RU2134266C1 - Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1) - Google Patents

Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1) Download PDF

Info

Publication number
RU2134266C1
RU2134266C1 RU95109927/04A RU95109927A RU2134266C1 RU 2134266 C1 RU2134266 C1 RU 2134266C1 RU 95109927/04 A RU95109927/04 A RU 95109927/04A RU 95109927 A RU95109927 A RU 95109927A RU 2134266 C1 RU2134266 C1 RU 2134266C1
Authority
RU
Russia
Prior art keywords
ylmethyl
indol
benzimidazole
indole
methylpyrrolidin
Prior art date
Application number
RU95109927/04A
Other languages
English (en)
Russian (ru)
Other versions
RU95109927A (ru
Inventor
Юджин Мейкор Джон (US)
Юджин Мейкор Джон
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU95109927A publication Critical patent/RU95109927A/ru
Application granted granted Critical
Publication of RU2134266C1 publication Critical patent/RU2134266C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
RU95109927/04A 1992-11-02 1993-10-19 Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1) RU2134266C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
US07/970,758 1992-11-02
PCT/US1993/009790 WO1994010171A1 (en) 1992-11-02 1993-10-19 5-arylindole derivatives and their use as serotonin (5-ht1) agonists

Publications (2)

Publication Number Publication Date
RU95109927A RU95109927A (ru) 1997-01-10
RU2134266C1 true RU2134266C1 (ru) 1999-08-10

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95109927/04A RU2134266C1 (ru) 1992-11-02 1993-10-19 Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1)

Country Status (27)

Country Link
US (1) US5886008A (esLanguage)
EP (2) EP0666858B1 (esLanguage)
JP (1) JP2788551B2 (esLanguage)
KR (1) KR0163371B1 (esLanguage)
CN (1) CN1051313C (esLanguage)
AT (1) ATE202102T1 (esLanguage)
AU (1) AU685066B2 (esLanguage)
BR (1) BR9307348A (esLanguage)
CA (2) CA2340999C (esLanguage)
CZ (1) CZ283001B6 (esLanguage)
DE (1) DE69330351T2 (esLanguage)
DK (1) DK0666858T3 (esLanguage)
EG (1) EG20396A (esLanguage)
ES (1) ES2157224T3 (esLanguage)
FI (2) FI111257B (esLanguage)
GR (1) GR3036579T3 (esLanguage)
HU (1) HU222235B1 (esLanguage)
IL (1) IL107386A (esLanguage)
MY (1) MY109696A (esLanguage)
NO (1) NO309652B1 (esLanguage)
NZ (1) NZ257059A (esLanguage)
PL (1) PL176091B1 (esLanguage)
PT (1) PT666858E (esLanguage)
RU (1) RU2134266C1 (esLanguage)
TW (1) TW251284B (esLanguage)
WO (1) WO1994010171A1 (esLanguage)
ZA (1) ZA938137B (esLanguage)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232162C2 (ru) * 1998-09-01 2004-07-10 Верналис Рисерч Лимитед Пирролоиндолы, пиридиноиндолы и азепиноиндолы в качестве агонистов 5-нт2с
RU2434863C2 (ru) * 2006-03-22 2011-11-27 Янссен Фармацевтика Н.В. Производные циклических алкиламинов в качестве ингибиторов взаимодействия между mdm2 и р53

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
KR970701182A (ko) * 1994-02-10 1997-03-17 스피겔 알렌 제이 벤조다이아제핀 수용체 부위의 작용물질 및 길항물질로서의 5-헤테로아릴인돌 유도체(5-heteroarylindole derivatives as benzodiazepine receptor site agonists and antagonists)
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
JPH11502816A (ja) * 1995-03-20 1999-03-09 イーライ・リリー・アンド・カンパニー ５−置換−３−（１，２，３，６−テトラヒドロピリジン−４−イル）−および３−（ピペリジン−４−イル）−１ｈ−インドール類：新規５−ｈｔ▲下１ｆ▼アゴニスト
AU7261196A (en) * 1995-10-10 1997-04-30 Eli Lilly And Company N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists
SK179899A3 (en) 1997-07-03 2001-12-03 Du Pont Pharm Co Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6353008B1 (en) * 1998-06-30 2002-03-05 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
ATE503483T1 (de) 2002-10-30 2011-04-15 Merck Sharp & Dohme Hemmer der akt aktivität
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
CA2522430A1 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
DE602004020073D1 (de) * 2003-08-21 2009-04-30 Osi Pharm Inc 3-substituierte imidazopyridinderivate als c-kit-inhibitoren
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
WO2005032484A2 (en) 2003-10-03 2005-04-14 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
AU2004293078B2 (en) 2003-11-25 2012-01-19 3M Innovative Properties Company Substituted imidazo ring systems and methods
DE102004014304A1 (de) * 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
HK1215170A1 (zh) 2012-11-14 2016-08-19 The Johns Hopkins University 治療精神分裂症的方法和組合物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
SMT202100222T1 (it) * 2015-04-29 2021-05-07 Janssen Pharmaceutica Nv Azabenzimidazoli e loro uso come modulatori del recettore ampa.
WO2016176463A1 (en) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Indolone compounds and their use as ampa receptor modulators
JP6804469B2 (ja) 2015-04-29 2020-12-23 ヤンセン ファーマシューティカ エヌ．ベー． ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
KR20170141768A (ko) 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 이미다조피라진 및 피라졸로피리미딘 및 ampa 수용체 조절제로서의 이의 용도
EA034167B8 (ru) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Фармацевтические композиции леветирацетама пролонгированного высвобождения
CN108137561B (zh) 2015-11-06 2021-03-26 豪夫迈·罗氏有限公司 二氢吲哚-2-酮衍生物
WO2017076931A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives for use in the treatment of cns and related disorders
WO2017076932A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
RS60504B1 (sr) 2015-11-06 2020-08-31 Hoffmann La Roche Derivati indolin-2-ona
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法
WO2025104490A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
WO2025104491A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
US4983622A (en) * 1984-02-06 1991-01-08 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
US5340838A (en) * 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
CA2091562C (en) * 1990-10-15 2001-03-27 John Eugene Macor Indole derivatives useful in psychotherapeutics
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
FR2672602B1 (fr) * 1991-02-12 1993-06-04 Centre Nat Rech Scient Composes derives des beta-carbolines ligands du recepteur des benzodiazepines ayant un effet agoniste inverse et antagoniste vis-a-vis des benzodiazepines et medicaments les contenant.
US5229401A (en) * 1991-09-23 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino benzo[b]thiophene compounds
US5187159A (en) * 1991-10-07 1993-02-16 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
US5378846A (en) * 1993-06-11 1995-01-03 Russian-American Institute For New Drug Development 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Справочник практического врача. - М.: Медицина, ч.2, 1990, с.94, 117. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232162C2 (ru) * 1998-09-01 2004-07-10 Верналис Рисерч Лимитед Пирролоиндолы, пиридиноиндолы и азепиноиндолы в качестве агонистов 5-нт2с
RU2434863C2 (ru) * 2006-03-22 2011-11-27 Янссен Фармацевтика Н.В. Производные циклических алкиламинов в качестве ингибиторов взаимодействия между mdm2 и р53

Also Published As

Publication number Publication date
EP1094064A1 (en) 2001-04-25
HUT66011A (en) 1994-08-29
GR3036579T3 (en) 2001-12-31
RU95109927A (ru) 1997-01-10
NZ257059A (en) 1997-07-27
US5886008A (en) 1999-03-23
CA2340999C (en) 2005-01-04
IL107386A0 (en) 1994-01-25
MY109696A (en) 1997-04-30
AU685066B2 (en) 1998-01-15
EP0666858A1 (en) 1995-08-16
HU222235B1 (hu) 2003-05-28
FI20002505A7 (fi) 2000-11-15
CZ283001B6 (cs) 1997-12-17
JPH07508759A (ja) 1995-09-28
CA2148380A1 (en) 1994-05-11
FI20002505L (fi) 2000-11-15
FI111257B (fi) 2003-06-30
EG20396A (en) 1999-02-28
DK0666858T3 (da) 2001-08-27
ATE202102T1 (de) 2001-06-15
AU5329494A (en) 1994-05-24
DE69330351D1 (de) 2001-07-19
DE69330351T2 (de) 2001-09-20
CA2340999A1 (en) 1994-05-11
PT666858E (pt) 2001-09-28
WO1994010171A1 (en) 1994-05-11
EP0666858B1 (en) 2001-06-13
TW251284B (esLanguage) 1995-07-11
FI934825A0 (fi) 1993-11-01
KR0163371B1 (ko) 1998-12-01
ZA938137B (en) 1995-05-02
NO951633L (no) 1995-04-28
PL308669A1 (en) 1995-08-21
NO951633D0 (no) 1995-04-28
KR950704313A (ko) 1995-11-17
BR9307348A (pt) 1999-05-11
PL176091B1 (pl) 1999-04-30
FI934825L (fi) 1994-05-03
NO309652B1 (no) 2001-03-05
CZ110895A3 (en) 1995-11-15
JP2788551B2 (ja) 1998-08-20
IL107386A (en) 1999-03-12
CN1051313C (zh) 2000-04-12
CA2148380C (en) 2001-08-14
ES2157224T3 (es) 2001-08-16
CN1094727A (zh) 1994-11-09

Similar Documents

Publication Publication Date Title
RU2134266C1 (ru) Производные 5-арилиндола и их применение в качестве агонистов серотонина (5-нт1)
AU671959B2 (en) Indole derivatives
US7592454B2 (en) Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
US5834493A (en) Indole derivatives as 5-HT1A and/or 5-HT2 ligands
FI92067B (fi) Menetelmä valmistaa terapeuttisesti aktiivisia mono- tai disubstituoituja (imidatsol-4-yyli)metyylipyrido/4,3-b/indol- ja atsepino/4,3-b/indol-1-oneja
SK2592002A3 (en) Tricyclic inhibitors of poly(adp-ribose) polymerases
CZ59996A3 (en) 5-arylindole derivatives per se and for treating diseases, intermediates for their preparation and pharmaceutical compositions based thereon
JPH07506825A (ja) ５−ｈｔ１レセプターアゴニストとしての縮合イミダゾール及びトリアゾール誘導体
PL172388B1 (pl) Pochodne indolu PL PL PL PL PL PL PL PL PL
PL210413B1 (pl) Pochodne indoliloalkiloaminy
NZ228721A (en) Substituted indoles and indazoles and pharmaceutical compositions
RU2059623C1 (ru) Тетрагидробензимидазольное производное или его фармацевтически приемлемая соль и фармацевтическая композиция на его основе, проявляющая активность 5-ht3-антагониста
CA2685318A1 (en) 5-(aminoazacyclyl)-3-sulfonyl-1h-indazoles as 5-hydroxytryptamine-6 ligands for the treatment of cns disorders

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20031020