CY1110959T1 - Εκφραση βιολογικως δραστικων πολυπεπτιδιων σε λεμνα ("duckweed") - Google Patents

Εκφραση βιολογικως δραστικων πολυπεπτιδιων σε λεμνα ("duckweed")

Info

Publication number
CY1110959T1
CY1110959T1 CY20101101098T CY101101098T CY1110959T1 CY 1110959 T1 CY1110959 T1 CY 1110959T1 CY 20101101098 T CY20101101098 T CY 20101101098T CY 101101098 T CY101101098 T CY 101101098T CY 1110959 T1 CY1110959 T1 CY 1110959T1
Authority
CY
Cyprus
Prior art keywords
duckweed
expression
biologically active
active polypeptides
polypeptide
Prior art date
Application number
CY20101101098T
Other languages
English (en)
Inventor
Anne-Marie Stomp
Lynn Dickey
John Gasdaska
Original Assignee
Biolex Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolex Therapeutics, Inc. filed Critical Biolex Therapeutics, Inc.
Publication of CY1110959T1 publication Critical patent/CY1110959T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Παρέχονται μέθοδοι, ακολουθίες νουκλεϊκών οξέων, και μετασχηματισμένο φυτό λέμνας («duckweed») ή καλλιέργειες φυματίων λέμνας για την έκφραση και την έκκριση βιολογικώς δραστικών πολυπεπτιδίων από τροποποιημένη με γενετική μηχανική λέμνα. Η έκφραση ανασυνδυασμένων πολυπεπτιδίων σε λέμνα βελτιώνεται τροποποιώντας την ακολουθία νουκλεοτιδίων της κασέτας έκφρασης που κωδικεύει το πολυπεπτίδιο για βελτιωμένη έκφραση σε λέμνα. Η ανάκτηση βιολογικώς δραστικών πολυπεπτιδίων από λέμνα βελτιώνεται συνδέοντας το βιολογικώς δραστικό πολυπεπτίδιο σε ένα σηματοδοτικό πεπτίδιο που κατευθύνει την έκκριση του πολυπεπτιδίου μέσα στο μέσο καλλιέργειας.
CY20101101098T 2000-07-31 2010-11-30 Εκφραση βιολογικως δραστικων πολυπεπτιδιων σε λεμνα ("duckweed") CY1110959T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22170500P 2000-07-31 2000-07-31
US29333001P 2001-05-23 2001-05-23
EP01967946A EP1305437B1 (en) 2000-07-31 2001-07-26 Expression of biologically active polypeptides in duckweed

Publications (1)

Publication Number Publication Date
CY1110959T1 true CY1110959T1 (el) 2015-06-11

Family

ID=26916048

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101101098T CY1110959T1 (el) 2000-07-31 2010-11-30 Εκφραση βιολογικως δραστικων πολυπεπτιδιων σε λεμνα ("duckweed")

Country Status (14)

Country Link
US (4) US6815184B2 (el)
EP (1) EP1305437B1 (el)
JP (1) JP4795619B2 (el)
CN (2) CN1451048A (el)
AT (1) ATE479761T1 (el)
AU (2) AU2001288226B2 (el)
CA (1) CA2417415C (el)
CY (1) CY1110959T1 (el)
DE (1) DE60142971D1 (el)
DK (1) DK1305437T3 (el)
HK (1) HK1055317A1 (el)
NZ (1) NZ523912A (el)
PT (1) PT1305437E (el)
WO (1) WO2002010414A2 (el)

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Also Published As

Publication number Publication date
CA2417415C (en) 2012-10-09
JP4795619B2 (ja) 2011-10-19
ATE479761T1 (de) 2010-09-15
AU8822601A (en) 2002-02-13
HK1055317A1 (en) 2004-01-02
DE60142971D1 (de) 2010-10-14
WO2002010414A3 (en) 2002-12-27
NZ523912A (en) 2005-03-24
PT1305437E (pt) 2010-11-12
EP1305437B1 (en) 2010-09-01
US20090282584A1 (en) 2009-11-12
CA2417415A1 (en) 2002-02-07
US20120258491A1 (en) 2012-10-11
EP1305437A2 (en) 2003-05-02
US20020088027A1 (en) 2002-07-04
US6815184B2 (en) 2004-11-09
CN101676400A (zh) 2010-03-24
DK1305437T3 (da) 2010-12-13
WO2002010414A9 (en) 2003-10-30
AU2001288226B2 (en) 2007-07-26
CN1451048A (zh) 2003-10-22
JP2004504848A (ja) 2004-02-19
WO2002010414A2 (en) 2002-02-07
US20050060776A1 (en) 2005-03-17

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