IL152315A - Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them - Google Patents

Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them

Info

Publication number
IL152315A
IL152315A IL152315A IL15231501A IL152315A IL 152315 A IL152315 A IL 152315A IL 152315 A IL152315 A IL 152315A IL 15231501 A IL15231501 A IL 15231501A IL 152315 A IL152315 A IL 152315A
Authority
IL
Israel
Prior art keywords
ctla4 mutant
mutant molecule
molecule
ctla4
cell
Prior art date
Application number
IL152315A
Other languages
English (en)
Hebrew (he)
Other versions
IL152315A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL152315A0 publication Critical patent/IL152315A0/xx
Publication of IL152315A publication Critical patent/IL152315A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL152315A 2000-05-26 2001-05-23 Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them IL152315A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (2)

Publication Number Publication Date
IL152315A0 IL152315A0 (en) 2003-05-29
IL152315A true IL152315A (en) 2010-04-15

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
IL152315A IL152315A (en) 2000-05-26 2001-05-23 Soluble mutant ALTC4 molecules and pharmaceutical preparations containing them

Country Status (41)

Country Link
EP (3) EP1248802B9 (OSRAM)
JP (1) JP4328525B2 (OSRAM)
KR (2) KR100895134B1 (OSRAM)
CN (2) CN1309735C (OSRAM)
AR (1) AR031699A1 (OSRAM)
AT (1) ATE271066T1 (OSRAM)
AU (2) AU2001263466C1 (OSRAM)
BE (1) BE2011C041I2 (OSRAM)
BR (1) BRPI0111191B8 (OSRAM)
CA (1) CA2409748C (OSRAM)
CY (2) CY2011019I1 (OSRAM)
CZ (1) CZ304451B6 (OSRAM)
DE (2) DE60104282T2 (OSRAM)
DK (1) DK1248802T3 (OSRAM)
EC (1) ECSP024365A (OSRAM)
EE (2) EE05458B1 (OSRAM)
EG (1) EG24459A (OSRAM)
ES (2) ES2571852T3 (OSRAM)
FR (1) FR11C0053I2 (OSRAM)
GE (1) GEP20053658B (OSRAM)
HK (1) HK1048126B (OSRAM)
HU (2) HU228137B1 (OSRAM)
IL (1) IL152315A (OSRAM)
LT (1) LT5133B (OSRAM)
LU (1) LU91902I2 (OSRAM)
LV (1) LV12994B (OSRAM)
MX (1) MXPA02011534A (OSRAM)
MY (1) MY136113A (OSRAM)
NO (2) NO330797B1 (OSRAM)
PE (1) PE20011338A1 (OSRAM)
PL (1) PL206267B1 (OSRAM)
PT (1) PT1248802E (OSRAM)
RU (1) RU2283847C2 (OSRAM)
SI (1) SI1248802T1 (OSRAM)
SK (1) SK288131B6 (OSRAM)
TR (1) TR200402703T4 (OSRAM)
TW (2) TWI319405B (OSRAM)
UA (1) UA87432C2 (OSRAM)
UY (1) UY26723A1 (OSRAM)
WO (1) WO2001092337A2 (OSRAM)
ZA (1) ZA200208944B (OSRAM)

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US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
JP2004517806A (ja) * 2000-07-03 2004-06-17 ブリストル−マイヤーズ　スクイブ　カンパニー 可溶性ｃｔｌａ４分子を使用するリウマチ疾患の処置方法
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
AU2002305716B2 (en) 2001-05-23 2007-10-25 Bristol-Myers Squibb Company Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules
AU2003243152A1 (en) * 2002-04-19 2003-11-03 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
EP1575998A4 (en) * 2002-12-23 2007-07-25 Bristol Myers Squibb Co PROCESS FOR CULTIVATING MAMMALIAN CELLS FOR PROTEIN PRODUCTION
CA2508925C (en) 2002-12-23 2012-08-28 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
MXPA05007019A (es) 2002-12-30 2005-08-18 Amgen Inc Terapia de combinacion con factores co-estimuladores.
WO2005044188A2 (en) 2003-10-27 2005-05-19 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
WO2007076032A2 (en) 2005-12-20 2007-07-05 Bristol-Myers Squibb Company Compositions and methods for producing a composition
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
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US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
WO2011113019A2 (en) * 2010-03-12 2011-09-15 Abbott Biotherapeutics Corp. Ctla4 proteins and their uses
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WO2013010537A1 (en) 2011-07-20 2013-01-24 Aarhus Universitet Method of treating morphea
WO2013148049A1 (en) * 2012-03-29 2013-10-03 The General Hospital Corporation Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4)
HUE048925T2 (hu) 2012-05-11 2020-09-28 Medimmune Ltd CTLA-4 variánsok
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
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US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
EA039141B1 (ru) 2014-01-13 2021-12-09 Эмджен Инк. Рекомбинантный белок с пониженным содержанием высокоманнозных гликоформ, способ его получения и применение
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
PT3926051T (pt) 2014-06-04 2024-06-20 Amgen Inc Métodos de colheita de culturas de células de mamíferos
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CA2997947A1 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
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US11261233B2 (en) 2016-09-19 2022-03-01 OncoC4, Inc. CD80 and CD86 binding protein compositions and uses thereof
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
CN111031790A (zh) 2017-04-20 2020-04-17 E开创生物技术股份有限公司 产生基因修改的动物的方法
KR102758545B1 (ko) * 2017-10-10 2025-01-23 알파인 이뮨 사이언시즈, 인코포레이티드 Ctla-4 변이체 면역조절 단백질 및 이의 용도
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CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
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US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
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Also Published As

Publication number Publication date
HK1048126B (en) 2005-03-04
SK288131B6 (sk) 2013-10-02
AR031699A1 (es) 2003-10-01
EP1536234B1 (en) 2016-03-16
PT1248802E (pt) 2004-11-30
NO20025656D0 (no) 2002-11-25
LT5133B (lt) 2004-05-25
HK1071931A1 (en) 2005-08-05
FR11C0053I2 (fr) 2013-01-11
NO330797B1 (no) 2011-07-18
HK1048126A1 (en) 2003-03-21
EE05557B1 (et) 2012-08-15
HUP0302201A2 (hu) 2003-10-28
BRPI0111191B8 (pt) 2021-05-25
EG24459A (en) 2009-07-16
ZA200208944B (en) 2004-02-13
SK15702002A3 (sk) 2004-01-08
PL206267B1 (pl) 2010-07-30
NO2011027I2 (OSRAM) 2011-12-15
UA87432C2 (uk) 2009-07-27
WO2001092337A2 (en) 2001-12-06
ES2571852T3 (es) 2016-05-27
TW200906857A (en) 2009-02-16
TWI319405B (en) 2010-01-11
WO2001092337A3 (en) 2002-05-10
EP1536234A3 (en) 2009-06-03
EP1248802B9 (en) 2005-05-11
HU228137B1 (en) 2012-12-28
LT2002114A (en) 2003-12-29
CZ304451B6 (cs) 2014-05-14
UY26723A1 (es) 2001-12-28
CY2011019I2 (el) 2016-12-14
KR100895134B1 (ko) 2009-05-04
NO20025656L (no) 2002-11-25
NO2011027I1 (no) 2012-01-09
HUP0302201A3 (en) 2010-01-28
KR20030009502A (ko) 2003-01-29
EE200200659A (et) 2004-06-15
TWI314933B (en) 2009-09-21
BR0111191A (pt) 2004-07-06
EP1248802A2 (en) 2002-10-16
RU2283847C2 (ru) 2006-09-20
DE122011100063I1 (de) 2012-06-14
DE60104282T2 (de) 2005-10-13
CY1117625T1 (el) 2017-04-26
AU2001263466B2 (en) 2006-04-27
CN1309735C (zh) 2007-04-11
HUS1300012I1 (hu) 2016-08-29
CA2409748A1 (en) 2001-12-06
DK1248802T3 (da) 2004-11-15
EP1248802B1 (en) 2004-07-14
LV12994B (en) 2003-08-20
PE20011338A1 (es) 2002-01-13
PL366231A1 (en) 2005-01-24
CZ20023892A3 (cs) 2003-09-17
JP4328525B2 (ja) 2009-09-09
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
ECSP024365A (es) 2003-03-31
EP3029062A1 (en) 2016-06-08
FR11C0053I1 (OSRAM) 2012-01-13
IL152315A0 (en) 2003-05-29
CY2011019I1 (el) 2016-12-14
TR200402703T4 (tr) 2004-11-22
JP2004511213A (ja) 2004-04-15
EP1536234A2 (en) 2005-06-01
ATE271066T1 (de) 2004-07-15
AU6346601A (en) 2001-12-11
CN101255192A (zh) 2008-09-03
ES2225549T3 (es) 2005-03-16
EE05458B1 (et) 2011-08-15
DE60104282D1 (de) 2004-08-19
EE201100050A (et) 2011-10-17
AU2001263466C1 (en) 2006-10-26
CA2409748C (en) 2008-09-16
CN1441810A (zh) 2003-09-10
MXPA02011534A (es) 2004-08-12
BE2011C041I2 (OSRAM) 2020-08-20
KR100889887B1 (ko) 2009-03-24
BRPI0111191B1 (pt) 2019-12-31
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MY136113A (en) 2008-08-29
GEP20053658B (en) 2005-11-10

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