DK1218401T3 - 4-Benzylaminoquinolin-konjugat med galdesyre og deres heteroanaloger, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse - Google Patents
4-Benzylaminoquinolin-konjugat med galdesyre og deres heteroanaloger, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelseInfo
- Publication number
- DK1218401T3 DK1218401T3 DK00964126T DK00964126T DK1218401T3 DK 1218401 T3 DK1218401 T3 DK 1218401T3 DK 00964126 T DK00964126 T DK 00964126T DK 00964126 T DK00964126 T DK 00964126T DK 1218401 T3 DK1218401 T3 DK 1218401T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- preparation
- heteroanalogs
- benzylaminoquinoline
- conjugate
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- IEIBZPOWNOCCAT-UHFFFAOYSA-N n-benzylquinolin-4-amine Chemical compound C=1C=NC2=CC=CC=C2C=1NCC1=CC=CC=C1 IEIBZPOWNOCCAT-UHFFFAOYSA-N 0.000 title abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- 239000003613 bile acid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000001883 cholelithiasis Diseases 0.000 abstract 1
- 208000001130 gallstones Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1999145385 DE19945385A1 (de) | 1999-09-22 | 1999-09-22 | Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE2000128193 DE10028193A1 (de) | 2000-06-09 | 2000-06-09 | Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1218401T3 true DK1218401T3 (da) | 2004-10-04 |
Family
ID=26005994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00964126T DK1218401T3 (da) | 1999-09-22 | 2000-09-06 | 4-Benzylaminoquinolin-konjugat med galdesyre og deres heteroanaloger, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6339077B1 (enExample) |
| EP (1) | EP1218401B1 (enExample) |
| JP (1) | JP4833471B2 (enExample) |
| KR (1) | KR20030010575A (enExample) |
| CN (1) | CN1158299C (enExample) |
| AT (1) | ATE269352T1 (enExample) |
| AU (1) | AU779412B2 (enExample) |
| BR (1) | BR0014233A (enExample) |
| CA (1) | CA2385445A1 (enExample) |
| CZ (1) | CZ2002992A3 (enExample) |
| DE (1) | DE50006842D1 (enExample) |
| DK (1) | DK1218401T3 (enExample) |
| EE (1) | EE200200143A (enExample) |
| ES (1) | ES2218222T3 (enExample) |
| HK (1) | HK1049169B (enExample) |
| HR (1) | HRP20020238A2 (enExample) |
| HU (1) | HUP0203045A3 (enExample) |
| IL (1) | IL148739A0 (enExample) |
| NO (1) | NO20021337L (enExample) |
| NZ (1) | NZ517899A (enExample) |
| PL (1) | PL353992A1 (enExample) |
| PT (1) | PT1218401E (enExample) |
| RU (1) | RU2247125C2 (enExample) |
| SK (1) | SK3862002A3 (enExample) |
| WO (1) | WO2001021642A1 (enExample) |
| YU (1) | YU19302A (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| ITMI20021025A1 (it) * | 2002-05-14 | 2003-11-14 | Nicox Sa | Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale |
| CZ301037B6 (cs) * | 2007-09-06 | 2009-10-21 | Vysoká škola chemicko-technologická v Praze | Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy |
| ES2488821T3 (es) * | 2009-03-24 | 2014-08-29 | Abbvie Bahamas Ltd. | Proceso de preparación de un compuesto antiviral |
| PH12012501846A1 (en) * | 2010-04-02 | 2013-02-04 | Firmenich Incorporated | Sweet flavor modifier |
| RU2617700C2 (ru) | 2011-08-12 | 2017-04-26 | Синомикс, Инк. | Производные 4-аминохинолин-3-карбоновой кислоты и содержащие их композиции для усиления сладкого вкуса |
| BR112017008738B1 (pt) | 2014-11-07 | 2021-06-15 | Firmenich Incorporated | Ácidos 4-amino-5-(ciclohexilóxi)quinolina-3-carboxílicos substituídos como modificadores de sabores adoçantes |
| WO2020041673A1 (en) | 2018-08-23 | 2020-02-27 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes |
| WO2020117945A1 (en) | 2018-12-04 | 2020-06-11 | President And Fellows Of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
| JPH0667846B2 (ja) * | 1989-04-28 | 1994-08-31 | 一 滝川 | 利胆剤 |
| IT1259419B (it) * | 1991-05-24 | 1996-03-18 | Erba Carlo Spa | Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi |
| TW289021B (enExample) * | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| IT1274000B (it) * | 1994-04-06 | 1997-07-14 | Alfa Wassermann Spa | Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi |
| DE4432708A1 (de) | 1994-09-14 | 1996-03-21 | Hoechst Ag | Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JPH09315979A (ja) * | 1996-05-24 | 1997-12-09 | Tokyo Tanabe Co Ltd | 利胆剤 |
| WO1998056757A1 (fr) * | 1997-06-11 | 1998-12-17 | Sankyo Company, Limited | Derives de benzylamine |
-
2000
- 2000-09-06 CZ CZ2002992A patent/CZ2002992A3/cs unknown
- 2000-09-06 DK DK00964126T patent/DK1218401T3/da active
- 2000-09-06 PT PT00964126T patent/PT1218401E/pt unknown
- 2000-09-06 YU YU19302A patent/YU19302A/sh unknown
- 2000-09-06 IL IL14873900A patent/IL148739A0/xx unknown
- 2000-09-06 SK SK386-2002A patent/SK3862002A3/sk unknown
- 2000-09-06 EP EP00964126A patent/EP1218401B1/de not_active Expired - Lifetime
- 2000-09-06 AT AT00964126T patent/ATE269352T1/de not_active IP Right Cessation
- 2000-09-06 CN CNB008131554A patent/CN1158299C/zh not_active Expired - Fee Related
- 2000-09-06 PL PL00353992A patent/PL353992A1/xx not_active Application Discontinuation
- 2000-09-06 EE EEP200200143A patent/EE200200143A/xx unknown
- 2000-09-06 WO PCT/EP2000/008691 patent/WO2001021642A1/de not_active Ceased
- 2000-09-06 DE DE50006842T patent/DE50006842D1/de not_active Expired - Lifetime
- 2000-09-06 BR BR0014233-6A patent/BR0014233A/pt not_active IP Right Cessation
- 2000-09-06 HK HK03101156.5A patent/HK1049169B/zh not_active IP Right Cessation
- 2000-09-06 HR HR20020238A patent/HRP20020238A2/xx not_active Application Discontinuation
- 2000-09-06 HU HU0203045A patent/HUP0203045A3/hu unknown
- 2000-09-06 NZ NZ517899A patent/NZ517899A/en unknown
- 2000-09-06 AU AU75156/00A patent/AU779412B2/en not_active Ceased
- 2000-09-06 ES ES00964126T patent/ES2218222T3/es not_active Expired - Lifetime
- 2000-09-06 RU RU2002110440/04A patent/RU2247125C2/ru not_active IP Right Cessation
- 2000-09-06 JP JP2001525216A patent/JP4833471B2/ja not_active Expired - Fee Related
- 2000-09-06 KR KR1020027003757A patent/KR20030010575A/ko not_active Ceased
- 2000-09-06 CA CA002385445A patent/CA2385445A1/en not_active Abandoned
- 2000-09-22 US US09/667,668 patent/US6339077B1/en not_active Expired - Lifetime
-
2002
- 2002-03-18 NO NO20021337A patent/NO20021337L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1218401B1 (de) | 2004-06-16 |
| RU2247125C2 (ru) | 2005-02-27 |
| CA2385445A1 (en) | 2001-03-29 |
| HRP20020238A2 (en) | 2004-04-30 |
| IL148739A0 (en) | 2002-09-12 |
| YU19302A (sh) | 2004-11-25 |
| WO2001021642A1 (de) | 2001-03-29 |
| EE200200143A (et) | 2003-04-15 |
| HK1049169B (zh) | 2005-04-22 |
| AU7515600A (en) | 2001-04-24 |
| BR0014233A (pt) | 2002-05-21 |
| PT1218401E (pt) | 2004-10-29 |
| AU779412B2 (en) | 2005-01-20 |
| US6339077B1 (en) | 2002-01-15 |
| SK3862002A3 (en) | 2003-01-09 |
| NZ517899A (en) | 2004-03-26 |
| CZ2002992A3 (cs) | 2002-06-12 |
| ATE269352T1 (de) | 2004-07-15 |
| JP4833471B2 (ja) | 2011-12-07 |
| NO20021337L (no) | 2002-05-15 |
| NO20021337D0 (no) | 2002-03-18 |
| PL353992A1 (en) | 2003-12-15 |
| CN1158299C (zh) | 2004-07-21 |
| KR20030010575A (ko) | 2003-02-05 |
| HUP0203045A3 (en) | 2004-06-28 |
| ES2218222T3 (es) | 2004-11-16 |
| HK1049169A1 (en) | 2003-05-02 |
| CN1374968A (zh) | 2002-10-16 |
| HUP0203045A2 (hu) | 2003-01-28 |
| EP1218401A1 (de) | 2002-07-03 |
| DE50006842D1 (de) | 2004-07-22 |
| JP2003510255A (ja) | 2003-03-18 |
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