ATE522598T1 - Direkte expression von peptiden in nährmedien - Google Patents

Direkte expression von peptiden in nährmedien

Info

Publication number
ATE522598T1
ATE522598T1 AT09006784T AT09006784T ATE522598T1 AT E522598 T1 ATE522598 T1 AT E522598T1 AT 09006784 T AT09006784 T AT 09006784T AT 09006784 T AT09006784 T AT 09006784T AT E522598 T1 ATE522598 T1 AT E522598T1
Authority
AT
Austria
Prior art keywords
direct expression
peptides
producing
nutrition media
glycine
Prior art date
Application number
AT09006784T
Other languages
English (en)
Inventor
Nozar Mehta
Martha Ray
Christopher Meenan
Angelo Consalvo
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Application granted granted Critical
Publication of ATE522598T1 publication Critical patent/ATE522598T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
AT09006784T 1997-04-16 1998-04-15 Direkte expression von peptiden in nährmedien ATE522598T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4370097P 1997-04-16 1997-04-16

Publications (1)

Publication Number Publication Date
ATE522598T1 true ATE522598T1 (de) 2011-09-15

Family

ID=21928441

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09006784T ATE522598T1 (de) 1997-04-16 1998-04-15 Direkte expression von peptiden in nährmedien
AT98918334T ATE484572T1 (de) 1997-04-16 1998-04-15 Direkte expression von peptiden ins kulturmedium

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98918334T ATE484572T1 (de) 1997-04-16 1998-04-15 Direkte expression von peptiden ins kulturmedium

Country Status (14)

Country Link
US (5) US6103495A (de)
EP (2) EP2088188B1 (de)
JP (2) JP4907751B2 (de)
AT (2) ATE522598T1 (de)
AU (1) AU742270B2 (de)
CA (1) CA2285658C (de)
DE (1) DE69841939D1 (de)
DK (2) DK2088188T3 (de)
ES (1) ES2375330T3 (de)
HU (1) HUP0001272A3 (de)
LT (1) LT4701B (de)
NO (1) NO327325B1 (de)
RU (1) RU2218407C2 (de)
WO (1) WO1998046722A1 (de)

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US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US20050215476A1 (en) * 2004-01-21 2005-09-29 Unigene Laboratories Inc. Amidated parathyroid hormone fragments and uses thereof
US8227241B2 (en) * 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
US7531518B2 (en) * 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060089723A1 (en) * 2004-10-25 2006-04-27 Murphy Kieran P Method for bone augmentation
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
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US20060275812A1 (en) * 2005-06-01 2006-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Assay for agonists and antagonists of ion channels and for regulators of genetic expression
US7825231B2 (en) 2005-06-01 2010-11-02 Darren P. Wolfe Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
CA2613471C (en) 2005-06-24 2016-09-06 Unigene Laboratories, Inc. Cell lines for expressing enzyme useful in the preparation of amidated products
EP2046826B1 (de) 2006-07-24 2011-09-14 Biorexis Pharmaceutical Corporation Exendin-fusionsproteine
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
RU2370280C2 (ru) * 2007-10-08 2009-10-20 Институт физико-химической биологии им. А.Н.Белозерского СПОСОБ СУПЕРПРОДУКЦИИ В РАСТЕНИИ АНТИТЕЛ ПРОТИВ ОНКОГЕНА HER2/neu
US9422559B2 (en) 2010-06-02 2016-08-23 Shi-Lung Lin Production and utilization of a novel anti-cancer drug in therapy
US9399773B2 (en) 2012-08-10 2016-07-26 Shi-Lung Lin Production and extraction of MicroRNA precursor as drug for cancer therapy
DK2389388T3 (en) 2009-01-22 2017-05-01 Keybioscience Ag TREATMENT FOR Obesity
AU2012271453B2 (en) 2011-06-15 2017-07-06 Resother Pharma Aps Anti-inflammatory pharmaceutical products
WO2013025248A1 (en) 2011-08-12 2013-02-21 Mello Biotechnology, Inc. Inducable expression from the eukaryotic pol -2 promoter in prokaryotes
LT3095484T (lt) 2011-11-02 2018-08-10 Keybioscience Ag Kalcitonino mimetikai, skirti ligų ir sutrikimų gydymui
WO2013067357A1 (en) 2011-11-02 2013-05-10 Nu-Co Development Gmbh Peptide analogs for treating diseases and disorders
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US9102751B2 (en) * 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10196662B2 (en) 2012-08-10 2019-02-05 Mello Biotechnology, Inc. Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors
WO2014138241A1 (en) 2013-03-05 2014-09-12 Enteris Biopharma, Inc. Pharmaceuticals for oral delivery
CA2926052A1 (en) 2013-10-03 2015-04-09 Janssen Biotech, Inc. Protoxin-ii variants and methods of use
NO3068796T3 (de) 2013-11-14 2018-06-30
CN103709236B (zh) * 2013-12-23 2015-04-15 江南大学 一种可提高分泌效率的信号肽及其应用
ES2929218T3 (es) 2015-01-12 2022-11-28 Enteris Biopharma Inc Formas farmacéuticas orales sólidas
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
MX2017012654A (es) 2015-04-02 2018-01-09 Janssen Biotech Inc Variantes de protoxina-ii y metodos de uso.
WO2017095458A1 (en) 2015-12-02 2017-06-08 Chih-Li Lin A COMPOSITION AND METHOD OF USING miR-302 PRECURSORS AS DRUGS FOR TREATING ALZHEIMER'S DISEASES
WO2017095489A1 (en) 2015-12-02 2017-06-08 Shi-Lung Lin Use of microrna precursors as drugs for inducing cd34-positive adult stem cell expansion
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB202001024D0 (en) 2020-01-24 2020-03-11 Key Bioscience Ag Oxyntomodulin mimetics

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Also Published As

Publication number Publication date
EP1005526A1 (de) 2000-06-07
EP2088188B1 (de) 2011-08-31
NO995014D0 (no) 1999-10-14
EP2088188A1 (de) 2009-08-12
US6210925B1 (en) 2001-04-03
HUP0001272A3 (en) 2012-12-28
RU2218407C2 (ru) 2003-12-10
ATE484572T1 (de) 2010-10-15
CA2285658C (en) 2011-10-04
CA2285658A1 (en) 1998-10-22
JP2012024108A (ja) 2012-02-09
EP1005526A4 (de) 2005-02-09
ES2375330T3 (es) 2012-02-28
EP1005526B1 (de) 2010-10-13
AU742270B2 (en) 2001-12-20
JP4907751B2 (ja) 2012-04-04
JP5634971B2 (ja) 2014-12-03
US6103495A (en) 2000-08-15
DK1005526T3 (da) 2011-02-07
WO1998046722A1 (en) 1998-10-22
DE69841939D1 (de) 2010-11-25
NO995014L (no) 1999-12-13
NO327325B1 (no) 2009-06-08
HUP0001272A1 (hu) 2000-08-28
LT99133A (en) 2000-04-25
JP2002501379A (ja) 2002-01-15
LT4701B (lt) 2000-09-25
US7968311B2 (en) 2011-06-28
US20040191865A1 (en) 2004-09-30
US20020045211A1 (en) 2002-04-18
US6627438B2 (en) 2003-09-30
US6737250B2 (en) 2004-05-18
US20010055789A1 (en) 2001-12-27
AU7127998A (en) 1998-11-11
DK2088188T3 (da) 2012-01-02
WO1998046722A9 (en) 1999-11-18

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