RU2250212C2 - Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов - Google Patents

Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов Download PDF

Info

Publication number
RU2250212C2
RU2250212C2 RU2002123046/04A RU2002123046A RU2250212C2 RU 2250212 C2 RU2250212 C2 RU 2250212C2 RU 2002123046/04 A RU2002123046/04 A RU 2002123046/04A RU 2002123046 A RU2002123046 A RU 2002123046A RU 2250212 C2 RU2250212 C2 RU 2250212C2
Authority
RU
Russia
Prior art keywords
formula
compound
salt
acid
compounds
Prior art date
Application number
RU2002123046/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2002123046A (ru
Inventor
Герхард БРАЙПОЛЬ (DE)
Герхард Брайполь
Вольфганг ХОЛЛА (DE)
Вольфганг ХОЛЛА
Хайнер ЙЕНДРАЛЛА (DE)
Хайнер ЙЕНДРАЛЛА
Герхард БЕК (DE)
Герхард БЕК
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2002123046A publication Critical patent/RU2002123046A/ru
Application granted granted Critical
Publication of RU2250212C2 publication Critical patent/RU2250212C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
RU2002123046/04A 2000-01-28 2001-01-18 Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов RU2250212C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10003586.8 2000-01-28
DE10003586 2000-01-28

Publications (2)

Publication Number Publication Date
RU2002123046A RU2002123046A (ru) 2004-01-10
RU2250212C2 true RU2250212C2 (ru) 2005-04-20

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002123046/04A RU2250212C2 (ru) 2000-01-28 2001-01-18 Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов

Country Status (29)

Country Link
US (2) US20010031858A1 (cg-RX-API-DMAC7.html)
EP (1) EP1254159B9 (cg-RX-API-DMAC7.html)
JP (1) JP4778181B2 (cg-RX-API-DMAC7.html)
KR (1) KR100758141B1 (cg-RX-API-DMAC7.html)
CN (1) CN1176104C (cg-RX-API-DMAC7.html)
AR (1) AR027246A1 (cg-RX-API-DMAC7.html)
AT (1) ATE325810T1 (cg-RX-API-DMAC7.html)
AU (1) AU779722B2 (cg-RX-API-DMAC7.html)
BR (1) BR0107804A (cg-RX-API-DMAC7.html)
CA (1) CA2398497C (cg-RX-API-DMAC7.html)
CZ (1) CZ20022583A3 (cg-RX-API-DMAC7.html)
DE (1) DE60119491T2 (cg-RX-API-DMAC7.html)
DK (1) DK1254159T3 (cg-RX-API-DMAC7.html)
EE (1) EE200200410A (cg-RX-API-DMAC7.html)
ES (1) ES2262632T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20020631A2 (cg-RX-API-DMAC7.html)
HU (1) HUP0301986A2 (cg-RX-API-DMAC7.html)
IL (2) IL150897A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA02006762A (cg-RX-API-DMAC7.html)
NO (1) NO20023577L (cg-RX-API-DMAC7.html)
NZ (1) NZ520427A (cg-RX-API-DMAC7.html)
PL (1) PL356801A1 (cg-RX-API-DMAC7.html)
PT (1) PT1254159E (cg-RX-API-DMAC7.html)
RU (1) RU2250212C2 (cg-RX-API-DMAC7.html)
SK (1) SK10842002A3 (cg-RX-API-DMAC7.html)
TW (1) TWI236481B (cg-RX-API-DMAC7.html)
WO (1) WO2001055175A2 (cg-RX-API-DMAC7.html)
YU (1) YU51202A (cg-RX-API-DMAC7.html)
ZA (1) ZA200205990B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
EP2560493B1 (en) * 2010-04-20 2018-06-06 Chiral Quest, Inc. An enantioselective process for cycloalkenyl b-substituted alanines
JP5913352B2 (ja) * 2010-11-29 2016-04-27 高砂香料工業株式会社 不斉水素化触媒、およびそれを用いた光学活性カルボニル化合物の製造方法
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134695C1 (ru) * 1993-10-15 1999-08-20 Рон-Пуленк Рорер Фармасьютикалз Инк. Антитромботические азациклоалкилалканоилпептиды
RU2142469C1 (ru) * 1993-06-03 1999-12-10 Астра Актиеболаг Пептидные производные, их стереоизомеры или физиологически приемлемые соли, обладающие противотромбозной, противосвертывающей или противовоспалительной активностью, способ их получения, фармацевтическая композиция, способ подавления тромбина, способ подавления кининогеназ, применение соединений в качестве исходных в синтезе ингибитора тромбина

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
EP1384725A3 (en) * 1994-04-26 2007-02-21 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
IL125003A (en) * 1995-12-20 2001-12-23 Aventis Pharma Inc Process for the preparation of N-ACETYL- (L) - 4-CYANOPHENYLALANINE AC- (L) -PHE (4-CN) -OH and for the preparation of N-ACETYL- (L) -P- AMIDINOPHENYLALANINE- CYCLOHEXYLGYLCINE-3 C) - N-METHYLPYRID) ALANINE AC (L) -PAPH-CHG- PALME (3) -NH2
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2142469C1 (ru) * 1993-06-03 1999-12-10 Астра Актиеболаг Пептидные производные, их стереоизомеры или физиологически приемлемые соли, обладающие противотромбозной, противосвертывающей или противовоспалительной активностью, способ их получения, фармацевтическая композиция, способ подавления тромбина, способ подавления кининогеназ, применение соединений в качестве исходных в синтезе ингибитора тромбина
RU2134695C1 (ru) * 1993-10-15 1999-08-20 Рон-Пуленк Рорер Фармасьютикалз Инк. Антитромботические азациклоалкилалканоилпептиды

Also Published As

Publication number Publication date
NO20023577D0 (no) 2002-07-26
BR0107804A (pt) 2002-10-22
DK1254159T3 (da) 2006-09-11
HK1051866A1 (en) 2003-08-22
TWI236481B (en) 2005-07-21
AU4051601A (en) 2001-08-07
CN1396928A (zh) 2003-02-12
NZ520427A (en) 2004-02-27
EP1254159B9 (en) 2006-06-28
HRP20020631A2 (en) 2004-12-31
CN1176104C (zh) 2004-11-17
WO2001055175A3 (en) 2002-02-21
AR027246A1 (es) 2003-03-19
US20040225109A1 (en) 2004-11-11
ATE325810T1 (de) 2006-06-15
WO2001055175A2 (en) 2001-08-02
JP4778181B2 (ja) 2011-09-21
CA2398497C (en) 2011-04-26
AU779722B2 (en) 2005-02-10
JP2003523364A (ja) 2003-08-05
SK10842002A3 (sk) 2003-04-01
US20010031858A1 (en) 2001-10-18
DE60119491T2 (de) 2006-11-16
IL150897A0 (en) 2003-02-12
IL150897A (en) 2008-08-07
HUP0301986A2 (hu) 2003-09-29
ES2262632T3 (es) 2006-12-01
MXPA02006762A (es) 2002-10-23
ZA200205990B (en) 2003-04-30
KR100758141B1 (ko) 2007-09-13
KR20030019306A (ko) 2003-03-06
RU2002123046A (ru) 2004-01-10
DE60119491D1 (de) 2006-06-14
CZ20022583A3 (cs) 2002-10-16
PT1254159E (pt) 2006-07-31
CA2398497A1 (en) 2001-08-02
EP1254159A2 (en) 2002-11-06
EP1254159B1 (en) 2006-05-10
PL356801A1 (en) 2004-07-12
US7084250B2 (en) 2006-08-01
NO20023577L (no) 2002-08-28
EE200200410A (et) 2003-12-15
YU51202A (sh) 2005-11-28

Similar Documents

Publication Publication Date Title
JP2579323B2 (ja) ジアミン類の選択的アミジン化
US4515920A (en) Synthesis of peptides and proteins
RU2250212C2 (ru) Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов
JPH0699373B2 (ja) Ｎ−アルキル化α−アミノ酸の合成方法
BG65832B1 (bg) Метод за синтез на естери на n-[(s)-1-карбоксибутил]-(s)- аланин и приложението му при синтеза на периндоприл
CN114106089A (zh) 一种经由碳氢活化芳基化合成β2AR别构调节剂化合物的方法
JP4044614B2 (ja) Ｎ―アセチル―（Ｌ）―４―シアノフェニルアラニンＡｃ―（Ｌ）―Ｐｈｅ（４―ＣＮ）―ＯＨおよびＮ―アセチル―（Ｌ）―ｐ―アミジノフェニルアラニン―シクロヘキシルグリシン―β―（３―Ｎ―メチルピリジニウム）―アラニン Ａｃ―（Ｌ）―ｐＡｐｈ―Ｃｈｇ―ＰａｌＭｅ（３）―ＮＨ２の新規な製法
US20020198400A1 (en) Synthesis of 3-amino-3-aryl propanoates
NZ523217A (en) Chemical process
HK1051866B (en) Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides
KR20160081864A (ko) 티올기를 갖는 d-체 또는 l-체 아미노산 유도체의 제조 방법
JPH1143475A (ja) 光学活性Ｎ−カルボベンゾキシ−ｔｅｒｔ−ロイシンの製造法
US20080234493A1 (en) Process for the Preparation of 2-[N-[{S)-1-Ethoxycarbonyl-3-Phenylpropyl]-(S)-Alanyl]-(1S,3S,5S)-2-Azabicyclo[3.3.0]Oct- an-3-Carboxylic Acid
RU2072358C1 (ru) Способ получения n-ацетил-фенилаланил-метионинов
JPS642119B2 (cg-RX-API-DMAC7.html)
JP3832919B2 (ja) 光学活性シアンヒドリンの製造法
JPH10291970A (ja) α、β−不飽和アミノ酸誘導体の製法
WO2002048103A1 (en) Process for preparing active esters

Legal Events

Date Code Title Description
PD4A Correction of name of patent owner
MM4A The patent is invalid due to non-payment of fees

Effective date: 20070119