ES2151908T3 - Derivados del acido fenil-ciclohexano-carboxilico sustituidos con heterociclo. - Google Patents

Derivados del acido fenil-ciclohexano-carboxilico sustituidos con heterociclo.

Info

Publication number
ES2151908T3
ES2151908T3 ES94101543T ES94101543T ES2151908T3 ES 2151908 T3 ES2151908 T3 ES 2151908T3 ES 94101543 T ES94101543 T ES 94101543T ES 94101543 T ES94101543 T ES 94101543T ES 2151908 T3 ES2151908 T3 ES 2151908T3
Authority
ES
Spain
Prior art keywords
derivatives
cyclhexan
heterociclo
phenyl
acid substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94101543T
Other languages
English (en)
Inventor
Ulrich E Dr Muller
Jurgen Dr Dressel
Peter Dr Fey
Rudolf H Dr Hanko
Walter Dr Hubsch
Thomas Dr Kramer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2151908T3 publication Critical patent/ES2151908T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

DERIVADOS DE LA FORMULA (I) EN LA CUAL B Y D FORMAN JUNTOS UN RESTO DE LA FORMULA REPRESENTADA, REPRESENTANDO T UN RESTO DE LA FORMULA REPRESENTADA O TETRAZOLILO. LAS COMBINACIONES SE PUEDEN EMPLEAR COMO SUSTANCIAS ACTIVAS EN MEDICAMENTOS PARA EL TRATAMIENTO DE PRESION ARTERIAL ELEVADA Y ATEROESCLOROSIS.
ES94101543T 1993-02-15 1994-02-02 Derivados del acido fenil-ciclohexano-carboxilico sustituidos con heterociclo. Expired - Lifetime ES2151908T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4304455A DE4304455A1 (de) 1993-02-15 1993-02-15 Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate

Publications (1)

Publication Number Publication Date
ES2151908T3 true ES2151908T3 (es) 2001-01-16

Family

ID=6480447

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94101543T Expired - Lifetime ES2151908T3 (es) 1993-02-15 1994-02-02 Derivados del acido fenil-ciclohexano-carboxilico sustituidos con heterociclo.

Country Status (25)

Country Link
US (1) US5395840A (es)
EP (1) EP0611767B1 (es)
JP (1) JPH06293741A (es)
KR (1) KR940019708A (es)
CN (1) CN1057085C (es)
AT (1) ATE196141T1 (es)
AU (1) AU672262B2 (es)
CA (1) CA2115536C (es)
CZ (1) CZ289096B6 (es)
DE (2) DE4304455A1 (es)
DK (1) DK0611767T3 (es)
ES (1) ES2151908T3 (es)
FI (1) FI106716B (es)
GR (1) GR3034957T3 (es)
IL (1) IL108625A (es)
MY (1) MY131595A (es)
NO (1) NO300810B1 (es)
NZ (1) NZ250864A (es)
PH (1) PH30172A (es)
PL (1) PL177834B1 (es)
PT (1) PT611767E (es)
RU (1) RU2119480C1 (es)
SK (1) SK15294A3 (es)
UA (1) UA35574C2 (es)
ZA (1) ZA94984B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW300219B (es) * 1991-09-14 1997-03-11 Hoechst Ag
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) * 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
SK179899A3 (en) 1997-07-03 2001-12-03 Du Pont Pharm Co Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
BR9915381A (pt) * 1998-11-17 2001-08-14 Basf Ag Uso de um composto, e, composto
DE19924818A1 (de) 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
DE19924819A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren)
DE10044792A1 (de) 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
KR101415348B1 (ko) * 2006-05-09 2014-07-04 미츠비시 가스 가가쿠 가부시키가이샤 4-(4-알킬시클로헥실)벤즈알데히드
JP5721706B2 (ja) 2009-06-17 2015-05-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルス複製の阻害剤
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
AU2013282869B2 (en) 2012-06-29 2015-12-24 Pfizer Inc. Novel 4-(substituted-amino)-7H-pyrrolo[2,3-d]pyrimidines as LRRK2 inhibitors
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
PT3068782T (pt) 2013-11-13 2018-10-08 Vertex Pharma Métodos de preparação de inibidores da replicação de vírus da gripe
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
WO2015092592A1 (en) 2013-12-17 2015-06-25 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
DK0461039T3 (da) * 1990-06-08 1999-06-14 Hoechst Marion Roussel Inc Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4031635A1 (de) * 1990-10-05 1992-04-09 Thomae Gmbh Dr K Substituierte 1-benzyl-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate

Also Published As

Publication number Publication date
CN1057085C (zh) 2000-10-04
SK15294A3 (en) 1994-12-07
IL108625A0 (en) 1994-05-30
KR940019708A (ko) 1994-09-14
NO300810B1 (no) 1997-07-28
AU672262B2 (en) 1996-09-26
CA2115536C (en) 2004-11-02
EP0611767A1 (de) 1994-08-24
PL302213A1 (en) 1994-08-22
CN1108257A (zh) 1995-09-13
EP0611767B1 (de) 2000-09-06
FI940659A0 (fi) 1994-02-11
DK0611767T3 (da) 2001-01-02
RU2119480C1 (ru) 1998-09-27
PL177834B1 (pl) 2000-01-31
US5395840A (en) 1995-03-07
FI940659A7 (fi) 1994-08-16
GR3034957T3 (en) 2001-02-28
MY131595A (en) 2007-08-30
CZ32994A3 (en) 1994-08-17
CA2115536A1 (en) 1994-08-16
UA35574C2 (uk) 2001-04-16
FI106716B (fi) 2001-03-30
JPH06293741A (ja) 1994-10-21
AU5480794A (en) 1994-08-18
NO940506D0 (no) 1994-02-14
DE59409509D1 (de) 2000-10-12
ZA94984B (en) 1994-08-24
PH30172A (en) 1997-01-21
NZ250864A (en) 1995-03-28
CZ289096B6 (cs) 2001-11-14
ATE196141T1 (de) 2000-09-15
PT611767E (pt) 2001-02-28
DE4304455A1 (de) 1994-08-18
IL108625A (en) 1997-09-30
NO940506L (es) 1994-08-16

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