AU2749502A - Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy - Google Patents

Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Info

Publication number
AU2749502A
AU2749502A AU2749502A AU2749502A AU2749502A AU 2749502 A AU2749502 A AU 2749502A AU 2749502 A AU2749502 A AU 2749502A AU 2749502 A AU2749502 A AU 2749502A AU 2749502 A AU2749502 A AU 2749502A
Authority
AU
Australia
Prior art keywords
photochemotherapy
esters
group
alkyl group
aminolevulinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2749502A
Other languages
English (en)
Inventor
Jo Klaveness
Nils Olav Nilsen
Jon Erik Braenden
Aslak Godal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photocure ASA
Original Assignee
Photocure ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure ASA filed Critical Photocure ASA
Publication of AU2749502A publication Critical patent/AU2749502A/xx
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2749502A 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy Pending AU2749502A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0018528.0A GB0018528D0 (en) 2000-07-27 2000-07-27 Compounds
PCT/GB2001/003336 WO2002010120A1 (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Publications (1)

Publication Number Publication Date
AU2749502A true AU2749502A (en) 2002-02-13

Family

ID=9896500

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2749502A Pending AU2749502A (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
AU2002227495A Ceased AU2002227495B2 (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2002227495A Ceased AU2002227495B2 (en) 2000-07-27 2001-07-25 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Country Status (19)

Country Link
US (2) US7217736B2 (cg-RX-API-DMAC7.html)
EP (1) EP1313695B1 (cg-RX-API-DMAC7.html)
JP (1) JP5010088B2 (cg-RX-API-DMAC7.html)
KR (1) KR20030028554A (cg-RX-API-DMAC7.html)
CN (1) CN1318388C (cg-RX-API-DMAC7.html)
AT (1) ATE349417T1 (cg-RX-API-DMAC7.html)
AU (2) AU2749502A (cg-RX-API-DMAC7.html)
CA (1) CA2416307C (cg-RX-API-DMAC7.html)
CZ (1) CZ2003260A3 (cg-RX-API-DMAC7.html)
DE (1) DE60125555T2 (cg-RX-API-DMAC7.html)
DK (1) DK1313695T3 (cg-RX-API-DMAC7.html)
ES (1) ES2276844T3 (cg-RX-API-DMAC7.html)
GB (1) GB0018528D0 (cg-RX-API-DMAC7.html)
HU (1) HUP0301427A2 (cg-RX-API-DMAC7.html)
NO (1) NO20030398L (cg-RX-API-DMAC7.html)
NZ (1) NZ523927A (cg-RX-API-DMAC7.html)
PT (1) PT1313695E (cg-RX-API-DMAC7.html)
RU (1) RU2246483C2 (cg-RX-API-DMAC7.html)
WO (1) WO2002010120A1 (cg-RX-API-DMAC7.html)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492420B2 (en) * 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
PL205109B1 (pl) * 1998-11-02 2010-03-31 Elan Pharma Int Ltd Wielocząstkowa kompozycja metylofenidatu o modyfikowanym uwalnianiu i jej zastosowanie
US20090297602A1 (en) * 1998-11-02 2009-12-03 Devane John G Modified Release Loxoprofen Compositions
US6833140B2 (en) 2001-06-11 2004-12-21 Xenoport, Inc. Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
GB0118251D0 (en) * 2001-07-26 2001-09-19 Photocure Asa Method
AU2003268380A1 (en) * 2002-10-04 2004-05-04 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
DE10312659A1 (de) * 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
EP1626742A1 (en) 2003-05-22 2006-02-22 Elan Pharma International Limited Sterilization of dispersions of nanoparticulate active agents with gamma radiation
CA2437638A1 (en) 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
JP2005350418A (ja) * 2004-06-11 2005-12-22 Shibuya Kogyo Co Ltd 標的細胞の死滅方法と標的細胞を死滅させるための薬剤及び該薬剤の製造装置
CN101010076B (zh) 2004-09-02 2010-06-09 克斯莫石油株式会社 健康功能改善剂
CN101068538A (zh) 2004-11-04 2007-11-07 什诺波特有限公司 加巴喷丁前体药物持续释放口服剂型
GB0424833D0 (en) 2004-11-10 2004-12-15 Photocure Asa Method
WO2006096462A1 (en) * 2005-03-03 2006-09-14 Elan Pharma International Limited Nanoparticulate compositions of heterocyclic amide derivatives
JP4934293B2 (ja) * 2005-07-05 2012-05-16 コスモ石油株式会社 植物活力剤組成物
JP4934292B2 (ja) * 2005-07-05 2012-05-16 コスモ石油株式会社 ５−アミノレブリン酸エステルリン酸類塩、その製造方法及びその用途
GB0609809D0 (en) * 2006-05-17 2006-06-28 Photocure Asa Product
AU2007272501A1 (en) * 2006-07-12 2008-01-17 Elan Pharma International Limited Nanoparticulate formulations of modafinil
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
GB0700580D0 (en) 2007-01-11 2007-02-21 Photocure Asa Use
US20090036952A1 (en) 2007-07-30 2009-02-05 National Yang-Ming University Induction driven light module and use thereof
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
KR100883560B1 (ko) * 2007-08-23 2009-02-17 (주) 위디어 신규한 5-아미노레불린 산 유도체 및 이의 제조방법
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
JP2011506425A (ja) * 2007-12-14 2011-03-03 フォトデルマ エスアー 治療的及び美容的方法に有用な新規化合物
GB0804190D0 (en) * 2008-03-06 2008-04-16 Ge Healthcare Ltd Ester imaging agents
US8563605B2 (en) 2008-05-14 2013-10-22 Sbi Pharmaceuticals Co., Ltd. Therapeutic agent for male sterility
CA2735426A1 (en) 2008-09-01 2010-03-04 Swedish Pharma Ab New 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis
GB0823472D0 (en) 2008-12-23 2009-01-28 Photocure Asa Product
GB0900461D0 (en) 2009-01-12 2009-02-11 Photocure Asa Photodynamic therapy device
WO2010142456A1 (en) * 2009-06-11 2010-12-16 Photocure Asa Solid compositions comprising 5-aminolevulinic acid
RU2526803C2 (ru) * 2009-06-11 2014-08-27 ФотоКьюэр АСА Полутвердые композиции и фармацевтические продукты
CA2790827A1 (en) * 2010-03-01 2011-09-09 Photocure Asa Cosmetic compositions
EP2394642A1 (en) 2010-06-10 2011-12-14 Universite De Geneve 5-ALA ester formulations and use thereof
EP2585111A1 (en) 2010-06-23 2013-05-01 Photocure ASA Hyperosmotic preparations comprising 5 -amino levulinic acid or derivative as photosensitizing agent
EP2590714B1 (en) 2010-07-09 2017-03-08 Photocure ASA Devices containing dry compositions for use in photodynamic therapy
CN103270168A (zh) 2010-12-24 2013-08-28 爱科来株式会社 癌细胞的检测方法
WO2012097264A2 (en) 2011-01-13 2012-07-19 Qlt Inc. Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof
EP2766049A1 (en) 2011-10-14 2014-08-20 Photocure ASA Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester
WO2013053904A1 (en) 2011-10-14 2013-04-18 Photocure Asa Stent
AP4045A (en) 2011-12-19 2017-02-28 Photocure Asa Irradiation apparatus
WO2013092936A2 (en) 2011-12-20 2013-06-27 Galderma Research & Development Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne
MX2015000429A (es) 2012-07-11 2015-07-14 Dermira Inc Composiciones farmaceuticas para el suministro topico de fotosesibilizadores y usos de los mismos.
AU2013298525B2 (en) 2012-08-03 2017-12-14 Photocure Asa Compounds
GB201215675D0 (en) * 2012-09-03 2012-10-17 Univ Exeter Compound
GB201221123D0 (en) 2012-11-23 2013-01-09 Photocure As Device for photodynamic treatment
GB201306369D0 (en) 2013-04-09 2013-05-22 Photocure As Irradiation device
BR112016014073A2 (pt) 2013-12-20 2017-08-08 Galderma Res & Dev Tratamento fotodinâmico de pulso de pele fotodanificada
AU2015210638B2 (en) 2014-02-03 2017-07-20 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
EP3095464A1 (en) 2015-05-19 2016-11-23 Universite De Geneve 5-ala derivatives and use thereof
AR105592A1 (es) 2015-08-03 2017-10-18 Quadriga Biosciences Inc b-AMINOÁCIDOS b-SUSTITUIDOS Y ANÁLOGOS COMO AGENTES QUIMIOTERAPÉUTICOS Y USOS DE LOS MISMOS
GB201522309D0 (en) * 2015-12-17 2016-02-03 Photocure Asa Use
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN106187793A (zh) 2016-01-26 2016-12-07 赵鸣 5‑氨基酮戊酸及其衍生物的盐化合物和应用
KR20190112096A (ko) 2017-02-06 2019-10-02 쓰리스킨 에이에스 자외선 차단제 조성물
PL3641882T3 (pl) * 2017-06-21 2024-02-26 Photocure Asa Sposób przygotowania ciekłej kompozycji farmaceutycznej oraz urządzenie do stosowania w takim sposobie
EP3868372A1 (en) 2020-02-19 2021-08-25 JLP Health GmbH A pharmaceutical combination of an artemisinin compound and a heme synthesis modulator for treating cancer
CN111635464B (zh) * 2020-05-12 2022-03-25 上海易全化学有限公司 一种5-氨基酮戊酸葡聚糖酯的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2411382C3 (de) 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB2058077B (en) 1979-06-08 1983-03-09 Szelke M Enkephalin analogues
CA1236029A (en) * 1984-05-14 1988-05-03 Edmund Sandborn Pharmaceutical solutions comprising dimethyl sulfoxide
SE460947B (sv) 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
JPS6452778A (en) * 1987-05-30 1989-02-28 Tokuyama Soda Kk Fulgide compound and production thereof
JPH0745502B2 (ja) * 1987-11-10 1995-05-17 株式会社トクヤマ 新規化合物及びそれを含む組成物
US5079262A (en) 1989-07-28 1992-01-07 Queen's University At Kingston Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
US5955490A (en) * 1989-07-28 1999-09-21 Queen's University At Kingston Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
US5234940A (en) * 1989-07-28 1993-08-10 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
US5422093A (en) * 1989-07-28 1995-06-06 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
JP2767318B2 (ja) 1990-04-11 1998-06-18 株式会社コスモ総合研究所 ５―アミノレブリン酸アルキルエステル又はその塩及びその製造方法並びにこれを有効成分とする除草剤
US5219878A (en) * 1990-10-05 1993-06-15 Queen's University Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents
WO1992006097A1 (en) 1990-10-05 1992-04-16 Queen's University At Kingston Porphyrin derivatives
JP2747644B2 (ja) * 1993-08-19 1998-05-06 株式会社コスモ総合研究所 植物成長調節剤
GB9318841D0 (en) 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition
JP2896963B2 (ja) * 1994-11-28 1999-05-31 株式会社コスモ総合研究所 植物の耐塩性向上剤
US6992107B1 (en) * 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6492420B2 (en) * 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
GB9504948D0 (en) * 1995-03-10 1995-04-26 Norwegian Radium Hospital Rese Compounds
DE122006000051I2 (de) * 1995-03-10 2010-07-08 Photocure Asa Hoffsveien 48 Ester der 5-Aminolevulinsäure als Mittel zur Photosensibilisierung in der Chemotherapie
GB9700396D0 (en) * 1997-01-10 1997-02-26 Photocure As Photochemotherapeutic compositions
FR2777782B1 (fr) 1998-04-22 2001-05-18 Alexandre Marti Solution pour la preparation d'une substance pharmaceutique pour le diagnostic et/ou le traitement de lesions tissulaires
GB0018527D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Composition
GB0118251D0 (en) 2001-07-26 2001-09-19 Photocure Asa Method
GB0128052D0 (en) 2001-11-22 2002-01-16 Drug Discovery Lab As Compounds

Also Published As

Publication number Publication date
NO20030398D0 (no) 2003-01-24
GB0018528D0 (en) 2000-09-13
DK1313695T3 (da) 2007-04-30
US20040106679A1 (en) 2004-06-03
CN1318388C (zh) 2007-05-30
CA2416307A1 (en) 2002-02-07
EP1313695B1 (en) 2006-12-27
ATE349417T1 (de) 2007-01-15
CN1460099A (zh) 2003-12-03
US7217736B2 (en) 2007-05-15
KR20030028554A (ko) 2003-04-08
DE60125555D1 (de) 2007-02-08
PT1313695E (pt) 2007-01-31
WO2002010120A1 (en) 2002-02-07
DE60125555T2 (de) 2007-10-11
JP2004505105A (ja) 2004-02-19
CZ2003260A3 (cs) 2003-06-18
CA2416307C (en) 2013-01-22
RU2246483C2 (ru) 2005-02-20
JP5010088B2 (ja) 2012-08-29
NO20030398L (no) 2003-03-12
HUP0301427A2 (hu) 2003-09-29
NZ523927A (en) 2004-07-30
US7563819B1 (en) 2009-07-21
ES2276844T3 (es) 2007-07-01
AU2002227495B2 (en) 2006-01-05
EP1313695A1 (en) 2003-05-28

Similar Documents

Publication Publication Date Title
AU2749502A (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
CA2215069A1 (en) Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
TW200614983A (en) 5-substituted-2-phenylamino benzamides as MEK inhibitors
WO2002100833A1 (en) Rho KINASE INHIBITORS
EP1829863A4 (en) ARYLALKANSÄUREDERIVAT
DK1689721T3 (da) Aminopyrazolderivater som GSK-3-ihibitorer
MA30821B1 (fr) Derives de pyrazoline utiles comme antagonistes des recepteurs de mineralocorticoïdes
EA201170094A1 (ru) Производные замещенного пиримидо[2,1-а]изохинолин-4-она
PL1685142T3 (pl) Pochodne kwasu fosfinowego, inhibitory beta-sekterazy do leczenia choroby Alzheimera
IN2015DN00837A (cg-RX-API-DMAC7.html)
PT2420491E (pt) Compostos de piperidina 3,5-substituída como inibidores de renina
NO20060114L (no) Naftylenderivater som cytokrom P450-inhibitorer
WO2006043149A3 (en) Novel dicarboxylic acid derivatives
CY1110613T1 (el) Υποκατεστημενες θειαζολες και η χρησιμοποιηση τους για την παρασκευη φαρμακων
NO20064982L (no) 1,3,4-oksadiazol-2-oner som PPAR delta modulatorer og anvendelse derav
DE602006008962D1 (de) Verfahren zur herstellung von valsartan
ZA200704913B (en) 3-[2-(3-acylamino-2-oxo-2H-pyridin-1-YL)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors
WO2001070693A3 (en) Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
BRPI0413741A (pt) métodos para preparar thip e para preparar um composto, e, composto
NO20053805L (no) Diarylmetylindenpiperidinderivater, framgangsmate for fremstilling derav, og anvendelse derav
TNSN08287A1 (en) 3,5-substituted piperidine compounds as renin inhibitors
WO2008146917A1 (ja) リンコマイシン誘導体及びこれを有効成分とする抗菌剤
ECSP055546A (es) Derivados novedosos de piridiletanol (feniletil) aminas como inhibidores de la biosíntesis de colesterol, procesos para su preparación, y composiciones farmaceuticas que los contienen
EP1707560A4 (en) HYDROXAMIC ACID DERIVATIVE AND THE DERIVATIVE INHIBITOR OF THE GENERATION OF AGE
TH62592A (th) ฟลูออรีนคาร์บอกซีลิกแอซิดเอสเทอร์ใหม่ กรรมวิธีสำหรับการผลิตของสารนั้น และการใช้สารนั้นเป็นสารรักษาโรค