RU2142946C1 - Производные пиразола и фармацевтическая композиция, содержащая их - Google Patents

Производные пиразола и фармацевтическая композиция, содержащая их Download PDF

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RU2142946C1
RU2142946C1 RU95113969/04A RU95113969A RU2142946C1 RU 2142946 C1 RU2142946 C1 RU 2142946C1 RU 95113969/04 A RU95113969/04 A RU 95113969/04A RU 95113969 A RU95113969 A RU 95113969A RU 2142946 C1 RU2142946 C1 RU 2142946C1
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alkyl
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amino
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compound
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RU95113969A (ru
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м Стивен Фараси Уиль (US)
Стивен Фараси Уильям
МакКован Уэлч Уиллард (младший) (US)
МакКован Уэлч Уиллард (младший)
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Пфайзер Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU95113969/04A 1992-12-17 1993-11-03 Производные пиразола и фармацевтическая композиция, содержащая их RU2142946C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99222592A 1992-12-17 1992-12-17
US07/992225 1992-12-17
PCT/US1993/010359 WO1994013643A1 (en) 1992-12-17 1993-11-03 Pyrazoles and pyrazolopyrimidines having crf antagonist activity

Publications (2)

Publication Number Publication Date
RU95113969A RU95113969A (ru) 1997-08-10
RU2142946C1 true RU2142946C1 (ru) 1999-12-20

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US (1) US5712303A (enExample)
EP (1) EP0674624B1 (enExample)
JP (1) JP2862374B2 (enExample)
KR (1) KR0170567B1 (enExample)
CN (1) CN1060768C (enExample)
AT (1) ATE175961T1 (enExample)
AU (1) AU690527B2 (enExample)
BR (1) BR9307659A (enExample)
CA (1) CA2150483C (enExample)
CZ (1) CZ284157B6 (enExample)
DE (1) DE69323212T2 (enExample)
DK (1) DK0674624T3 (enExample)
EG (1) EG20397A (enExample)
ES (1) ES2126661T3 (enExample)
FI (1) FI113648B (enExample)
GR (1) GR3029568T3 (enExample)
HU (1) HUT67457A (enExample)
IL (1) IL107946A (enExample)
MX (2) MX9308042A (enExample)
MY (1) MY131382A (enExample)
NO (2) NO304831B1 (enExample)
NZ (1) NZ257770A (enExample)
PL (1) PL175831B1 (enExample)
RU (1) RU2142946C1 (enExample)
TW (1) TW238303B (enExample)
WO (1) WO1994013643A1 (enExample)
ZA (1) ZA939404B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2270832C2 (ru) * 2000-10-10 2006-02-27 Ф.Хоффманн-Ля Рош Аг Производные пиразола для лечения вирусных заболеваний
RU2305545C2 (ru) * 2001-04-06 2007-09-10 Лабораторьос Дель Др.Эстев,С.А. Применение производных пиразолина при получении лечебного средства для предупреждения и/или лечения болезней, связанных с пролиферацией клеток
RU2318822C2 (ru) * 2001-12-04 2008-03-10 Ф.Хоффманн-Ля Рош Аг Производные пиразола с конденсированным циклом
RU2408585C2 (ru) * 2003-07-22 2011-01-10 Астекс Терепьютикс Лимитед 3,4-замещенные 1h-пиразольные соединения и их применение в качестве циклин-зависимых киназ (cdk) и модуляторов гликоген синтаз киназы-3 (gsk-3)
RU2772212C2 (ru) * 2016-04-29 2022-05-18 Фгх Биотех, Инк. Двухзамещенные соединения пиразола для лечения заболеваний

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JP6762300B2 (ja) 2015-06-17 2020-09-30 中外製薬株式会社 アミノピラゾール誘導体
JP6931695B2 (ja) 2016-04-29 2021-09-08 エフジーエイチ バイオテック，インコーポレーテッド 疾患の治療のための二置換ピラゾール化合物
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RU2270832C2 (ru) * 2000-10-10 2006-02-27 Ф.Хоффманн-Ля Рош Аг Производные пиразола для лечения вирусных заболеваний
RU2305545C2 (ru) * 2001-04-06 2007-09-10 Лабораторьос Дель Др.Эстев,С.А. Применение производных пиразолина при получении лечебного средства для предупреждения и/или лечения болезней, связанных с пролиферацией клеток
RU2318822C2 (ru) * 2001-12-04 2008-03-10 Ф.Хоффманн-Ля Рош Аг Производные пиразола с конденсированным циклом
RU2408585C2 (ru) * 2003-07-22 2011-01-10 Астекс Терепьютикс Лимитед 3,4-замещенные 1h-пиразольные соединения и их применение в качестве циклин-зависимых киназ (cdk) и модуляторов гликоген синтаз киназы-3 (gsk-3)
RU2772212C2 (ru) * 2016-04-29 2022-05-18 Фгх Биотех, Инк. Двухзамещенные соединения пиразола для лечения заболеваний

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ZA939404B (en) 1995-06-15
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