ATE9595T1 - Verfahren zur enzymatischen herstellung von peptiden. - Google Patents

Verfahren zur enzymatischen herstellung von peptiden.

Info

Publication number
ATE9595T1
ATE9595T1 AT80301062T AT80301062T ATE9595T1 AT E9595 T1 ATE9595 T1 AT E9595T1 AT 80301062 T AT80301062 T AT 80301062T AT 80301062 T AT80301062 T AT 80301062T AT E9595 T1 ATE9595 T1 AT E9595T1
Authority
AT
Austria
Prior art keywords
optionally
amino acid
amides
peptide
peptides
Prior art date
Application number
AT80301062T
Other languages
English (en)
Inventor
Jack Taaning Johansen
Fred Widmer
Klaus Breddam
Original Assignee
De Forenede Bryggerier A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De Forenede Bryggerier A/S filed Critical De Forenede Bryggerier A/S
Application granted granted Critical
Publication of ATE9595T1 publication Critical patent/ATE9595T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT80301062T 1979-04-06 1980-04-02 Verfahren zur enzymatischen herstellung von peptiden. ATE9595T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK144379 1979-04-06
EP80301062A EP0017485B1 (de) 1979-04-06 1980-04-02 Verfahren zur enzymatischen Herstellung von Peptiden

Publications (1)

Publication Number Publication Date
ATE9595T1 true ATE9595T1 (de) 1984-10-15

Family

ID=8104890

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80301062T ATE9595T1 (de) 1979-04-06 1980-04-02 Verfahren zur enzymatischen herstellung von peptiden.

Country Status (18)

Country Link
US (2) US4339534A (de)
EP (1) EP0017485B1 (de)
JP (1) JPS6339237B2 (de)
AT (1) ATE9595T1 (de)
AU (1) AU545416B2 (de)
BR (1) BR8008024A (de)
CA (1) CA1160973A (de)
CS (1) CS254954B2 (de)
DE (1) DE3069259D1 (de)
FI (1) FI70597C (de)
HU (1) HU186734B (de)
IE (1) IE50256B1 (de)
IL (1) IL59776A (de)
NZ (1) NZ193375A (de)
RO (1) RO80806A (de)
SU (1) SU1378785A3 (de)
WO (1) WO1980002157A1 (de)
ZA (1) ZA801929B (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
WO1982004069A1 (en) * 1981-05-20 1982-11-25 Andresen Finn Hede A process for the preparation of insulin derivatives
WO1983001074A1 (en) * 1981-09-15 1983-03-31 Andresen, Finn, Hede Enzymatic preparation of human insulin or b-30 esters thereof
DK149824C (da) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
JPS59112952A (ja) * 1982-12-21 1984-06-29 Taisho Pharmaceut Co Ltd ペプチド誘導体
GB8430255D0 (en) * 1984-11-30 1985-01-09 Erba Farmitalia Biologically active oligopeptides
FR2584077B1 (fr) * 1985-06-28 1988-07-08 Irceba L-di ou tripeptides possedant une activite biologique utilisable en medecine humaine et veterinaire, procede pour leur obtention et medicament en contenant
JPH01501995A (ja) * 1986-04-10 1989-07-13 コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼイション 酵素合成方法
US4935355A (en) * 1986-04-15 1990-06-19 Synthetech, Inc. Preparation of dipeptides
US5350681A (en) * 1986-08-18 1994-09-27 The Coca-Cola Company Enzymatic membrane method for the synthesis and separation of peptides
US5202235A (en) * 1986-08-18 1993-04-13 The Coca-Cola Company Enzymatic method for the synthesis and separation of peptides
US5336601A (en) * 1986-08-18 1994-08-09 The Coca-Cola Company Enzymatic membrane method for the snythesis and separation of peptides
US5002871A (en) * 1986-08-18 1991-03-26 The Coca-Cola Company Enzymatic membrane method for the synthesis and separation of peptides
US5037741A (en) * 1986-08-18 1991-08-06 The Coca Cola Company Enzymatic method for the synthesis and separation of peptides
DK72587D0 (da) * 1987-02-13 1987-02-13 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk fremstilling af dipeptider
US4892820A (en) * 1987-06-10 1990-01-09 The Nutrasweet Company Solvent system for enzymatic coupling process
US5268267A (en) * 1987-08-21 1993-12-07 The General Hospital Corporation Method for diagnosing small cell carcinoma
DE3733198A1 (de) * 1987-10-01 1989-04-13 Kernforschungsanlage Juelich Enzymatisches verfahren zur herstellung von dipeptiden
DE3741515A1 (de) * 1987-12-08 1989-06-22 Degussa Verfahren zur herstellung von dipeptiden
DK15888D0 (da) * 1988-01-14 1988-01-14 Carlsberg Biotechnology Ltd Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden
DE3803124A1 (de) * 1988-02-03 1989-08-10 Degussa Verfahren zur enzymatischen peptidsynthese
DE68924196T2 (de) * 1988-06-03 1996-05-09 Sharp Kk Elektronische Anordnung mit einer Kalenderfunktion.
DK163435C (da) * 1988-08-12 1992-07-20 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf
US5002872A (en) * 1989-05-10 1991-03-26 W. R. Grace & Co.-Conn. Enzyme mediated coupling reactions
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5169780A (en) * 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5279954A (en) * 1989-06-30 1994-01-18 Board Of Regents Of The University Of Nebraska And Bionebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
DE4014564C1 (de) * 1990-05-07 1991-07-18 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
DK133990D0 (da) * 1990-05-30 1990-05-30 Carlsberg Biotechnology Ltd Fremgangsmaade til fremstilling af derivater af growth hormone releasing factor (grf) og peptider anvendelige som mellemprodukter ved fremgangsmaaden
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
KR930002966B1 (ko) * 1990-11-24 1993-04-16 주식회사 미 원 디펩티드의 제조방법
CA2115159A1 (en) * 1991-08-08 1993-02-09 Jeffrey A. Bibbs Production of peptide amides
DE59205565D1 (de) * 1991-10-07 1996-04-11 Hoechst Ag Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung
EP0566824A1 (de) * 1992-01-28 1993-10-27 F. Hoffmann-La Roche Ag Enzymatische Peptidsynthese
US5356805A (en) * 1992-03-03 1994-10-18 Meiji Seika Kaisha, Ltd. Gamma-polyglutamate hydrolase
FR2721030B1 (fr) * 1994-06-09 1996-08-30 Pasteur Institut Composés modifiant la transmission sérotoninergique; applications diagnostiques et thérapeutiques.
ATE211483T1 (de) 1993-10-04 2002-01-15 Pasteur Institut Verbindungen, die die serotoninerge übertragung beeinflussen; ihre diagnostischen und therapeutischen anwendungen
US6187579B1 (en) * 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
US5369017A (en) * 1994-02-04 1994-11-29 The Scripps Research Institute Process for solid phase glycopeptide synthesis
US5585359A (en) * 1994-09-29 1996-12-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU4415796A (en) * 1994-12-07 1996-06-26 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
JPH11505522A (ja) * 1995-04-21 1999-05-21 ノバルティス・アクチエンゲゼルシャフト エンドセリン阻害剤としてのｎ−アロイルアミノ酸アミド
US5985627A (en) * 1997-02-28 1999-11-16 Carlsberg Laboratory Modified carboxypeptidase
NL1006069C2 (nl) * 1997-05-16 1998-11-17 Dsm Nv Werkwijze voor de bereiding van peptiden.
WO2000027800A1 (en) * 1998-11-09 2000-05-18 Smithkline Beecham Corporation Ccr-3 receptor antagonists
US20030060413A1 (en) * 2001-09-06 2003-03-27 Zimmer Robert H. Derivatives of pseudo-peptides, their preparation and their biological uses
US7671029B2 (en) 1999-08-06 2010-03-02 Immupharma Sa Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances
US6908900B2 (en) * 2001-01-17 2005-06-21 Zimmer & Associates Ag Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients
US6624147B1 (en) * 1999-09-28 2003-09-23 Rijksuniversiteit Leiden Inhibitors of prenylated pyrophosphate consuming enzymes
US6939693B2 (en) * 1999-10-29 2005-09-06 Novus International, Inc. Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids
US6605590B1 (en) 1999-10-29 2003-08-12 Novus International, Inc. Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids
PT2308874E (pt) 2005-12-07 2013-04-26 Basilea Pharmaceutica Ag Monobactamas ligadas por pontes, úteis como inibidores de beta-lactamase
CN103073618A (zh) * 2013-01-15 2013-05-01 吉尔生化（上海）有限公司 一种苄氧羰基丙氨酰丙氨酸的制备方法
AU2017246706B2 (en) 2016-04-04 2020-09-17 Research Triangle Institute Neuropeptide s receptor (NPSR) agonists
CN107936089B (zh) * 2017-11-07 2021-01-29 重庆大学 一种合成苯丙氨酰-赖氨酸二肽的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3972773A (en) * 1975-04-29 1976-08-03 Sagami Chemical Research Center Process for producing peptide
US4119493A (en) * 1975-10-23 1978-10-10 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide
US4116768A (en) * 1975-04-29 1978-09-26 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide
US4086136A (en) * 1975-10-23 1978-04-25 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide using a serine or thiol proteinase
JPS5411294A (en) * 1977-05-23 1979-01-27 Toyo Soda Mfg Co Ltd Recovery of protease
JPS5411293A (en) * 1977-05-23 1979-01-27 Toyo Soda Mfg Co Ltd Recovery of protease

Also Published As

Publication number Publication date
US4806473A (en) 1989-02-21
ZA801929B (en) 1981-11-25
IL59776A (en) 1985-01-31
JPS56500519A (de) 1981-04-23
FI70597C (fi) 1986-09-24
NZ193375A (en) 1983-06-14
SU1378785A3 (ru) 1988-02-28
EP0017485B1 (de) 1984-09-26
IE800694L (en) 1980-10-06
RO80806A (ro) 1983-02-01
US4339534A (en) 1982-07-13
AU545416B2 (en) 1985-07-11
FI70597B (fi) 1986-06-06
WO1980002157A1 (en) 1980-10-16
FI801035A (fi) 1980-10-07
IE50256B1 (en) 1986-03-19
DE3069259D1 (en) 1984-10-31
HU186734B (en) 1985-09-30
CS239980A2 (en) 1987-07-16
AU5981580A (en) 1980-10-22
IL59776A0 (en) 1980-06-30
EP0017485A1 (de) 1980-10-15
CA1160973A (en) 1984-01-24
CS254954B2 (en) 1988-02-15
BR8008024A (pt) 1981-03-31
JPS6339237B2 (de) 1988-08-04

Similar Documents

Publication Publication Date Title
ATE9595T1 (de) Verfahren zur enzymatischen herstellung von peptiden.
ATE1745T1 (de) Verfahren zur herstellung von carbonsaeureamiden und peptiden.
HU902697D0 (en) Process for the enzymatic removal of the n-terminal sequence of proteins
PT975761E (pt) Interferao beta humano recombinante com solubilidade melhorada
GB8700204D0 (en) Pancreatic secretory trypsin inhibitor & variants
MX167236B (es) Peptidos sinteticos de timosina -1 y metodo para su obtencion
ATE40556T1 (de) Verfahren zur synthese von peptiden.
DE69019077T2 (de) Verfahren zur herstellung von c-terminalen alpha-amidierten peptiden.
SE7501342L (de)
DE69033395D1 (de) Verfahren zur Identifizierung und Herstellung von Bindungsstellen aufeinanderwirkender Proteine
DE69829654D1 (de) Verfahren zur herstellung von rhizoferrin
DE58901435D1 (de) Verfahren zur herstellung von dipeptiden mit n-terminalen nichtproteinogenen aminosaeuren.
ATE15209T1 (de) Verfahren zur herstellung von carbonsaeureamidgruppen enthaltenden verbindungen, insbesondere von peptiden.
ATE101616T1 (de) Verfahren zur herstellung von dipeptiden.
DE68904578T2 (de) Enzym zur alpha-amidierung von c-termini und verfahren zu dessen herstellung.
DE59106487D1 (de) Verfahren zur herstellung von peptiden.
DE3853092D1 (de) Verfahren zur Herstellung von Proteinen, die nicht in Proteinen vorkommende Aminosäuren enthalten.
EP0326799A3 (de) Verfahren zur enzymatischen Peptidsynthese
GB1533129A (en) Process for producing a peptide in the presence of an enzyme
DE69316936T2 (de) Verfahren zur Herstellung von Peptiden mit C-terminalem Prolin-Amid
ATE102950T1 (de) Verfahren zur herstellung von dipeptiden mit cterminalen nicht-proteinogenen aminosaeuren.
ATE76081T1 (de) Verfahren zur herstellung von dipeptiden mit nterminalen nichtproteinogenen aminosaeuren.
BE791217A (en) Nitrocellulose-based nail varnish - contng scleroprotein derivs for protection and nurture of nails