RU2266121C2 - Спонтанно диспергирующиеся композиции, содержащие n-бензоилстауроспорин - Google Patents

Спонтанно диспергирующиеся композиции, содержащие n-бензоилстауроспорин Download PDF

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Publication number
RU2266121C2
RU2266121C2 RU2001124597/15A RU2001124597A RU2266121C2 RU 2266121 C2 RU2266121 C2 RU 2266121C2 RU 2001124597/15 A RU2001124597/15 A RU 2001124597/15A RU 2001124597 A RU2001124597 A RU 2001124597A RU 2266121 C2 RU2266121 C2 RU 2266121C2
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RU
Russia
Prior art keywords
surfactant
composition
bioavailability
composition according
benzoylstaurosporine
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Application number
RU2001124597/15A
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English (en)
Russian (ru)
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RU2001124597A (ru
Inventor
Пол МАТТЕУЗ Грэм (GB)
Пол МАТТЕУЗ Грэм
ХЭБЕРЛИН Барбара (CH)
ХЭБЕРЛИН Барбара
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Новартис Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847896&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2266121(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2001124597A publication Critical patent/RU2001124597A/ru
Application granted granted Critical
Publication of RU2266121C2 publication Critical patent/RU2266121C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2001124597/15A 1999-02-16 2000-02-14 Спонтанно диспергирующиеся композиции, содержащие n-бензоилстауроспорин RU2266121C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9903547.9 1999-02-16
GBGB9903547.9A GB9903547D0 (en) 1999-02-16 1999-02-16 Organic compounds

Publications (2)

Publication Number Publication Date
RU2001124597A RU2001124597A (ru) 2003-06-20
RU2266121C2 true RU2266121C2 (ru) 2005-12-20

Family

ID=10847896

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001124597/15A RU2266121C2 (ru) 1999-02-16 2000-02-14 Спонтанно диспергирующиеся композиции, содержащие n-бензоилстауроспорин

Country Status (34)

Country Link
US (3) US20020061873A1 (enExample)
EP (1) EP1152750B1 (enExample)
JP (2) JP5057610B2 (enExample)
KR (2) KR20080064914A (enExample)
CN (1) CN100367930C (enExample)
AR (2) AR022589A1 (enExample)
AT (1) ATE430554T1 (enExample)
AU (1) AU765776B2 (enExample)
BR (1) BRPI0008228B8 (enExample)
CA (1) CA2362277C (enExample)
CL (1) CL2009001682A1 (enExample)
CZ (1) CZ303979B6 (enExample)
DE (1) DE60042151D1 (enExample)
DK (1) DK1152750T3 (enExample)
EC (1) ECSP083351A (enExample)
ES (1) ES2326783T3 (enExample)
GB (1) GB9903547D0 (enExample)
HK (1) HK1045807B (enExample)
HU (1) HUP0105364A3 (enExample)
ID (1) ID30504A (enExample)
IL (3) IL144512A0 (enExample)
MY (1) MY128362A (enExample)
NO (1) NO331232B1 (enExample)
NZ (1) NZ513529A (enExample)
PE (1) PE20001499A1 (enExample)
PL (1) PL198330B1 (enExample)
PT (1) PT1152750E (enExample)
RU (1) RU2266121C2 (enExample)
SI (1) SI1152750T1 (enExample)
SK (1) SK286967B6 (enExample)
TR (1) TR200102385T2 (enExample)
TW (1) TWI240636B (enExample)
WO (1) WO2000048571A1 (enExample)
ZA (1) ZA200106677B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2742650C2 (ru) * 2015-12-09 2021-02-09 Фосфейдженикс Лимитед Фармацевтический состав
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
US11753435B2 (en) 2016-12-21 2023-09-12 Avecho Biotechnology Limited Process

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US7795246B2 (en) 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) * 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
BR0208306A (pt) * 2001-03-26 2004-03-09 Novartis Ag Composições farmacêuticas
PL392652A1 (pl) 2001-05-16 2010-12-06 Novartis Ag Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację
EP1441737B1 (en) 2001-10-30 2006-08-09 Novartis AG Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
US20060115500A1 (en) * 2002-07-23 2006-06-01 Jithan Aukunuru Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
TWI324604B (en) * 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
GB0419159D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
WO2008021347A2 (en) * 2006-08-16 2008-02-21 Novartis Ag Method for making solid dispersions of highly crystalline therapeutic compounds
FR2918566B1 (fr) 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
WO2009067221A2 (en) * 2007-11-20 2009-05-28 Cephalon, Inc. Microemulsion containing indolocarbazole compound and dosage forms containing the same
EP2229936B1 (en) * 2009-03-09 2015-05-06 PharmaSol GmbH Nanonized testosterone formulations for improved bioavailability
WO2011000811A2 (en) * 2009-06-30 2011-01-06 Novartis Ag Organic compounds
AU2010335654B2 (en) * 2009-12-22 2015-04-09 Leo Pharma A/S Cutaneous composition comprising vitamin D analogue and a mixture of solvent and surfactants
JO3337B1 (ar) * 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
US9387446B2 (en) * 2011-09-22 2016-07-12 Ariel-University Research And Development Company Ltd. Emulsions and methods of making emulsions
EP4058465A1 (en) 2019-11-14 2022-09-21 Cohbar Inc. Cxcr4 antagonist peptides

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GB2270842A (en) * 1992-09-25 1994-03-30 Sandoz Ltd Emulsion preconcentrates containing cyclosporins
WO1996013273A1 (en) * 1994-10-26 1996-05-09 Novartis Ag Pharmaceutical compositions
EP0657164B1 (en) * 1993-12-11 1999-10-27 Novartis AG Pharmaceutical compositions containing staurosporine derivatives and a polyalkylene glycol glyceride

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Publication number Priority date Publication date Assignee Title
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
GB2270842A (en) * 1992-09-25 1994-03-30 Sandoz Ltd Emulsion preconcentrates containing cyclosporins
EP0657164B1 (en) * 1993-12-11 1999-10-27 Novartis AG Pharmaceutical compositions containing staurosporine derivatives and a polyalkylene glycol glyceride
WO1996013273A1 (en) * 1994-10-26 1996-05-09 Novartis Ag Pharmaceutical compositions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2742650C2 (ru) * 2015-12-09 2021-02-09 Фосфейдженикс Лимитед Фармацевтический состав
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
US11753435B2 (en) 2016-12-21 2023-09-12 Avecho Biotechnology Limited Process

Also Published As

Publication number Publication date
CN100367930C (zh) 2008-02-13
NO331232B1 (no) 2011-11-07
PL350556A1 (en) 2002-12-16
KR20080064914A (ko) 2008-07-09
TWI240636B (en) 2005-10-01
ES2326783T3 (es) 2009-10-20
US8722664B2 (en) 2014-05-13
CA2362277A1 (en) 2000-08-24
EP1152750A1 (en) 2001-11-14
SK11722001A3 (sk) 2001-12-03
CN1339963A (zh) 2002-03-13
JP2012111763A (ja) 2012-06-14
CA2362277C (en) 2010-03-30
IL144512A (en) 2011-03-31
HK1045807B (zh) 2008-12-05
BRPI0008228B8 (pt) 2021-05-25
MY128362A (en) 2007-01-31
GB9903547D0 (en) 1999-04-07
ZA200106677B (en) 2003-01-14
AU765776B2 (en) 2003-10-02
SI1152750T1 (sl) 2009-10-31
JP5057610B2 (ja) 2012-10-24
US20140056974A1 (en) 2014-02-27
DE60042151D1 (de) 2009-06-18
AR082579A2 (es) 2012-12-19
CL2009001682A1 (es) 2010-07-23
KR100880859B1 (ko) 2009-01-30
PL198330B1 (pl) 2008-06-30
WO2000048571A1 (en) 2000-08-24
NZ513529A (en) 2003-10-31
NO20013964D0 (no) 2001-08-15
PT1152750E (pt) 2009-08-07
ATE430554T1 (de) 2009-05-15
AU3154200A (en) 2000-09-04
CZ20012931A3 (cs) 2001-11-14
HUP0105364A3 (en) 2003-02-28
HUP0105364A2 (hu) 2002-05-29
US20020061873A1 (en) 2002-05-23
ECSP083351A (es) 2008-08-29
HK1045807A1 (zh) 2002-12-13
DK1152750T3 (da) 2009-08-24
CZ303979B6 (cs) 2013-07-31
AR022589A1 (es) 2002-09-04
ID30504A (id) 2001-12-13
KR20010093281A (ko) 2001-10-27
IL192666A0 (en) 2009-02-11
JP2002537242A (ja) 2002-11-05
IL144512A0 (en) 2002-05-23
TR200102385T2 (tr) 2002-09-23
US20080070897A1 (en) 2008-03-20
SK286967B6 (sk) 2009-08-06
BR0008228A (pt) 2001-10-30
PE20001499A1 (es) 2001-01-12
EP1152750B1 (en) 2009-05-06
BRPI0008228B1 (pt) 2016-08-23
NO20013964L (no) 2001-10-15
US8575147B2 (en) 2013-11-05

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