RU2119480C1 - Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли - Google Patents

Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли Download PDF

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Publication number
RU2119480C1
RU2119480C1 RU94004975A RU94004975A RU2119480C1 RU 2119480 C1 RU2119480 C1 RU 2119480C1 RU 94004975 A RU94004975 A RU 94004975A RU 94004975 A RU94004975 A RU 94004975A RU 2119480 C1 RU2119480 C1 RU 2119480C1
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RU
Russia
Prior art keywords
mmol
phenyl
acid
substituted
unbranched
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RU94004975A
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English (en)
Russian (ru)
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RU94004975A (ru
Inventor
Мюллер Ульрих
Дрессель Юрген
Фай Петер
Ханко Рудольф
Хюбш Вальтер
Крэмер Томас
Мюллер-Глиманн Маттиас
Бойк Мартин
Кацда Станислав
Вольфейль Штефан
Кнорр Андреас
Сташ Йоганнес-Петер
Цайсс Зигфрид
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Байер Аг
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Publication of RU94004975A publication Critical patent/RU94004975A/ru
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Publication of RU2119480C1 publication Critical patent/RU2119480C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU94004975A 1993-02-15 1994-02-14 Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли RU2119480C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4304455.7 1993-02-15
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4304455.7 1993-02-15

Publications (2)

Publication Number Publication Date
RU94004975A RU94004975A (ru) 1995-11-10
RU2119480C1 true RU2119480C1 (ru) 1998-09-27

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Family Applications (1)

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RU94004975A RU2119480C1 (ru) 1993-02-15 1994-02-14 Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли

Country Status (25)

Country Link
US (1) US5395840A (enExample)
EP (1) EP0611767B1 (enExample)
JP (1) JPH06293741A (enExample)
KR (1) KR940019708A (enExample)
CN (1) CN1057085C (enExample)
AT (1) ATE196141T1 (enExample)
AU (1) AU672262B2 (enExample)
CA (1) CA2115536C (enExample)
CZ (1) CZ289096B6 (enExample)
DE (2) DE4304455A1 (enExample)
DK (1) DK0611767T3 (enExample)
ES (1) ES2151908T3 (enExample)
FI (1) FI106716B (enExample)
GR (1) GR3034957T3 (enExample)
IL (1) IL108625A (enExample)
MY (1) MY131595A (enExample)
NO (1) NO300810B1 (enExample)
NZ (1) NZ250864A (enExample)
PH (1) PH30172A (enExample)
PL (1) PL177834B1 (enExample)
PT (1) PT611767E (enExample)
RU (1) RU2119480C1 (enExample)
SK (1) SK15294A3 (enExample)
UA (1) UA35574C2 (enExample)
ZA (1) ZA94984B (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
RU2246490C2 (ru) * 1999-05-29 2005-02-20 Байер Акциенгезельшафт Замещенные амиды фенилциклогексанкарбоновой кислоты, промежуточные соединения и лекарственное средство на их основе

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TW300219B (enExample) * 1991-09-14 1997-03-11 Hoechst Ag
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
JP2002507996A (ja) 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
JP2002529537A (ja) * 1998-11-17 2002-09-10 ビーエーエスエフ アクチェンゲゼルシャフト ２−フェニルベンズイミダゾールおよび２−フェニルインドール、その製造方法ならびに使用
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
WO2007129707A1 (ja) 2006-05-09 2007-11-15 Mitsubishi Gas Chemical Company, Inc. ４－（４－アルキルシクロヘキシル）ベンズアルデヒド
GEP20207129B (en) 2009-06-17 2020-07-10 Vertex Pharma Inhibitors of influenza viruses replication
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EA025186B1 (ru) 2012-06-29 2016-11-30 Пфайзер Инк. НОВЫЕ 4-(ЗАМЕЩЕННЫЙ АМИНО)-7Н-ПИРРОЛО[2,3-d]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LRRK2
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
HUE038820T2 (hu) 2013-11-13 2018-11-28 Vertex Pharma Eljárás influenzavírusok replikációjának inhibitorai elõállítására
PT3068776T (pt) 2013-11-13 2019-08-26 Vertex Pharma Inibidores da replicação de vírus da gripe
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
WO2023171679A1 (ja) * 2022-03-08 2023-09-14 Ｋｊケミカルズ株式会社 高安全性アミド化合物を含有する組成物

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US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
DE69130192T2 (de) * 1990-06-08 1999-03-25 Hoechst Marion Roussel, Puteaux Benzimidazol-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246490C2 (ru) * 1999-05-29 2005-02-20 Байер Акциенгезельшафт Замещенные амиды фенилциклогексанкарбоновой кислоты, промежуточные соединения и лекарственное средство на их основе
RU2246490C9 (ru) * 1999-05-29 2005-09-20 Байер Акциенгезельшафт Замещенные амиды фенилциклогексанкарбоновой кислоты, промежуточные соединения и лекарственное средство на их основе

Also Published As

Publication number Publication date
KR940019708A (ko) 1994-09-14
AU5480794A (en) 1994-08-18
CN1057085C (zh) 2000-10-04
ATE196141T1 (de) 2000-09-15
ES2151908T3 (es) 2001-01-16
FI940659A7 (fi) 1994-08-16
DK0611767T3 (da) 2001-01-02
NO940506D0 (no) 1994-02-14
EP0611767A1 (de) 1994-08-24
NO940506L (enExample) 1994-08-16
FI106716B (fi) 2001-03-30
CA2115536A1 (en) 1994-08-16
UA35574C2 (uk) 2001-04-16
EP0611767B1 (de) 2000-09-06
FI940659A0 (fi) 1994-02-11
US5395840A (en) 1995-03-07
PL177834B1 (pl) 2000-01-31
DE59409509D1 (de) 2000-10-12
PH30172A (en) 1997-01-21
PT611767E (pt) 2001-02-28
JPH06293741A (ja) 1994-10-21
CZ32994A3 (en) 1994-08-17
MY131595A (en) 2007-08-30
IL108625A0 (en) 1994-05-30
CA2115536C (en) 2004-11-02
NZ250864A (en) 1995-03-28
PL302213A1 (en) 1994-08-22
ZA94984B (en) 1994-08-24
CN1108257A (zh) 1995-09-13
IL108625A (en) 1997-09-30
DE4304455A1 (de) 1994-08-18
GR3034957T3 (en) 2001-02-28
AU672262B2 (en) 1996-09-26
NO300810B1 (no) 1997-07-28
CZ289096B6 (cs) 2001-11-14
SK15294A3 (en) 1994-12-07

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