SE7812194L - PROCEDURE FOR THE PREPARATION OF TIENOBENSODIAZEPINES - Google Patents

PROCEDURE FOR THE PREPARATION OF TIENOBENSODIAZEPINES

Info

Publication number
SE7812194L
SE7812194L SE7812194A SE7812194A SE7812194L SE 7812194 L SE7812194 L SE 7812194L SE 7812194 A SE7812194 A SE 7812194A SE 7812194 A SE7812194 A SE 7812194A SE 7812194 L SE7812194 L SE 7812194L
Authority
SE
Sweden
Prior art keywords
tienobensodiazepines
procedure
preparation
piperazino
benzodiazepines
Prior art date
Application number
SE7812194A
Other languages
Swedish (sv)
Other versions
SE429045B (en
Inventor
J K Chakrabarti
D E Tupper
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10459213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE7812194(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of SE7812194L publication Critical patent/SE7812194L/en
Publication of SE429045B publication Critical patent/SE429045B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Thieno¢1,5!benzodiazepines having useful CNS activity containing the novel tricyclic ring system : the 10-position being substituted by an amino, preferably a piperazino, group.
SE7812194A 1974-11-26 1978-11-27 INTERMEDIATE FOR USE IN THE PREPARATION OF TIENOBENZODIAZEPINES SE429045B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51240/74A GB1533235A (en) 1974-11-26 1974-11-26 Benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
SE7812194L true SE7812194L (en) 1978-11-27
SE429045B SE429045B (en) 1983-08-08

Family

ID=10459213

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7513185A SE421209B (en) 1974-11-26 1975-11-24 ANALOGY PROCEDURE FOR THE PREPARATION OF TIENOBENZODIAZEPINES
SE7812194A SE429045B (en) 1974-11-26 1978-11-27 INTERMEDIATE FOR USE IN THE PREPARATION OF TIENOBENZODIAZEPINES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7513185A SE421209B (en) 1974-11-26 1975-11-24 ANALOGY PROCEDURE FOR THE PREPARATION OF TIENOBENZODIAZEPINES

Country Status (30)

Country Link
JP (1) JPS6044314B2 (en)
AR (1) AR221203A1 (en)
AT (1) AT351547B (en)
AU (1) AU506340B2 (en)
BE (1) BE835932A (en)
BG (1) BG29573A3 (en)
CA (1) CA1075687A (en)
CH (2) CH613455A5 (en)
CS (1) CS236753B2 (en)
DD (1) DD123343A5 (en)
DE (1) DE2552403C2 (en)
DK (1) DK146887C (en)
ES (1) ES443011A1 (en)
FR (1) FR2292479A1 (en)
GB (1) GB1533235A (en)
HK (1) HK58681A (en)
HU (1) HU172493B (en)
IE (1) IE42564B1 (en)
IL (1) IL48502A (en)
KE (1) KE3163A (en)
MY (1) MY8200149A (en)
NL (1) NL186088C (en)
NZ (1) NZ179335A (en)
PH (2) PH11669A (en)
PL (1) PL100135B1 (en)
RO (1) RO69912A (en)
SE (2) SE421209B (en)
SU (2) SU629879A3 (en)
YU (1) YU298375A (en)
ZA (1) ZA757344B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62792A (en) * 1980-05-07 1985-02-28 Byk Gulden Lomberg Chem Fab Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
GB9009229D0 (en) 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
NZ247703A (en) * 1992-05-29 1995-07-26 Lilly Industries Ltd Thienobenzdiazepine derivatives and medicaments thereof
CA2234641A1 (en) * 1995-11-01 1997-05-09 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
HUP0003718A3 (en) 1997-09-02 2002-11-28 Welfide Corp Fused thiophene derivatives, use thereof and pharmaceutical compositions containing them
PL199016B1 (en) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Method of manufacture of alanzapine, new derivative of n-demethyl olanzapine and method of manufacture of new derivative of n-demethyl olanzapine
SI21270A (en) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Crystal forms of olanzapine and procedures for their preparation
DE10301923B3 (en) * 2003-01-17 2004-09-16 Krka Tovarna Zdravil, D.D. Process and intermediates for the production of olanzapine
AR047460A1 (en) * 2004-01-27 2006-01-18 Synthon Bv PROCESS FOR THE MANUFACTURE OF 2-METHYL-4- (4-METHYL-1-PIPERAZINYL) ACETATE -10H-TIENO [2,3-B] [1,5] BENZODIAZEPIN (OLANZAPINE ACETATE)
AR048272A1 (en) 2004-03-18 2006-04-12 Lek Pharmaceuticals SYNTHESIS OF 2 METHYL - 4- (4- METHYL -1- PIPERAZINIL) - 10 H- TIENO (2,3-B) (1,5) BENZODIAZEPIN AND ITS SALTS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF MENTAL DISEASES.
CN1980710B (en) * 2004-06-30 2013-06-12 阿特西斯公司 Substituted azepine derivatives as serotonin receptor modulators
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine

Also Published As

Publication number Publication date
CH613454A5 (en) 1979-09-28
AR221203A1 (en) 1981-01-15
IE42564L (en) 1976-05-26
AU506340B2 (en) 1979-12-20
NL7513833A (en) 1976-05-31
PH11669A (en) 1978-05-19
IE42564B1 (en) 1980-09-10
SE7513185L (en) 1976-05-27
PH24534A (en) 1990-08-03
JPS6044314B2 (en) 1985-10-02
DD123343A5 (en) 1976-12-12
FR2292479A1 (en) 1976-06-25
SE421209B (en) 1981-12-07
ZA757344B (en) 1976-11-24
IL48502A0 (en) 1976-01-30
YU298375A (en) 1982-10-31
NZ179335A (en) 1978-11-13
KE3163A (en) 1981-10-16
DK146887B (en) 1984-01-30
DE2552403C2 (en) 1986-06-19
DK524175A (en) 1976-05-27
AT351547B (en) 1979-07-25
MY8200149A (en) 1982-12-31
CH613455A5 (en) 1979-09-28
HK58681A (en) 1981-12-04
SU626702A3 (en) 1978-09-30
SE429045B (en) 1983-08-08
CS236753B2 (en) 1985-05-15
DK146887C (en) 1984-07-09
NL186088B (en) 1990-04-17
JPS5176296A (en) 1976-07-01
HU172493B (en) 1978-09-28
NL186088C (en) 1990-09-17
FR2292479B1 (en) 1978-07-28
PL100135B1 (en) 1978-09-30
BE835932A (en) 1976-05-25
RO69912A (en) 1980-08-15
IL48502A (en) 1980-01-31
CA1075687A (en) 1980-04-15
ATA898275A (en) 1979-01-15
GB1533235A (en) 1978-11-22
ES443011A1 (en) 1977-07-01
AU8685875A (en) 1977-05-26
SU629879A3 (en) 1978-10-25
DE2552403A1 (en) 1976-08-12
BG29573A3 (en) 1980-12-12

Similar Documents

Publication Publication Date Title
SE7812194L (en) PROCEDURE FOR THE PREPARATION OF TIENOBENSODIAZEPINES
GB1459226A (en) Core assembly for moulding apparatus
ES422001A1 (en) Imidazo {8 5,1-f{9 -as-triazines
IE40046L (en) Benzimidazole derivatives
ES442864A1 (en) Antireproductive imidazo{8 2,1-a{9 isoquinoline compounds
IE42109L (en) Benzimidazole-2-carbamate derivatives.
IE40141L (en) Benzimidazole-2-carbamate derivatives
ES444752A1 (en) Bead rings of pneumatic tires
ES430106A1 (en) 7-(Halomethylaryl)acetamidocephalosporin derivatives
AR217034A1 (en) PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2-CHLORO-6H-TIENO- (3,2-F) -C-TRIAZOL- (4,3-A) (, 4) DIAZEPINE
ES441266A1 (en) 7-Substituted benzofuran derivatives
ES430763A1 (en) 7-(Cyanomethylaryl)acetamide-cephalosporin derivatives
SE419989B (en) ANALOGY PROCEDURE FOR PREPARATION OF S-TRIOZOLO (4,3-A) (1,5) BENZODIAZEPINES
ES423586A1 (en) 1,4-Dithiino(2,3-c)pyrrole derivatives
EG14087A (en) Process for preparing of 7,8,9,10-tetrahydrothieno(3,2-e)pyrido(4,3-b)indole compounds and their medicinal use
ES411710A1 (en) Nitroimidazolyl-triazolo-pyridazine compounds
ES425444A1 (en) Bis-(polyhalogenoanilino)-anthraquinones
GB1338365A (en) Process for preparing 7-chloro-1-methyl-5-phenyl-2,3-dihydro- 1h-1,4-benzo-diazepine-2-one
ES426023A1 (en) New 6-aza-1,4 -benzodiazepine
JPS5283931A (en) Antigen of catechol amine derivatives
CH542211A (en) Process for the preparation of amino dihydro-10,11 dibenzo (b, f) azepines
SU550823A1 (en) Common derivatives of 2-aryl-sabstituted 4,5,6,7-tetrahydroiso_or methanoiso)indols possessing sedative actionof central nervous system
AU488547B2 (en) Sulphur ring compounds
GB1333501A (en) Process for the preparation of 7-chlorobenzodiazepine de rivatives
PH10784A (en) Process for the production of 6-phenyl-4h-s-triazole(4,3-a)benzodiazepine

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 7812194-4

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7812194-4

Format of ref document f/p: F