ATE178652T1 - Verbessertes verfahren zur herstellung von endotoxinbindungsproteinen - Google Patents

Verbessertes verfahren zur herstellung von endotoxinbindungsproteinen

Info

Publication number
ATE178652T1
ATE178652T1 AT93913992T AT93913992T ATE178652T1 AT E178652 T1 ATE178652 T1 AT E178652T1 AT 93913992 T AT93913992 T AT 93913992T AT 93913992 T AT93913992 T AT 93913992T AT E178652 T1 ATE178652 T1 AT E178652T1
Authority
AT
Austria
Prior art keywords
binding proteins
improved method
endotoxin binding
producing endotoxin
endotoxin
Prior art date
Application number
AT93913992T
Other languages
English (en)
Inventor
Lynn S Grinna
Original Assignee
Xoma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Corp filed Critical Xoma Corp
Application granted granted Critical
Publication of ATE178652T1 publication Critical patent/ATE178652T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93913992T 1992-05-19 1993-05-19 Verbessertes verfahren zur herstellung von endotoxinbindungsproteinen ATE178652T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88550192A 1992-05-19 1992-05-19
CN93109452A CN1060216C (zh) 1992-05-19 1993-06-21 制备内毒素结合蛋白质的改进方法

Publications (1)

Publication Number Publication Date
ATE178652T1 true ATE178652T1 (de) 1999-04-15

Family

ID=36829817

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93913992T ATE178652T1 (de) 1992-05-19 1993-05-19 Verbessertes verfahren zur herstellung von endotoxinbindungsproteinen

Country Status (12)

Country Link
US (1) US5439807A (de)
EP (1) EP0642579B1 (de)
JP (2) JP3391453B2 (de)
CN (1) CN1060216C (de)
AT (1) ATE178652T1 (de)
AU (1) AU669723B2 (de)
CA (2) CA2276548C (de)
DE (1) DE69324359T2 (de)
DK (1) DK0642579T3 (de)
ES (1) ES2132239T3 (de)
GR (1) GR3030419T3 (de)
WO (1) WO1993023540A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
DK0682524T3 (da) * 1993-02-02 2002-01-28 Xoma Technology Ltd Farmaceutiske præparater indeholdende et baktericid/permeabilitetsforøgende protein og et afspændingsmiddel
US6214789B1 (en) 1993-03-12 2001-04-10 Xoma Corporation Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
AU7175694A (en) * 1993-06-17 1995-01-17 Xoma Corporation Lipopolysaccharide binding protein derivatives
US5770561A (en) * 1993-07-14 1998-06-23 Xoma Corporation Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products
AU7330994A (en) * 1993-07-14 1995-02-13 Xoma Corporation Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products
US6759203B1 (en) 1993-09-22 2004-07-06 Xoma Corporation Method for quantifying BPI in body fluids
WO1995008344A1 (en) * 1993-09-22 1995-03-30 Xoma Corporation Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic
CN1133634A (zh) * 1993-09-22 1996-10-16 爱克斯欧玛公司 定量体液中的bpi的方法
US5578572A (en) * 1994-01-14 1996-11-26 Xoma Corporation Anti-gram-positive bacterial methods and materials
WO1995019179A1 (en) * 1994-01-14 1995-07-20 Xoma Corporation Anti-fungal methods and materials
US5447913A (en) * 1994-03-11 1995-09-05 Xoma Corporation Therapeutic uses of bactericidal/permeability-increasing protein dimer products
US5578568A (en) * 1994-04-22 1996-11-26 Xoma Corporation Method of treating conditions associated with intestinal ischemia/reperfusion
US5932544A (en) * 1994-05-31 1999-08-03 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) compositions
US6271203B1 (en) 1994-07-07 2001-08-07 Xoma Corporation Anti-protozoan methods and materials
US5646114A (en) * 1994-07-11 1997-07-08 Xoma Corporation Anti-protozoan methods
US5494896A (en) * 1995-03-31 1996-02-27 Xoma Corporation Method of treating conditions associated with burn injuries
JP2001520631A (ja) * 1995-07-20 2001-10-30 ゾーマ コーポレイション 抗真菌性ペプチド
CA2253837C (en) * 1996-05-10 2002-07-02 Xoma Corporation Therapeutic uses of bpi protein products for human meningococcemia
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
WO1997044056A1 (en) * 1996-05-23 1997-11-27 Xoma Corporation Therapeutic uses of bpi protein products in humans with hemorrhage due to trauma
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US6013631A (en) 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
US6719973B1 (en) * 1998-12-24 2004-04-13 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
WO2001027289A2 (en) * 1999-10-15 2001-04-19 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
EP2311962B1 (de) 2002-03-29 2013-03-13 XOMA Technology Ltd. Multigene Vectoren und Methoden für eine erhöhte Expression von rekombinanten Polypeptiden
EP1741440A1 (de) 2005-07-08 2007-01-10 Mellitus S.L. Verwendung von BPI-proteine zur Behandlung von stoffwechselbedingten Erkrankungen und Herzkreislaufstörungen
GB201319620D0 (en) 2013-11-06 2013-12-18 Norwegian University Of Science And Technology Immunosuppressive agents and their use in therapy
GB201319621D0 (en) 2013-11-06 2013-12-18 Norwegian University Of Science And Technology Antimicrobial agents and their use in therapy
CN105866080B (zh) * 2016-04-05 2019-11-12 中国科学院苏州生物医学工程技术研究所 重组鲎三因子试剂及其检测内毒素的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198541A (en) * 1987-08-11 1993-03-30 New York University Dna encoding bactericidal/permeability-increasing proteins
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
DE68929334T2 (de) * 1988-06-23 2005-08-18 Associates of Cape Cod, Inc., Falmouth Verfahren zumm Assay von Endotoxin-Konzentration
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein

Also Published As

Publication number Publication date
WO1993023540A3 (en) 1994-01-20
EP0642579B1 (de) 1999-04-07
CA2276548A1 (en) 1993-11-25
ES2132239T3 (es) 1999-08-16
CA2136208C (en) 1999-08-10
GR3030419T3 (en) 1999-09-30
WO1993023540A2 (en) 1993-11-25
CA2276548C (en) 2001-07-31
JPH08500730A (ja) 1996-01-30
DE69324359D1 (de) 1999-05-12
JP2003125794A (ja) 2003-05-07
AU4382093A (en) 1993-12-13
CN1060216C (zh) 2001-01-03
CA2136208A1 (en) 1993-11-25
DE69324359T2 (de) 1999-11-04
EP0642579A1 (de) 1995-03-15
US5439807A (en) 1995-08-08
JP3391453B2 (ja) 2003-03-31
DK0642579T3 (da) 1999-10-18
HK1014198A1 (en) 1999-09-24
CN1096822A (zh) 1994-12-28
AU669723B2 (en) 1996-06-20

Similar Documents

Publication Publication Date Title
ATE178652T1 (de) Verbessertes verfahren zur herstellung von endotoxinbindungsproteinen
RU2218407C2 (ru) Прямая экспрессия пептидов в культуральные среды
ATE46536T1 (de) Verfahren zur herstellung von reifen proteinen in wirtzellen von wirbeltieren.
BG101171A (en) Antibodies which bind to insect gut proteins and their use
RU94045919A (ru) Антитела, клетки, полипептид, днк векторы, способ получения полипептида, способ получения антитела, фармацевтическая композиция
DE59608743D1 (de) Verfahren zur herstellung von rekombinanten proteinen in e. coli mittels hochzelldichte-fermentation
ATE313633T1 (de) Expressionsvektoren die für bispezifische proteine kodieren, und verfahren zur herstellung von biologisch-aktiven bispezifischen fusionsproteine in zellen von säugertieren
AR013422A1 (es) UN VECTOR DE EXPRESIoN REPLICABLE QUE COMPRENDE UN ÁCIDO NUCLEICO QUE CODIFICA PARA UN POLIPÉPTIDO, UNA CÉLULA HUÉSPED ANIMAL AISLADA INCAPAZ DE CONDUCIR A UN ORGANISMO COMPLETO, UN MICROORGANISMO, UN MÉTODO PARA PRODUCIR UN POLIPEPTIDO DE SEC IN N° 2, UNA PROTEíNA DE FUSIoN, UN ANTICUERPO MONOCLONA
ATE366814T1 (de) Gl50 moleküle, sowie verwendungen derselben
ATE270337T1 (de) Materialen und methoden im zusammenhang mit bindung und präsentation von substanzen auf zelloberflächen
ATE341626T1 (de) Membranproteine aus säugetierzellen; verwandte reagentien
DE69132814D1 (de) Neues insulinähnliches wachstumsfaktor bindendes protein igfbp-5
ATE419358T1 (de) Gebrauchsverfaheren eines neuen lysyloxidase- verwandten proteins
DE69132813D1 (de) Genetisches igfbp-5 rodierendes material
PT97355A (pt) Processo para a preparacao de polipeptidos recombinantes contendo uma sequencia de aminoacidos de uma proteina de celulas
OA08354A (en) Monoclonal antibodies and antigens for human non-small cell lung carcimonas.
WO2001042283A3 (en) Sex-chromosome-specific proteins, species specific and sperm specific proteins and methods for their identification and isolation
ATE189700T1 (de) Genetisches igfbp-4 rodierendes material
DE59108128D1 (de) Verfahren zur Herstellung von Fremdproteinen in Streptomyceten
ATE233321T1 (de) Verbesserungen in der herstellung von proteinen in wirtszellen
ATE318919T1 (de) Verfahren zur herstellung von proteinen in transformierten hefezellen
WO2000032746A3 (en) Netrin-like and ependymin-like nucleic acids and polypeptides and uses thereof

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee