedades reumáticas al usar una molécula ctla4 soluble
CZ305380B6 (cs) 2001-05-23 2015-08-26 Bristol-Myers Squibb Company Léčivo pro inhibici rejekce transplantovaných buněk ostrůvků slinivky břišní
EP1496931A4 (en) * 2002-04-19 2009-07-01 Bristol Myers Squibb Co METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
TWI328614B (en) 2002-12-23 2010-08-11 Bristol Myers Squibb Co Product quality enhancement in mammalian cell culture processes for protein production
TWI312368B (en) 2002-12-23 2009-07-21 Bristol Myers Squibb Compan Mammalian cell culture processes for protein production
AU2003299971A1 (en) 2002-12-30 2004-07-29 Amgen Inc. Combination therapy with co-stimulatory factors
WO2005044188A2 (en) 2003-10-27 2005-05-19 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
JP5096369B2 (ja) 2005-12-20 2012-12-12 ブリストル−マイヤーズ スクイブ カンパニー 組成物および組成物の製造方法
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
GB0620934D0 (en) 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
KR101546441B1 (ko) 2006-12-20 2015-08-24 엠엠알글로벌, 인코포레이티드 항체 및 이들의 제조 및 사용 방법
RU2506275C2 (ru) * 2007-11-01 2014-02-10 Астеллас Фарма Инк. Иммуносупрессорные полипептиды и нуклеиновые кислоты
PL2344540T3 (pl) * 2008-10-02 2018-05-30 Aptevo Research And Development Llc Białka wiążące wiele celów antagonistyczne względem cd86
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
TW201134481A (en) 2010-03-12 2011-10-16 Abbott Biotherapeutics Corp CTLA4 proteins and their uses
KR20130129438A (ko) 2011-02-23 2013-11-28 암젠 인크 Uvc 노출을 위한 세포 배양 배지 및 이와 관련된 방법
WO2013010537A1 (en) 2011-07-20 2013-01-24 Aarhus Universitet Method of treating morphea
SG10201609447XA (en) * 2012-05-11 2017-01-27 Medimmune Llc Ctla-4 variants
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
CN106029896B (zh) 2014-01-13 2020-10-27 美国安进公司 调控鸟氨酸代谢以操控重组蛋白的高甘露糖糖型含量
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
SI3926051T1 (sl) 2014-06-04 2024-06-28 Amgen Inc. Postopki zbiranja celičnih kultur sesalcev
LT3227454T (lt) 2014-12-01 2020-07-27 Amgen Inc. Glikoproteino glikano sudedamosios dalies kiekio keitimo procedūra
US10590457B2 (en) 2015-02-11 2020-03-17 Bristol Myers-Squibb Company Compositions for cell culture and methods of using the same
SMT202100467T1 (it) 2015-04-17 2021-09-14 Alpine Immune Sciences Inc Proteine immunomodulatorie con affinità regolabili
AU2016321298A1 (en) 2015-09-09 2018-03-29 The Trustees Of Columbia University In The City Of New York Reduction of ER-MAM localized APP-C99 and methods of treating Alzheimer's Disease
EP3374493A1 (en) 2015-11-09 2018-09-19 Bristol-Myers Squibb Company Methods to manipulate quality attributes of polypeptides produced in cho cells
CN116942793A (zh) 2016-09-19 2023-10-27 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
MX2019012567A (es) 2017-04-20 2020-02-13 Egenesis Inc Metodos para generar animales geneticamente modificados.
JP7749319B2 (ja) 2017-10-10 2025-10-06 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
AU2019205273B2 (en) 2018-01-03 2024-04-04 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
CN115227824A (zh) * 2018-11-12 2022-10-25 中南大学湘雅二医院 免疫检查点的抑制剂在制备治疗青光眼和其他眼部免疫损伤机制相关疾病药物中的应用
MX2022002337A (es) 2019-08-27 2022-06-08 Tonix Pharma Ltd Polipéptidos de tff2 modificados.
AU2020396490C1 (en) 2019-12-06 2023-04-27 Regeneron Pharmaceuticals, Inc. Anti-VEGF protein compositions and methods for producing the same
CN115803009A (zh) 2020-05-08 2023-03-14 瑞泽恩制药公司 用于治疗眼病和癌症的vegf阱和微阱及方法
EP4168807A1 (en) 2020-06-18 2023-04-26 Regeneron Pharmaceuticals, Inc. Heavy peptide approach to accurately measure unprocessed c-terminal lysine
CN116601279A (zh) 2020-07-28 2023-08-15 思进股份有限公司 用于生产多肽的方法和系统
JP2025500887A (ja) 2021-12-16 2025-01-15 ブリストル－マイヤーズ スクイブ カンパニー ウイルス不活化用界面活性剤
AU2023228815A1 (en) 2022-03-02 2024-09-12 Regeneron Pharmaceuticals, Inc. Manufacturing process for high titer antibody

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434131A (en) * 1991-06-27 1995-07-18 Bristol Myers Squibb Co. Chimeric CTLA4 receptor and methods for its use
US5851795A (en) * 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5844095A (en) 1991-06-27 1998-12-01 Bristol-Myers Squibb Company CTLA4 Ig fusion proteins
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
ZA98533B (en) * 1997-01-31 1999-07-22 Bristol Myers Squibb Co Soluble CTLA4 mutant molecules and uses thereof.
JP3521382B2 (ja) * 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
GB9809280D0 (en) * 1998-04-30 1998-07-01 Rpms Technology Ltd Immunosupression
AU1102000A (en) * 1998-10-07 2000-04-26 Millennium Pharmaceuticals, Inc. Novel th2-specific molecules and uses thereof
UY26815A1 (es) * 2000-07-03 2002-01-31 Bristol Myers Squibb Co Métodos para tratar enfermedades reumáticas al usar una molécula ctla4 soluble

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434131A (en) * 1991-06-27 1995-07-18 Bristol Myers Squibb Co. Chimeric CTLA4 receptor and methods for its use
US5851795A (en) * 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
г. *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148049A1 (en) * 2012-03-29 2013-10-03 The General Hospital Corporation Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4)
US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
WO2014004857A1 (en) * 2012-06-27 2014-01-03 Orban Biotech Llc Ctla4 fusion proteins for the treatment of diabetes
US10233242B2 (en) 2012-06-27 2019-03-19 Dmnomore CTLA4 fusion proteins for the treatment of diabetes
EP3811966A1 (en) * 2012-06-27 2021-04-28 Phaim Pharma Ltd Ctla4 fusion proteins for the treatment of diabetes
US11286303B2 (en) 2012-06-27 2022-03-29 Phaim Pharma Ltd CTLA4 fusion proteins for the treatment of diabetes

Also Published As

Publication number Publication date
AU6346601A (en) 2001-12-11
EE05458B1 (et) 2011-08-15
DE122011100063I1 (de) 2012-06-14
ECSP024365A (es) 2003-03-31
CZ20023892A3 (cs) 2003-09-17
CY2011019I1 (el) 2016-12-14
IL152315A (en) 2010-04-15
KR100889887B1 (ko) 2009-03-24
PL206267B1 (pl) 2010-07-30
EP3029062A1 (en) 2016-06-08
EE05557B1 (et) 2012-08-15
NO2011027I2 (OSRAM) 2011-12-15
BE2011C041I2 (OSRAM) 2020-08-20
CN1441810A (zh) 2003-09-10
WO2001092337A3 (en) 2002-05-10
EP1536234A3 (en) 2009-06-03
BR0111191A (pt) 2004-07-06
LV12994B (en) 2003-08-20
AU2001263466B2 (en) 2006-04-27
CZ304451B6 (cs) 2014-05-14
HUS1300012I1 (hu) 2016-08-29
EE201100050A (et) 2011-10-17
TR200402703T4 (tr) 2004-11-22
JP4328525B2 (ja) 2009-09-09
SK288131B6 (sk) 2013-10-02
IL152315A0 (en) 2003-05-29
NO330797B1 (no) 2011-07-18
EG24459A (en) 2009-07-16
UY26723A1 (es) 2001-12-28
PE20011338A1 (es) 2002-01-13
AR031699A1 (es) 2003-10-01
HK1048126B (en) 2005-03-04
TWI314933B (en) 2009-09-21
AU2001263466C1 (en) 2006-10-26
HUP0302201A3 (en) 2010-01-28
HU228137B1 (en) 2012-12-28
GEP20053658B (en) 2005-11-10
EE200200659A (et) 2004-06-15
TWI319405B (en) 2010-01-11
HK1048126A1 (en) 2003-03-21
WO2001092337A2 (en) 2001-12-06
EP1248802B9 (en) 2005-05-11
SK15702002A3 (sk) 2004-01-08
EP1536234B1 (en) 2016-03-16
SI1248802T1 (en) 2005-02-28
DE60104282T2 (de) 2005-10-13
CN101255192A (zh) 2008-09-03
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
BRPI0111191B1 (pt) 2019-12-31
LT5133B (lt) 2004-05-25
EP1536234A2 (en) 2005-06-01
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
CN1309735C (zh) 2007-04-11
NO20025656D0 (no) 2002-11-25
BRPI0111191B8 (pt) 2021-05-25
CA2409748A1 (en) 2001-12-06
ES2571852T3 (es) 2016-05-27
KR20030009502A (ko) 2003-01-29
PT1248802E (pt) 2004-11-30
PL366231A1 (en) 2005-01-24
MY136113A (en) 2008-08-29
EP1248802B1 (en) 2004-07-14
FR11C0053I1 (OSRAM) 2012-01-13
NO20025656L (no) 2002-11-25
DE60104282D1 (de) 2004-08-19
UA87432C2 (uk) 2009-07-27
HUP0302201A2 (hu) 2003-10-28
TW200906857A (en) 2009-02-16
MXPA02011534A (es) 2004-08-12
KR100895134B1 (ko) 2009-05-04
DK1248802T3 (da) 2004-11-15
FR11C0053I2 (fr) 2013-01-11
JP2004511213A (ja) 2004-04-15
ES2225549T3 (es) 2005-03-16
LT2002114A (en) 2003-12-29
NO2011027I1 (no) 2012-01-09
HK1071931A1 (en) 2005-08-05
CY1117625T1 (el) 2017-04-26
CA2409748C (en) 2008-09-16
ZA200208944B (en) 2004-02-13
ATE271066T1 (de) 2004-07-15

Similar Documents

Publication Publication Date Title
RU2283847C2 (ru) Растворимый мутантный ctla4 и его применение
US20210115107A1 (en) Methods of treatment using ctla4 molecules
AU2006203199B2 (en) Soluble CTLA4 mutant molecules and uses thereof
HK1225393A1 (en) Soluble ctla4 mutant molecules and uses thereof
BG107210A (bg) Разтворими ctla4 мутантни молекули и тяхното използване
NZ542231A (en) Soluble CTLA4 mutant fusion molecules and uses thereof
HK1071931B (en) Soluble ctla4 mutant molecules and uses thereof

Legal Events

Date Code Title Description
ND4A Extension of patent duration

Free format text: CLAIMS: 1-3,6-11,14-16,51,61-65

Extension date: 20260523