MX2020004935A - Terapias con celulas inmunitarias multifuncionales. - Google Patents

Terapias con celulas inmunitarias multifuncionales.

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Publication number
MX2020004935A
MX2020004935A MX2020004935A MX2020004935A MX2020004935A MX 2020004935 A MX2020004935 A MX 2020004935A MX 2020004935 A MX2020004935 A MX 2020004935A MX 2020004935 A MX2020004935 A MX 2020004935A MX 2020004935 A MX2020004935 A MX 2020004935A
Authority
MX
Mexico
Prior art keywords
car
adapter
car cell
immune cell
cell therapies
Prior art date
Application number
MX2020004935A
Other languages
English (en)
Inventor
David M Hilbert
Jeffrey S Swers
David W Lafleur
Original Assignee
Arcellx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcellx Inc filed Critical Arcellx Inc
Publication of MX2020004935A publication Critical patent/MX2020004935A/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Epidemiology (AREA)
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  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se proporcionan composiciones a base de receptores de antígenos quiméricos (CAR) multifuncionales y su uso para direccionar las respuestas inmunitarias a las células objetivo. Las composiciones tienen usos que incluyen tratar los trastornos hiperproliferativos, por ejemplo, el cáncer. Los métodos proporcionados incluyen generalmente el uso de una célula CAR en combinación con un adaptador. El adaptador confiere la capacidad de modular, alterar y/o redireccionar la respuesta inmunitaria mediada por linfocitos CAR in vitro e in vivo. En algunas modalidades, la célula CAR comprende una modificación genética que reduce o elimina la expresión de un determinante antigénico dirigido.
MX2020004935A 2017-11-14 2018-11-14 Terapias con celulas inmunitarias multifuncionales. MX2020004935A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762585770P 2017-11-14 2017-11-14
US201862717165P 2018-08-10 2018-08-10
PCT/US2018/060902 WO2019099440A1 (en) 2017-11-14 2018-11-14 Multifunctional immune cell therapies

Publications (1)

Publication Number Publication Date
MX2020004935A true MX2020004935A (es) 2020-09-25

Family

ID=66539901

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Application Number Title Priority Date Filing Date
MX2020004935A MX2020004935A (es) 2017-11-14 2018-11-14 Terapias con celulas inmunitarias multifuncionales.

Country Status (13)

Country Link
US (2) US11730763B2 (es)
EP (1) EP3710034A4 (es)
JP (2) JP7356435B2 (es)
KR (1) KR20200087176A (es)
CN (1) CN111511383A (es)
AU (1) AU2018368431B2 (es)
BR (1) BR112020008939A2 (es)
CA (1) CA3082410A1 (es)
IL (1) IL274677A (es)
MX (1) MX2020004935A (es)
PH (1) PH12020550242A1 (es)
SG (1) SG11202003168WA (es)
WO (1) WO2019099440A1 (es)

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EP3710067A4 (en) 2017-11-14 2021-10-27 Arcellx, Inc. AREA D CONTAINING POLYPEPTIDES AND ASSOCIATED USES
US11464803B2 (en) 2017-11-14 2022-10-11 Arcellx, Inc. D-domain containing polypeptides and uses thereof
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EP4313083A1 (en) * 2021-03-26 2024-02-07 Arcellx, Inc. Multifunctional immune cell therapies
AU2022388811A1 (en) 2021-11-15 2024-05-16 Arcellx, Inc. D-domain containing polypeptides and uses thereof
WO2024059740A1 (en) * 2022-09-14 2024-03-21 Synthego Corporation Genetically modified polynucleotides and cells expressing modified mhc proteins and uses thereof

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