RU2170104C2 - Способы переноса генов in vivo для заживления ран - Google Patents

Способы переноса генов in vivo для заживления ран Download PDF

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Publication number
RU2170104C2
RU2170104C2 RU98120477/14A RU98120477A RU2170104C2 RU 2170104 C2 RU2170104 C2 RU 2170104C2 RU 98120477/14 A RU98120477/14 A RU 98120477/14A RU 98120477 A RU98120477 A RU 98120477A RU 2170104 C2 RU2170104 C2 RU 2170104C2
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gene
dna
matrix
cells
tissue
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RU98120477/14A
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English (en)
Russian (ru)
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RU98120477A (ru
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Стивен А. Гоулдстейн
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Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6953—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a fibre, a textile, a slab or a sheet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
RU98120477/14A 1996-04-12 1997-04-11 Способы переноса генов in vivo для заживления ран RU2170104C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/631,334 US5962427A (en) 1994-02-18 1996-04-12 In vivo gene transfer methods for wound healing
US08/631,334 1996-04-12

Publications (2)

Publication Number Publication Date
RU98120477A RU98120477A (ru) 2000-09-10
RU2170104C2 true RU2170104C2 (ru) 2001-07-10

Family

ID=24530760

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Application Number Title Priority Date Filing Date
RU98120477/14A RU2170104C2 (ru) 1996-04-12 1997-04-11 Способы переноса генов in vivo для заживления ран

Country Status (12)

Country Link
US (1) US5962427A (enExample)
EP (2) EP0892644B1 (enExample)
JP (1) JP4114952B2 (enExample)
CN (2) CN1226835A (enExample)
AT (1) ATE298253T1 (enExample)
AU (1) AU710386B2 (enExample)
CA (1) CA2251655C (enExample)
DE (1) DE69733605T2 (enExample)
NO (1) NO323843B1 (enExample)
PL (1) PL189174B1 (enExample)
RU (1) RU2170104C2 (enExample)
WO (1) WO1997038729A1 (enExample)

Cited By (7)

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RU2191388C1 (ru) * 2001-12-18 2002-10-20 Закрытое акционерное общество "РЕМЕТЭКС" Культура нервных стволовых клеток, биотрансплантат для аллопересадки и способ его приготовления
WO2003082346A1 (fr) * 2002-04-02 2003-10-09 'asgl-Farmatsevticheskie Innovatsii', Zakrytoe Aktsionernoe Obschestvo Proteine chimerique recombinante servant a l'administration ciblee d'adn dans des cellules cibles eucaryotes
RU2296588C2 (ru) * 2002-09-30 2007-04-10 Реджен Байотек, Инк. Заливочная композиция для стимуляции образования кости и сращения кости, содержащая сульфат кальция и вязкие биополимеры
RU2308954C2 (ru) * 2002-05-09 2007-10-27 Медиджинез Фармацевтическая композиция для лечения ран, содержащая плазму или сыворотку крови
WO2013100818A2 (en) 2011-12-29 2013-07-04 Obschestvo S Ogranichennoj Otvetstvennost'yu "Nekstgen" A biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating inquiries.
US11406739B2 (en) 2015-02-10 2022-08-09 “Nextgen” Company Limited Method for creating a personalized gene-activated implant for regenerating bone tissue
RU2793809C1 (ru) * 2022-02-03 2023-04-06 Генетик Диагностикс Энд Терапи 21 Лтд ДНК-вектор GDTT1.8NAS12-HIF1α для повышения уровня экспрессии целевого гена HIF1α и способ применения

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RU2191388C1 (ru) * 2001-12-18 2002-10-20 Закрытое акционерное общество "РЕМЕТЭКС" Культура нервных стволовых клеток, биотрансплантат для аллопересадки и способ его приготовления
WO2003082346A1 (fr) * 2002-04-02 2003-10-09 'asgl-Farmatsevticheskie Innovatsii', Zakrytoe Aktsionernoe Obschestvo Proteine chimerique recombinante servant a l'administration ciblee d'adn dans des cellules cibles eucaryotes
RU2308954C2 (ru) * 2002-05-09 2007-10-27 Медиджинез Фармацевтическая композиция для лечения ран, содержащая плазму или сыворотку крови
RU2296588C2 (ru) * 2002-09-30 2007-04-10 Реджен Байотек, Инк. Заливочная композиция для стимуляции образования кости и сращения кости, содержащая сульфат кальция и вязкие биополимеры
RU2519326C2 (ru) * 2011-12-29 2014-06-10 Общество с ограниченной ответственностью "НекстГен" Биокомпозит для обеспечения восстановительных процессов после повреждения у млекопитающего, способ его получения (варианты) и применения
WO2013100818A3 (en) * 2011-12-29 2013-09-06 Obschestvo S Ogranichennoj Otvetstvennost'yu "Nekstgen" A biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating inquiries.
WO2013100818A2 (en) 2011-12-29 2013-07-04 Obschestvo S Ogranichennoj Otvetstvennost'yu "Nekstgen" A biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating inquiries.
EP2797633A4 (en) * 2011-12-29 2015-01-14 Nextgen Company Ltd A biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating inquiries.
US9730959B2 (en) 2011-12-29 2017-08-15 “Nextgen” Company Limited Biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating injuries
EA031108B1 (ru) * 2011-12-29 2018-11-30 Общество с ограниченной ответственностью "ГИСТОГРАФТ" Биокомпозит для обеспечения восстановительных процессов костных тканей у млекопитающего, способы получения и применения биокомпозита
US11406739B2 (en) 2015-02-10 2022-08-09 “Nextgen” Company Limited Method for creating a personalized gene-activated implant for regenerating bone tissue
RU2793809C1 (ru) * 2022-02-03 2023-04-06 Генетик Диагностикс Энд Терапи 21 Лтд ДНК-вектор GDTT1.8NAS12-HIF1α для повышения уровня экспрессии целевого гена HIF1α и способ применения
RU2793971C1 (ru) * 2022-02-03 2023-04-11 Генетик Диагностикс Энд Терапи 21 Лтд ДНК-вектор GDTT1.8NAS12-ANGPT1 для повышения уровня экспрессии целевого гена ANGPT1, способ его получения и применения
RU2794133C1 (ru) * 2022-02-03 2023-04-11 Генетик Диагностикс Энд Терапи 21 Лтд ДНК-вектор GDTT1.8NAS12-VEGFA для повышения уровня экспрессии целевого гена VEGFA, способ его получения и применения

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ATE298253T1 (de) 2005-07-15
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PL189174B1 (pl) 2005-06-30
JP2001519767A (ja) 2001-10-23
WO1997038729A1 (en) 1997-10-23
DE69733605T2 (de) 2006-05-11
DE69733605D1 (de) 2005-07-28
US5962427A (en) 1999-10-05
NO984729D0 (no) 1998-10-09
CA2251655A1 (en) 1997-10-23
JP4114952B2 (ja) 2008-07-09
EP0892644B1 (en) 2005-06-22
EP0892644A4 (en) 1999-07-14
PL343864A1 (en) 2001-09-10
CA2251655C (en) 2010-09-21
CN1226835A (zh) 1999-08-25
AU710386B2 (en) 1999-09-16
WO1997038729A8 (en) 1999-04-22
NO323843B1 (no) 2007-07-09
AU2821297A (en) 1997-11-07

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