RU2119480C1 - Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли - Google Patents

Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли Download PDF

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Publication number
RU2119480C1
RU2119480C1 RU94004975A RU94004975A RU2119480C1 RU 2119480 C1 RU2119480 C1 RU 2119480C1 RU 94004975 A RU94004975 A RU 94004975A RU 94004975 A RU94004975 A RU 94004975A RU 2119480 C1 RU2119480 C1 RU 2119480C1
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RU
Russia
Prior art keywords
mmol
phenyl
acid
substituted
unbranched
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RU94004975A
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English (en)
Russian (ru)
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RU94004975A (ru
Inventor
Мюллер Ульрих
Дрессель Юрген
Фай Петер
Ханко Рудольф
Хюбш Вальтер
Крэмер Томас
Мюллер-Глиманн Маттиас
Бойк Мартин
Кацда Станислав
Вольфейль Штефан
Кнорр Андреас
Сташ Йоганнес-Петер
Цайсс Зигфрид
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Байер Аг
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Publication of RU94004975A publication Critical patent/RU94004975A/ru
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Publication of RU2119480C1 publication Critical patent/RU2119480C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU94004975A 1993-02-15 1994-02-14 Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли RU2119480C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4304455.7 1993-02-15
DE4304455.7 1993-02-15
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate

Publications (2)

Publication Number Publication Date
RU94004975A RU94004975A (ru) 1995-11-10
RU2119480C1 true RU2119480C1 (ru) 1998-09-27

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RU94004975A RU2119480C1 (ru) 1993-02-15 1994-02-14 Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли

Country Status (25)

Country Link
US (1) US5395840A (enExample)
EP (1) EP0611767B1 (enExample)
JP (1) JPH06293741A (enExample)
KR (1) KR940019708A (enExample)
CN (1) CN1057085C (enExample)
AT (1) ATE196141T1 (enExample)
AU (1) AU672262B2 (enExample)
CA (1) CA2115536C (enExample)
CZ (1) CZ289096B6 (enExample)
DE (2) DE4304455A1 (enExample)
DK (1) DK0611767T3 (enExample)
ES (1) ES2151908T3 (enExample)
FI (1) FI106716B (enExample)
GR (1) GR3034957T3 (enExample)
IL (1) IL108625A (enExample)
MY (1) MY131595A (enExample)
NO (1) NO300810B1 (enExample)
NZ (1) NZ250864A (enExample)
PH (1) PH30172A (enExample)
PL (1) PL177834B1 (enExample)
PT (1) PT611767E (enExample)
RU (1) RU2119480C1 (enExample)
SK (1) SK15294A3 (enExample)
UA (1) UA35574C2 (enExample)
ZA (1) ZA94984B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246490C2 (ru) * 1999-05-29 2005-02-20 Байер Акциенгезельшафт Замещенные амиды фенилциклогексанкарбоновой кислоты, промежуточные соединения и лекарственное средство на их основе

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TW300219B (enExample) * 1991-09-14 1997-03-11 Hoechst Ag
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
EP0994877A1 (en) 1997-07-03 2000-04-26 Du Pont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
HRP20010451A2 (en) * 1998-11-17 2003-04-30 Basf Ag 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
EP2017252B1 (en) 2006-05-09 2012-12-19 Mitsubishi Gas Chemical Company, Inc. Preparation of 4-(4-alkylcyclohexyl)benzaldehyde
AU2010262905B2 (en) 2009-06-17 2015-04-16 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
KR20140014110A (ko) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
EP2723717A2 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
MX2013015058A (es) 2011-06-24 2014-01-20 Amgen Inc Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos.
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3255049A1 (en) 2012-06-29 2017-12-13 Pfizer Inc Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
EP3068782B1 (en) 2013-11-13 2018-05-23 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
ES2741444T3 (es) 2013-11-13 2020-02-11 Vertex Pharma Inhibidores de la replicación de virus de la gripe
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3350178B1 (en) 2015-09-14 2021-10-20 Pfizer Inc. Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors

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Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
AU7820091A (en) * 1990-06-08 1991-12-12 Roussel-Uclaf New benzimidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246490C2 (ru) * 1999-05-29 2005-02-20 Байер Акциенгезельшафт Замещенные амиды фенилциклогексанкарбоновой кислоты, промежуточные соединения и лекарственное средство на их основе
RU2246490C9 (ru) * 1999-05-29 2005-09-20 Байер Акциенгезельшафт Замещенные амиды фенилциклогексанкарбоновой кислоты, промежуточные соединения и лекарственное средство на их основе

Also Published As

Publication number Publication date
JPH06293741A (ja) 1994-10-21
DE59409509D1 (de) 2000-10-12
NZ250864A (en) 1995-03-28
CA2115536C (en) 2004-11-02
GR3034957T3 (en) 2001-02-28
US5395840A (en) 1995-03-07
CN1108257A (zh) 1995-09-13
CZ289096B6 (cs) 2001-11-14
ES2151908T3 (es) 2001-01-16
KR940019708A (ko) 1994-09-14
EP0611767A1 (de) 1994-08-24
PT611767E (pt) 2001-02-28
NO940506D0 (no) 1994-02-14
CZ32994A3 (en) 1994-08-17
UA35574C2 (uk) 2001-04-16
ZA94984B (en) 1994-08-24
FI106716B (fi) 2001-03-30
ATE196141T1 (de) 2000-09-15
IL108625A (en) 1997-09-30
SK15294A3 (en) 1994-12-07
MY131595A (en) 2007-08-30
AU5480794A (en) 1994-08-18
CA2115536A1 (en) 1994-08-16
PL177834B1 (pl) 2000-01-31
CN1057085C (zh) 2000-10-04
DE4304455A1 (de) 1994-08-18
NO940506L (enExample) 1994-08-16
AU672262B2 (en) 1996-09-26
DK0611767T3 (da) 2001-01-02
NO300810B1 (no) 1997-07-28
EP0611767B1 (de) 2000-09-06
FI940659A0 (fi) 1994-02-11
PH30172A (en) 1997-01-21
PL302213A1 (en) 1994-08-22
FI940659A7 (fi) 1994-08-16
IL108625A0 (en) 1994-05-30

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