RU2246483C2 - Эфиры 5-аминолевулиновой кислоты как фоточувствительные агенты в фотохимиотерапии - Google Patents

Эфиры 5-аминолевулиновой кислоты как фоточувствительные агенты в фотохимиотерапии Download PDF

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Publication number
RU2246483C2
RU2246483C2 RU2003105460/04A RU2003105460A RU2246483C2 RU 2246483 C2 RU2246483 C2 RU 2246483C2 RU 2003105460/04 A RU2003105460/04 A RU 2003105460/04A RU 2003105460 A RU2003105460 A RU 2003105460A RU 2246483 C2 RU2246483 C2 RU 2246483C2
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ala
compound
substituted
group
photochemotherapy
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RU2003105460/04A
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Russian (ru)
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RU2003105460A (ru
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Йо КЛАВЕНЕСС (NO)
Йо Клавенесс
Нильс Олаф НИЛЬСЕН (NO)
Нильс Олаф НИЛЬСЕН
Йон Эрик БРЕНДЕН (NO)
Йон Эрик БРЕНДЕН
Аслак ГОДАЛЬ (NO)
Аслак ГОДАЛЬ
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Фотокьюр Аса
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2003105460/04A 2000-07-27 2001-07-25 Эфиры 5-аминолевулиновой кислоты как фоточувствительные агенты в фотохимиотерапии RU2246483C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018528.0 2000-07-27
GBGB0018528.0A GB0018528D0 (en) 2000-07-27 2000-07-27 Compounds

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RU2003105460A RU2003105460A (ru) 2004-08-20
RU2246483C2 true RU2246483C2 (ru) 2005-02-20

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US (2) US7217736B2 (cg-RX-API-DMAC7.html)
EP (1) EP1313695B1 (cg-RX-API-DMAC7.html)
JP (1) JP5010088B2 (cg-RX-API-DMAC7.html)
KR (1) KR20030028554A (cg-RX-API-DMAC7.html)
CN (1) CN1318388C (cg-RX-API-DMAC7.html)
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NZ (1) NZ523927A (cg-RX-API-DMAC7.html)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2484111C2 (ru) * 2007-07-31 2013-06-10 Джи-И Хелткер Лимитед Агенты для оптической визуализации
RU2521228C2 (ru) * 2007-12-12 2014-06-27 ФотоКьюэр АСА Применение 5-аминолевулиновой кислоты и ее производных в твердой форме для фотодинамического лечения и диагностики
US10017459B2 (en) 2015-08-03 2018-07-10 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents and uses thereof
US10034847B2 (en) 2014-02-03 2018-07-31 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2484111C2 (ru) * 2007-07-31 2013-06-10 Джи-И Хелткер Лимитед Агенты для оптической визуализации
RU2484111C9 (ru) * 2007-07-31 2013-09-20 Джи-И Хелткер Лимитед Агенты для оптической визуализации
RU2521228C2 (ru) * 2007-12-12 2014-06-27 ФотоКьюэр АСА Применение 5-аминолевулиновой кислоты и ее производных в твердой форме для фотодинамического лечения и диагностики
US10034847B2 (en) 2014-02-03 2018-07-31 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
US10245246B2 (en) 2014-02-03 2019-04-02 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents
US10017459B2 (en) 2015-08-03 2018-07-10 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents and uses thereof
US10246406B2 (en) 2015-08-03 2019-04-02 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof

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AU2002227495B2 (en) 2006-01-05
AU2749502A (en) 2002-02-13
US7217736B2 (en) 2007-05-15
DE60125555D1 (de) 2007-02-08
DK1313695T3 (da) 2007-04-30
CN1318388C (zh) 2007-05-30
JP5010088B2 (ja) 2012-08-29
HUP0301427A2 (hu) 2003-09-29
PT1313695E (pt) 2007-01-31
US20040106679A1 (en) 2004-06-03
EP1313695A1 (en) 2003-05-28
KR20030028554A (ko) 2003-04-08
ES2276844T3 (es) 2007-07-01
WO2002010120A1 (en) 2002-02-07
NO20030398D0 (no) 2003-01-24
CZ2003260A3 (cs) 2003-06-18
NO20030398L (no) 2003-03-12
NZ523927A (en) 2004-07-30
US7563819B1 (en) 2009-07-21
CA2416307C (en) 2013-01-22
GB0018528D0 (en) 2000-09-13
ATE349417T1 (de) 2007-01-15
JP2004505105A (ja) 2004-02-19
CN1460099A (zh) 2003-12-03
DE60125555T2 (de) 2007-10-11
CA2416307A1 (en) 2002-02-07
EP1313695B1 (en) 2006-12-27

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