RU2247125C2 - Конъюгаты 4-бензиламинохинолинов с желчной кислотой и их гетероаналоги, способ их получения и лекарственные средства на основе этих соединений - Google Patents

Конъюгаты 4-бензиламинохинолинов с желчной кислотой и их гетероаналоги, способ их получения и лекарственные средства на основе этих соединений Download PDF

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Publication number
RU2247125C2
RU2247125C2 RU2002110440/04A RU2002110440A RU2247125C2 RU 2247125 C2 RU2247125 C2 RU 2247125C2 RU 2002110440/04 A RU2002110440/04 A RU 2002110440/04A RU 2002110440 A RU2002110440 A RU 2002110440A RU 2247125 C2 RU2247125 C2 RU 2247125C2
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RU
Russia
Prior art keywords
hydrogen atom
alkyl
acid
formula
compounds
Prior art date
Application number
RU2002110440/04A
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English (en)
Russian (ru)
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RU2002110440A (ru
Inventor
Армин ХОФМАЙСТЕР (DE)
Армин Хофмайстер
Ойген ФАЛЬК (DE)
Ойген Фальк
Хайнц-Вернер КЛЕЕМАН (DE)
Хайнц-Вернер КЛЕЕМАН
Ханс-Вилли ЯНСЕН (DE)
Ханс-Вилли ЯНСЕН
Мартин БИККЕЛЬ (DE)
Мартин Биккель
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999145385 external-priority patent/DE19945385A1/de
Priority claimed from DE2000128193 external-priority patent/DE10028193A1/de
Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2002110440A publication Critical patent/RU2002110440A/ru
Application granted granted Critical
Publication of RU2247125C2 publication Critical patent/RU2247125C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
RU2002110440/04A 1999-09-22 2000-09-06 Конъюгаты 4-бензиламинохинолинов с желчной кислотой и их гетероаналоги, способ их получения и лекарственные средства на основе этих соединений RU2247125C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE1999145385 DE19945385A1 (de) 1999-09-22 1999-09-22 Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19945385.3-43 1999-09-22
DE2000128193 DE10028193A1 (de) 2000-06-09 2000-06-09 Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente
DE10028193.1 2000-06-09

Publications (2)

Publication Number Publication Date
RU2002110440A RU2002110440A (ru) 2003-11-20
RU2247125C2 true RU2247125C2 (ru) 2005-02-27

Family

ID=26005994

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002110440/04A RU2247125C2 (ru) 1999-09-22 2000-09-06 Конъюгаты 4-бензиламинохинолинов с желчной кислотой и их гетероаналоги, способ их получения и лекарственные средства на основе этих соединений

Country Status (26)

Country Link
US (1) US6339077B1 (enExample)
EP (1) EP1218401B1 (enExample)
JP (1) JP4833471B2 (enExample)
KR (1) KR20030010575A (enExample)
CN (1) CN1158299C (enExample)
AT (1) ATE269352T1 (enExample)
AU (1) AU779412B2 (enExample)
BR (1) BR0014233A (enExample)
CA (1) CA2385445A1 (enExample)
CZ (1) CZ2002992A3 (enExample)
DE (1) DE50006842D1 (enExample)
DK (1) DK1218401T3 (enExample)
EE (1) EE200200143A (enExample)
ES (1) ES2218222T3 (enExample)
HK (1) HK1049169B (enExample)
HR (1) HRP20020238A2 (enExample)
HU (1) HUP0203045A3 (enExample)
IL (1) IL148739A0 (enExample)
NO (1) NO20021337L (enExample)
NZ (1) NZ517899A (enExample)
PL (1) PL353992A1 (enExample)
PT (1) PT1218401E (enExample)
RU (1) RU2247125C2 (enExample)
SK (1) SK3862002A3 (enExample)
WO (1) WO2001021642A1 (enExample)
YU (1) YU19302A (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
ES2488821T3 (es) * 2009-03-24 2014-08-29 Abbvie Bahamas Ltd. Proceso de preparación de un compuesto antiviral
PH12012501846A1 (en) * 2010-04-02 2013-02-04 Firmenich Incorporated Sweet flavor modifier
RU2617700C2 (ru) 2011-08-12 2017-04-26 Синомикс, Инк. Производные 4-аминохинолин-3-карбоновой кислоты и содержащие их композиции для усиления сладкого вкуса
BR112017008738B1 (pt) 2014-11-07 2021-06-15 Firmenich Incorporated Ácidos 4-amino-5-(ciclohexilóxi)quinolina-3-carboxílicos substituídos como modificadores de sabores adoçantes
WO2020041673A1 (en) 2018-08-23 2020-02-27 President And Fellows Of Harvard College Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes
WO2020117945A1 (en) 2018-12-04 2020-06-11 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639744A (en) * 1994-04-06 1997-06-17 Alfa Wassermann S.P.A. Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis
RU2104283C1 (ru) * 1991-05-24 1998-02-10 Фармиталиа Карло Эрба С.Р.Л. 17бета-замещенные 3-карбоксистероиды, способ их получения, фармкомпозиция

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
TW289021B (enExample) * 1993-05-08 1996-10-21 Hoechst Ag
DE4432708A1 (de) 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
WO1998056757A1 (fr) * 1997-06-11 1998-12-17 Sankyo Company, Limited Derives de benzylamine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2104283C1 (ru) * 1991-05-24 1998-02-10 Фармиталиа Карло Эрба С.Р.Л. 17бета-замещенные 3-карбоксистероиды, способ их получения, фармкомпозиция
US5639744A (en) * 1994-04-06 1997-06-17 Alfa Wassermann S.P.A. Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis

Also Published As

Publication number Publication date
EP1218401B1 (de) 2004-06-16
DK1218401T3 (da) 2004-10-04
CA2385445A1 (en) 2001-03-29
HRP20020238A2 (en) 2004-04-30
IL148739A0 (en) 2002-09-12
YU19302A (sh) 2004-11-25
WO2001021642A1 (de) 2001-03-29
EE200200143A (et) 2003-04-15
HK1049169B (zh) 2005-04-22
AU7515600A (en) 2001-04-24
BR0014233A (pt) 2002-05-21
PT1218401E (pt) 2004-10-29
AU779412B2 (en) 2005-01-20
US6339077B1 (en) 2002-01-15
SK3862002A3 (en) 2003-01-09
NZ517899A (en) 2004-03-26
CZ2002992A3 (cs) 2002-06-12
ATE269352T1 (de) 2004-07-15
JP4833471B2 (ja) 2011-12-07
NO20021337L (no) 2002-05-15
NO20021337D0 (no) 2002-03-18
PL353992A1 (en) 2003-12-15
CN1158299C (zh) 2004-07-21
KR20030010575A (ko) 2003-02-05
HUP0203045A3 (en) 2004-06-28
ES2218222T3 (es) 2004-11-16
HK1049169A1 (en) 2003-05-02
CN1374968A (zh) 2002-10-16
HUP0203045A2 (hu) 2003-01-28
EP1218401A1 (de) 2002-07-03
DE50006842D1 (de) 2004-07-22
JP2003510255A (ja) 2003-03-18

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Effective date: 20060907