SE7513185L - PROCEDURE FOR THE PREPARATION OF TIENOBENSODIAZEPINES - Google Patents

PROCEDURE FOR THE PREPARATION OF TIENOBENSODIAZEPINES

Info

Publication number
SE7513185L
SE7513185L SE7513185A SE7513185A SE7513185L SE 7513185 L SE7513185 L SE 7513185L SE 7513185 A SE7513185 A SE 7513185A SE 7513185 A SE7513185 A SE 7513185A SE 7513185 L SE7513185 L SE 7513185L
Authority
SE
Sweden
Prior art keywords
tienobensodiazepines
procedure
preparation
piperazino
benzodiazepines
Prior art date
Application number
SE7513185A
Other languages
Swedish (sv)
Other versions
SE421209B (en
Inventor
J K Chakrabarti
D E Tupper
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10459213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE7513185(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of SE7513185L publication Critical patent/SE7513185L/en
Publication of SE421209B publication Critical patent/SE421209B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Thieno¢1,5!benzodiazepines having useful CNS activity containing the novel tricyclic ring system : the 10-position being substituted by an amino, preferably a piperazino, group.
SE7513185A 1974-11-26 1975-11-24 ANALOGY PROCEDURE FOR THE PREPARATION OF TIENOBENZODIAZEPINES SE421209B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51240/74A GB1533235A (en) 1974-11-26 1974-11-26 Benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
SE7513185L true SE7513185L (en) 1976-05-27
SE421209B SE421209B (en) 1981-12-07

Family

ID=10459213

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7513185A SE421209B (en) 1974-11-26 1975-11-24 ANALOGY PROCEDURE FOR THE PREPARATION OF TIENOBENZODIAZEPINES
SE7812194A SE429045B (en) 1974-11-26 1978-11-27 INTERMEDIATE FOR USE IN THE PREPARATION OF TIENOBENZODIAZEPINES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7812194A SE429045B (en) 1974-11-26 1978-11-27 INTERMEDIATE FOR USE IN THE PREPARATION OF TIENOBENZODIAZEPINES

Country Status (30)

Country Link
JP (1) JPS6044314B2 (en)
AR (1) AR221203A1 (en)
AT (1) AT351547B (en)
AU (1) AU506340B2 (en)
BE (1) BE835932A (en)
BG (1) BG29573A3 (en)
CA (1) CA1075687A (en)
CH (2) CH613454A5 (en)
CS (1) CS236753B2 (en)
DD (1) DD123343A5 (en)
DE (1) DE2552403C2 (en)
DK (1) DK146887C (en)
ES (1) ES443011A1 (en)
FR (1) FR2292479A1 (en)
GB (1) GB1533235A (en)
HK (1) HK58681A (en)
HU (1) HU172493B (en)
IE (1) IE42564B1 (en)
IL (1) IL48502A (en)
KE (1) KE3163A (en)
MY (1) MY8200149A (en)
NL (1) NL186088C (en)
NZ (1) NZ179335A (en)
PH (2) PH11669A (en)
PL (1) PL100135B1 (en)
RO (1) RO69912A (en)
SE (2) SE421209B (en)
SU (2) SU629879A3 (en)
YU (1) YU298375A (en)
ZA (1) ZA757344B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62792A (en) * 1980-05-07 1985-02-28 Byk Gulden Lomberg Chem Fab Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
DE69329887T2 (en) * 1992-05-29 2001-05-23 Eli Lilly And Co., Ltd. Thienobenzodiazepine derivatives for the treatment of disorders of the central nervous system
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
AU700078B2 (en) * 1995-11-01 1998-12-17 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
AU739385B2 (en) * 1997-09-02 2001-10-11 Mitsubishi Pharma Corporation Condensed thiophene compounds and pharmaceutical use thereof
PL199016B1 (en) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Method of manufacture of alanzapine, new derivative of n-demethyl olanzapine and method of manufacture of new derivative of n-demethyl olanzapine
SI21270A (en) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Crystal forms of olanzapine and procedures for their preparation
DE10301923B3 (en) 2003-01-17 2004-09-16 Krka Tovarna Zdravil, D.D. Process and intermediates for the production of olanzapine
AR047460A1 (en) * 2004-01-27 2006-01-18 Synthon Bv PROCESS FOR THE MANUFACTURE OF 2-METHYL-4- (4-METHYL-1-PIPERAZINYL) ACETATE -10H-TIENO [2,3-B] [1,5] BENZODIAZEPIN (OLANZAPINE ACETATE)
AR048272A1 (en) 2004-03-18 2006-04-12 Lek Pharmaceuticals SYNTHESIS OF 2 METHYL - 4- (4- METHYL -1- PIPERAZINIL) - 10 H- TIENO (2,3-B) (1,5) BENZODIAZEPIN AND ITS SALTS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF MENTAL DISEASES.
RU2485125C2 (en) * 2004-06-30 2013-06-20 Эсерсис, Инк. SUBSTITUTED AZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING DISEASES, DISORDERS AND/OR PATHOLOGICAL CONDITIONS WHEREIN 5HT2c-RECEPTOR FUNCTION MODULATION IS DESIRABLE
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine

Also Published As

Publication number Publication date
SU629879A3 (en) 1978-10-25
NL186088C (en) 1990-09-17
IE42564L (en) 1976-05-26
SE421209B (en) 1981-12-07
DK524175A (en) 1976-05-27
HU172493B (en) 1978-09-28
JPS5176296A (en) 1976-07-01
BG29573A3 (en) 1980-12-12
DE2552403A1 (en) 1976-08-12
DK146887B (en) 1984-01-30
HK58681A (en) 1981-12-04
RO69912A (en) 1980-08-15
DE2552403C2 (en) 1986-06-19
YU298375A (en) 1982-10-31
DK146887C (en) 1984-07-09
NZ179335A (en) 1978-11-13
KE3163A (en) 1981-10-16
JPS6044314B2 (en) 1985-10-02
GB1533235A (en) 1978-11-22
ES443011A1 (en) 1977-07-01
AU506340B2 (en) 1979-12-20
SE429045B (en) 1983-08-08
CS236753B2 (en) 1985-05-15
CH613455A5 (en) 1979-09-28
DD123343A5 (en) 1976-12-12
AU8685875A (en) 1977-05-26
SE7812194L (en) 1978-11-27
AR221203A1 (en) 1981-01-15
PH24534A (en) 1990-08-03
PL100135B1 (en) 1978-09-30
AT351547B (en) 1979-07-25
ZA757344B (en) 1976-11-24
BE835932A (en) 1976-05-25
CA1075687A (en) 1980-04-15
ATA898275A (en) 1979-01-15
FR2292479A1 (en) 1976-06-25
FR2292479B1 (en) 1978-07-28
CH613454A5 (en) 1979-09-28
IL48502A0 (en) 1976-01-30
PH11669A (en) 1978-05-19
IE42564B1 (en) 1980-09-10
MY8200149A (en) 1982-12-31
NL7513833A (en) 1976-05-31
NL186088B (en) 1990-04-17
IL48502A (en) 1980-01-31
SU626702A3 (en) 1978-09-30

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