RU2125574C1 - Тиенобензодиазепины или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция - Google Patents
Тиенобензодиазепины или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция Download PDFInfo
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- RU2125574C1 RU2125574C1 RU93005057A RU93005057A RU2125574C1 RU 2125574 C1 RU2125574 C1 RU 2125574C1 RU 93005057 A RU93005057 A RU 93005057A RU 93005057 A RU93005057 A RU 93005057A RU 2125574 C1 RU2125574 C1 RU 2125574C1
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- RU
- Russia
- Prior art keywords
- alkyl
- methyl
- pharmaceutically acceptable
- thienobenzodiazepines
- compound
- Prior art date
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- 150000003839 salts Chemical class 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 41
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 claims abstract description 9
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- 229940095102 methyl benzoate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
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- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
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- 238000000159 protein binding assay Methods 0.000 description 1
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- 201000000980 schizophrenia Diseases 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
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- 239000000741 silica gel Substances 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
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- 235000010356 sorbitol Nutrition 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
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- 239000012730 sustained-release form Substances 0.000 description 1
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- FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9211379.4 | 1992-05-29 | ||
| GB929211379A GB9211379D0 (en) | 1992-05-29 | 1992-05-29 | Pharmaceutical compounds |
| GB939309025A GB9309025D0 (en) | 1993-04-30 | 1993-04-30 | Pharmaceutical compounds |
| GB9309025.6 | 1993-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93005057A RU93005057A (ru) | 1996-02-27 |
| RU2125574C1 true RU2125574C1 (ru) | 1999-01-27 |
Family
ID=26300951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93005057A RU2125574C1 (ru) | 1992-05-29 | 1993-05-28 | Тиенобензодиазепины или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0582368B1 (show.php) |
| JP (1) | JP3219541B2 (show.php) |
| CN (1) | CN1043994C (show.php) |
| AT (1) | ATE198891T1 (show.php) |
| AU (1) | AU668159B2 (show.php) |
| CA (1) | CA2097016A1 (show.php) |
| CZ (1) | CZ282783B6 (show.php) |
| DE (1) | DE69329887T2 (show.php) |
| DK (1) | DK0582368T3 (show.php) |
| ES (1) | ES2153373T3 (show.php) |
| FI (1) | FI101538B1 (show.php) |
| GR (1) | GR3035587T3 (show.php) |
| HU (1) | HU218278B (show.php) |
| IL (1) | IL105827A (show.php) |
| MX (1) | MX9303124A (show.php) |
| MY (1) | MY109943A (show.php) |
| NO (1) | NO305125B1 (show.php) |
| NZ (1) | NZ247703A (show.php) |
| PT (1) | PT582368E (show.php) |
| RU (1) | RU2125574C1 (show.php) |
| TW (1) | TW268005B (show.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
| US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
| EG24221A (en) * | 1995-03-24 | 2008-11-10 | Lilly Co Eli | Process for preparing olanzapine |
| EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
| US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
| PL329217A1 (en) * | 1996-03-25 | 1999-03-15 | Lilly Co Eli | Pain relieving method |
| BR9708145A (pt) * | 1996-03-25 | 1999-07-27 | Lilly Co Eli | Processo para tratamento de dor de enxaqueca |
| PL187926B1 (pl) * | 1996-03-25 | 2004-11-30 | Lilly Co Eli | Kompozycja farmaceutyczna do leczenia bólu |
| AU720366B2 (en) * | 1996-09-23 | 2000-06-01 | Eli Lilly And Company | Olanzapine dihydrate D |
| ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
| JP2001501207A (ja) * | 1996-09-24 | 2001-01-30 | イーライ・リリー・アンド・カンパニー | コーティングされた粒子製剤 |
| CA2882560C (en) | 2012-08-21 | 2020-10-27 | Ortho-Clinical Diagnostics, Inc. | Haptens of risperidone and paliperidone for use in immunoassays |
| AU2013305930B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Haptens of paliperidone |
| AU2013305970B2 (en) | 2012-08-21 | 2017-08-17 | Saladax Biomedical Inc. | Antibodies to aripiprazole haptens and use thereof |
| PL2888373T3 (pl) | 2012-08-21 | 2018-08-31 | Janssen Pharmaceutica Nv | Przeciwciała dla arypiprazolu i ich zastosowanie |
| PT3305784T (pt) | 2012-08-21 | 2020-10-23 | Janssen Pharmaceutica Nv | Haptenos de quetiapina para utilização em ensaios imunológicos |
| JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
| WO2014031662A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine and use thereof |
| PL2888286T3 (pl) | 2012-08-21 | 2018-07-31 | Janssen Pharmaceutica Nv | Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie |
| ES2870004T3 (es) | 2012-08-21 | 2021-10-26 | Janssen Pharmaceutica Nv | Anticuerpos contra la risperidona y uso de los mismos |
| EP2888277A4 (en) | 2012-08-21 | 2016-05-18 | Ortho Clinical Diagnostics Inc | ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF |
| ES2654413T3 (es) | 2012-08-21 | 2018-02-13 | Janssen Pharmaceutica, N.V. | Anticuerpos a quetiapina y uso de los mismos |
| WO2014031645A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to risperidone haptens and use thereof |
| ES3057437T3 (en) | 2012-08-21 | 2026-03-02 | Janssen Pharmaceutica Nv | Antibodies to olanzapine haptens and use thereof |
| ES2701062T3 (es) * | 2012-08-21 | 2019-02-20 | Janssen Pharmaceutica Nv | Haptenos de olanzapina |
| WO2014031584A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Haptens of aripiprazole and their use in immunoassays |
| JP6949025B2 (ja) | 2015-12-17 | 2021-10-13 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンに対する抗体及びその使用 |
| CN108368180B (zh) | 2015-12-17 | 2022-07-26 | 詹森药业有限公司 | 喹硫平的抗体及其用途 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH569730A5 (show.php) * | 1972-04-04 | 1975-11-28 | Wander Ag Dr A | |
| US3962248A (en) * | 1972-04-04 | 1976-06-08 | Sandoz, Inc. | Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines |
| US4061752A (en) * | 1975-08-06 | 1977-12-06 | Sandoz Ltd. | 6-Piperazino-11-methylene-dibenzazepines[b,e] |
| SU626702A3 (ru) * | 1974-11-26 | 1978-09-30 | Лилли Индастриз Лимитед (Фирма) | Способ получени тиено (1,5) бензодиазепинов или их солей |
| GB1554275A (en) * | 1975-09-24 | 1979-10-17 | Sandoz Ltd | Dibenzo(b,e)-(1,4)diazepines |
| GB1592329A (en) * | 1976-11-10 | 1981-07-08 | Sandoz Ltd | Morphanthridines |
| US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1993
- 1993-05-26 DE DE69329887T patent/DE69329887T2/de not_active Expired - Fee Related
- 1993-05-26 EP EP93304102A patent/EP0582368B1/en not_active Expired - Lifetime
- 1993-05-26 TW TW082104161A patent/TW268005B/zh active
- 1993-05-26 AT AT93304102T patent/ATE198891T1/de not_active IP Right Cessation
- 1993-05-26 DK DK93304102T patent/DK0582368T3/da active
- 1993-05-26 AU AU39807/93A patent/AU668159B2/en not_active Ceased
- 1993-05-26 CA CA002097016A patent/CA2097016A1/en not_active Abandoned
- 1993-05-26 NZ NZ247703A patent/NZ247703A/en unknown
- 1993-05-26 NO NO931917A patent/NO305125B1/no not_active IP Right Cessation
- 1993-05-26 ES ES93304102T patent/ES2153373T3/es not_active Expired - Lifetime
- 1993-05-26 PT PT93304102T patent/PT582368E/pt unknown
- 1993-05-27 MX MX9303124A patent/MX9303124A/es not_active IP Right Cessation
- 1993-05-28 MY MYPI93001036A patent/MY109943A/en unknown
- 1993-05-28 IL IL10582793A patent/IL105827A/xx not_active IP Right Cessation
- 1993-05-28 CZ CZ931024A patent/CZ282783B6/cs not_active IP Right Cessation
- 1993-05-28 JP JP12642993A patent/JP3219541B2/ja not_active Expired - Fee Related
- 1993-05-28 HU HU9301579A patent/HU218278B/hu not_active IP Right Cessation
- 1993-05-28 CN CN93108212A patent/CN1043994C/zh not_active Expired - Fee Related
- 1993-05-28 FI FI932445A patent/FI101538B1/fi active
- 1993-05-28 RU RU93005057A patent/RU2125574C1/ru active
-
2001
- 2001-03-15 GR GR20010400431T patent/GR3035587T3/el not_active IP Right Cessation
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH569730A5 (show.php) * | 1972-04-04 | 1975-11-28 | Wander Ag Dr A | |
| US3962248A (en) * | 1972-04-04 | 1976-06-08 | Sandoz, Inc. | Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines |
| SU626702A3 (ru) * | 1974-11-26 | 1978-09-30 | Лилли Индастриз Лимитед (Фирма) | Способ получени тиено (1,5) бензодиазепинов или их солей |
| SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
| GB1533235A (en) * | 1974-11-26 | 1978-11-22 | Lilly Industries Ltd | Benzodiazepine derivatives |
| US4061752A (en) * | 1975-08-06 | 1977-12-06 | Sandoz Ltd. | 6-Piperazino-11-methylene-dibenzazepines[b,e] |
| GB1554275A (en) * | 1975-09-24 | 1979-10-17 | Sandoz Ltd | Dibenzo(b,e)-(1,4)diazepines |
| GB1592329A (en) * | 1976-11-10 | 1981-07-08 | Sandoz Ltd | Morphanthridines |
| US4308207A (en) * | 1976-11-10 | 1981-12-29 | Sandoz Ltd. | Morphanthridine derivatives |
| US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
Non-Patent Citations (1)
| Title |
|---|
| Машковский М.Д. Лекарственные средства. - М.: Медицина, 1988, ч.1, с.233 - 236. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2185383C1 (ru) * | 2001-05-22 | 2002-07-20 | Институт молекулярной генетики РАН | ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН |
Also Published As
| Publication number | Publication date |
|---|---|
| IL105827A0 (en) | 1993-09-22 |
| CZ102493A3 (en) | 1993-12-15 |
| MY109943A (en) | 1997-10-31 |
| IL105827A (en) | 1997-02-18 |
| DK0582368T3 (da) | 2001-02-05 |
| CN1043994C (zh) | 1999-07-07 |
| DE69329887D1 (de) | 2001-03-01 |
| JP3219541B2 (ja) | 2001-10-15 |
| FI101538B (fi) | 1998-07-15 |
| NO931917D0 (no) | 1993-05-26 |
| FI101538B1 (fi) | 1998-07-15 |
| CA2097016A1 (en) | 1993-11-30 |
| HU9301579D0 (en) | 1993-09-28 |
| HU218278B (en) | 2000-07-28 |
| CN1085903A (zh) | 1994-04-27 |
| PT582368E (pt) | 2001-05-31 |
| NO931917L (no) | 1993-11-30 |
| TW268005B (show.php) | 1996-01-11 |
| CZ282783B6 (cs) | 1997-10-15 |
| ATE198891T1 (de) | 2001-02-15 |
| JPH0687862A (ja) | 1994-03-29 |
| NO305125B1 (no) | 1999-04-06 |
| FI932445A0 (fi) | 1993-05-28 |
| FI932445L (fi) | 1993-11-30 |
| ES2153373T3 (es) | 2001-03-01 |
| EP0582368B1 (en) | 2001-01-24 |
| HUT66180A (en) | 1994-09-28 |
| DE69329887T2 (de) | 2001-05-23 |
| EP0582368A1 (en) | 1994-02-09 |
| AU668159B2 (en) | 1996-04-26 |
| MX9303124A (es) | 1993-11-01 |
| GR3035587T3 (en) | 2001-06-29 |
| NZ247703A (en) | 1995-07-26 |
| AU3980793A (en) | 1993-12-02 |
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