DE60142971D1 - Expression biologisch aktiver polypeptide in wasserlinse - Google Patents
Expression biologisch aktiver polypeptide in wasserlinseInfo
- Publication number
- DE60142971D1 DE60142971D1 DE60142971T DE60142971T DE60142971D1 DE 60142971 D1 DE60142971 D1 DE 60142971D1 DE 60142971 T DE60142971 T DE 60142971T DE 60142971 T DE60142971 T DE 60142971T DE 60142971 D1 DE60142971 D1 DE 60142971D1
- Authority
- DE
- Germany
- Prior art keywords
- expression
- duckweed
- biologically active
- active polypeptides
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22170500P | 2000-07-31 | 2000-07-31 | |
US29333001P | 2001-05-23 | 2001-05-23 | |
PCT/US2001/023400 WO2002010414A2 (en) | 2000-07-31 | 2001-07-26 | Expression of biologically active polypeptides in duckweed |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60142971D1 true DE60142971D1 (de) | 2010-10-14 |
Family
ID=26916048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60142971T Expired - Lifetime DE60142971D1 (de) | 2000-07-31 | 2001-07-26 | Expression biologisch aktiver polypeptide in wasserlinse |
Country Status (14)
Country | Link |
---|---|
US (4) | US6815184B2 (de) |
EP (1) | EP1305437B1 (de) |
JP (1) | JP4795619B2 (de) |
CN (2) | CN1451048A (de) |
AT (1) | ATE479761T1 (de) |
AU (2) | AU8822601A (de) |
CA (1) | CA2417415C (de) |
CY (1) | CY1110959T1 (de) |
DE (1) | DE60142971D1 (de) |
DK (1) | DK1305437T3 (de) |
HK (1) | HK1055317A1 (de) |
NZ (1) | NZ523912A (de) |
PT (1) | PT1305437E (de) |
WO (1) | WO2002010414A2 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
US7161064B2 (en) * | 1997-08-12 | 2007-01-09 | North Carolina State University | Method for producing stably transformed duckweed using microprojectile bombardment |
AU4570397A (en) | 1997-10-10 | 1999-05-03 | Yeda Research And Development Co. Ltd. | Transgenic lemnaceae |
US6815184B2 (en) * | 2000-07-31 | 2004-11-09 | Biolex, Inc. | Expression of biologically active polypeptide in duckweed |
US8022270B2 (en) | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
US7959910B2 (en) * | 2000-07-31 | 2011-06-14 | Biolex Therapeutics, Inc. | C-terminally truncated interferon alpha variants |
US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
US20030100945A1 (en) | 2001-11-23 | 2003-05-29 | Mindguard Ltd. | Implantable intraluminal device and method of using same in treating aneurysms |
CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US20100196345A1 (en) * | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
US7951557B2 (en) * | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
US7176024B2 (en) * | 2003-05-30 | 2007-02-13 | Biolex, Inc. | Bioreactor for growing biological materials supported on a liquid surface |
EA036531B1 (ru) | 2003-11-05 | 2020-11-19 | Роше Гликарт Аг | Гуманизированное антитело типа ii к cd20 (варианты), фармацевтическая композиция, содержащая эти варианты антитела, и их применение |
CA2555609A1 (en) | 2004-02-11 | 2005-08-25 | Biolex, Inc. | Expression of plasminogen and microplasminogen in duckweed |
JP4809347B2 (ja) * | 2004-06-14 | 2011-11-09 | ノボザイムス アクティーゼルスカブ | ポリペプチド製造用シグナルペプチド |
US7527947B2 (en) | 2004-06-14 | 2009-05-05 | Novozymes A/S | Signal peptide for producing a polypeptide |
US20060024272A1 (en) * | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
WO2006082515A2 (en) | 2005-02-07 | 2006-08-10 | Glycart Biotechnology Ag | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
EP1871882A1 (de) * | 2005-03-25 | 2008-01-02 | GlycArt Biotechnology AG | Auf mcsp gerichtete antigenbindende moleküle mit erhöhter fc-rezeptor-bindungsaffinität und effektorfunktion |
CN101228189A (zh) * | 2005-05-09 | 2008-07-23 | 格黎卡特生物技术股份公司 | 具有修饰的fc区域和改变的与fc受体的结合的抗原结合分子 |
BRPI0615397B1 (pt) * | 2005-08-26 | 2023-10-03 | Roche Glycart Ag | Anticorpo anti-cd20, composição farmacêutica que o contém e uso do mesmo |
EP1976883B1 (de) * | 2006-01-17 | 2012-10-03 | Medarex, Inc. | Monoklonale antikörper gegen cd30 ohne fucosyl- und xylosylreste |
US7622573B2 (en) * | 2006-01-17 | 2009-11-24 | Biolex, Inc. | Expression control elements from the lemnaceae family |
AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
EP2074144A4 (de) | 2006-09-05 | 2011-03-16 | Medarex Inc | Antikörper gegen knochenmorphogene proteine und rezeptoren dafür und verfahren zu ihrer anwendung |
SG178789A1 (en) | 2007-02-16 | 2012-03-29 | Merrimack Pharmaceuticals Inc | Antibodies against erbb3 and uses thereof |
EP3366762B1 (de) | 2007-05-07 | 2020-07-08 | Protalix Ltd. | Grossvolumiger einweg-bioreaktor |
AU2008279087A1 (en) * | 2007-07-25 | 2009-01-29 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of HCV infection using same |
US9308257B2 (en) | 2007-11-28 | 2016-04-12 | Medimmune, Llc | Protein formulation |
MY159543A (en) | 2008-11-28 | 2017-01-13 | Merial Inc | Recombinant avian influenza vaccine and uses thereof |
WO2010096545A2 (en) * | 2009-02-18 | 2010-08-26 | Biolex Thepapeutids, Inc. | Aseptic bioreactor system for processing biological materials |
EP2435562A1 (de) | 2009-05-26 | 2012-04-04 | Biolex Therapeutics, Inc. | Zusammensetzungen und verfahren zur herstellung von aglycosyliertem plasminogen |
WO2011005502A2 (en) | 2009-06-23 | 2011-01-13 | Biolex Therapeutics, Inc. | Methods and compositions for the cryopreservation of duckweed |
RU2570554C2 (ru) | 2009-08-31 | 2015-12-10 | Роше Гликарт Аг | Гуманизированные моноклональные антитела к сеа с созревшей аффинностью |
PE20121685A1 (es) | 2009-12-28 | 2012-12-28 | Merial Ltd | Antigeno ndv recombinante y usos del mismo |
CA2792117C (en) | 2010-03-12 | 2016-09-20 | Merial Limited | Foot and mouth disease virus recombinant vaccines and uses thereof |
WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
US20120213781A1 (en) | 2011-02-11 | 2012-08-23 | Zyngenia, Inc. | Monovalent and Multivalent Multispecific Complexes and Uses Thereof |
PL2681244T3 (pl) | 2011-03-02 | 2018-04-30 | Roche Glycart Ag | Przeciwciała przeciwko antygenowi rakowo-płodowemu |
CA2837169C (en) | 2011-05-24 | 2021-11-09 | Zyngenia, Inc. | Multispecific complexes comprising angiopoietin-2-binding peptide and their uses |
EP2809780B1 (de) | 2012-02-01 | 2018-05-02 | Protalix Ltd. | Inhalierbare flüssige formulierungen der dnase i |
CA2859490A1 (en) | 2012-04-05 | 2013-10-10 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing hydrophobin |
US20160017021A1 (en) | 2013-03-06 | 2016-01-21 | Protalix Ltd. | TNF alpha INHIBITOR POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, CELLS EXPRESSING SAME AND METHODS OF PRODUCING SAME |
WO2014136117A1 (en) | 2013-03-06 | 2014-09-12 | Protalix Ltd. | USE OF PLANT CELLS EXPRESSING A TNFalpha POLYPEPTIDE INHIBITOR IN THERAPY |
TWI463012B (zh) * | 2013-04-01 | 2014-12-01 | Lemnaceae Fermentation Inc | 浮萍水解物及其用途 |
EP3010939A2 (de) | 2013-06-17 | 2016-04-27 | Asana BioSciences, LLC | 5t4-gerichtetes immunfusionsmolekül und verfahren |
MX366208B (es) * | 2013-08-21 | 2019-07-02 | Cold Spring Harbor Laboratory | Transformación de la lenteja de agua y sus usos. |
CN103609304B (zh) * | 2013-11-22 | 2015-08-19 | 中国科学院成都生物研究所 | 一种快速提高浮萍淀粉含量的方法 |
ES2901273T3 (es) | 2015-04-06 | 2022-03-21 | Subdomain Llc | Polipéptidos que contienen dominios de unión de novo y usos de los mismos |
WO2017095823A1 (en) | 2015-11-30 | 2017-06-08 | The Regents Of The University Of California | Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen |
CN108699156A (zh) | 2016-03-01 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 具有降低的adcp的奥滨尤妥珠单抗和利妥昔单抗变体 |
IL245102A0 (en) | 2016-04-13 | 2016-07-31 | Yeda Res & Dev | Cultivation of wolffia plants |
MX2020004935A (es) | 2017-11-14 | 2020-09-25 | Arcellx Inc | Terapias con celulas inmunitarias multifuncionales. |
AU2018369639A1 (en) | 2017-11-14 | 2020-04-23 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
CN116419747A (zh) | 2020-08-07 | 2023-07-11 | 福蒂斯治疗公司 | 靶向cd46的免疫偶联物及其使用方法 |
WO2022081775A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Aav8 affinity agents |
WO2022081779A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
JP2024508587A (ja) | 2021-02-19 | 2024-02-28 | アヴィタイド エルエルシー | Aav2親和剤 |
WO2023122327A2 (en) | 2021-12-24 | 2023-06-29 | Avitide LLC | Chi domain affinity ligands and agents |
WO2024025911A1 (en) | 2022-07-29 | 2024-02-01 | Avitide LLC | An affinity agent comprising a ligand that binds vce and comprises seq id no: 1 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8315980D0 (en) | 1983-06-10 | 1983-07-13 | Biogen Nv | Producing hybrid dna sequences |
US4956282A (en) | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
US5256410A (en) * | 1988-12-01 | 1993-10-26 | Schering Corporation | Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon |
US5850032A (en) | 1992-04-01 | 1998-12-15 | Union Camp Corporation | Method for production of plant biological products in precocious neomorphic embryoids |
US6288302B1 (en) * | 1992-11-04 | 2001-09-11 | National Science Council Of R.O.C. | Application of α-amylase gene promoter and signal sequence in the production of recombinant proteins in transgenic plants and transgenic plant seeds |
US5569828A (en) * | 1993-03-24 | 1996-10-29 | Pioneer Hi-Bred International, Inc. | Maize chlorotic dwarf virus and resistance thereto |
US5780709A (en) * | 1993-08-25 | 1998-07-14 | Dekalb Genetics Corporation | Transgenic maize with increased mannitol content |
US5693506A (en) | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
WO1997004122A1 (en) | 1995-07-20 | 1997-02-06 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
WO1998036085A1 (en) | 1997-02-13 | 1998-08-20 | Applied Phytologics, Inc. | Production of mature proteins in plants |
US6066781A (en) | 1997-02-13 | 2000-05-23 | Applied Phytologics, Inc. | Production of mature proteins in plants |
US7161064B2 (en) * | 1997-08-12 | 2007-01-09 | North Carolina State University | Method for producing stably transformed duckweed using microprojectile bombardment |
CA2288895A1 (en) * | 1997-08-12 | 1999-02-18 | North Carolina State University | Genetically engineered duckweed |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
AU4570397A (en) * | 1997-10-10 | 1999-05-03 | Yeda Research And Development Co. Ltd. | Transgenic lemnaceae |
US6095546A (en) * | 1997-12-03 | 2000-08-01 | Tekonsha Engineering Company | Trailer hitch cover and accessory components |
US6096546A (en) | 1998-01-30 | 2000-08-01 | Board Of Trustees, Rutgers, The State University Of New Jersey | Methods for recovering polypeptides from plants and portions thereof |
JP2002506647A (ja) | 1998-03-19 | 2002-03-05 | バレンティス・インコーポレーテッド | インターフェロンαプラスミドおよび送達システム、およびこれを作製しそして使用する方法 |
US6815184B2 (en) * | 2000-07-31 | 2004-11-09 | Biolex, Inc. | Expression of biologically active polypeptide in duckweed |
-
2001
- 2001-07-26 US US09/915,873 patent/US6815184B2/en not_active Expired - Fee Related
- 2001-07-26 CA CA2417415A patent/CA2417415C/en not_active Expired - Fee Related
- 2001-07-26 DE DE60142971T patent/DE60142971D1/de not_active Expired - Lifetime
- 2001-07-26 AU AU8822601A patent/AU8822601A/xx active Pending
- 2001-07-26 DK DK01967946.3T patent/DK1305437T3/da active
- 2001-07-26 EP EP01967946A patent/EP1305437B1/de not_active Expired - Lifetime
- 2001-07-26 NZ NZ523912A patent/NZ523912A/en not_active IP Right Cessation
- 2001-07-26 AU AU2001288226A patent/AU2001288226B2/en not_active Ceased
- 2001-07-26 CN CN01815064A patent/CN1451048A/zh active Pending
- 2001-07-26 CN CN200910174763A patent/CN101676400A/zh active Pending
- 2001-07-26 AT AT01967946T patent/ATE479761T1/de active
- 2001-07-26 PT PT01967946T patent/PT1305437E/pt unknown
- 2001-07-26 WO PCT/US2001/023400 patent/WO2002010414A2/en active IP Right Grant
- 2001-07-26 JP JP2002516330A patent/JP4795619B2/ja not_active Expired - Fee Related
-
2003
- 2003-10-17 HK HK03107543.4A patent/HK1055317A1/xx unknown
-
2004
- 2004-06-22 US US10/873,846 patent/US20050060776A1/en not_active Abandoned
-
2007
- 2007-07-16 US US11/778,480 patent/US20090282584A1/en not_active Abandoned
-
2010
- 2010-11-30 CY CY20101101098T patent/CY1110959T1/el unknown
-
2011
- 2011-09-14 US US13/232,602 patent/US20120258491A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1305437B1 (de) | 2010-09-01 |
US20050060776A1 (en) | 2005-03-17 |
WO2002010414A2 (en) | 2002-02-07 |
US20020088027A1 (en) | 2002-07-04 |
CA2417415C (en) | 2012-10-09 |
US6815184B2 (en) | 2004-11-09 |
AU2001288226B2 (en) | 2007-07-26 |
US20120258491A1 (en) | 2012-10-11 |
CN1451048A (zh) | 2003-10-22 |
CN101676400A (zh) | 2010-03-24 |
DK1305437T3 (da) | 2010-12-13 |
ATE479761T1 (de) | 2010-09-15 |
AU8822601A (en) | 2002-02-13 |
JP2004504848A (ja) | 2004-02-19 |
US20090282584A1 (en) | 2009-11-12 |
JP4795619B2 (ja) | 2011-10-19 |
WO2002010414A9 (en) | 2003-10-30 |
NZ523912A (en) | 2005-03-24 |
PT1305437E (pt) | 2010-11-12 |
HK1055317A1 (en) | 2004-01-02 |
CA2417415A1 (en) | 2002-02-07 |
WO2002010414A3 (en) | 2002-12-27 |
CY1110959T1 (el) | 2015-06-11 |
EP1305437A2 (de) | 2003-05-02 |
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