RU2218407C2 - Прямая экспрессия пептидов в культуральные среды - Google Patents

Прямая экспрессия пептидов в культуральные среды Download PDF

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Publication number
RU2218407C2
RU2218407C2 RU99124196/13A RU99124196A RU2218407C2 RU 2218407 C2 RU2218407 C2 RU 2218407C2 RU 99124196/13 A RU99124196/13 A RU 99124196/13A RU 99124196 A RU99124196 A RU 99124196A RU 2218407 C2 RU2218407 C2 RU 2218407C2
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Prior art keywords
peptide
vector according
peptide product
nucleic acids
medium
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RU99124196/13A
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English (en)
Russian (ru)
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RU99124196A (ru
Inventor
Нозар М. МЕХТА
Марта В. Л. РЭЙ
Кристофер П. МИНАН
Анджело П. КОНСАЛВО
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Юниджен Лэбораториз Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
RU99124196/13A 1997-04-16 1998-04-15 Прямая экспрессия пептидов в культуральные среды RU2218407C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4370097P 1997-04-16 1997-04-16
US60/043,700 1997-04-16

Publications (2)

Publication Number Publication Date
RU99124196A RU99124196A (ru) 2001-09-20
RU2218407C2 true RU2218407C2 (ru) 2003-12-10

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RU99124196/13A RU2218407C2 (ru) 1997-04-16 1998-04-15 Прямая экспрессия пептидов в культуральные среды

Country Status (14)

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US (5) US6103495A (cg-RX-API-DMAC7.html)
EP (2) EP2088188B1 (cg-RX-API-DMAC7.html)
JP (2) JP4907751B2 (cg-RX-API-DMAC7.html)
AT (2) ATE522598T1 (cg-RX-API-DMAC7.html)
AU (1) AU742270B2 (cg-RX-API-DMAC7.html)
CA (1) CA2285658C (cg-RX-API-DMAC7.html)
DE (1) DE69841939D1 (cg-RX-API-DMAC7.html)
DK (2) DK1005526T3 (cg-RX-API-DMAC7.html)
ES (1) ES2375330T3 (cg-RX-API-DMAC7.html)
HU (1) HUP0001272A3 (cg-RX-API-DMAC7.html)
LT (1) LT4701B (cg-RX-API-DMAC7.html)
NO (1) NO327325B1 (cg-RX-API-DMAC7.html)
RU (1) RU2218407C2 (cg-RX-API-DMAC7.html)
WO (1) WO1998046722A1 (cg-RX-API-DMAC7.html)

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SI3095484T1 (en) 2011-11-02 2018-08-31 Keybioscience Ag Calcitonin mimetics for the treatment of diseases and disorders
CA2854175A1 (en) 2011-11-02 2013-05-10 Keybioscience Ag Peptide analogs for treating diseases and disorders
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US9102751B2 (en) * 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10196662B2 (en) 2012-08-10 2019-02-05 Mello Biotechnology, Inc. Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors
US9457086B2 (en) 2013-03-05 2016-10-04 Enteris Biopharma, Inc. Pharmaceuticals for oral delivery
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CN103709236B (zh) * 2013-12-23 2015-04-15 江南大学 一种可提高分泌效率的信号肽及其应用
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Publication number Priority date Publication date Assignee Title
WO2009048354A1 (en) * 2007-10-08 2009-04-16 Federalnoe Gosudarstvennoe Unitarnoe Predpriyatie 'gosudarstvenny Nauchny Tsentr 'nauchno-Issledovatelsky Institut Organicheskikh Poluproduktov I Krasitelei (Niopik) Method for overproducing anti-her2/neu oncogene antibodies in plant

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Publication number Publication date
LT4701B (lt) 2000-09-25
DK1005526T3 (da) 2011-02-07
WO1998046722A1 (en) 1998-10-22
ATE522598T1 (de) 2011-09-15
US20040191865A1 (en) 2004-09-30
JP2012024108A (ja) 2012-02-09
WO1998046722A9 (en) 1999-11-18
NO995014D0 (no) 1999-10-14
EP1005526A4 (en) 2005-02-09
US6103495A (en) 2000-08-15
ATE484572T1 (de) 2010-10-15
JP2002501379A (ja) 2002-01-15
US6210925B1 (en) 2001-04-03
US6627438B2 (en) 2003-09-30
EP1005526A1 (en) 2000-06-07
JP4907751B2 (ja) 2012-04-04
HUP0001272A1 (hu) 2000-08-28
DE69841939D1 (de) 2010-11-25
LT99133A (en) 2000-04-25
EP2088188B1 (en) 2011-08-31
HUP0001272A3 (en) 2012-12-28
US6737250B2 (en) 2004-05-18
AU7127998A (en) 1998-11-11
EP1005526B1 (en) 2010-10-13
CA2285658C (en) 2011-10-04
US7968311B2 (en) 2011-06-28
US20020045211A1 (en) 2002-04-18
US20010055789A1 (en) 2001-12-27
NO327325B1 (no) 2009-06-08
DK2088188T3 (da) 2012-01-02
NO995014L (no) 1999-12-13
EP2088188A1 (en) 2009-08-12
JP5634971B2 (ja) 2014-12-03
AU742270B2 (en) 2001-12-20
CA2285658A1 (en) 1998-10-22
ES2375330T3 (es) 2012-02-28

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