GB1533235A - Benzodiazepine derivatives - Google Patents
Benzodiazepine derivativesInfo
- Publication number
- GB1533235A GB1533235A GB51240/74A GB5124074A GB1533235A GB 1533235 A GB1533235 A GB 1533235A GB 51240/74 A GB51240/74 A GB 51240/74A GB 5124074 A GB5124074 A GB 5124074A GB 1533235 A GB1533235 A GB 1533235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Priority Applications (42)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU742191705A SU629879A3 (en) | 1974-11-26 | 1974-11-25 | Method of obtaining thieno(1,5)-benzodiazepines or salts thereof |
GB51240/74A GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
IL48502A IL48502A (en) | 1974-11-26 | 1975-11-20 | Tthieno(1,5)benzodiazepine derivatives their preparation and pharmaceutical compositions containing them |
CA240,082A CA1075687A (en) | 1974-11-26 | 1975-11-20 | Benzodiazepine derivatives |
DK524175A DK146887C (en) | 1974-11-26 | 1975-11-20 | ANALOGY PROCEDURE FOR THE PREPARATION OF THIENO (1,5) BENZODIAZEPINE DERIVATIVES |
IL54634A IL54634A (en) | 1974-11-26 | 1975-11-20 | Thieno (1,5) benzodiazepine derivatives |
AU86858/75A AU506340B2 (en) | 1974-11-26 | 1975-11-21 | Benzodiazepine derivatives |
PH17788A PH11669A (en) | 1974-11-26 | 1975-11-21 | Thienobenzo(1,5)diazepine derivatives and the pharmaceutical formulation thereof |
DE2552403A DE2552403C2 (en) | 1974-11-26 | 1975-11-22 | Thieno [1,5] -benzodiazepines, process for their preparation and pharmaceutical compositions containing them |
NZ185594A NZ185594A (en) | 1974-11-26 | 1975-11-24 | 10-substituted-4h-thieno-(2,3-b),(3,2-b) or (3,4-b-(1,5) benzodiazepines |
CH604478A CH613455A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
CH1517275A CH613454A5 (en) | 1974-11-26 | 1975-11-24 | Process for the preparation of new benzodiazepine derivatives |
ZA757344A ZA757344B (en) | 1974-11-26 | 1975-11-24 | Benzodiazepine derivatives |
NZ179335A NZ179335A (en) | 1974-11-26 | 1975-11-24 | 10-substituted aminothieno(2,3-b,3,2-b or 3,4-b)(1,5)benzodiazepines |
SE7513185A SE421209B (en) | 1974-11-26 | 1975-11-24 | ANALOGY PROCEDURE FOR THE PREPARATION OF TIENOBENZODIAZEPINES |
AR261340A AR221203A1 (en) | 1974-11-26 | 1975-11-25 | AN INTERMEDIATE COMPOUND WITHOUT THERAPEUTIC ACTIVITY CONSISTING OF A DERIVATIVE OF TIENO (4,5) BENZODIAZEPINA, AND A PROCEDURE FOR PREPARING A TIENO- (1,5) BENZODIAZEPINA BASED ON SUCH INTERMEDIARY |
FR7535900A FR2292479A1 (en) | 1974-11-26 | 1975-11-25 | BENZODIAZEPINE DERIVATIVES |
YU02983/75A YU298375A (en) | 1974-11-26 | 1975-11-25 | Process for obtaining benzodiazepine derivatives |
BE6045266A BE835932A (en) | 1974-11-26 | 1975-11-25 | BENZODIAZEPINE DERIVATIVES |
DD189666A DD123343A5 (en) | 1974-11-26 | 1975-11-25 | |
IE2565/75A IE42564B1 (en) | 1974-11-26 | 1975-11-25 | Benzodiazepine derivatives |
RO7584018A RO69912A (en) | 1974-11-26 | 1975-11-25 | PROCESS FOR THE PREPARATION OF TIENO (1,5) BENZODIAZEPINES |
IE1607/79A IE42565B1 (en) | 1974-11-26 | 1975-11-25 | Thieno (1,5) benzodiazepine intermediates |
JP50141080A JPS6044314B2 (en) | 1974-11-26 | 1975-11-25 | Thieno [1.5] Production method of benzodiazepine |
HU75LI00000284A HU172493B (en) | 1974-11-26 | 1975-11-26 | Process for preparing thieno-benzodiazepine derivatives |
AT898275A AT351547B (en) | 1974-11-26 | 1975-11-26 | METHOD FOR PRODUCING NEW THIENO- (1,5) -BENZODIAZEPINES AND THEIR ACID ADDITION SALTS |
ES443011A ES443011A1 (en) | 1974-11-26 | 1975-11-26 | Benzodiazepine derivatives |
NLAANVRAGE7513833,A NL186088C (en) | 1974-11-26 | 1975-11-26 | PROCESS FOR PREPARING A MEDICINAL PRODUCT, WITH AN EFFECT ON THE CENTRAL NERVOUS SYSTEM CONTAINING AT LEAST ONE DERIVATIVE OF AN AMINO-THIENOBENZO-N-HETEROSOVEN COMPOUND, AND PROCESS FOR THE PREPARATION OF THIS PRODUCT |
PL1975184991A PL100135B1 (en) | 1974-11-26 | 1975-11-26 | METHOD OF MAKING NEW DERIVATIVES OF TIENO / 1.5 / BENZODUAZEPINES |
BG7531601A BG29573A3 (en) | 1974-11-26 | 1975-11-26 | Method of obtaining of benzodiazepin derivatives |
CS757991A CS236753B2 (en) | 1974-11-26 | 1975-11-26 | Processing of thieno (1,5) benzodiazepine derivatives |
SU762406250A SU626702A3 (en) | 1974-11-26 | 1976-10-07 | Method of producing thieno/1,5/benzodiazepine or their salts |
PH19480A PH24534A (en) | 1974-11-26 | 1977-02-22 | Benzothieno(1,5)diazepine intermediates |
US05/787,197 US4115568A (en) | 1974-11-26 | 1977-04-13 | Thieno[3,2-b]-[1,5]benzodiazepines |
US05/787,189 US4172831A (en) | 1974-11-26 | 1977-04-13 | Thieno-benzodiazepines |
US05/802,381 US4115574A (en) | 1974-11-26 | 1977-06-01 | Benzodiazepine derivatives |
SE7812194A SE429045B (en) | 1974-11-26 | 1978-11-27 | INTERMEDIATE FOR USE IN THE PREPARATION OF TIENOBENZODIAZEPINES |
DK375479A DK147020C (en) | 1974-11-26 | 1979-09-07 | THIENO (1,5) BENZODIAZEPINE COMPOUNDS FOR USE AS INTERMEDIATES |
KE3163A KE3163A (en) | 1974-11-26 | 1981-09-24 | Benzodiazepine derivatives |
HK586/81A HK58681A (en) | 1974-11-26 | 1981-11-26 | Benzodiazepine derivatives |
YU123482A YU123482A (en) | 1974-11-26 | 1982-06-09 | Process for obtaining benzodiazepine derivatives |
MY149/82A MY8200149A (en) | 1974-11-26 | 1982-12-30 | Benzodiazepine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB51240/74A GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1533235A true GB1533235A (en) | 1978-11-22 |
Family
ID=10459213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB51240/74A Expired GB1533235A (en) | 1974-11-26 | 1974-11-26 | Benzodiazepine derivatives |
Country Status (30)
Country | Link |
---|---|
JP (1) | JPS6044314B2 (en) |
AR (1) | AR221203A1 (en) |
AT (1) | AT351547B (en) |
AU (1) | AU506340B2 (en) |
BE (1) | BE835932A (en) |
BG (1) | BG29573A3 (en) |
CA (1) | CA1075687A (en) |
CH (2) | CH613455A5 (en) |
CS (1) | CS236753B2 (en) |
DD (1) | DD123343A5 (en) |
DE (1) | DE2552403C2 (en) |
DK (1) | DK146887C (en) |
ES (1) | ES443011A1 (en) |
FR (1) | FR2292479A1 (en) |
GB (1) | GB1533235A (en) |
HK (1) | HK58681A (en) |
HU (1) | HU172493B (en) |
IE (1) | IE42564B1 (en) |
IL (1) | IL48502A (en) |
KE (1) | KE3163A (en) |
MY (1) | MY8200149A (en) |
NL (1) | NL186088C (en) |
NZ (1) | NZ179335A (en) |
PH (2) | PH11669A (en) |
PL (1) | PL100135B1 (en) |
RO (1) | RO69912A (en) |
SE (2) | SE421209B (en) |
SU (2) | SU629879A3 (en) |
YU (1) | YU298375A (en) |
ZA (1) | ZA757344B (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0354781A2 (en) * | 1988-08-11 | 1990-02-14 | Lilly Industries Limited | Benzodiazepine compounds and their use as pharmaceuticals |
EP0454436A1 (en) * | 1990-04-25 | 1991-10-30 | Lilly Industries Limited | Pharmaceutical compounds |
AU668159B2 (en) * | 1992-05-29 | 1996-04-26 | Lilly Industries Limited | Pharmaceutical compounds |
EP1016664A1 (en) * | 1997-09-02 | 2000-07-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused thiophene compounds and medicinal use thereof |
WO2004000847A1 (en) * | 2002-06-20 | 2003-12-31 | Adamed Sp. Z O.O. | A process for the preparation of olanzapine and an intermediate therefor |
WO2004006933A2 (en) | 2002-07-15 | 2004-01-22 | Krka, D.D., Novo Mesto | Crystal forms of olanzapine and processes for their preparation |
WO2004065390A1 (en) * | 2003-01-17 | 2004-08-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of olanzapine |
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
WO2005090359A2 (en) | 2004-03-18 | 2005-09-29 | Lek Pharmaceuticals D.D. | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof |
WO2011009831A1 (en) | 2009-07-20 | 2011-01-27 | Lek Pharmaceuticals D.D. | Process for the purification of olanzapine |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL62792A (en) * | 1980-05-07 | 1985-02-28 | Byk Gulden Lomberg Chem Fab | Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them |
US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
AU700078B2 (en) * | 1995-11-01 | 1998-12-17 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
DK1778243T3 (en) * | 2004-06-30 | 2013-02-04 | Athersys Inc | Substituted azepine derivatives as serotonin receptor modulators |
-
1974
- 1974-11-25 SU SU742191705A patent/SU629879A3/en active
- 1974-11-26 GB GB51240/74A patent/GB1533235A/en not_active Expired
-
1975
- 1975-11-20 CA CA240,082A patent/CA1075687A/en not_active Expired
- 1975-11-20 DK DK524175A patent/DK146887C/en active
- 1975-11-20 IL IL48502A patent/IL48502A/en unknown
- 1975-11-21 AU AU86858/75A patent/AU506340B2/en not_active Expired
- 1975-11-21 PH PH17788A patent/PH11669A/en unknown
- 1975-11-22 DE DE2552403A patent/DE2552403C2/en not_active Expired
- 1975-11-24 NZ NZ179335A patent/NZ179335A/en unknown
- 1975-11-24 CH CH604478A patent/CH613455A5/en not_active IP Right Cessation
- 1975-11-24 ZA ZA757344A patent/ZA757344B/en unknown
- 1975-11-24 CH CH1517275A patent/CH613454A5/en not_active IP Right Cessation
- 1975-11-24 SE SE7513185A patent/SE421209B/en not_active IP Right Cessation
- 1975-11-25 FR FR7535900A patent/FR2292479A1/en active Granted
- 1975-11-25 IE IE2565/75A patent/IE42564B1/en unknown
- 1975-11-25 BE BE6045266A patent/BE835932A/en not_active IP Right Cessation
- 1975-11-25 JP JP50141080A patent/JPS6044314B2/en not_active Expired
- 1975-11-25 YU YU02983/75A patent/YU298375A/en unknown
- 1975-11-25 AR AR261340A patent/AR221203A1/en active
- 1975-11-25 RO RO7584018A patent/RO69912A/en unknown
- 1975-11-25 DD DD189666A patent/DD123343A5/xx unknown
- 1975-11-26 NL NLAANVRAGE7513833,A patent/NL186088C/en not_active IP Right Cessation
- 1975-11-26 CS CS757991A patent/CS236753B2/en unknown
- 1975-11-26 BG BG7531601A patent/BG29573A3/en unknown
- 1975-11-26 PL PL1975184991A patent/PL100135B1/en unknown
- 1975-11-26 ES ES443011A patent/ES443011A1/en not_active Expired
- 1975-11-26 AT AT898275A patent/AT351547B/en not_active IP Right Cessation
- 1975-11-26 HU HU75LI00000284A patent/HU172493B/en unknown
-
1976
- 1976-10-07 SU SU762406250A patent/SU626702A3/en active
-
1977
- 1977-02-22 PH PH19480A patent/PH24534A/en unknown
-
1978
- 1978-11-27 SE SE7812194A patent/SE429045B/en not_active IP Right Cessation
-
1981
- 1981-09-24 KE KE3163A patent/KE3163A/en unknown
- 1981-11-26 HK HK586/81A patent/HK58681A/en unknown
-
1982
- 1982-12-30 MY MY149/82A patent/MY8200149A/en unknown
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0354781A2 (en) * | 1988-08-11 | 1990-02-14 | Lilly Industries Limited | Benzodiazepine compounds and their use as pharmaceuticals |
EP0354781A3 (en) * | 1988-08-11 | 1991-04-03 | Lilly Industries Limited | Benzodiazepine compounds and their use as pharmaceuticals |
EP0454436A1 (en) * | 1990-04-25 | 1991-10-30 | Lilly Industries Limited | Pharmaceutical compounds |
AU668159B2 (en) * | 1992-05-29 | 1996-04-26 | Lilly Industries Limited | Pharmaceutical compounds |
US6271225B1 (en) | 1997-09-02 | 2001-08-07 | Welfide Corporation | Fused thiophene compounds and medicinal use thereof |
EP1016664A4 (en) * | 1997-09-02 | 2001-01-24 | Yoshitomi Pharmaceutical | Fused thiophene compounds and medicinal use thereof |
US6455521B1 (en) | 1997-09-02 | 2002-09-24 | Mitsubishi Pharma Corporation | Condensed thiophene compounds and pharmaceutical use thereof |
EP1016664A1 (en) * | 1997-09-02 | 2000-07-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused thiophene compounds and medicinal use thereof |
EP1669359A1 (en) * | 2002-06-20 | 2006-06-14 | Adamed SP. Z O.O. | A process for the preparation of olanzapine and an intermediate therefor |
WO2004000847A1 (en) * | 2002-06-20 | 2003-12-31 | Adamed Sp. Z O.O. | A process for the preparation of olanzapine and an intermediate therefor |
HRP20041075B1 (en) * | 2002-06-20 | 2008-05-31 | Adamed Sp.Z.O.O. | A process for the preparation of olanzapine and an intermediate therefor |
CN100338069C (en) * | 2002-06-20 | 2007-09-19 | 阿达梅德公司 | Process for the preparation of olanzapine and an intermediate therefor |
WO2004006933A2 (en) | 2002-07-15 | 2004-01-22 | Krka, D.D., Novo Mesto | Crystal forms of olanzapine and processes for their preparation |
WO2004065390A1 (en) * | 2003-01-17 | 2004-08-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of olanzapine |
EA007950B1 (en) * | 2003-01-17 | 2007-02-27 | Крка, Товарна Здравил, Д.Д., Ново Место | Process and intermediates for the preparation of olanzapine |
DE10301923B3 (en) * | 2003-01-17 | 2004-09-16 | Krka Tovarna Zdravil, D.D. | Process and intermediates for the production of olanzapine |
US7498433B2 (en) | 2003-01-17 | 2009-03-03 | Krka, Tovarna Zdravil, D.D. | Process and intermediates for the preparation of olanzapine |
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
WO2005090359A2 (en) | 2004-03-18 | 2005-09-29 | Lek Pharmaceuticals D.D. | Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof |
WO2011009831A1 (en) | 2009-07-20 | 2011-01-27 | Lek Pharmaceuticals D.D. | Process for the purification of olanzapine |
EP2292624A1 (en) | 2009-07-20 | 2011-03-09 | LEK Pharmaceuticals d.d. | Process for the purification of olanzapine |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19951123 |