DK2088188T3 - Direkte ekspression af peptider i dyrkningsmedier - Google Patents

Direkte ekspression af peptider i dyrkningsmedier

Info

Publication number
DK2088188T3
DK2088188T3 DK09006784.4T DK09006784T DK2088188T3 DK 2088188 T3 DK2088188 T3 DK 2088188T3 DK 09006784 T DK09006784 T DK 09006784T DK 2088188 T3 DK2088188 T3 DK 2088188T3
Authority
DK
Denmark
Prior art keywords
direct expression
peptides
culture media
producing
glycine
Prior art date
Application number
DK09006784.4T
Other languages
English (en)
Inventor
Nozar M Mehta
Martha V L Ray
Christopher P Meenan
Angelo P Consalvo
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Application granted granted Critical
Publication of DK2088188T3 publication Critical patent/DK2088188T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
DK09006784.4T 1997-04-16 1998-04-15 Direkte ekspression af peptider i dyrkningsmedier DK2088188T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4370097P 1997-04-16 1997-04-16
EP98918334A EP1005526B1 (en) 1997-04-16 1998-04-15 Direct expression of peptides into culture media

Publications (1)

Publication Number Publication Date
DK2088188T3 true DK2088188T3 (da) 2012-01-02

Family

ID=21928441

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09006784.4T DK2088188T3 (da) 1997-04-16 1998-04-15 Direkte ekspression af peptider i dyrkningsmedier
DK98918334.8T DK1005526T3 (da) 1997-04-16 1998-04-15 Direkte ekspression af peptider i kulturmedium

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98918334.8T DK1005526T3 (da) 1997-04-16 1998-04-15 Direkte ekspression af peptider i kulturmedium

Country Status (14)

Country Link
US (5) US6103495A (da)
EP (2) EP1005526B1 (da)
JP (2) JP4907751B2 (da)
AT (2) ATE522598T1 (da)
AU (1) AU742270B2 (da)
CA (1) CA2285658C (da)
DE (1) DE69841939D1 (da)
DK (2) DK2088188T3 (da)
ES (1) ES2375330T3 (da)
HU (1) HUP0001272A3 (da)
LT (1) LT4701B (da)
NO (1) NO327325B1 (da)
RU (1) RU2218407C2 (da)
WO (1) WO1998046722A1 (da)

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PT3095484T (pt) 2011-11-02 2018-06-20 Keybioscience Ag Miméticas de calcitonina para tratar doenças e distúrbios
CA2854175A1 (en) 2011-11-02 2013-05-10 Keybioscience Ag Peptide analogs for treating diseases and disorders
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US9102751B2 (en) * 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10196662B2 (en) 2012-08-10 2019-02-05 Mello Biotechnology, Inc. Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors
EP2964193B1 (en) 2013-03-05 2019-12-11 Enteris BioPharma, Inc. Pharmaceuticals for oral delivery
CN105793277B (zh) 2013-10-03 2020-09-15 詹森生物科技公司 原毒素-ii变体及其使用方法
PL3321278T3 (pl) 2013-11-14 2019-06-28 Keybioscience Ag Mimetyki kalcytoniny do leczenia chorób i zaburzeń
CN103709236B (zh) * 2013-12-23 2015-04-15 江南大学 一种可提高分泌效率的信号肽及其应用
KR102294577B1 (ko) 2015-01-12 2021-08-26 엔터리스 바이오파마, 인크. 고체 경구 제형
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
JP6985151B2 (ja) 2015-04-02 2021-12-22 ヤンセン バイオテツク，インコーポレーテツド プロトキシン−ｉｉ変異体及びその使用方法
WO2017095458A1 (en) 2015-12-02 2017-06-08 Chih-Li Lin A COMPOSITION AND METHOD OF USING miR-302 PRECURSORS AS DRUGS FOR TREATING ALZHEIMER'S DISEASES
CN108431227A (zh) 2015-12-02 2018-08-21 林希龙 使用微核醣核酸前驱物作为诱导cd34阳性成体干细胞增殖的药物
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
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Also Published As

Publication number Publication date
US6210925B1 (en) 2001-04-03
WO1998046722A1 (en) 1998-10-22
AU742270B2 (en) 2001-12-20
NO995014L (no) 1999-12-13
US20010055789A1 (en) 2001-12-27
RU2218407C2 (ru) 2003-12-10
DE69841939D1 (de) 2010-11-25
DK1005526T3 (da) 2011-02-07
US20040191865A1 (en) 2004-09-30
NO995014D0 (no) 1999-10-14
US6627438B2 (en) 2003-09-30
EP2088188B1 (en) 2011-08-31
US6103495A (en) 2000-08-15
JP5634971B2 (ja) 2014-12-03
LT99133A (en) 2000-04-25
US6737250B2 (en) 2004-05-18
NO327325B1 (no) 2009-06-08
WO1998046722A9 (en) 1999-11-18
JP4907751B2 (ja) 2012-04-04
US7968311B2 (en) 2011-06-28
EP1005526B1 (en) 2010-10-13
HUP0001272A3 (en) 2012-12-28
LT4701B (lt) 2000-09-25
ATE484572T1 (de) 2010-10-15
JP2012024108A (ja) 2012-02-09
EP1005526A4 (en) 2005-02-09
ATE522598T1 (de) 2011-09-15
CA2285658C (en) 2011-10-04
CA2285658A1 (en) 1998-10-22
ES2375330T3 (es) 2012-02-28
EP1005526A1 (en) 2000-06-07
EP2088188A1 (en) 2009-08-12
US20020045211A1 (en) 2002-04-18
AU7127998A (en) 1998-11-11
HUP0001272A1 (hu) 2000-08-28
JP2002501379A (ja) 2002-01-15

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