CZ303979B6 - Spontánne dispergovatelná farmaceutická kompozice N-benzoylstaurosporinu - Google Patents
Spontánne dispergovatelná farmaceutická kompozice N-benzoylstaurosporinu Download PDFInfo
- Publication number
- CZ303979B6 CZ303979B6 CZ20012931A CZ20012931A CZ303979B6 CZ 303979 B6 CZ303979 B6 CZ 303979B6 CZ 20012931 A CZ20012931 A CZ 20012931A CZ 20012931 A CZ20012931 A CZ 20012931A CZ 303979 B6 CZ303979 B6 CZ 303979B6
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- CZ
- Czechia
- Prior art keywords
- benzoylstaurosporine
- composition
- surfactant
- pharmaceutical composition
- oral administration
- Prior art date
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- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
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- 239000002563 ionic surfactant Substances 0.000 description 1
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- 208000032839 leukemia Diseases 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N linoleic acid group Chemical group C(CCCCCCC\C=C/C\C=C/CCCCC)(=O)O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 125000005481 linolenic acid group Chemical group 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
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- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
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- 235000003702 sterols Nutrition 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903547.9A GB9903547D0 (en) | 1999-02-16 | 1999-02-16 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20012931A3 CZ20012931A3 (cs) | 2001-11-14 |
| CZ303979B6 true CZ303979B6 (cs) | 2013-07-31 |
Family
ID=10847896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20012931A CZ303979B6 (cs) | 1999-02-16 | 2000-02-14 | Spontánne dispergovatelná farmaceutická kompozice N-benzoylstaurosporinu |
Country Status (34)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795246B2 (en) | 1998-08-06 | 2010-09-14 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| EP1372611B1 (en) * | 2001-03-26 | 2006-05-17 | Novartis AG | Pharmaceutical composition comprising a poorly water-soluble staurosporine, a surfactant and a water-soluble polymer |
| CA2444867C (en) | 2001-05-16 | 2010-08-17 | Novartis Ag | Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent |
| US7973031B2 (en) | 2001-10-30 | 2011-07-05 | Novartis Ag | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| WO2004009056A1 (en) * | 2002-07-23 | 2004-01-29 | Novartis Ag | Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent |
| US7842791B2 (en) | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
| GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
| GB0419159D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| PT2054040E (pt) * | 2006-08-16 | 2011-06-30 | Novartis Ag | Método para produzir dispersões sólidas de compostos terapêuticos altamente cristalinos |
| FR2918566B1 (fr) | 2007-07-11 | 2009-10-09 | Pierre Fabre Medicament Sa | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
| WO2009067221A2 (en) * | 2007-11-20 | 2009-05-28 | Cephalon, Inc. | Microemulsion containing indolocarbazole compound and dosage forms containing the same |
| EP2229936B1 (en) * | 2009-03-09 | 2015-05-06 | PharmaSol GmbH | Nanonized testosterone formulations for improved bioavailability |
| WO2011000811A2 (en) * | 2009-06-30 | 2011-01-06 | Novartis Ag | Organic compounds |
| CN102781425B (zh) * | 2009-12-22 | 2014-08-13 | 利奥制药有限公司 | 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物 |
| JO3337B1 (ar) * | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| US9387446B2 (en) * | 2011-09-22 | 2016-07-12 | Ariel-University Research And Development Company Ltd. | Emulsions and methods of making emulsions |
| ES2981002T3 (es) | 2015-12-09 | 2024-10-04 | Avecho Biotechnology Ltd | Formulación farmacéutica |
| KR20190032265A (ko) * | 2015-12-09 | 2019-03-27 | 포스파제닉스 리미티드 | 약제학적 제형 |
| AU2017381395A1 (en) | 2016-12-21 | 2019-06-20 | Phosphagenics Limited | Process |
| US20220395553A1 (en) | 2019-11-14 | 2022-12-15 | Cohbar, Inc. | Cxcr4 antagonist peptides |
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| EP0657164A1 (en) * | 1993-12-11 | 1995-06-14 | Ciba-Geigy Ag | Pharmaceutical compositions containing staurosphorine derivatives |
| EP0711556A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenöse Lösungen für ein Staurosporinderivat |
| EP0733358A2 (de) * | 1995-03-21 | 1996-09-25 | Ciba-Geigy Ag | Intravenös applizierbare Nanosuspensionen |
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| US4963367A (en) | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| DE3824034C1 (enExample) * | 1988-07-15 | 1989-09-14 | Gustav 7290 Freudenstadt De Memminger | |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| CA2108266C (en) | 1991-04-19 | 2003-06-03 | Albert J. Owen | Convertible microemulsion formulations |
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| US5981568A (en) * | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| US5639474A (en) | 1993-07-01 | 1997-06-17 | Hanmi Pharm. Ind., Ltd. | Cyclosporin soft capsule composition |
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| WO1995022331A1 (en) | 1994-02-18 | 1995-08-24 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
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| DE19641672A1 (de) | 1996-10-10 | 1998-04-16 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen |
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-
1999
- 1999-02-16 GB GBGB9903547.9A patent/GB9903547D0/en not_active Ceased
-
2000
- 2000-02-14 AU AU31542/00A patent/AU765776B2/en not_active Expired
- 2000-02-14 HU HU0105364A patent/HUP0105364A3/hu unknown
- 2000-02-14 DE DE60042151T patent/DE60042151D1/de not_active Expired - Lifetime
- 2000-02-14 BR BRPI0008228A patent/BRPI0008228B8/pt not_active IP Right Cessation
- 2000-02-14 PT PT00909165T patent/PT1152750E/pt unknown
- 2000-02-14 PL PL350556A patent/PL198330B1/pl unknown
- 2000-02-14 NZ NZ513529A patent/NZ513529A/en not_active IP Right Cessation
- 2000-02-14 SK SK1172-2001A patent/SK286967B6/sk not_active IP Right Cessation
- 2000-02-14 KR KR1020087015449A patent/KR20080064914A/ko not_active Withdrawn
- 2000-02-14 DK DK00909165T patent/DK1152750T3/da active
- 2000-02-14 CA CA2362277A patent/CA2362277C/en not_active Expired - Lifetime
- 2000-02-14 PE PE2000000113A patent/PE20001499A1/es not_active Application Discontinuation
- 2000-02-14 CZ CZ20012931A patent/CZ303979B6/cs not_active IP Right Cessation
- 2000-02-14 AR ARP000100627A patent/AR022589A1/es not_active Application Discontinuation
- 2000-02-14 AT AT00909165T patent/ATE430554T1/de active
- 2000-02-14 CN CNB008038244A patent/CN100367930C/zh not_active Expired - Lifetime
- 2000-02-14 TR TR2001/02385T patent/TR200102385T2/xx unknown
- 2000-02-14 WO PCT/EP2000/001196 patent/WO2000048571A1/en not_active Ceased
- 2000-02-14 RU RU2001124597/15A patent/RU2266121C2/ru active
- 2000-02-14 EP EP00909165A patent/EP1152750B1/en not_active Expired - Lifetime
- 2000-02-14 IL IL14451200A patent/IL144512A0/xx active IP Right Grant
- 2000-02-14 KR KR1020017009391A patent/KR100880859B1/ko not_active Expired - Lifetime
- 2000-02-14 ID IDW00200101649A patent/ID30504A/id unknown
- 2000-02-14 HK HK02106758.7A patent/HK1045807B/zh not_active IP Right Cessation
- 2000-02-14 SI SI200031035T patent/SI1152750T1/sl unknown
- 2000-02-14 JP JP2000599363A patent/JP5057610B2/ja not_active Expired - Fee Related
- 2000-02-14 ES ES00909165T patent/ES2326783T3/es not_active Expired - Lifetime
- 2000-02-15 MY MYPI20000530A patent/MY128362A/en unknown
- 2000-03-13 TW TW089104503A patent/TWI240636B/zh not_active IP Right Cessation
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2001
- 2001-02-14 ZA ZA200106677A patent/ZA200106677B/en unknown
- 2001-07-23 IL IL144512A patent/IL144512A/en not_active IP Right Cessation
- 2001-08-15 US US09/930,335 patent/US20020061873A1/en not_active Abandoned
- 2001-08-15 NO NO20013964A patent/NO331232B1/no not_active IP Right Cessation
-
2007
- 2007-09-21 US US11/859,077 patent/US8575147B2/en not_active Expired - Fee Related
-
2008
- 2008-07-04 EC EC2008003351A patent/ECSP083351A/es unknown
- 2008-07-07 IL IL192666A patent/IL192666A0/en unknown
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2009
- 2009-07-31 CL CL2009001682A patent/CL2009001682A1/es unknown
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2011
- 2011-08-05 AR ARP110102851A patent/AR082579A2/es not_active Application Discontinuation
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2012
- 2012-01-05 JP JP2012000816A patent/JP2012111763A/ja active Pending
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2013
- 2013-10-15 US US14/053,661 patent/US8722664B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0657164A1 (en) * | 1993-12-11 | 1995-06-14 | Ciba-Geigy Ag | Pharmaceutical compositions containing staurosphorine derivatives |
| EP0711556A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenöse Lösungen für ein Staurosporinderivat |
| EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
| EP0733358A2 (de) * | 1995-03-21 | 1996-09-25 | Ciba-Geigy Ag | Intravenös applizierbare Nanosuspensionen |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Effective date: 20200214 |